Rapgef2 (Rap guanine nucleotide exchange factor 2) - Rat Genome Database

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Gene: Rapgef2 (Rap guanine nucleotide exchange factor 2) Rattus norvegicus
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Symbol: Rapgef2
Name: Rap guanine nucleotide exchange factor 2
RGD ID: 1306434
Description: Enables protein kinase binding activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of ERK1 and ERK2 cascade; and positive regulation of GTPase activity. Located in several cellular components, including neuron projection; neuronal cell body; and synapse. Part of protein-containing complex. Human ortholog(s) of this gene implicated in familial adult myoclonic epilepsy 7. Orthologous to human RAPGEF2 (Rap guanine nucleotide exchange factor 2); PARTICIPATES IN adenosine signaling pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 2-methoxyethanol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CNrasGEF; cyclic nucleotide ras GEF; LOC102553473; LOC310533; neural RAP guanine nucleotide exchange protein; nRap GEP; PDZ domain-containing guanine nucleotide exchange factor 1; PDZ-GEF1; RA-GEF-1; Rap guanine nucleotide exchange factor (GEF) 2; rap guanine nucleotide exchange factor 6-like; ras/Rap1-associating GEF-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82166,505,868 - 166,728,139 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2166,505,868 - 166,726,698 (-)EnsemblGRCr8
mRatBN7.22164,207,513 - 164,322,157 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2164,207,513 - 164,244,247 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2171,425,256 - 171,539,995 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02169,440,712 - 169,555,299 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02164,049,532 - 164,164,134 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02177,836,191 - 178,057,378 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2177,836,202 - 178,057,157 (-)Ensemblrn6Rnor6.0
Rnor_5.02197,171,946 - 197,285,983 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42170,472,420 - 170,587,987 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2158,305,258 - 158,419,241 (-)NCBICelera
RGSC_v3.12170,422,533 - 170,512,880 (-)NCBI
Cytogenetic Map2q33NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methoxyethanol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
allethrin  (EXP)
amitrole  (EXP)
antirheumatic drug  (ISO)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
caffeine  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
Enterolactone  (ISO)
fenvalerate  (EXP)
fluoranthene  (ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
geldanamycin  (ISO)
gentamycin  (EXP)
hemin  (ISO)
hexadecanoic acid  (ISO)
hydroquinone  (ISO)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
N,N-diethyl-m-toluamide  (EXP)
Nor-9-carboxy-delta9-THC  (ISO)
ochratoxin A  (ISO)
oxaliplatin  (EXP)
paracetamol  (EXP,ISO)
permethrin  (EXP)
potassium chromate  (ISO)
propiconazole  (EXP,ISO)
pyrethrins  (EXP)
quercetin  (ISO)
rac-lactic acid  (ISO)
sevoflurane  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
taurine  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone enanthate  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
topotecan  (EXP)
triacsin C  (ISO)
triadimefon  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vitamin E  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating adrenergic receptor signaling pathway  (ISO,ISS)
adenylate cyclase-modulating G protein-coupled receptor signaling pathway  (ISO,ISS)
blood vessel development  (ISO,ISS)
brain-derived neurotrophic factor receptor signaling pathway  (IMP)
cell differentiation  (IEA)
cellular response to cAMP  (ISO,ISS)
cellular response to cGMP  (ISO,ISS)
cellular response to nerve growth factor stimulus  (IDA)
establishment of endothelial barrier  (ISO,ISS)
establishment of endothelial intestinal barrier  (ISO)
forebrain neuron development  (ISO,ISS)
G protein-coupled receptor signaling pathway  (ISO,ISS)
negative regulation of cell population proliferation  (ISO,ISS)
negative regulation of dendrite morphogenesis  (ISO,ISS)
negative regulation of melanin biosynthetic process  (ISO,ISS)
nerve growth factor signaling pathway  (IDA)
nervous system development  (IEA)
neuron migration  (ISO,ISS)
neuron projection development  (IBA,ISO,ISS)
neuropeptide signaling pathway  (ISO,ISS)
positive regulation of cAMP-dependent protein kinase activity  (ISO,ISS)
positive regulation of dendritic cell apoptotic process  (ISO,ISS)
positive regulation of ERK1 and ERK2 cascade  (IEA,IMP,ISO,ISS)
positive regulation of GTPase activity  (IDA,IMP,ISO,ISS)
positive regulation of microvillus assembly  (ISO)
positive regulation of neuron migration  (ISO,ISS)
positive regulation of neuron projection development  (IMP)
positive regulation of protein kinase activity  (IMP,ISO,ISS)
positive regulation of vasculogenesis  (ISO,ISS)
Rap protein signal transduction  (IBA,ISO,ISS)
Ras protein signal transduction  (IBA)
regulation of cell junction assembly  (ISO,ISS)
regulation of modification of postsynaptic structure  (ISO)
regulation of neuron projection development  (IEA)
regulation of synaptic plasticity  (IDA)
signal transduction  (IEA)
small GTPase-mediated signal transduction  (IEA)
ventricular system development  (ISO,ISS)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rap1-PDZ-GEF1 interacts with a neurotrophin receptor at late endosomes, leading to sustained activation of Rap1 and ERK and neurite outgrowth. Hisata S, etal., J Cell Biol. 2007 Aug 27;178(5):843-60.
