Txk (TXK tyrosine kinase) - Rat Genome Database

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Gene: Txk (TXK tyrosine kinase) Rattus norvegicus
Analyze
Symbol: Txk
Name: TXK tyrosine kinase
RGD ID: 1306481
Description: Predicted to enable non-membrane spanning protein tyrosine kinase activity. Predicted to be involved in several processes, including positive regulation of immune response; positive regulation of macromolecule biosynthetic process; and regulation of platelet activation. Predicted to act upstream of or within NK T cell differentiation. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be active in plasma membrane. Orthologous to human TXK (TXK tyrosine kinase); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC305311; tyrosine-protein kinase TXK
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81435,817,270 - 35,873,454 (+)NCBIGRCr8
mRatBN7.21435,463,369 - 35,519,448 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1435,463,944 - 35,519,448 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1435,828,243 - 35,884,548 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01437,132,987 - 37,189,292 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01435,621,349 - 35,677,656 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01438,029,809 - 38,085,822 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1438,030,189 - 38,085,919 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01437,840,106 - 37,896,117 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41437,867,565 - 37,923,075 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11437,870,891 - 37,926,425 (+)NCBI
Celera1434,718,226 - 34,773,309 (+)NCBICelera
Cytogenetic Map14p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:10213685   PMID:10523612   PMID:11859127   PMID:12081135   PMID:12477932   PMID:17177976   PMID:18292523  


Genomics

Comparative Map Data
Txk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81435,817,270 - 35,873,454 (+)NCBIGRCr8
mRatBN7.21435,463,369 - 35,519,448 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1435,463,944 - 35,519,448 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1435,828,243 - 35,884,548 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01437,132,987 - 37,189,292 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01435,621,349 - 35,677,656 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01438,029,809 - 38,085,822 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1438,030,189 - 38,085,919 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01437,840,106 - 37,896,117 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41437,867,565 - 37,923,075 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11437,870,891 - 37,926,425 (+)NCBI
Celera1434,718,226 - 34,773,309 (+)NCBICelera
Cytogenetic Map14p11NCBI
TXK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38448,066,393 - 48,134,250 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl448,066,393 - 48,134,250 (-)EnsemblGRCh38hg38GRCh38
GRCh37448,068,410 - 48,136,267 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36447,763,167 - 47,831,030 (-)NCBINCBI36Build 36hg18NCBI36
Build 34447,909,688 - 47,977,201NCBI
Celera448,517,268 - 48,584,988 (-)NCBICelera
Cytogenetic Map4p12NCBI
HuRef447,388,494 - 47,456,038 (-)NCBIHuRef
CHM1_1448,067,554 - 48,135,380 (-)NCBICHM1_1
T2T-CHM13v2.0448,033,459 - 48,101,082 (-)NCBIT2T-CHM13v2.0
Txk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39572,853,321 - 72,910,337 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl572,853,321 - 72,910,120 (-)EnsemblGRCm39 Ensembl
GRCm38572,695,978 - 72,752,992 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl572,695,978 - 72,752,777 (-)EnsemblGRCm38mm10GRCm38
MGSCv37573,087,217 - 73,144,012 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36572,975,117 - 73,015,737 (-)NCBIMGSCv36mm8
Celera569,944,742 - 70,002,864 (-)NCBICelera
Cytogenetic Map5C3.2NCBI
cM Map538.44NCBI
Txk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955443474,099 - 556,697 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955443474,099 - 556,697 (+)NCBIChiLan1.0ChiLan1.0
TXK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2379,730,977 - 79,801,494 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1479,992,362 - 80,063,009 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0474,039,292 - 74,086,744 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1484,750,804 - 84,818,671 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl484,750,804 - 84,818,671 (+)Ensemblpanpan1.1panPan2
TXK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11343,911,881 - 43,977,499 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1343,914,534 - 43,976,655 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1343,865,388 - 43,929,029 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01344,512,768 - 44,576,339 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1344,514,039 - 44,576,331 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11344,190,147 - 44,253,820 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01343,722,001 - 43,785,908 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01344,605,279 - 44,668,806 (-)NCBIUU_Cfam_GSD_1.0
Txk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528532,066,522 - 32,108,331 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648214,190,409 - 14,245,943 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648214,190,409 - 14,231,690 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TXK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl837,977,986 - 38,046,933 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1837,977,222 - 38,047,876 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2840,028,569 - 40,096,747 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TXK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1272,120,429 - 2,186,950 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl272,140,685 - 2,190,398 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604748,133,664 - 48,203,278 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Txk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476118,841,795 - 18,897,458 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476118,841,795 - 18,897,564 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Txk
323 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:328
Count of miRNA genes:196
Interacting mature miRNAs:223
Transcripts:ENSRNOT00000035623
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14826709053267090Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14908897839057237Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
71117Niddm17Non-insulin dependent diabetes mellitus QTL 172.35blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)141759376142336881Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141762256142337007Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141854133263541332Rat
61420Pia6Pristane induced arthritis QTL 64.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)141863134542337007Rat
10755459Coatc15Coat color QTL 150.01681coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)141983694464836944Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143032009280829842Rat
2324617Coatc2Coat color QTL 20.001coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)143076702539153750Rat
1300154Bp189Blood pressure QTL 1893.04arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)143088377768757901Rat

