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Gene: Lrpprc (leucine-rich pentatricopeptide repeat containing) Rattus norvegicus

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Symbol:

Lrpprc

Name:

leucine-rich pentatricopeptide repeat containing

RGD ID:

1306575

Description:

Predicted to enable several functions, including beta-tubulin binding activity; mRNA 3'-UTR binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in mitochondrial mRNA polyadenylation; negative regulation of mitochondrial mRNA catabolic process; and regulation of mitochondrial translation. Predicted to act upstream of or within negative regulation of mitochondrial RNA catabolic process. Predicted to be located in several cellular components, including condensed nuclear chromosome; mitochondrial nucleoid; and perinuclear region of cytoplasm. Predicted to be part of ribonucleoprotein complex. Predicted to be active in mitochondrion and nucleus. Human ortholog(s) of this gene implicated in French Canadian Leigh disease and Leigh disease. Orthologous to human LRPPRC (leucine rich pentatricopeptide repeat containing); PARTICIPATES IN CRM1 export pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; aconitine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

130 kDa leucine-rich protein; leucine rich protein 157; leucine-rich PPR motif-containing protein, mitochondrial; leucine-rich PPR-motif containing; leucine-rich protein 157; LOC313867; LRP 130; Lrp157; rLRP157

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	15,612,638 - 15,695,113 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	6	15,612,655 - 15,695,116 (+)	Ensembl				GRCr8
mRatBN7.2	6	9,859,816 - 9,942,294 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	9,859,867 - 9,942,293 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	6	10,148,236 - 10,230,722 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	10,457,631 - 10,540,115 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	9,979,042 - 10,061,742 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	7,984,043 - 8,066,874 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	7,984,019 - 8,066,868 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	6	7,919,928 - 8,001,949 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	6	8,086,606 - 8,168,261 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	6	9,581,533 - 9,663,935 (+)	NCBI		Celera
RGSC_v3.1	6	8,086,606 - 8,168,261 (-)	NCBI
Cytogenetic Map	6	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

cytochrome-c oxidase deficiency disease (ISO)

epilepsy (ISO)

French Canadian Leigh disease (ISO)

genetic disease (ISO)

Leigh disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,6-dimethoxyphenol (ISO)

3',5'-cyclic UMP (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

aconitine (EXP)

acrolein (ISO)

acrylamide (ISO)

actinomycin D (ISO)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

amitrole (EXP)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

Brodifacoum (EXP)

butanal (ISO)

Butylbenzyl phthalate (EXP)

C60 fullerene (EXP)

cadmium dichloride (EXP,ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

chromium(6+) (ISO)

clofibric acid (EXP)

clozapine (ISO)

corosolic acid (ISO)

cyclosporin A (ISO)

dexamethasone (ISO)

dicrotophos (ISO)

dioxygen (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

enzyme inhibitor (ISO)

epoxiconazole (ISO)

ethyl methanesulfonate (ISO)

finasteride (EXP)

flutamide (EXP)

folic acid (ISO)

formaldehyde (ISO)

furfural (ISO)

gentamycin (EXP)

ginsenoside Re (ISO)

indometacin (ISO)

isoprenaline (EXP)

ivermectin (ISO)

methapyrilene (EXP)

methimazole (EXP)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

morphine (ISO)

N-methyl-4-phenylpyridinium (ISO)

Nutlin-3 (ISO)

oxaliplatin (EXP)

ozone (ISO)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

pirinixic acid (EXP,ISO)

rotenone (EXP)

S-butyl-DL-homocysteine (S,R)-sulfoximine (EXP)