4. Requirement for Plk2 in orchestrated ras and rap signaling, homeostatic structural plasticity, and memory. Lee KJ, etal., Neuron. 2011 Mar 10;69(5):957-73. doi: 10.1016/j.neuron.2011.02.004.
5. nRap GEP: a novel neural GDP/GTP exchange protein for rap1 small G protein that interacts with synaptic scaffolding molecule (S-SCAM). Ohtsuka T, etal., Biochem Biophys Res Commun. 1999 Nov;265(1):38-44.
6. Direct binding of the beta1 adrenergic receptor to the cyclic AMP-dependent guanine nucleotide exchange factor CNrasGEF leads to Ras activation. Pak Y, etal., Mol Cell Biol. 2002 Nov;22(22):7942-52.
7. The guanine nucleotide exchange factor CNrasGEF activates ras in response to cAMP and cGMP. Pham N, etal., Curr Biol. 2000 May 4;10(9):555-8.
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10608844   PMID:10608883   PMID:10873669   PMID:10934204   PMID:11168587   PMID:11359771   PMID:11598133   PMID:16272156   PMID:17826737   PMID:19453629   PMID:19635461   PMID:21840392  
PMID:21864586   PMID:22797597   PMID:23800469   PMID:23885123   PMID:24567337   PMID:29476059   PMID:30053369   PMID:32885411  


Genomics

Comparative Map Data
Rapgef2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82166,505,868 - 166,728,139 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2166,505,868 - 166,726,698 (-)EnsemblGRCr8
mRatBN7.22164,207,513 - 164,322,157 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2164,207,513 - 164,244,247 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2171,425,256 - 171,539,995 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02169,440,712 - 169,555,299 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02164,049,532 - 164,164,134 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02177,836,191 - 178,057,378 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2177,836,202 - 178,057,157 (-)Ensemblrn6Rnor6.0
Rnor_5.02197,171,946 - 197,285,983 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42170,472,420 - 170,587,987 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2158,305,258 - 158,419,241 (-)NCBICelera
RGSC_v3.12170,422,533 - 170,512,880 (-)NCBI
Cytogenetic Map2q33NCBI
RAPGEF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384159,103,079 - 159,360,173 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4159,103,013 - 159,360,174 (+)Ensemblhg38GRCh38
GRCh374160,024,231 - 160,281,325 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364160,408,448 - 160,500,752 (+)NCBIBuild 36Build 36hg18NCBI36
Celera4157,529,482 - 157,621,655 (+)NCBICelera
Cytogenetic Map4q32.1NCBI
HuRef4155,939,342 - 156,031,440 (+)NCBIHuRef
CHM1_14160,165,501 - 160,257,796 (+)NCBICHM1_1
T2T-CHM13v2.04162,453,893 - 162,710,940 (+)NCBIT2T-CHM13v2.0
Rapgef2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39378,969,818 - 79,194,681 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl378,969,823 - 79,193,824 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38379,062,511 - 79,286,545 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl379,062,516 - 79,286,517 (-)Ensemblmm10GRCm38
MGSCv37378,866,450 - 78,949,797 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36379,148,443 - 79,372,981 (-)NCBIMGSCv36mm8
MGSCv36379,728,293 - 79,956,813 (-)NCBIMGSCv36mm8
Celera379,094,490 - 79,178,178 (-)NCBICelera
Cytogenetic Map3E3NCBI
cM Map334.91NCBI
Rapgef2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547112,670,764 - 12,815,430 (+)Ensembl
ChiLan1.0NW_00495547112,670,837 - 12,838,910 (+)NCBIChiLan1.0ChiLan1.0
RAPGEF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23156,967,271 - 157,228,616 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14157,322,566 - 157,584,039 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04151,419,402 - 151,680,769 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14163,316,387 - 163,489,514 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4163,316,396 - 163,487,495 (+)EnsemblpanPan2panpan1.1
RAPGEF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11556,133,094 - 56,353,609 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1556,174,578 - 56,352,569 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1556,473,491 - 56,715,382 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01556,855,560 - 57,097,663 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1556,855,619 - 57,097,663 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11556,092,734 - 56,334,363 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01556,190,343 - 56,432,335 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01556,504,459 - 56,746,362 