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Gene: Ivns1abp (influenza virus NS1A binding protein) Rattus norvegicus

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Symbol:

Ivns1abp

Name:

influenza virus NS1A binding protein

RGD ID:

1306290

Description:

Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in several processes, including negative regulation of protein ubiquitination; proteasome-mediated ubiquitin-dependent protein catabolic process; and response to virus. Predicted to act upstream of or within negative regulation of intrinsic apoptotic signaling pathway. Predicted to be located in nucleus. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in immunodeficiency 70. Orthologous to human IVNS1ABP (influenza virus NS1A binding protein); PARTICIPATES IN influenza A pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC289089

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	65,977,069 - 65,996,685 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	65,977,045 - 65,997,547 (+)	Ensembl				GRCr8
mRatBN7.2	13	63,427,040 - 63,446,701 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	63,427,041 - 63,446,701 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	66,046,767 - 66,066,387 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	67,311,389 - 67,331,009 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	64,574,305 - 64,593,936 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	68,702,970 - 68,722,472 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	68,702,820 - 68,722,472 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	13	73,670,179 - 73,684,851 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	13	66,228,241 - 66,235,533 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	13	63,369,286 - 63,376,578 (+)	NCBI		Celera
RGSC_v3.1	13	66,231,168 - 66,250,662 (+)	NCBI
Cytogenetic Map	13	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

immunodeficiency 70 (ISO)

Prostatic Neoplasms (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-catechin (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP,ISO)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

2-hydroxypropanoic acid (ISO)

3,3',4,4'-tetrachlorobiphenyl (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3H-1,2-dithiole-3-thione (EXP)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

7,12-dimethyltetraphene (ISO)

acetamide (EXP)

aflatoxin B1 (ISO)

aldrin (ISO)

all-trans-retinoic acid (ISO)

amiodarone (EXP)

amphetamine (EXP)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

Aroclor 1254 (ISO)

arsane (ISO)

arsenic atom (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[b]fluoranthene (ISO)

beta-lapachone (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

choline (ISO)

ciguatoxin CTX1B (ISO)

clofibrate (ISO)

cobalt dichloride (ISO)

copper atom (EXP,ISO)

copper(0) (EXP,ISO)

copper(II) sulfate (ISO)

coumarin (ISO)

coumestrol (ISO)

crocidolite asbestos (ISO)

cycloheximide (ISO)

cyclosporin A (ISO)

cytochalasin D (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

endosulfan (EXP)

epoxiconazole (ISO)

flutamide (EXP)

folic acid (ISO)

formaldehyde (ISO)

FR900359 (ISO)

fulvestrant (ISO)

furan (EXP)

gentamycin (EXP)

hydrogen peroxide (ISO)

ivermectin (ISO)

ketamine (EXP)

L-methionine (ISO)

levofloxacin (EXP)

maneb (ISO)

mercury atom (ISO)

mercury(0) (ISO)

methamphetamine (ISO)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

N-methyl-4-phenylpyridinium (ISO)

nickel sulfate (ISO)

ozone (ISO)

paracetamol (EXP,ISO)

paraquat (ISO)

pentanal (ISO)

pirinixic acid (ISO)

progesterone (ISO)

quercetin (ISO)

rac-lactic acid (ISO)

resveratrol (ISO)

rimonabant (ISO)

rotenone (EXP)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

tamoxifen (ISO)

tetrachloromethane (ISO)

titanium dioxide (ISO)

trichostatin A (ISO)

triphenyl phosphate (ISO)

trovafloxacin (ISO)

urethane (ISO)

valproic acid (ISO)

vincristine (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of intrinsic apoptotic signaling pathway (ISO)

negative regulation of protein ubiquitination (IEA,ISO)

proteasome-mediated ubiquitin-dependent protein catabolic process (IBA)

response to virus (IEA,ISO)

RNA splicing (IEA,ISO)

Cellular Component

Cul3-RING ubiquitin ligase complex (IBA)

cytoplasm (IBA)

cytosol (IEA,ISO)

nucleus (IEA,ISO)

Molecular Function

protein binding (ISO)

ubiquitin-like ligase-substrate adaptor activity (IBA)

