Gene:	Vav2 ( Rattus norvegicus ) vav 2 guanine nucleotide exchange factor
Synonyms:	Vav2 oncogene ; Vav2_predicted; LOC296603; Vav2 oncogene (predicted);
ArrayIDs:	rc_AI177124_at; rc_AA819193_at; 1384171_x_at; 1384170_at; 1393349_x_at; rc_AA893593_g_at; rc_AA893593_at; rc_AA819193_g_at; 1384169_a_at; rc_AA900477_s_at;  (details...)
Gene Type:	protein-coding
Additional Data
Homologs
Homo sapiens: VAV2     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Vav2     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Vav2 Rat Celera Assembly 3 5380146 - 5548622     RGSC genome assembly v3.4 3 6153679 - 6347676     Cytogenetic 3 p12     genome assembly 3.1 3 6155986 - 6347501 Mus musculus Vav2 Mouse genome assembly build 36.1 2 27119155 - 27282347     Cytogenetic 2 2 A3 Homo sapiens VAV2 human genome assembly 9 133656570 - 133886959     Human genome assembly build 36.2 9 135616837 - 135847226     Cytogenetic 9 q34.1   View comparative maps:      NCBI MapViewer
Genome
View:
Browsers:	Select a browser to viewGene (GBrowse)Gene and SNPs (GBrowse)UCSCVCMAPEnsemblNCBIECRVISTAVISTA+UCSC
Annotation
Molecular Function	Gene Ontology protein binding,  epidermal growth factor receptor binding,  guanyl-nucleotide exchange factor activity (details...)
Biological Process	Gene Ontology cell projection assembly,  small GTPase mediated signal transduction,  induction of apoptosis by extracellular signals ...  (details...)
Cellular Component	Gene Ontology cytoplasm,  plasma membrane,  cytosol (details...)
External Links
Databases	DATABASE ID SOURCE SMART: SH3 IPI SMART: SH2 IPI SMART: RhoGEF IPI SMART: PH IPI SMART: CH IPI SMART: C1 IPI PROSITE: ZF_DAG_PE_1 IPI PROSITE: ZF_DAG_PE_2 IPI PROSITE: SH3 IPI PROSITE: CH IPI PROSITE: DH_1 IPI PROSITE: DH_2 IPI PROSITE: PH_DOMAIN IPI PROSITE: SH2 IPI UNIPARC: UPI000021D629 IPI KEGG Report: rno:296603 ENTREZGENE HomoloGene Group ID: 2530 ENTREZGENE Germonline: 1306285 Pfam: SH3_1 IPI Pfam: SH3_2 IPI Pfam: C1_1 IPI Pfam: CH IPI Pfam: PH IPI Pfam: RhoGEF IPI Pfam: SH2 IPI KEGG Pathway: 04062 ENTREZGENE KEGG Pathway: 04810 ENTREZGENE KEGG Pathway: 04662 ENTREZGENE KEGG Pathway: 04660 ENTREZGENE KEGG Pathway: 04664 ENTREZGENE KEGG Pathway: 04666 ENTREZGENE KEGG Pathway: 04510 ENTREZGENE KEGG Pathway: 04670 ENTREZGENE KEGG Pathway: 04650 ENTREZGENE InterPro: SH3_region. IPI InterPro: SH3_domain. IPI InterPro: SH3_2. IPI InterPro: SH2. IPI InterPro: Prot_Kinase_C-like_PE/DAG_bd. IPI InterPro: Pleckstrin_homology. IPI InterPro: PH_type. IPI InterPro: GDS_CDC24_CS. IPI InterPro: DH-domain. IPI InterPro: Calponin_act_bd. IPI InterPro: Calponin-homology. IPI IPI: IPI00195126 IPI Ensembl Protein: ENSRNOP00000009893 IPI Gene3D-CATH: SH2 IPI Gene3D-CATH: PH_type IPI Gene3D-CATH: RhoGEF IPI Gene3D-CATH: Calponin-homology IPI Entrez Gene: Vav2 ENTREZGENE Ensembl Genes: ENSRNOG00000007422 IPI Superfamily-SCOP: DH-domain IPI Superfamily-SCOP: SH3 IPI Superfamily-SCOP: Calponin-homology IPI PRINTS: SH3DOMAIN. IPI PRINTS: SH2DOMAIN. IPI
Sequences	Nucleotide: XM_001075347 Get FASTA Search GEO Profiles Nucleotide: XM_001075402 Get FASTA Search GEO Profiles Nucleotide: NM_001106563 Get FASTA Search GEO Profiles Nucleotide: XM_001075369 Get FASTA Search GEO Profiles Nucleotide: XM_001075315 Get FASTA Search GEO Profiles Nucleotide: XM_216030 Get FASTA Search GEO Profiles Nucleotide: CH474001 Get FASTA Search GEO Profiles (View all 7 Nucleotide Accessions) Protein: XP_001075369 Get FASTA Protein: EDL93437 Get FASTA Protein: NP_001100033 Get FASTA Protein: XP_001075402 Get FASTA Protein: XP_001075315 Get FASTA Protein: XP_001075347 Get FASTA Protein: XP_216030 Get FASTA (View all 7 Protein Accessions)
Clusters	UniGene: 98555
References
Curated References	3 references in RGD related to Vav2
Other References	1 other references at PubMed related to Vav2
Database Information
RGD ID	1306285
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 23-OCT-08: Vav2 vav 2 guanine nucleotide exchange factor Vav2 Vav2 oncogene APPROVED Nomenclature updated to reflect human and mouse nomenclature 1299863 30-APR-08: Vav2 Vav2 oncogene Vav2_predicted Vav2 oncogene (predicted) APPROVED 'predicted' is removed 2292626 12-JAN-05: Vav2_predicted Vav2 oncogene (predicted) APPROVED Symbol and Name status set to approved 70820