SB 431542 (ISO)

sodium arsenite (ISO)

sodium chloride (ISO)

sulfadimethoxine (EXP)

sulindac (EXP)

sunitinib (ISO)

tanespimycin (ISO)

thapsigargin (ISO)

thimerosal (ISO)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

topotecan (EXP)

trichostatin A (ISO)

trimellitic anhydride (ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

autophagy (IEA)

biological_process (ND)

mitochondrial mRNA polyadenylation (IEA,ISO)

mRNA transport (IEA)

negative regulation of mitochondrial mRNA catabolic process (IEA,ISO)

negative regulation of mitochondrial RNA catabolic process (ISO)

regulation of mitochondrial translation (IBA,ISO)

Cellular Component

condensed nuclear chromosome (IEA,ISO,ISS)

cytoplasm (IEA,ISO)

cytoskeleton (IEA,ISO,ISS)

microtubule (IEA,ISO)

mitochondrial matrix (IEA,ISO)

mitochondrial nucleoid (IEA,ISO)

mitochondrion (IBA,IEA,ISO,ISS)

nuclear inner membrane (IEA)

nuclear outer membrane (IEA)

nucleoplasm (IEA)

nucleus (IBA,IEA,ISO,ISS)

perinuclear region of cytoplasm (IEA,ISO,ISS)

ribonucleoprotein complex (IEA,ISO)

Molecular Function

actin filament binding (ISO,ISS)

beta-tubulin binding (IEA,ISO,ISS)

DNA binding (IEA)

mRNA 3'-UTR binding (IBA)

mRNA binding (IEA,ISO)

protein binding (ISO)

RNA binding (IEA,ISO)

single-stranded DNA binding (IEA,ISO)

ubiquitin protein ligase binding (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

CRM1 export pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Defects in energy homeostasis in Leigh syndrome French Canadian variant through PGC-1alpha/LRP130 complex.	Cooper MP, etal., Genes Dev. 2006 Nov 1;20(21):2996-3009. Epub 2006 Oct 18.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	Identification of a gene causing human cytochrome c oxidase deficiency by integrative genomics.	Mootha VK, etal., Proc Natl Acad Sci U S A. 2003 Jan 21;100(2):605-10. Epub 2003 Jan 14.
6.	Postage for the messenger: designating routes for nuclear mRNA export.	Natalizio BJ and Wente SR, Trends Cell Biol. 2013 Aug;23(8):365-73. doi: 10.1016/j.tcb.2013.03.006. Epub 2013 Apr 11.
7.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
8.	GOA pipeline	RGD automated data pipeline
9.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
11.	Comprehensive gene review and curation	RGD comprehensive gene curation

Additional References at PubMed

PMID:12071956	PMID:12762840	PMID:12832482	PMID:14651853	PMID:15525270	PMID:17339062	PMID:18063578	PMID:18614015	PMID:19725078	PMID:19946888	PMID:21525035	PMID:21880015
PMID:22045337	PMID:22658674	PMID:22681889	PMID:26316108

Genomics

Comparative Map Data

Lrpprc
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	15,612,638 - 15,695,113 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	6	15,612,655 - 15,695,116 (+)	Ensembl				GRCr8
mRatBN7.2	6	9,859,816 - 9,942,294 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	9,859,867 - 9,942,293 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	6	10,148,236 - 10,230,722 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	10,457,631 - 10,540,115 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	9,979,042 - 10,061,742 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	7,984,043 - 8,066,874 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	7,984,019 - 8,066,868 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	6	7,919,928 - 8,001,949 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	6	8,086,606 - 8,168,261 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	6	9,581,533 - 9,663,935 (+)	NCBI		Celera
RGSC_v3.1	6	8,086,606 - 8,168,261 (-)	NCBI
Cytogenetic Map	6	q12	NCBI

LRPPRC
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	43,886,224 - 43,996,265 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	43,886,224 - 43,996,226 (-)	Ensembl			hg38	GRCh38
GRCh37	2	44,113,363 - 44,223,128 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	43,968,391 - 44,076,648 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	2	44,026,537 - 44,134,795	NCBI
Celera	2	43,952,087 - 44,062,100 (-)	NCBI		Celera
Cytogenetic Map	2	p21	NCBI
HuRef	2	43,849,689 - 43,959,564 (-)	NCBI		HuRef
CHM1_1	2	44,042,771 - 44,152,581 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	2	43,891,557 - 44,001,630 (-)	NCBI		T2T-CHM13v2.0

Lrpprc
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	85,012,675 - 85,098,214 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	85,012,675 - 85,098,217 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	17	84,705,247 - 84,790,786 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	84,705,247 - 84,790,789 (-)	Ensembl			mm10	GRCm38
MGSCv37	17	85,104,587 - 85,190,126 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	17	84,613,573 - 84,698,841 (-)	NCBI		MGSCv36	mm8
Celera	17	89,073,226 - 89,158,633 (-)	NCBI		Celera
Cytogenetic Map	17	E4	NCBI
cM Map	17	55.02	NCBI

Lrpprc
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955441	11,011,831 - 11,116,979 (-)	Ensembl
ChiLan1.0	NW_004955441	11,012,910 - 11,116,965 (-)	NCBI	ChiLan1.0	ChiLan1.0

LRPPRC
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	82,421,380 - 82,530,685 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	82,425,351 - 82,535,405 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	43,975,949 - 44,083,846 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	44,914,578 - 45,021,434 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	44,914,578 - 45,021,434 (-)	Ensembl			panPan2	panpan1.1

LRPPRC
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	46,325,312 - 46,438,376 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	46,327,223 - 46,438,342 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	46,188,975 - 46,300,206 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	47,205,831 - 47,317,113 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	47,203,961 - 47,317,132 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	46,914,258 - 47,025,488 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	47,203,848 - 47,313,376 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	47,387,584 - 47,498,808 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Lrpprc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	36,532,488 - 36,638,283 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936508	7,961,042 - 8,068,274 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936508	7,961,079 - 8,068,228 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LRPPRC
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	96,474,549 - 96,595,143 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	3	96,474,510 - 96,590,706 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	102,630,054 - 102,744,878 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LRPPRC
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	63,263,101 - 63,380,607 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666045	48,506,466 - 48,623,733 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Lrpprc
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624738	25,338,098 - 25,452,676 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624738	25,340,588 - 25,452,593 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Lrpprc
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	7	8,118,972 - 8,202,147 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Lrpprc
371 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	20
Count of miRNA genes:	18
Interacting mature miRNAs:	19
Transcripts:	ENSRNOT00000008200
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
8552962	Pigfal16	Plasma insulin-like growth factor 1 level QTL 16	9.4		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	6	1975879	46975879	Rat
7411603	Foco13	Food consumption QTL 13	5.5	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	6	1975879	46975879	Rat
1598843	Cm63	Cardiac mass QTL 63	2.6		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	6	1	44788383	Rat
7411542	Bw127	Body weight QTL 127	5.5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	1975879	46975879	Rat
8693699	Alc37	Alcohol consumption QTL 37	2.6	0.224	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	6	13717169	27053860	Rat
2293706	Bmd20	Bone mineral density QTL 20	4.3	0.0002	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	6	1	25740059	Rat
2292616	Ept15	Estrogen-induced pituitary tumorigenesis QTL 15	4.4		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	6	1	44788383	Rat
9589048	Scfw3	Subcutaneous fat weight QTL 3	4.57	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	6	1975879	46975879	Rat
2301964	Bp323	Blood pressure QTL 323	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	1	86868070	Rat
2293709	Bss23	Bone structure and strength QTL 23	5.18	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	6	3239989	48239989	Rat
2293650	Bss31	Bone structure and strength QTL 31	5.05	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	6	3239989	48239989	Rat
1300128	Rf16	Renal function QTL 16	3.89		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	6	1	40163351	Rat
70196	BpQTLcluster7	Blood pressure QTL cluster 7	6.82		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	1	20510098	Rat
70199	Coreg1	Compensatory renal growth QTL 1	11.8		kidney mass (VT:0002707)	compensatory renal growth score (CMO:0001894)	6	14599473	63457687	Rat
1300164	Rf15	Renal function QTL 15	3.12		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	6	3239989	48239989	Rat
1358190	Ept1	Estrogen-induced pituitary tumorigenesis QTL 1	4.4		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	6	1	44788383	Rat
2293656	Bss28	Bone structure and strength QTL 28	6.79	0.0001	femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	6	3239989	48239989	Rat
9589129	Insul24	Insulin level QTL 24	19.06	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	6	1975879	46975879	Rat
8693690	Alc35	Alcohol consumption QTL 35	2.2	0.606	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	6	13717169	27053860	Rat

Markers in Region

D6Got4

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	9,892,700 - 9,892,994 (-)	MAPPER	mRatBN7.2
Rnor_6.0	6	8,033,341 - 8,033,634	NCBI	Rnor6.0
Rnor_5.0	6	7,969,226 - 7,969,519	UniSTS	Rnor5.0
RGSC_v3.4	6	8,135,903 - 8,136,197	RGD	RGSC3.4
RGSC_v3.4	6	8,135,904 - 8,136,197	UniSTS	RGSC3.4
Celera	6	9,614,357 - 9,614,650	UniSTS
RGSC_v3.1	6	8,135,903 - 8,136,197	RGD
Cytogenetic Map	6	q12	UniSTS

RH132068

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	9,890,527 - 9,890,736 (-)	MAPPER	mRatBN7.2
Rnor_6.0	6	8,035,599 - 8,035,807	NCBI	Rnor6.0
Rnor_5.0	6	7,971,484 - 7,971,692	UniSTS	Rnor5.0
RGSC_v3.4	6	8,138,162 - 8,138,370	UniSTS	RGSC3.4
Celera	6	9,612,184 - 9,612,392	UniSTS
Cytogenetic Map	6	q12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001008519	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC120701	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY293808	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473947	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000008200 ⟹ ENSRNOP00000008200

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	6	15,612,655 - 15,695,116 (+)	Ensembl
mRatBN7.2 Ensembl	6	9,859,867 - 9,942,293 (+)	Ensembl
Rnor_6.0 Ensembl	6	7,984,019 - 8,066,868 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000144781 ⟹ ENSRNOP00000112298

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	6	15,612,655 - 15,695,111 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000173713 ⟹ ENSRNOP00000109406

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	6	15,612,662 - 15,695,111 (+)	Ensembl

RefSeq Acc Id:

NM_001008519 ⟹ NP_001008519

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	15,612,638 - 15,695,113 (+)	NCBI
mRatBN7.2	6	9,859,816 - 9,942,294 (+)	NCBI
Rnor_6.0	6	7,984,043 - 8,066,874 (-)	NCBI
Rnor_5.0	6	7,919,928 - 8,001,949 (-)	NCBI
RGSC_v3.4	6	8,086,606 - 8,168,261 (-)	RGD
Celera	6	9,581,533 - 9,663,935 (+)	RGD

Sequence:

show sequence

CGGTGAACCATGTCAGCCCTGCTGAGACCCGCGCGTTGGCTGCTAGGGGCAGCGGCGGTCCCGC
GCCTCCCGCTGTCCCTGCGCCTCCCTGCGGGCGGCCCCGGCAGGCTGCCCTCTGTCGTCCGGGT
GGCGGCCGCTGGTGGCCGGCCGGCTGCAGGAGAGCTGCTGAGCCAAGCCAGGTTGTATGCCATC
GTCGCTGAAAAAAAGGATCTTCCAGAGGAGCCTGCTCCTGTGAGAAGGAGTGGCAGTCAGTTTG
ATTGGGCCCTAATGAGACTGGATAATTCTGTCCGGAGAACGGGCCGCATTACCAAGGGGCTTCT
GCAGAAAGTCTTTGAGAGCACGTGCCGCTCAGGGAGCCCAGGGAGTAACCAGGCCTTGCTTCTG
CTGCGCAGCTGCGGCTCGCTCCTGCCCGAACTGAGTCTTGCAGAGAGGACAGAATTTGCTCATA
AGATATGGGACAAACTTCAGCAGTTAGGCACTGTGTACGATGTCAGTCATTATAATGCTTTACT
TAAAGTATATCTTCAAAATGAATACCGATTCTCACCTACTGACTTCCTGGCAAAGATGGAGGGA
GCAAACATTCAACCGAACCGAGTGACATACCAGAGGCTGATCGCTGCCTATTGTAGTGTTGGGG
ACATTGAAGGCGCCAGCAAGATCCTTGGATTTATGAAAACGAGGGACCTTCCAATCACAGAGGC
TGTGTTCAGTGCGCTCGTCACAGGGCACGCCAGAGCTGGGGATATGGAGAGTGCAGAGAATATT
CTCACAGTGATGAAACAGGCTGGCATTGAGCCTGGGCCAGACACGTATCTGGCCTTGTTGAACG
CACATGCTGAGAAGGGTGACATTGACCATGTTAAGCAGATTCTGGAGAAAGTGGAAAAATCGGA
TCATTACTTTATGGACCGTGATTTCTTGCAAATTATTGTTAGCTTTAGTAAAGCTGGATATCCT
CAGTATGTCTCAGAAATTTTGGAGAAGATTACCTATGAGAGAAGATCTATTCCAGATGCAATGA
ACCTCATTTTGCTTTTAGTCACTGAGAAGTTAGAAGACACGGCGTTCCAGGTTTTACTGGCATT
ACCCCTGGCCAGGGATGAGACCTCAAGTAGTTTTGGCAGTTTCTTTTTGCGGCACTGTGTGACT
ATGGATACGCCTGCTGAGAAGCTGATAGACTACTGTAAGAGACTGAGGGACGCCAAGGTGCACA
GCTCTTCACTGCAGTTCACCCTGCACTGTGCTCTTCAAGCCAATAAGACTGCTTTGGCAAAAGC
AGTGATGGAGGCTCTGAGGGATGAAGGGTTTCCTATCCGAACTCACTATTTCTGGCCGTTGCTT
GTTGGACATCAGAAAACAAAAAATGTTCAAGGAATAATAGATATTCTTAAAATCATGAAGGAAA
TGGGAGTGGATCCCGATCAGGAAACATACATAAATTATGTGTTTCCCTGCTTCGGTAGTGTGCA
GTCGGCTCGAGCTGCTCTGCAGGAAAATAAATGTCTGCCTAAAAGTACTACATTCGCTCAAGCC
GAAGTGAGAAATGAAGCAATAAATGGGAATTTACAGAACATTTTGTCATTTTTGGAATCGAATG
CATTGCCTTTCTCGTTTAATTCTTTGAGAGGCAGCCTAATTCTAGGCTTTAGGAGGTCGATGAA
TATAGATCTTTGGAGCAAGATAACAGAATTGCTGTACAAGGATGACCGTTATTGCCAAAAACCT
CCAGGACCAACGGAAGCTGTTGGCTATTTTCTTTATAACTTGATTGACAGCATGAGTGACTCAG
AGGTGCAGGCCAAGGAGGAGCGCTTGAGACAATACTTCCATCAGCTTCGAGAAATGAATGTTAA
AGTTTCTGAAAACATCTACAAAGGCATTTGTAATTTGCTGGATAACTACCATGTTCCTGAATTG
ATTAAGGATGTTAAGGTTCTGGTTGACAGAGAGAAGATAGATTCTCGAAAAACCTCCCAGTTTA
CCTCATCTGATTTGGAGTCAACCCTTGAGAAGCTTAAAGCTGAAGGCCATCCTGTAGGAGACCC
CCTGAAGCAGCTCATCTTGCTGCTCTGTTCTGAGGAGAATATGCAAAAGGCCCTTGAAGTGAAA
GCAAAATACGAGTCAGACATGGTTATTGGAGGCTATGCAGCTTTAATAAATTTGTGCTGTCGAC
ATGATAATGCAGAAGATGCACTGAACTTGAAACAAGAATTTGACCGCTTAGATCCTTCAGCTGT
TCTTGACACTGCCAAGTATGTAGCCCTGGTAAAAGTATTGGGAAAGCATGGCAGAGTGCAAGAT
GCTATTAACATTCTAAAGGAGATGAAAGAGAAGGATGTTGTTATCAAAGATGCAGCAGTCTTGT
CCTTCTTCCACATCCTGAATGGTGCAGCTTTAAGAGGTGAAATTGAGACAGTAAAACAGTTGCA
TGAAGCCATCGTGACTCTTGGGTTGGCAAAGCCATCCAGCAACATAAGCTTCCCATTGGTCACT
GTGCACCTGGAAAAGGATGATTTACCTGCTGCTCTTGAAGCCAGCATTGCCTGCCATGAAAAAT
ATAAAGTATTACCCAGGATTCATGATGTCTTATGTAAGCTAATAGAAAAAGGCGAGACTGACTT
AATCCAGAAAGCGATGGACTTTGTCAGCCAAGAGCAGGGCGAGATGTCGATGCTCTACGACCTC
TTCTTTGCTTTCCTGCAGACGGGAAACTACAAAGAGGCCAAGAAGATTATTGAGACTCCAGGCA
TTAGAGCTCGGCCTACACGACTTCAGTGGTTTTGTGATAGATGCATTGCCAATAATCAGGTTGA
AACTCTTGAGAAGTTAGTGGAGCTGACCGAGAAGCTGTTTGAATGTGACAGAGACCAGATGTAC
TACAACTTACTGAAACTATACAAAATAAGCGGTGACTGGCAAAGAGCGGATGCTGTCTGGAATA
AAATGCAAGAAGAGAATCTTATCCCTCGAGAACGGACACTGCGACTGTTAGCTGGGATCCTGAA
AACCAGCAACCAGGAGGTTCCTTTTGACGTTCCTGAGTTGTGGTTTGGAGATGACAGGTCTTCC
CTGAGTTCATCCTCACCCTCAGCAGGAGACACCGTGACTGAGAAGATGTTGTTGTCTGACTGCA
GACTGAAGAAGAGTAAGGATGCATATAATATCTTCCTCAAAGCCGAAAAGCAAGATGTCGTCTT
CAGCAGTGAGGCTTACAGCACCCTGGTTGGCTTGCTGCTGAGCAAAGATGACTTCACACGAGCC
ATGCATGTGAAAGATTTCGCTGAGACCCACATCAAGGGCTTCACACTGAACGGTGCTGCCAGCA
GCCTCCTCATCATCGCGCAAGTTAGGCGGGATTATTTGAAAGTGGCTCTAGAAACTCTGAAGGC
AGCCTTGGATCTGGAACAGGTGCCTTCTGAGCTGGCCGTGACCCGCCTTATCCAGGCACTGGCC
TTGCAGGGTGATGTGAAAAGCATAGAGACCATTCAGAAGATGGTGAAAGGGCTNGACGCGATTG
AGCTCTCAAGAATGGTCTTCATCAACAACATTGCTCTGGCCCAGATGAAGAATAATGAAATTGA
TGCTGCCATAGAAAATATCGAGCACATGCTTGCCTCAGAGAATCAGACCGTGGAACACCAGTAC
TTTGGCTTGTCGTACTTATTCAGGAAAGTGATAGAGGAGCAGATGGAGCCAGCGCTCGAAAAGT
TAAGCATCATGTCTGAGAGGTTGGCCAATCAGTTTGCACTTTACAAACCCGTCACTGATCTCTT
CCTTCAGCTTGTGGATTCAGGCAAGGTGGATGAGGCCAGAGCCCTCTTGGAGAGATGCGGCGCC
ATTGCCGAGCAGACCTCAATTCTGTCGGTGTTCTGTCTCAGGACGTCTCAGAAACCAAAAAAGG
CCCCGGTTCTGAAGACCTTGTTAGAGCTGATTCCCGAGTTACGTGAGAATGACAGAGTGTACTC
CTGCAGCATGAAAAGCTATGTCGCAGACAAAGACGTGGCCTCCGCTAAAGCGCTGTATGAGCAT
TTGACAGCAAAGAACATGAAGCTGGACGACCTCTTTTTGAAGCGCTACGCATCTTTGCTCAAGG
ATGTGGGCGAGCCGGTCCCCTTCACTGAGCCCCCTGAAAGCTTTGGATTTTACATAAAGCAACT
