Lrrc8c (leucine rich repeat containing 8 VRAC subunit C) - Rat Genome Database

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Gene: Lrrc8c (leucine rich repeat containing 8 VRAC subunit C) Heterocephalus glaber
Analyze
Symbol: Lrrc8c
Name: leucine rich repeat containing 8 VRAC subunit C
RGD ID: 18905616
Description: ENCODES a protein that exhibits volume-sensitive anion channel activity (ortholog); INVOLVED IN aspartate transmembrane transport (ortholog); cellular response to osmotic stress (ortholog); cyclic-GMP-AMP transmembrane import across plasma membrane (ortholog); ASSOCIATED WITH multiple sclerosis (ortholog); FOUND IN cytoplasm (ortholog); endoplasmic reticulum (ortholog); monoatomic ion channel complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: leucine rich repeat containing 8 family member C; Leucine-rich repeat-containing protein 8C; volume-regulated anion channel subunit LRRC8C
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247428,009,901 - 8,096,652 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247428,010,849 - 8,096,567 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:21993625   PMID:22301074  


Genomics

Comparative Map Data
Lrrc8c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247428,009,901 - 8,096,652 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247428,010,849 - 8,096,567 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
LRRC8C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38189,615,824 - 89,719,533 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl189,633,072 - 89,769,903 (+)EnsemblGRCh38hg38GRCh38
GRCh37190,098,679 - 90,185,092 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36189,871,350 - 89,953,169 (+)NCBINCBI36Build 36hg18NCBI36
Celera188,344,351 - 88,430,780 (+)NCBICelera
Cytogenetic Map1p22.2NCBI
HuRef188,215,951 - 88,302,419 (+)NCBIHuRef
CHM1_1190,213,622 - 90,300,056 (+)NCBICHM1_1
T2T-CHM13v2.0189,459,056 - 89,562,765 (+)NCBIT2T-CHM13v2.0
Lrrc8c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395105,666,850 - 105,760,884 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5105,667,254 - 105,760,884 (+)EnsemblGRCm39 Ensembl
GRCm385105,519,345 - 105,613,018 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5105,519,388 - 105,613,018 (+)EnsemblGRCm38mm10GRCm38
MGSCv375105,948,490 - 106,037,973 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365105,759,773 - 105,849,256 (+)NCBIMGSCv36mm8
Celera5102,631,726 - 102,729,227 (+)NCBICelera
Cytogenetic Map5E5NCBI
cM Map550.68NCBI
Lrrc8c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8144,528,721 - 4,621,259 (-)NCBIGRCr8
mRatBN7.2144,223,901 - 4,315,590 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl144,227,832 - 4,315,249 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx144,224,741 - 4,312,023 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0145,524,900 - 5,612,184 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0144,230,446 - 4,317,709 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0145,283,655 - 5,378,738 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl145,283,647 - 5,378,726 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0145,274,372 - 5,369,435 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4145,306,227 - 5,393,820 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1145,306,353 - 5,393,463 (-)NCBI
Celera144,390,675 - 4,477,877 (-)NCBICelera
Cytogenetic Map14p22NCBI
Lrrc8c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554234,460,212 - 4,494,317 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554234,460,212 - 4,494,317 (-)NCBIChiLan1.0ChiLan1.0
LRRC8C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21137,298,993 - 137,386,330 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11136,454,826 - 136,542,198 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0192,299,691 - 92,384,733 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1191,001,695 - 91,134,865 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl191,105,551 - 91,138,447 (+)Ensemblpanpan1.1panPan2
LRRC8C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1658,895,769 - 58,932,729 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl658,899,996 - 58,932,729 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha661,605,421 - 61,690,225 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0659,407,523 - 59,492,055 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl659,409,555 - 59,493,796 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1658,981,235 - 59,065,445 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0658,934,585 - 59,019,172 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0659,414,770 - 59,499,275 (-)NCBIUU_Cfam_GSD_1.0
Lrrc8c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505899,823,337 - 99,897,484 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365379,049,944 - 9,124,619 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365379,050,495 - 9,124,649 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRRC8C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4126,957,105 - 127,037,216 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14126,957,099 - 127,079,042 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24138,996,955 - 139,119,829 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LRRC8C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12043,752,341 - 43,842,958 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2043,752,370 - 43,842,766 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603374,090,984 - 74,181,626 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000008781   ⟹   ENSHGLP00000008686
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247428,009,901 - 8,096,652 (-)Ensembl
RefSeq Acc Id: XM_004841304   ⟹   XP_004841361
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247428,010,849 - 8,096,567 (-)NCBI
RefSeq Acc Id: XM_004841305   ⟹   XP_004841362
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247428,010,849 - 8,096,492 (-)NCBI
RefSeq Acc Id: XM_021255414   ⟹   XP_021111073
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247428,010,849 - 8,076,022 (-)NCBI
RefSeq Acc Id: XM_021255415   ⟹   XP_021111074
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247428,010,849 - 8,076,021 (-)NCBI
RefSeq Acc Id: XM_021255416   ⟹   XP_021111075
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247428,010,849 - 8,071,424 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004841361 (Get FASTA)   NCBI Sequence Viewer  
  XP_004841362 (Get FASTA)   NCBI Sequence Viewer  
  XP_021111073 (Get FASTA)   NCBI Sequence Viewer  
  XP_021111074 (Get FASTA)   NCBI Sequence Viewer  
  XP_021111075 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB08359 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000008686
Reference Protein Sequences
RefSeq Acc Id: XP_004841361   ⟸   XM_004841304
- Peptide Label: isoform X2
- UniProtKB: G5BGE8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004841362   ⟸   XM_004841305
- Peptide Label: isoform X2
- UniProtKB: G5BGE8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021111073   ⟸   XM_021255414
- Peptide Label: isoform X1
RefSeq Acc Id: XP_021111074   ⟸   XM_021255415
- Peptide Label: isoform X2
- UniProtKB: G5BGE8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021111075   ⟸   XM_021255416
- Peptide Label: isoform X2
- UniProtKB: G5BGE8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000008686   ⟸   ENSHGLT00000008781


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000006264 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000008781 ENTREZGENE
Gene3D-CATH 3.80.10.10 UniProtKB/TrEMBL
InterPro Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/TrEMBL
  LRRC8_Pannexin-like UniProtKB/TrEMBL
KEGG Report hgl:101726711 UniProtKB/TrEMBL
NCBI Gene Lrrc8c ENTREZGENE
PANTHER PTHR48051 UniProtKB/TrEMBL
  VOLUME-REGULATED ANION CHANNEL SUBUNIT LRRC8C-LIKE UniProtKB/TrEMBL
Pfam LRR_8 UniProtKB/TrEMBL
  Pannexin_like UniProtKB/TrEMBL
PROSITE LRR UniProtKB/TrEMBL
SMART LRR_TYP UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/TrEMBL
UniProt G5BGE8 ENTREZGENE, UniProtKB/TrEMBL