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rapgef2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530133,800,312 - 33,963,070 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365765,583,805 - 5,746,671 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365765,583,847 - 5,746,583 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAPGEF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl848,021,604 - 48,277,454 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1848,183,518 - 48,277,476 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2850,390,322 - 50,684,115 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RAPGEF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17105,672,583 - 105,883,544 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7105,624,608 - 105,884,366 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603785,337,825 - 85,597,514 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rapgef2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248483,968,362 - 4,182,885 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248483,968,845 - 4,184,740 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Rapgef2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1374,112,626 - 74,327,233 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Rapgef2
1482 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:923
Count of miRNA genes:293
Interacting mature miRNAs:392
Transcripts:ENSRNOT00000012792, ENSRNOT00000029340
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2163997722225110681Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149957381221199885Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2138595962205135428Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2145807215220931416Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2124537199209621565Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085199723085Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2145807215190807215Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085199723085Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2159440891205135267Rat
10043139Iddm55Insulin dependent diabetes mellitus QTL 553.10.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2150313808195313808Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085199723085Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085199723085Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2159440891220931218Rat
12879845Cm89Cardiac mass QTL 890.008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085178247591Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2143565208188565208Rat
12879846Cm90Cardiac mass QTL 900.011heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)2154723085178247591Rat
12879847Am4Aortic mass QTL 40.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085178247591Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2154723085199723085Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2139067258192287892Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2159440760195313808Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2144882354205135428Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2139067258184067258Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2159440760228950743Rat
2301415Cm67Cardiac mass QTL 670.003heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085178247591Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2143746578205135428Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
11565180Kidm56Kidney mass QTL 560.003kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085178247591Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150096616195096616Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
11565181Bw176Body weight QTL 1760.002body mass (VT:0001259)body weight (CMO:0000012)2154723085178247591Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2145306936212705578Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2147287892192287892Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660223841096Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
631520Bp73Blood pressure QTL 730.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149806826170653323Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150096616195096616Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2165453811210453811Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2163253030208253030Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166372086229820014Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2145807215173074435Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
23 13 85 217 91 90 59 158 59 6 493 286 22 195 117 124 31 34 34

