Gene: Rps6kc1 (ribosomal protein S6 kinase C1) Rattus norvegicus
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Symbol:
Rps6kc1
Name:
ribosomal protein S6 kinase C1
RGD ID:
1306578
Description:
Predicted to enable ATP binding activity; phosphatidylinositol binding activity; and protein serine/threonine kinase activity. Predicted to be located in endosome; lysosome; and membrane. Predicted to be active in early endosome and postsynaptic density. Orthologous to human RPS6KC1 (ribosomal protein S6 kinase C1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type:
protein-coding
RefSeq Status:
VALIDATED
Previously known as:
LOC289342; ribosomal protein S6 kinase delta-1; ribosomal protein S6 kinase, 52kDa, polypeptide 1; ribosomal protein S6 kinase, polypeptide 1; ribosomal protein S6 kinase, polypeptide C1
RGD Orthologs
Alliance Orthologs
More Info
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More Info
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 13 104,877,296 - 105,021,490 (-) NCBI GRCr8 GRCr8 GRCr8 GRCr8 Ensembl 13 104,877,296 - 105,021,435 (-) Ensembl GRCr8 mRatBN7.2 13 102,346,160 - 102,491,000 (-) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 13 102,346,160 - 102,490,303 (-) Ensembl mRatBN7.2 UTH_Rnor_SHR_Utx 13 104,866,235 - 105,010,379 (-) NCBI UTH_Rnor_SHR_Utx UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 13 106,250,216 - 106,394,359 (-) NCBI UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 13 103,465,218 - 103,609,348 (-) NCBI UTH_Rnor_WKY_Bbb_1.0 UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 13 109,338,761 - 109,589,209 (-) NCBI Rnor_6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 13 109,338,762 - 109,483,891 (-) Ensembl rn6 Rnor6.0 Rnor_5.0 13 113,940,375 - 114,084,609 (-) NCBI Rnor_5.0 Rnor_5.0 rn5 RGSC_v3.4 13 106,842,538 - 106,989,914 (-) NCBI RGSC_v3.4 RGSC_v3.4 rn4 Celera 13 101,819,362 - 101,958,886 (-) NCBI Celera RGSC_v3.1 13 107,032,348 - 107,186,512 (-) NCBI Cytogenetic Map 13 q27 NCBI
JBrowse:
Imported Disease Annotations - ClinVar
Only show annotations with direct experimental evidence (0 objects hidden)
Rps6kc1 Rat (-)-epigallocatechin 3-gallate multiple interactions ISO RPS6KC1 (Homo sapiens) 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of RPS6KC1 mRNA CTD PMID:22079256 Rps6kc1 Rat 1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene multiple interactions ISO Rps6kc1 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Rps6kc1 Rat 1,2-dimethylhydrazine decreases expression ISO Rps6kc1 (Mus musculus) 6480464 1,2-Dimethylhydrazine results in decreased expression of RPS6KC1 mRNA CTD PMID:22206623 Rps6kc1 Rat 1,2-dimethylhydrazine multiple interactions ISO Rps6kc1 (Mus musculus) 6480464 [1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of RPS6KC1 mRNA CTD PMID:22206623 Rps6kc1 Rat 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO Rps6kc1 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Rps6kc1 Rat 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO Rps6kc1 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Rps6kc1 Rat 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of RPS6KC1 mRNA CTD PMID:22298810 Rps6kc1 Rat 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of RPS6KC1 mRNA CTD PMID:33387578 Rps6kc1 Rat 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RPS6KC1 (Homo sapiens) 6480464 [Tetrachlorodibenzodioxin co-treated with 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide] results in increased expression of RPS6KC1 mRNA CTD PMID:29704546 Rps6kc1 Rat 2,4,4'-trichlorobiphenyl multiple interactions ISO Rps6kc1 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Rps6kc1 Rat 2,4-dinitrotoluene affects expression EXP 6480464 2,4-dinitrotoluene affects the expression of RPS6KC1 mRNA CTD PMID:21346803 Rps6kc1 Rat 2,6-dinitrotoluene affects expression EXP 6480464 2,6-dinitrotoluene affects the expression of RPS6KC1 mRNA CTD PMID:21346803 Rps6kc1 Rat 3,4-methylenedioxymethamphetamine increases expression ISO Rps6kc1 (Mus musculus) 6480464 N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of RPS6KC1 mRNA CTD PMID:20188158 Rps6kc1 Rat 3,4-methylenedioxymethamphetamine decreases expression ISO Rps6kc1 (Mus musculus) 6480464 N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of RPS6KC1 mRNA CTD PMID:26251327 Rps6kc1 Rat 4,4'-sulfonyldiphenol increases methylation ISO RPS6KC1 (Homo sapiens) 6480464 bisphenol S results in increased methylation of RPS6KC1 gene CTD PMID:31601247 Rps6kc1 Rat aflatoxin B1 increases methylation ISO RPS6KC1 (Homo sapiens) 6480464 Aflatoxin B1 results in increased methylation of RPS6KC1 gene CTD PMID:27153756 Rps6kc1 Rat aristolochic acid A decreases expression ISO RPS6KC1 (Homo sapiens) 6480464 aristolochic acid I results in decreased expression of RPS6KC1 mRNA CTD PMID:33212167 Rps6kc1 Rat arsane multiple interactions ISO RPS6KC1 (Homo sapiens) 6480464 [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... CTD PMID:39836092 Rps6kc1 Rat arsenic atom multiple interactions ISO RPS6KC1 (Homo sapiens) 6480464 [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... CTD PMID:39836092 Rps6kc1 Rat arsenite(3-) multiple interactions ISO RPS6KC1 (Homo sapiens) 6480464 arsenite inhibits the reaction [G3BP1 protein binds to RPS6KC1 mRNA] CTD PMID:32406909 Rps6kc1 Rat atrazine affects methylation EXP 6480464 Atrazine affects the methylation of RPS6KC1 gene CTD PMID:35440735 Rps6kc1 Rat benzo[a]pyrene decreases expression ISO RPS6KC1 (Homo sapiens) 6480464 Benzo(a)pyrene results in decreased expression of RPS6KC1 mRNA CTD PMID:20064835 Rps6kc1 Rat benzo[a]pyrene increases methylation ISO RPS6KC1 (Homo sapiens) 6480464 Benzo(a)pyrene results in increased methylation of RPS6KC1 promoter CTD PMID:27901495 Rps6kc1 Rat benzo[a]pyrene diol epoxide I decreases expression ISO RPS6KC1 (Homo sapiens) 6480464 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of RPS6KC1 mRNA CTD PMID:19150397 Rps6kc1 Rat benzo[a]pyrene diol epoxide I affects expression ISO RPS6KC1 (Homo sapiens) 6480464 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of RPS6KC1 mRNA CTD PMID:20382639 Rps6kc1 Rat bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of RPS6KC1 mRNA CTD PMID:25181051|PMID:30816183|PMID:32528016|PMID:34947998 Rps6kc1 Rat bisphenol F increases expression ISO Rps6kc1 (Mus musculus) 6480464 bisphenol F results in increased expression of RPS6KC1 mRNA CTD PMID:38685157 Rps6kc1 Rat bortezomib increases expression ISO RPS6KC1 (Homo sapiens) 6480464 Bortezomib results in increased expression of RPS6KC1 mRNA CTD PMID:20977926 Rps6kc1 Rat cadmium dichloride decreases expression ISO RPS6KC1 (Homo sapiens) 6480464 Cadmium Chloride results in decreased expression of RPS6KC1 mRNA CTD PMID:38568856 Rps6kc1 Rat caffeine affects phosphorylation ISO RPS6KC1 (Homo sapiens) 6480464 Caffeine affects the phosphorylation of RPS6KC1 protein CTD PMID:35688186 Rps6kc1 Rat choline multiple interactions ISO Rps6kc1 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation more ... CTD PMID:20938992 