Molecular Pathway Annotations Click to see Annotation Detail View

influenza A pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:15485691	PMID:16320578	PMID:22970292	PMID:23825951	PMID:24625528	PMID:25619834	PMID:31505169

Genomics

Comparative Map Data

Ivns1abp
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	65,977,069 - 65,996,685 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	65,977,045 - 65,997,547 (+)	Ensembl				GRCr8
mRatBN7.2	13	63,427,040 - 63,446,701 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	63,427,041 - 63,446,701 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	66,046,767 - 66,066,387 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	67,311,389 - 67,331,009 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	64,574,305 - 64,593,936 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	68,702,970 - 68,722,472 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	68,702,820 - 68,722,472 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	13	73,670,179 - 73,684,851 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	13	66,228,241 - 66,235,533 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	13	63,369,286 - 63,376,578 (+)	NCBI		Celera
RGSC_v3.1	13	66,231,168 - 66,250,662 (+)	NCBI
Cytogenetic Map	13	q21	NCBI

IVNS1ABP
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	185,296,388 - 185,317,243 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	185,292,931 - 185,317,780 (-)	Ensembl			hg38	GRCh38
GRCh37	1	185,265,520 - 185,286,375 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	183,532,143 - 183,553,084 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	1	158,376,215 - 158,397,156 (-)	NCBI		Celera
Cytogenetic Map	1	q25.3	NCBI
HuRef	1	156,500,884 - 156,521,692 (-)	NCBI		HuRef
CHM1_1	1	186,687,273 - 186,708,214 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	184,653,292 - 184,680,201 (-)	NCBI		T2T-CHM13v2.0

Ivns1abp
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	151,220,237 - 151,240,196 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	151,220,228 - 151,240,173 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	1	151,344,486 - 151,364,445 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	151,344,477 - 151,364,422 (+)	Ensembl			mm10	GRCm38
MGSCv37	1	153,191,628 - 153,211,575 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	1	153,106,716 - 153,126,663 (+)	NCBI		MGSCv36	mm8
Celera	1	153,774,124 - 153,794,094 (+)	NCBI		Celera
Cytogenetic Map	1	G1	NCBI
cM Map	1	64.06	NCBI

Ivns1abp
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955406	23,866,705 - 23,881,321 (-)	Ensembl
ChiLan1.0	NW_004955406	23,866,705 - 23,881,184 (-)	NCBI	ChiLan1.0	ChiLan1.0

IVNS1ABP
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	64,403,270 - 64,425,137 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	64,088,435 - 64,107,348 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	160,822,327 - 160,843,022 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	164,974,734 - 164,995,608 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	164,974,734 - 164,995,608 (-)	Ensembl			panPan2	panpan1.1

IVNS1ABP
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	18,430,970 - 18,444,573 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	18,431,553 - 18,444,573 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	18,015,226 - 18,036,593 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	18,163,391 - 18,184,748 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	18,149,299 - 18,184,203 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	18,073,072 - 18,094,438 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	18,180,728 - 18,202,078 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	18,311,980 - 18,333,334 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Ivns1abp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	87,068,767 - 87,088,386 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936481	4,915,516 - 4,935,403 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936481	4,915,516 - 4,935,130 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

IVNS1ABP
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	126,453,155 - 126,479,587 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	9	126,459,542 - 126,480,126 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	138,907,583 - 138,917,437 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

IVNS1ABP
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	44,083,696 - 44,104,760 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	25	44,083,762 - 44,104,947 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666055	45,289,143 - 45,310,235 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ivns1abp
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624814	8,270,489 - 8,290,553 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624814	8,270,510 - 8,291,971 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Ivns1abp
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	10	30,772,117 - 30,791,961 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Ivns1abp
157 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	31
Count of miRNA genes:	26
Interacting mature miRNAs:	29
Transcripts:	ENSRNOT00000003558
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1298066	Bp159	Blood pressure QTL 159		0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	48639634	93639634	Rat
10755495	Bp387	Blood pressure QTL 387	3.78		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	37216241	90057603	Rat
1354655	Bp241	Blood pressure QTL 241	3.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	38975045	103588154	Rat
70220	Bp55	Blood pressure QTL 55	5.75		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	13	39924693	84924693	Rat
71119	Thym2	Thymus enlargement QTL 2	3.8		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	13	48749814	87285480	Rat
61391	Bp5	Blood pressure QTL 5	5.6		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	24853925	69853925	Rat
4889861	Pur29	Proteinuria QTL 29	13.8	0.005	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	13	39968211	83286298	Rat
619615	Bp80	Blood pressure QTL 80		0.0354	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	7421791	87286911	Rat
61340	Bp25	Blood pressure QTL 25	4.2	0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	37087983	82087983	Rat
1581573	Uae36	Urinary albumin excretion QTL 36			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	6002008	88706694	Rat
1549897	Stresp12	Stress response QTL 12	3.35		stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	13	40983585	85983585	Rat
724564	Uae11	Urinary albumin excretion QTL 11	5.7		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	13	47354258	94285672	Rat
7207885	Glom27	Glomerulus QTL 27	3.9		kidney glomerulus integrity trait (VT:0010546)	kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)	13	21120177	109350286	Rat
738027	Lnnr6	Liver neoplastic nodule remodeling QTL 6	3.3		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	13	65613454	109350286	Rat
738026	Lnnr5	Liver neoplastic nodule remodeling QTL 5	3.29		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	13	62424592	88113509	Rat
1558644	Cm45	Cardiac mass QTL 45	3.6	0.002	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	13	26244808	71244808	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	13	33794096	78794096	Rat
61349	Bp31	Blood pressure QTL 31	5.75		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	13	39924693	84924693	Rat
1576318	Schws5	Schwannoma susceptibility QTL 5		0.0351	nervous system integrity trait (VT:0010566)	post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)	13	64497900	109350286	Rat
2303563	Bw89	Body weight QTL 89	6		body mass (VT:0001259)	body weight (CMO:0000012)	13	34834947	79834947	Rat
1354621	Rf47	Renal function QTL 47	3.7		kidney renin amount (VT:0010559)	kidney renin level (CMO:0002166)	13	11081740	103588154	Rat
1581554	Pur11	Proteinuria QTL 11			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	6002008	88706694	Rat
12879477	Bp401	Blood pressure QTL 401			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	39814726	84814726	Rat
1331750	Bp220	Blood pressure QTL 220	2.98		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	39968211	84968211	Rat
6893338	Cm76	Cardiac mass QTL 76	0	0.99	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	13	26244808	71244808	Rat
12879475	Bp400	Blood pressure QTL 400			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	64375743	109350286	Rat
11530006	Niddm72	Non-insulin dependent diabetes mellitus QTL 72		0.001	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	13	38286298	83286298	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	1	103588154	Rat

Markers in Region

D13Rat181

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	13	65,982,282 - 65,982,501 (+)	Marker Load Pipeline
mRatBN7.2	13	63,432,298 - 63,432,517 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	68,708,070 - 68,708,288	NCBI	Rnor6.0
Rnor_5.0	13	73,670,449 - 73,670,667	UniSTS	Rnor5.0
RGSC_v3.4	13	66,222,150 - 66,222,368	UniSTS	RGSC3.4
RGSC_v3.4	13	66,222,149 - 66,222,368	RGD	RGSC3.4
Celera	13	63,363,195 - 63,363,413	UniSTS
RGSC_v3.1	13	66,236,229 - 66,236,448	RGD
SHRSP x BN Map	13	23.8399	RGD
SHRSP x BN Map	13	23.8399	UniSTS
Cytogenetic Map	13	q21	UniSTS

RH143231

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	63,444,575 - 63,444,689 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	68,720,347 - 68,720,460	NCBI	Rnor6.0
Rnor_5.0	13	73,682,726 - 73,682,839	UniSTS	Rnor5.0
RGSC_v3.4	13	66,234,427 - 66,234,540	UniSTS	RGSC3.4
Celera	13	63,375,472 - 63,375,585	UniSTS
RH 3.4 Map	13	300.4	UniSTS
Cytogenetic Map	13	q21	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001401342	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006249989	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039090454	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AY553870	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473958	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000003558 ⟹ ENSRNOP00000003558

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	65,977,045 - 65,997,547 (+)	Ensembl
mRatBN7.2 Ensembl	13	63,427,041 - 63,446,635 (+)	Ensembl
Rnor_6.0 Ensembl	13	68,707,776 - 68,722,469 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000066419 ⟹ ENSRNOP00000061111

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	13	68,709,243 - 68,713,268 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000077691

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	13	68,702,879 - 68,707,767 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000080481

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	13	68,709,515 - 68,710,026 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000081269

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	13	68,709,910 - 68,713,690 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000083301 ⟹ ENSRNOP00000071484

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	65,986,944 - 65,996,682 (+)	Ensembl
mRatBN7.2 Ensembl	13	63,427,041 - 63,445,927 (+)	Ensembl
Rnor_6.0 Ensembl	13	68,709,225 - 68,721,653 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000084458

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	13	68,717,092 - 68,717,728 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000085906

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	65,977,069 - 65,995,636 (+)	Ensembl
mRatBN7.2 Ensembl	13	63,427,041 - 63,445,652 (+)	Ensembl
Rnor_6.0 Ensembl	13	68,714,161 - 68,721,453 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000087301

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	13	68,702,820 - 68,707,767 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000087997 ⟹ ENSRNOP00000072879

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	65,977,069 - 65,996,681 (+)	Ensembl
mRatBN7.2 Ensembl	13	63,427,082 - 63,446,701 (+)	Ensembl
Rnor_6.0 Ensembl	13	68,707,776 - 68,722,472 (+)	Ensembl

RefSeq Acc Id:

NM_001401342 ⟹ NP_001388271

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	65,977,069 - 65,996,685 (+)	NCBI
mRatBN7.2	13	63,427,085 - 63,446,701 (+)	NCBI

RefSeq Acc Id:

XM_006249989 ⟹ XP_006250051

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	65,977,132 - 65,988,544 (+)	NCBI
mRatBN7.2	13	63,427,040 - 63,438,560 (+)	NCBI
Rnor_6.0	13	68,702,970 - 68,714,331 (+)	NCBI
Rnor_5.0	13	73,670,179 - 73,684,851 (+)	NCBI

Sequence:

show sequence

CGGTCGCCCCGCGCTCCTTCCAGCGCCTTCCGCCTTCAGCCCGTCGAAGCTCTGGAGATGAATT
TCGCCATCTCTTCAGAGATGACCCAGATTATGATGCATGATTATCACAGAAGAAATTCATGTCT
ATAGCTTTTAAGGACTTGATTACATCATTTTCAAGCCTGATAGTTTTGGAACCACCATTAAAGC
CTAAGACGTCTACCTTACTCAGCCACCTGTCTTCACACCATAACCAAGTGCTTTGTTTCAACAC
TCCTTTGTCTTTCGACACATTTCTCTTCAGTAATAGTTGCCAAATTTATAAGGAAAAATGATTC
CCAATGGATATTTGATGTTTGAAGATGAAAATTTTATTGAATCTTCTGTTGCCAAATTAAATGC
CTTGAGGAAAAGTGGGCAATTCTGTGATGTTCGACTTCAGGTCTGTGGCCATGAGATGCTGGCA
CACAGGGCAGTCCTGGCTTGCTGTAGCCCCTATCTATTTGAAATCTTTAATAGTGACAGTGACC
CTCATGGAGTTTCTCACGTGAAGTTGGATGATCTCAATCCAGAAGCTGTTGAAGTCTTGCTGAA
TTACGCATACACTGCTCAGTTGAAAGCTGATAAGGAATTAGTGAAAGATGTTTATTCTGCAGCG
AAGAAGCTGAAGATGGACCGAGTAAAGCAGGTCTGTGGAGATTATTTACTATCTAGGATGGATG
TTACTAGCTGCATCTCTTATCGGAATTTTGCAAGTTGTATGGGAGACTCTCGTTTGTTGAATAA
AGTTGATGCCTATATTCAGGAGCATTTGTTACAAATTTCAGAAGAGGAGGAATTTCTTAAGCTT
CCGAGACTAAAGTTGGAGGTAATGCTTGAAGATAATGTTTGCTTGCCCAGCAATGGCAAGTTGT
ACACAAAGGTAATCAACTGGGTGCAGCGTAGCATCTGGGAGAATGGAGACAGCCTGGAAGAGCT
CATGGAAGAGGTTTATTAACAAAACTAGGATCCCCAAGACTGAAGAACCGAGAAGAAACCTCGA
GTGTATTGACACGTAAAGAAGCAGCAGTCCTGCCCCAGTTCTCCTAAGAAAAGTCCGCTGTGGG
CAGAGAGCGATGATGATTTAATGGTGTTTACTCCTTTACAGGGTTCTTACCTCTAAAGCTTTGT
GTTTTCAATGGTGTTGTTCTTACATATAGTCAGATTTGGGGCTGTTTTAAAAAAATACACAACA
AAAACAAAATTTGACGGCAAAGGGGACTAGGCCATGTGTTGGTTGAAGCAGTGGGGTAATTGAG
TGTATCACTGCACAGACCCGTCCACGCTCACTGAAGCTAACCTGCTCTGTCAGGCCTTAGTCCC
TGCCGTGACTACCTTCTATAAAGGCAGCAGATGCTCTTTCAATTCTGTGACTTCCCATGTGGGA
ATCAGATGCAGTAGTCATGTATTTGCATCTGTGCAGGAAGAATGCAGCTTGCTTGACTTTTTGC
ATTTGTTTTTTCTTTATGTGTTTTCTTGACATTACCTACAGGGGAGAAGTATGTTTATTCAAAC
AGTGCCATTTATCTTCAAAGGTGTAAACCATTCCGTGTTTTATTGTAAATATGTGTACTTAAGA
ATCTATGTGTTGTACTATACGTTTTTTCTTAATGTCACATAATAGAAGCTCTGGAAACAATGAA
GATTTCTTTCAAGCCAATCAAGCCAAGGACTGACTCTTCAGCCAGTATTAGAAGATTTTGTATT
TGATCTTGATTTTTGTTTTGTTTTTTGTTTGGTTTCGCTTTTTACATTTTTACTACTATGACAT
GTTTTTCTTTGCATCGGGATCCTGCCAGAGTAAGATGTCAAGACGCACACTGGAGGTTACCTTG
AGGCGGTTGTGTAATCTGCGTACTAGCGAGTAGCCATGGTGACAGTAGCCACATGGGTGTTCTG
TTGCTGTTTTGCAGGTTCAAACCTTGTACTACTCAGCTGATCACAAGCTGCTTGATGGGAACCC
ACTAGATGGACAGGCTGAGGTGTTTGGCAGTGATGATGACCACATTCAGTTTGTGCAG

hide sequence

RefSeq Acc Id:

XM_039090454 ⟹ XP_038946382

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	65,987,477 - 65,996,685 (+)	NCBI
mRatBN7.2	13	63,437,493 - 63,446,701 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001388271	(Get FASTA)	NCBI Sequence Viewer
	XP_006250051	(Get FASTA)	NCBI Sequence Viewer
	XP_038946382	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	ABI24163	(Get FASTA)	NCBI Sequence Viewer
	EDM09574	(Get FASTA)	NCBI Sequence Viewer
	EDM09575	(Get FASTA)	NCBI Sequence Viewer
	EDM09576	(Get FASTA)	NCBI Sequence Viewer
	EDM09577	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000003558
	ENSRNOP00000003558.7
	ENSRNOP00000071484
	ENSRNOP00000071484.2
	ENSRNOP00000072879.3
	ENSRNOP00000097868.1

RefSeq Acc Id:	XP_006250051 ⟸ XM_006249989
- Peptide Label:	isoform X2
- UniProtKB:	D4A0T2 (UniProtKB/TrEMBL), A6ICS2 (UniProtKB/TrEMBL)
- Sequence:	show sequence MIPNGYLMFEDENFIESSVAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSD SDPHGVSHVKLDDLNPEAVEVLLNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYLLSR MDVTSCISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKLEVMLEDNVCLPSNG KLYTKVINWVQRSIWENGDSLEELMEEVY hide sequence

Ensembl Acc Id:

ENSRNOP00000072879 ⟸ ENSRNOT00000087997

Ensembl Acc Id:

ENSRNOP00000061111 ⟸ ENSRNOT00000066419

Ensembl Acc Id:

ENSRNOP00000071484 ⟸ ENSRNOT00000083301

Ensembl Acc Id:

ENSRNOP00000003558 ⟸ ENSRNOT00000003558

RefSeq Acc Id:	XP_038946382 ⟸ XM_039090454
- Peptide Label:	isoform X1

RefSeq Acc Id:	NP_001388271 ⟸ NM_001401342
- UniProtKB:	A0A0G2K427 (UniProtKB/TrEMBL), A6ICS0 (UniProtKB/TrEMBL)

Protein Domains

BTB

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A0G2K427-F1-model_v2	AlphaFold	A0A0G2K427	1-642	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698889

Promoter ID:

EPDNEW_R9407

Type:

multiple initiation site

Name:

Ivns1abp_1

Description:

influenza virus NS1A binding protein

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	13	68,702,856 - 68,702,916	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1306290	AgrOrtholog
BioCyc Gene	G2FUF-17933	BioCyc
Ensembl Genes	ENSRNOG00000002618	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000003558	ENTREZGENE
	ENSRNOT00000003558.9	UniProtKB/TrEMBL
	ENSRNOT00000083301	ENTREZGENE
	ENSRNOT00000083301.3	UniProtKB/TrEMBL
	ENSRNOT00000085906.3	UniProtKB/TrEMBL
	ENSRNOT00000087997.3	UniProtKB/TrEMBL
Gene3D-CATH	1.25.40.420	UniProtKB/TrEMBL
	2.120.10.80	UniProtKB/TrEMBL
	Potassium Channel Kv1.1, Chain A	UniProtKB/TrEMBL
InterPro	BACK	UniProtKB/TrEMBL
	BTB-kelch_protein	UniProtKB/TrEMBL
	BTB/POZ-like	UniProtKB/TrEMBL
	BTB/POZ_fold	UniProtKB/TrEMBL
	Kelch-typ_b-propeller	UniProtKB/TrEMBL
	Kelch_1	UniProtKB/TrEMBL
NCBI Gene	289089	ENTREZGENE
PANTHER	BTB DOMAIN-CONTAINING PROTEIN	UniProtKB/TrEMBL
	INFLUENZA VIRUS NS1A-BINDING PROTEIN	UniProtKB/TrEMBL
	KELCH PROTEIN	UniProtKB/TrEMBL
	KELCH-LIKE PROTEIN DIABLO	UniProtKB/TrEMBL
	LD33804P	UniProtKB/TrEMBL
Pfam	BACK	UniProtKB/TrEMBL
	BTB	UniProtKB/TrEMBL
	Kelch_1	UniProtKB/TrEMBL
	Kelch_KLHDC2_KLHL20_DRC7	UniProtKB/TrEMBL
PhenoGen	Ivns1abp	PhenoGen
PIRSF	Kelch-like_protein_gigaxonin	UniProtKB/TrEMBL
PRINTS	KELCHREPEAT	UniProtKB/TrEMBL
PROSITE	BTB	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000002618	RatGTEx
SMART	BACK	UniProtKB/TrEMBL
	BTB	UniProtKB/TrEMBL
	Kelch	UniProtKB/TrEMBL
Superfamily-SCOP	SSF117281	UniProtKB/TrEMBL
	SSF54695	UniProtKB/TrEMBL
UniProt	A0A0G2K427	ENTREZGENE, UniProtKB/TrEMBL
	A0A0G2QC03_RAT	UniProtKB/TrEMBL
	A0A8I6ASP0_RAT	UniProtKB/TrEMBL
	A6ICS0	ENTREZGENE, UniProtKB/TrEMBL
	A6ICS2	ENTREZGENE, UniProtKB/TrEMBL
	D4A0T2	ENTREZGENE, UniProtKB/TrEMBL
	Q0IKU7_RAT	UniProtKB/TrEMBL
UniProt Secondary	F1LPV5	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Ivns1abp	influenza virus NS1A binding protein	Ivns1abp_predicted	influenza virus NS1A binding protein (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Ivns1abp_predicted	influenza virus NS1A binding protein (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)