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001107684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001428994 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006232511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006232512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006232513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761093 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761097 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761098 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281806 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281807 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281811 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281813 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000012792   ⟹   ENSRNOP00000012792
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2166,505,868 - 166,620,371 (-)Ensembl
mRatBN7.2 Ensembl2164,207,513 - 164,244,247 (-)Ensembl
Rnor_6.0 Ensembl2177,836,202 - 177,950,517 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000029340   ⟹   ENSRNOP00000037119
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2177,838,210 - 177,924,970 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000091135   ⟹   ENSRNOP00000068918
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2177,837,270 - 178,057,157 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109597   ⟹   ENSRNOP00000108017
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2166,505,868 - 166,596,931 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000120725   ⟹   ENSRNOP00000108754
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2166,505,868 - 166,726,698 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000126958   ⟹   ENSRNOP00000101433
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2166,505,868 - 166,596,100 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000136003   ⟹   ENSRNOP00000105776
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2166,505,868 - 166,726,698 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000140490   ⟹   ENSRNOP00000100308
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2166,505,868 - 166,726,698 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000166740   ⟹   ENSRNOP00000109880
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2166,505,868 - 166,595,977 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000168219   ⟹   ENSRNOP00000107936
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2166,505,868 - 166,700,438 (-)Ensembl
RefSeq Acc Id: NM_001107684   ⟹   NP_001101154
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82166,505,868 - 166,620,371 (-)NCBI
mRatBN7.22164,207,513 - 164,322,157 (-)NCBI
Rnor_6.02177,836,202 - 177,950,517 (-)NCBI
Rnor_5.02197,171,946 - 197,285,983 (-)NCBI
RGSC_v3.42170,472,420 - 170,587,987 (-)RGD
Celera2158,305,258 - 158,419,241 (-)RGD
Sequence:
RefSeq Acc Id: XM_063281806   ⟹   XP_063137876
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82166,505,876 - 166,728,139 (-)NCBI
RefSeq Acc Id: XM_063281807   ⟹   XP_063137877
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82166,505,876 - 166,728,139 (-)NCBI
RefSeq Acc Id: XM_063281808   ⟹   XP_063137878
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82166,505,876 - 166,728,139 (-)NCBI
RefSeq Acc Id: XM_063281809   ⟹   XP_063137879
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82166,505,876 - 166,701,616 (-)NCBI
RefSeq Acc Id: XM_063281810   ⟹   XP_063137880
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82166,505,876 - 166,620,625 (-)NCBI
RefSeq Acc Id: XM_063281811   ⟹   XP_063137881
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82166,505,876 - 166,628,728 (-)NCBI
RefSeq Acc Id: XM_063281812   ⟹   XP_063137882
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82166,505,876 - 166,632,879 (-)NCBI
RefSeq Acc Id: XM_063281813   ⟹   XP_063137883
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82166,505,876 - 166,620,735 (-)NCBI
RefSeq Acc Id: XM_063281814   ⟹   XP_063137884
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82166,505,876 - 166,595,783 (-)NCBI
RefSeq Acc Id: XM_063281815   ⟹   XP_063137885
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82166,505,876 - 166,604,460 (-)NCBI
RefSeq Acc Id: NP_001101154   ⟸   NM_001107684
- Sequence:
Ensembl Acc Id: ENSRNOP00000068918   ⟸   ENSRNOT00000091135
Ensembl Acc Id: ENSRNOP00000037119   ⟸   ENSRNOT00000029340
Ensembl Acc Id: ENSRNOP00000012792   ⟸   ENSRNOT00000012792
RefSeq Acc Id: XP_063137877   ⟸   XM_063281807
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063137878   ⟸   XM_063281808