Rps6kc1 Rat ciglitazone multiple interactions ISO RPS6KC1 (Homo sapiens) 6480464 [ciglitazone binds to PPARG protein alternative form] which results in increased expression of RPS6KC1 mRNA CTD PMID:16197558 Rps6kc1 Rat clofibrate multiple interactions ISO Rps6kc1 (Mus musculus) 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of RPS6KC1 mRNA; PPARA affects the reaction [[Clofibrate more ... CTD PMID:17585979 Rps6kc1 Rat cobalt dichloride increases expression ISO RPS6KC1 (Homo sapiens) 6480464 cobaltous chloride results in increased expression of RPS6KC1 mRNA CTD PMID:19320972 Rps6kc1 Rat coumarin decreases phosphorylation ISO RPS6KC1 (Homo sapiens) 6480464 coumarin results in decreased phosphorylation of RPS6KC1 protein CTD PMID:35688186 Rps6kc1 Rat cyclosporin A increases expression ISO RPS6KC1 (Homo sapiens) 6480464 Cyclosporine results in increased expression of RPS6KC1 mRNA CTD PMID:20106945 Rps6kc1 Rat DDT increases methylation EXP 6480464 DDT results in increased methylation of RPS6KC1 gene CTD PMID:31682807 Rps6kc1 Rat dicrotophos decreases expression ISO RPS6KC1 (Homo sapiens) 6480464 dicrotophos results in decreased expression of RPS6KC1 mRNA CTD PMID:28302478 Rps6kc1 Rat doxorubicin decreases expression ISO RPS6KC1 (Homo sapiens) 6480464 Doxorubicin results in decreased expression of RPS6KC1 mRNA CTD PMID:29803840 Rps6kc1 Rat ethanol multiple interactions ISO Rps6kc1 (Mus musculus) 6480464 Ethanol affects the expression of and affects the splicing of RPS6KC1 mRNA CTD PMID:30319688 Rps6kc1 Rat folic acid multiple interactions ISO Rps6kc1 (Mus musculus) 6480464 [1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of RPS6KC1 mRNA; [Methionine deficiency co-treated more ... CTD PMID:20938992|PMID:22206623 Rps6kc1 Rat FR900359 increases phosphorylation ISO RPS6KC1 (Homo sapiens) 6480464 FR900359 results in increased phosphorylation of RPS6KC1 protein CTD PMID:37730182 Rps6kc1 Rat furan increases methylation EXP 6480464 furan results in increased methylation of RPS6KC1 gene CTD PMID:22079235 Rps6kc1 Rat gallic acid increases expression ISO RPS6KC1 (Homo sapiens) 6480464 Gallic Acid results in increased expression of RPS6KC1 mRNA CTD PMID:34408198 Rps6kc1 Rat gallic acid decreases expression ISO RPS6KC1 (Homo sapiens) 6480464 Gallic Acid results in decreased expression of RPS6KC1 mRNA CTD PMID:34408198 Rps6kc1 Rat glyphosate increases methylation EXP 6480464 Glyphosate results in increased methylation of RPS6KC1 gene CTD PMID:31011160 Rps6kc1 Rat glyphosate affects methylation EXP 6480464 Glyphosate affects the methylation of RPS6KC1 gene CTD PMID:35440735 Rps6kc1 Rat L-methionine multiple interactions ISO Rps6kc1 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation more ... CTD PMID:20938992 Rps6kc1 Rat manganese atom multiple interactions ISO RPS6KC1 (Homo sapiens) 6480464 [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... CTD PMID:39836092 Rps6kc1 Rat manganese(0) multiple interactions ISO RPS6KC1 (Homo sapiens) 6480464 [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... CTD PMID:39836092 Rps6kc1 Rat manganese(II) chloride multiple interactions ISO RPS6KC1 (Homo sapiens) 6480464 [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... CTD PMID:39836092 Rps6kc1 Rat mercury atom decreases expression ISO Rps6kc1 (Mus musculus) 6480464 Mercury analog results in decreased expression of RPS6KC1 mRNA CTD PMID:25056781 Rps6kc1 Rat mercury(0) decreases expression ISO Rps6kc1 (Mus musculus) 6480464 Mercury analog results in decreased expression of RPS6KC1 mRNA CTD PMID:25056781 Rps6kc1 Rat methoxychlor affects methylation EXP 6480464 Methoxychlor affects the methylation of RPS6KC1 gene CTD PMID:35440735 Rps6kc1 Rat N,N-diethyl-m-toluamide multiple interactions EXP 6480464 [Permethrin co-treated with DEET] results in increased methylation of RPS6KC1 gene CTD PMID:33148267 Rps6kc1 Rat paracetamol multiple interactions ISO Rps6kc1 (Mus musculus) 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of RPS6KC1 mRNA; PPARA affects the reaction [[Clofibrate more ... CTD PMID:17585979 Rps6kc1 Rat paracetamol decreases expression EXP 6480464 Acetaminophen results in decreased expression of RPS6KC1 mRNA CTD PMID:33387578 Rps6kc1 Rat paracetamol increases expression ISO RPS6KC1 (Homo sapiens) 6480464 Acetaminophen results in increased expression of RPS6KC1 mRNA CTD PMID:22230336 Rps6kc1 Rat PCB138 multiple interactions ISO Rps6kc1 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Rps6kc1 Rat permethrin multiple interactions EXP 6480464 [Permethrin co-treated with DEET] results in increased methylation of RPS6KC1 gene CTD PMID:33148267 Rps6kc1 Rat potassium chromate decreases expression ISO RPS6KC1 (Homo sapiens) 6480464 potassium chromate(VI) results in decreased expression of RPS6KC1 mRNA CTD PMID:22079256 Rps6kc1 Rat potassium chromate multiple interactions ISO RPS6KC1 (Homo sapiens) 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of RPS6KC1 mRNA CTD PMID:22079256 Rps6kc1 Rat pregnenolone 16alpha-carbonitrile increases expression ISO Rps6kc1 (Mus musculus) 6480464 Pregnenolone Carbonitrile results in increased expression of RPS6KC1 mRNA CTD PMID:28903501 Rps6kc1 Rat resveratrol multiple interactions ISO RPS6KC1 (Homo sapiens) 6480464 [Plant Extracts co-treated with Resveratrol] results in increased expression of RPS6KC1 mRNA CTD PMID:23557933 Rps6kc1 Rat rotenone decreases expression EXP 6480464 Rotenone results in decreased expression of RPS6KC1 mRNA CTD PMID:19013527 Rps6kc1 Rat sodium arsenite increases methylation ISO RPS6KC1 (Homo sapiens) 6480464 sodium arsenite results in increased methylation of RPS6KC1 gene CTD PMID:24570342 Rps6kc1 Rat sodium arsenite decreases expression ISO RPS6KC1 (Homo sapiens) 6480464 sodium arsenite results in decreased expression of RPS6KC1 mRNA CTD PMID:39719251 Rps6kc1 Rat sodium arsenite multiple interactions ISO RPS6KC1 (Homo sapiens) 6480464 [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... CTD PMID:39836092 Rps6kc1 Rat sodium arsenite increases expression ISO RPS6KC1 (Homo sapiens) 6480464 sodium arsenite results in increased expression of RPS6KC1 mRNA CTD PMID:38568856 Rps6kc1 Rat sunitinib increases expression ISO RPS6KC1 (Homo sapiens) 6480464 Sunitinib results in increased expression of RPS6KC1 mRNA CTD PMID:31533062 Rps6kc1 Rat thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of RPS6KC1 mRNA CTD PMID:23411599 Rps6kc1 Rat thiram increases expression ISO RPS6KC1 (Homo sapiens) 6480464 Thiram results in increased expression of RPS6KC1 mRNA CTD PMID:38568856 Rps6kc1 Rat trichloroethene increases methylation EXP 6480464 Trichloroethylene results in increased methylation of RPS6KC1 gene CTD PMID:27618143 Rps6kc1 Rat triphenyl phosphate affects expression ISO RPS6KC1 (Homo sapiens) 6480464 triphenyl phosphate affects the expression of RPS6KC1 mRNA CTD PMID:37042841 Rps6kc1 Rat valproic acid increases expression ISO RPS6KC1 (Homo sapiens) 6480464 Valproic Acid results in increased expression of RPS6KC1 mRNA CTD PMID:29154799