AAAGGAAGCGAGAGAAAACCCCTCATGAAAGAAGCAGCTGTGTGTGTCTGTGTGTGTCTGTGTG
TCTGTGTGTCTGTGTCTGTGTGCACGCGCCTGTGTCTCAATGTTATTTCTAAAATGTACTTAGG
AAAAATAAACAACTGAAGATTAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001008519	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAQ74626	(Get FASTA)	NCBI Sequence Viewer
	EDM02689	(Get FASTA)	NCBI Sequence Viewer
	EDM02690	(Get FASTA)	NCBI Sequence Viewer
	EDM02691	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000008200
GenBank Protein	Q5SGE0	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001008519 ⟸ NM_001008519
- Peptide Label:	precursor
- UniProtKB:	Q5SGE0 (UniProtKB/Swiss-Prot), A6H9I4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSALLRPARWLLGAAAVPRLPLSLRLPAGGPGRLPSVVRVAAAGGRPAAGELLSQARLYAIVAE KKDLPEEPAPVRRSGSQFDWALMRLDNSVRRTGRITKGLLQKVFESTCRSGSPGSNQALLLLRS CGSLLPELSLAERTEFAHKIWDKLQQLGTVYDVSHYNALLKVYLQNEYRFSPTDFLAKMEGANI QPNRVTYQRLIAAYCSVGDIEGASKILGFMKTRDLPITEAVFSALVTGHARAGDMESAENILTV MKQAGIEPGPDTYLALLNAHAEKGDIDHVKQILEKVEKSDHYFMDRDFLQIIVSFSKAGYPQYV SEILEKITYERRSIPDAMNLILLLVTEKLEDTAFQVLLALPLARDETSSSFGSFFLRHCVTMDT PAEKLIDYCKRLRDAKVHSSSLQFTLHCALQANKTALAKAVMEALRDEGFPIRTHYFWPLLVGH QKTKNVQGIIDILKIMKEMGVDPDQETYINYVFPCFGSVQSARAALQENKCLPKSTTFAQAEVR NEAINGNLQNILSFLESNALPFSFNSLRGSLILGFRRSMNIDLWSKITELLYKDDRYCQKPPGP TEAVGYFLYNLIDSMSDSEVQAKEERLRQYFHQLREMNVKVSENIYKGICNLLDNYHVPELIKD VKVLVDREKIDSRKTSQFTSSDLESTLEKLKAEGHPVGDPLKQLILLLCSEENMQKALEVKAKY ESDMVIGGYAALINLCCRHDNAEDALNLKQEFDRLDPSAVLDTAKYVALVKVLGKHGRVQDAIN ILKEMKEKDVVIKDAAVLSFFHILNGAALRGEIETVKQLHEAIVTLGLAKPSSNISFPLVTVHL EKDDLPAALEASIACHEKYKVLPRIHDVLCKLIEKGETDLIQKAMDFVSQEQGEMSMLYDLFFA FLQTGNYKEAKKIIETPGIRARPTRLQWFCDRCIANNQVETLEKLVELTEKLFECDRDQMYYNL LKLYKISGDWQRADAVWNKMQEENLIPRERTLRLLAGILKTSNQEVPFDVPELWFGDDRSSLSS SSPSAGDTVTEKMLLSDCRLKKSKDAYNIFLKAEKQDVVFSSEAYSTLVGLLLSKDDFTRAMHV KDFAETHIKGFTLNGAASSLLIIAQVRRDYLKVALETLKAALDLEQVPSELAVTRLIQALALQG DVKSIETIQKMVKGLDAIELSRMVFINNIALAQMKNNEIDAAIENIEHMLASENQTVEHQYFGL SYLFRKVIEEQMEPALEKLSIMSERLANQFALYKPVTDLFLQLVDSGKVDEARALLERCGAIAE QTSILSVFCLRTSQKPKKAPVLKTLLELIPELRENDRVYSCSMKSYVADKDVASAKALYEHLTA KNMKLDDLFLKRYASLLKDVGEPVPFTEPPESFGFYIKQLKEARENPS hide sequence

Ensembl Acc Id:

ENSRNOP00000008200 ⟸ ENSRNOT00000008200

Ensembl Acc Id:

ENSRNOP00000112298 ⟸ ENSRNOT00000144781

Ensembl Acc Id:

ENSRNOP00000109406 ⟸ ENSRNOT00000173713

Protein Domains

PROP1-like PPR

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5SGE0-F1-model_v2	AlphaFold	Q5SGE0	1-1392	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13694377

Promoter ID:

EPDNEW_R4902

Type:

initiation region

Name:

Lrpprc_1

Description:

leucine-rich pentatricopeptide repeat containing

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	6	8,066,908 - 8,066,968	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1306575	AgrOrtholog
BioCyc Gene	G2FUF-38647	BioCyc
Ensembl Genes	ENSRNOG00000005877	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000008200	ENTREZGENE
Gene3D-CATH	1.25.40.10	UniProtKB/Swiss-Prot
InterPro	LRP130	UniProtKB/Swiss-Prot
	Pentatricopeptide_repeat	UniProtKB/Swiss-Prot
	PPR_long	UniProtKB/Swiss-Prot
	TPR-like_helical_dom_sf	UniProtKB/Swiss-Prot
KEGG Report	rno:313867	UniProtKB/Swiss-Prot
NCBI Gene	313867	ENTREZGENE
PANTHER	LEUCINE-RICH PPR MOTIF-CONTAINING PROTEIN, MITOCHONDRIAL	UniProtKB/Swiss-Prot
	PTHR46669	UniProtKB/Swiss-Prot
Pfam	PPR	UniProtKB/Swiss-Prot
	PPR_3	UniProtKB/Swiss-Prot
	PPR_long	UniProtKB/Swiss-Prot
PhenoGen	Lrpprc	PhenoGen
PROSITE	PPR	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000005877	RatGTEx
Superfamily-SCOP	SSF48452	UniProtKB/Swiss-Prot
UniProt	A0ABK0LY58_RAT	UniProtKB/TrEMBL
	A0ABK0M2X3_RAT	UniProtKB/TrEMBL
	A6H9I4	ENTREZGENE, UniProtKB/TrEMBL
	A6H9I5_RAT	UniProtKB/TrEMBL
	A6H9I6_RAT	UniProtKB/TrEMBL
	F1LM33_RAT	UniProtKB/TrEMBL
	LPPRC_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2012-10-02	Lrpprc	leucine-rich pentatricopeptide repeat containing	Lrpprc	leucine-rich PPR-motif containing	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Lrpprc	leucine-rich PPR-motif containing	Lrpprc_predicted	leucine-rich PPR-motif containing (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Lrpprc_predicted	leucine-rich PPR-motif containing (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

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