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063137876   ⟸   XM_063281806
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063137879   ⟸   XM_063281809
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063137882   ⟸   XM_063281812
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063137881   ⟸   XM_063281811
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063137883   ⟸   XM_063281813
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063137880   ⟸   XM_063281810
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063137885   ⟸   XM_063281815
- Peptide Label: isoform X9
RefSeq Acc Id: XP_063137884   ⟸   XM_063281814
- Peptide Label: isoform X8
- UniProtKB: F1M386 (UniProtKB/Swiss-Prot),   D3ZD17 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000101433   ⟸   ENSRNOT00000126958
Ensembl Acc Id: ENSRNOP00000105776   ⟸   ENSRNOT00000136003
Ensembl Acc Id: ENSRNOP00000100308   ⟸   ENSRNOT00000140490
Ensembl Acc Id: ENSRNOP00000108017   ⟸   ENSRNOT00000109597
Ensembl Acc Id: ENSRNOP00000109880   ⟸   ENSRNOT00000166740
Ensembl Acc Id: ENSRNOP00000107936   ⟸   ENSRNOT00000168219
Ensembl Acc Id: ENSRNOP00000108754   ⟸   ENSRNOT00000120725
Protein Domains
N-terminal Ras-GEF   PDZ   Ras-associating   Ras-GEF

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M386-F1-model_v2 AlphaFold F1M386 1-1496 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691400
Promoter ID:EPDNEW_R1908
Type:single initiation site
Name:Rapgef2_1
Description:Rap guanine nucleotide exchange factor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02178,057,104 - 178,057,164EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306434 AgrOrtholog
BioCyc Gene G2FUF-52736 BioCyc
Ensembl Genes ENSRNOG00000021581 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000120725 ENTREZGENE
  ENSRNOT00000126958 ENTREZGENE
  ENSRNOT00000136003 ENTREZGENE
  ENSRNOT00000140490 ENTREZGENE
  ENSRNOT00000166740 ENTREZGENE
  ENSRNOT00000168219 ENTREZGENE
Gene3D-CATH 1.10.840.10 UniProtKB/Swiss-Prot
  2.30.42.10 UniProtKB/Swiss-Prot
  2.60.120.10 UniProtKB/Swiss-Prot
  Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/Swiss-Prot
  Son of sevenless (SoS) protein Chain: S domain 1 UniProtKB/Swiss-Prot
InterPro cNMP-bd-like UniProtKB/Swiss-Prot
  cNMP-bd_dom UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
  PDZ_sf UniProtKB/Swiss-Prot
  RA_dom UniProtKB/Swiss-Prot
  Ras-like_Gua-exchang_fac_N UniProtKB/Swiss-Prot
  Ras_GEF_dom_sf UniProtKB/Swiss-Prot
  RASGEF_cat_dom UniProtKB/Swiss-Prot
  RASGEF_cat_dom_sf UniProtKB/Swiss-Prot
  RmlC-like_jellyroll UniProtKB/Swiss-Prot
  Ubiquitin-like_domsf UniProtKB/Swiss-Prot
KEGG Report rno:310533 UniProtKB/Swiss-Prot
NCBI Gene 310533 ENTREZGENE
PANTHER CYCLIC NUCLEOTIDE RAS GEF UniProtKB/Swiss-Prot
  CYTOSKELETON-ASSOCIATED PROTEIN 4 UniProtKB/Swiss-Prot
Pfam PDZ UniProtKB/Swiss-Prot
  PF00788 UniProtKB/Swiss-Prot
  RasGEF UniProtKB/Swiss-Prot
  RasGEF_N UniProtKB/Swiss-Prot
PhenoGen Rapgef2 PhenoGen
PROSITE CNMP_BINDING_3 UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
  PS50200 UniProtKB/Swiss-Prot
  RASGEF_CAT UniProtKB/Swiss-Prot
  RASGEF_NTER UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000021581 RatGTEx
SMART cNMP UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
  RasGEF UniProtKB/Swiss-Prot
  RasGEFN UniProtKB/Swiss-Prot
  SM00314 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48366 UniProtKB/Swiss-Prot
  SSF50156 UniProtKB/Swiss-Prot
  SSF51206 UniProtKB/Swiss-Prot
  SSF54236 UniProtKB/Swiss-Prot
UniProt A0ABK0KW23_RAT UniProtKB/TrEMBL
  A0ABK0L6B5_RAT UniProtKB/TrEMBL
  A0ABK0LDC2_RAT UniProtKB/TrEMBL
  A0ABK0LHZ7_RAT UniProtKB/TrEMBL
  A0ABK0LJJ5_RAT UniProtKB/TrEMBL
  A0ABK0LRW3_RAT UniProtKB/TrEMBL
  A0ABK0LWL6_RAT UniProtKB/TrEMBL
  D3ZD17 ENTREZGENE
  F1M386 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary D3ZD17 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-20 Rapgef2  Rap guanine nucleotide exchange factor 2  Rapgef2  Rap guanine nucleotide exchange factor (GEF) 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-07-29 Rapgef2  Rap guanine nucleotide exchange factor (GEF) 2  LOC102553473  rap guanine nucleotide exchange factor 6-like  Data merged from RGD:7554452 737654 PROVISIONAL
2013-12-17 LOC102553473  rap guanine nucleotide exchange factor 6-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 Rapgef2  Rap guanine nucleotide exchange factor (GEF) 2   Rapgef2_predicted  Rap guanine nucleotide exchange factor (GEF) 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Rapgef2_predicted  Rap guanine nucleotide exchange factor (GEF) 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED