Apol3l1 (apolipoprotein L3 like 1) - Rat Genome Database

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Gene: Apol3l1 (apolipoprotein L3 like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Apol3l1
Name: apolipoprotein L3 like 1
RGD ID: 1306480
Description: Predicted to enable lipid binding activity. Predicted to be involved in lipid transport and lipoprotein metabolic process. Predicted to be located in extracellular region.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Apol3; apolipoprotein L, 3; apolipoprotein L3; LOC315108
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Related Pseudogenes: Apol7b-ps1  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87111,169,307 - 111,178,306 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7111,169,307 - 111,178,307 (+)EnsemblGRCr8
mRatBN7.27109,288,725 - 109,297,728 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7109,288,725 - 109,297,723 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7111,044,263 - 111,053,281 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07113,267,831 - 113,276,845 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07113,229,712 - 113,238,717 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07118,685,022 - 118,694,016 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7118,685,022 - 118,694,015 (+)Ensemblrn6Rnor6.0
Rnor_5.07118,680,551 - 118,691,565 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47115,625,472 - 115,634,307 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7105,630,475 - 105,639,461 (+)NCBICelera
RGSC_v3.17115,659,701 - 115,668,536 (+)NCBI
Cytogenetic Map7q34NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:12761501   PMID:19946888  


Genomics

Variants

.
Variants in Apol3l1
60 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:42
Count of miRNA genes:40
Interacting mature miRNAs:40
Transcripts:ENSRNOT00000068221
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)792388565119280177Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)782111245123048330Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7104186212135371468Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)773618702118618702Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)793302009131686183Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)771621154114982716Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)785043242130043242Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)785497398130497398Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
1331723Bw25Body weight QTL 253.348body mass (VT:0001259)body weight (CMO:0000012)796700404111672180Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)783626689128626689Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)782111382132099989Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)773557047118557047Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)782111245123048330Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)796700404118618702Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7110725024135371468Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
10450862Kidm55Kidney mass QTL 554.9kidney mass (VT:0002707)kidney weight (CMO:0000081)772725037117725037Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)7100548246137014596Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
10450856Livw4Liver weight QTL 43.8liver mass (VT:0003402)liver weight (CMO:0000092)772725037117725037Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)778682549123682549Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)771621154119349044Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 157 91 90 59 92 59 6 356 192 11 134 81 92 31 13 13

Sequence


Ensembl Acc Id: ENSRNOT00000068221   ⟹   ENSRNOP00000060690
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7111,169,448 - 111,178,307 (+)Ensembl
Rnor_6.0 Ensembl7118,685,181 - 118,694,015 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000089135   ⟹   ENSRNOP00000075710
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7111,169,307 - 111,178,306 (+)Ensembl
mRatBN7.2 Ensembl7109,288,725 - 109,297,723 (+)Ensembl
Rnor_6.0 Ensembl7118,685,022 - 118,694,015 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000094760   ⟹   ENSRNOP00000096192
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7109,295,762 - 109,297,723 (+)Ensembl
RefSeq Acc Id: NM_001013175   ⟹   NP_001013193
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87111,169,307 - 111,178,306 (+)NCBI
mRatBN7.27109,288,725 - 109,297,724 (+)NCBI
Rnor_6.07118,685,181 - 118,694,016 (+)NCBI
Rnor_5.07118,680,551 - 118,691,565 (+)NCBI
RGSC_v3.47115,625,472 - 115,634,307 (+)RGD
Celera7105,630,634 - 105,639,461 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001277359   ⟹   NP_001264288
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87111,169,307 - 111,178,306 (+)NCBI
mRatBN7.27109,288,725 - 109,297,724 (+)NCBI
Rnor_6.07118,685,022 - 118,694,016 (+)NCBI
Rnor_5.07118,680,551 - 118,691,565 (+)NCBI
Celera7105,630,475 - 105,639,461 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039079252   ⟹   XP_038935180
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87111,176,862 - 111,178,306 (+)NCBI
mRatBN7.27109,296,280 - 109,297,728 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001013193 (Get FASTA)   NCBI Sequence Viewer  
  NP_001264288 (Get FASTA)   NCBI Sequence Viewer  
  XP_038935180 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH86447 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000075710
  ENSRNOP00000075710.1
RefSeq Acc Id: NP_001013193   ⟸   NM_001013175
- UniProtKB: Q5U1W1 (UniProtKB/TrEMBL),   A6HSG3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001264288   ⟸   NM_001277359
- UniProtKB: Q5U1W1 (UniProtKB/TrEMBL),   A6HSG3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075710   ⟸   ENSRNOT00000089135
Ensembl Acc Id: ENSRNOP00000060690   ⟸   ENSRNOT00000068221
RefSeq Acc Id: XP_038935180   ⟸   XM_039079252
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AP14 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000096192   ⟸   ENSRNOT00000094760

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5U1W1-F1-model_v2 AlphaFold Q5U1W1 1-336 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695448
Promoter ID:EPDNEW_R5973
Type:multiple initiation site
Name:Apol3_1
Description:apolipoprotein L, 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07118,685,022 - 118,685,082EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306480 AgrOrtholog
BioCyc Gene G2FUF-32869 BioCyc
Ensembl Genes ENSRNOG00000042771 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000089135 ENTREZGENE
  ENSRNOT00000089135.3 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7304352 IMAGE-MGC_LOAD
InterPro ApoL UniProtKB/TrEMBL
KEGG Report rno:315108 UniProtKB/TrEMBL
MGC_CLONE MGC:106019 IMAGE-MGC_LOAD
NCBI Gene 315108 ENTREZGENE
PANTHER ApoL UniProtKB/TrEMBL
  APOLIPOPROTEIN L2 UniProtKB/TrEMBL
Pfam ApoL UniProtKB/TrEMBL
PhenoGen Apol3l1 PhenoGen
RatGTEx ENSRNOG00000042771 RatGTEx
UniProt A0A8I6AP14 ENTREZGENE
  A6HSG3 ENTREZGENE, UniProtKB/TrEMBL
  Q5U1W1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-08-03 Apol3l1  apolipoprotein L3 like 1  Apol3  apolipoprotein L3  Name and Symbol changed 629549 APPROVED
2022-04-18 Apol3  apolipoprotein L3  Apol3  apolipoprotein L, 3  Name changed 629549 APPROVED
2005-12-06 Apol3  apolipoprotein L, 3  Apol3_predicted  apolipoprotein L, 3 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Apol3_predicted  apolipoprotein L, 3 (predicted)      Symbol and Name status set to approved 70820 APPROVED