Markers in Region
RH142374  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21435,516,296 - 35,516,460 (+)MAPPERmRatBN7.2
Rnor_6.01438,082,671 - 38,082,834NCBIRnor6.0
Rnor_5.01437,892,966 - 37,893,129UniSTSRnor5.0
RGSC_v3.41437,919,924 - 37,920,087UniSTSRGSC3.4
RGSC_v3.41437,972,923 - 37,973,086UniSTSRGSC3.4
Celera1434,770,158 - 34,770,321UniSTS
Cytogenetic Map14p11UniSTS
AU048888  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21435,495,447 - 35,495,572 (+)MAPPERmRatBN7.2
Rnor_6.01438,061,823 - 38,061,947NCBIRnor6.0
Rnor_5.01437,872,118 - 37,872,242UniSTSRnor5.0
RGSC_v3.41437,899,076 - 37,899,200UniSTSRGSC3.4
Celera1434,749,319 - 34,749,443UniSTS
Cytogenetic Map14p11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 8 19 3
Low 3 13 17 11 11 22 20 8
Below cutoff 18 30 28 28 8 10 39 13 16 8

Sequence


RefSeq Acc Id: ENSRNOT00000035623   ⟹   ENSRNOP00000030643
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1435,463,944 - 35,519,448 (+)Ensembl
Rnor_6.0 Ensembl1438,030,189 - 38,085,919 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000102361   ⟹   ENSRNOP00000077942
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1435,463,990 - 35,519,448 (+)Ensembl
RefSeq Acc Id: NM_001024255   ⟹   NP_001019426
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81435,817,948 - 35,873,452 (+)NCBI
mRatBN7.21435,463,944 - 35,519,448 (+)NCBI
Rnor_6.01438,030,312 - 38,085,822 (+)NCBI
Rnor_5.01437,840,106 - 37,896,117 (+)NCBI
RGSC_v3.41437,867,565 - 37,923,075 (+)RGD
Celera1434,718,226 - 34,773,309 (+)RGD
Sequence:
RefSeq Acc Id: XM_039091893   ⟹   XP_038947821
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81435,817,270 - 35,873,454 (+)NCBI
mRatBN7.21435,463,369 - 35,518,914 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001019426 (Get FASTA)   NCBI Sequence Viewer  
  XP_038947821 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH95847 (Get FASTA)   NCBI Sequence Viewer  
  EDL89986 (Get FASTA)   NCBI Sequence Viewer  
  EDL89987 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000030643
  ENSRNOP00000030643.3
  ENSRNOP00000077942.1
RefSeq Acc Id: NP_001019426   ⟸   NM_001024255
- UniProtKB: Q501W1 (UniProtKB/TrEMBL),   A0A8I5Y280 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000030643   ⟸   ENSRNOT00000035623
RefSeq Acc Id: XP_038947821   ⟸   XM_039091893
- Peptide Label: isoform X1
- UniProtKB: A0A8I5Y280 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000077942   ⟸   ENSRNOT00000102361
Protein Domains
Protein kinase   SH2   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q501W1-F1-model_v2 AlphaFold Q501W1 1-526 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699298
Promoter ID:EPDNEW_R9823
Type:multiple initiation site
Name:Txk_1
Description:TXK tyrosine kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01438,030,279 - 38,030,339EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306481 AgrOrtholog
BioCyc Gene G2FUF-15853 BioCyc
Ensembl Genes ENSRNOG00000025925 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000035623 ENTREZGENE
  ENSRNOT00000035623.5 UniProtKB/TrEMBL
  ENSRNOT00000102361.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.505.10 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7388955 IMAGE-MGC_LOAD
InterPro Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser-Thr/Tyr-Pkinase UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  SH3-like_dom UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
  Txk_SH2 UniProtKB/TrEMBL
  TXK_SH3 UniProtKB/TrEMBL
  Tyr_Pkinase_cat_dom UniProtKB/TrEMBL
  Tyr_prot_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:305311 UniProtKB/TrEMBL
MGC_CLONE MGC:112756 IMAGE-MGC_LOAD
NCBI Gene 305311 ENTREZGENE
PANTHER TYROSINE-PROTEIN KINASE UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE TXK UniProtKB/TrEMBL
Pfam Pkinase_Tyr UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
PharmGKB TXK RGD
PhenoGen Txk PhenoGen
PRINTS SH2DOMAIN UniProtKB/TrEMBL
  TYRKINASE UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000025925 RatGTEx
SMART SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
UniProt A0A8I5Y280 ENTREZGENE, UniProtKB/TrEMBL
  A6JD65_RAT UniProtKB/TrEMBL
  Q501W1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Txk  TXK tyrosine kinase  Txk_predicted  TXK tyrosine kinase (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Txk_predicted  TXK tyrosine kinase (predicted)      Symbol and Name status set to approved 70820 APPROVED