Ntpcr (nucleoside-triphosphatase, cancer-related) - Rat Genome Database

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Gene: Ntpcr (nucleoside-triphosphatase, cancer-related) Rattus norvegicus
Analyze
Symbol: Ntpcr
Name: nucleoside-triphosphatase, cancer-related
RGD ID: 1306192
Description: Predicted to enable ribonucleoside triphosphate phosphatase activity. Orthologous to human NTPCR (nucleoside-triphosphatase, cancer-related); PARTICIPATES IN thiamine metabolic pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cancer-related nucleoside-triphosphatase; LOC361443; nucleoside-triphosphatase C1orf57; nucleoside-triphosphatase C1orf57 homolog; RGD1306192; similar to RIKEN cDNA 2310079N02
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81970,598,816 - 70,612,580 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1970,593,274 - 70,613,197 (+)EnsemblGRCr8
mRatBN7.21953,701,496 - 53,715,260 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1953,695,976 - 53,715,202 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1960,492,517 - 60,506,338 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01961,350,872 - 61,364,561 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01963,426,814 - 63,440,504 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01958,565,576 - 58,579,276 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1958,565,576 - 58,579,265 (+)Ensemblrn6Rnor6.0
Rnor_5.01969,262,818 - 69,276,518 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41955,939,045 - 55,952,745 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1953,062,575 - 53,076,275 (+)NCBICelera
RGSC_v3.11955,935,403 - 55,957,241 (+)NCBI
Cytogenetic Map19q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
2. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:19946888   PMID:22681889   PMID:23376485   PMID:28755400   PMID:34800366  


Genomics

Comparative Map Data
Ntpcr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81970,598,816 - 70,612,580 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1970,593,274 - 70,613,197 (+)EnsemblGRCr8
mRatBN7.21953,701,496 - 53,715,260 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1953,695,976 - 53,715,202 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1960,492,517 - 60,506,338 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01961,350,872 - 61,364,561 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01963,426,814 - 63,440,504 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01958,565,576 - 58,579,276 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1958,565,576 - 58,579,265 (+)Ensemblrn6Rnor6.0
Rnor_5.01969,262,818 - 69,276,518 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41955,939,045 - 55,952,745 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1953,062,575 - 53,076,275 (+)NCBICelera
RGSC_v3.11955,935,403 - 55,957,241 (+)NCBI
Cytogenetic Map19q12NCBI
NTPCR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381232,950,611 - 232,983,882 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1232,950,564 - 232,983,882 (+)Ensemblhg38GRCh38
GRCh371233,086,357 - 233,119,628 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361231,152,993 - 231,180,842 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1206,356,751 - 206,384,600 (+)NCBICelera
Cytogenetic Map1q42.2NCBI
HuRef1203,576,326 - 203,604,129 (+)NCBIHuRef
CHM1_11234,359,916 - 234,387,769 (+)NCBICHM1_1
T2T-CHM13v2.01232,336,950 - 232,370,221 (+)NCBIT2T-CHM13v2.0
Ntpcr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398126,456,724 - 126,474,974 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8126,456,702 - 126,474,974 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm388125,729,975 - 125,748,235 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8125,729,963 - 125,748,235 (+)Ensemblmm10GRCm38
MGSCv378128,258,103 - 128,272,135 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv368128,620,319 - 128,634,300 (+)NCBIMGSCv36mm8
Celera8130,047,167 - 130,061,146 (+)NCBICelera
Cytogenetic Map8E2NCBI
cM Map873.65NCBI
Ntpcr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554926,253,087 - 6,279,016 (-)Ensembl
ChiLan1.0NW_0049554926,253,087 - 6,279,016 (-)NCBIChiLan1.0ChiLan1.0
NTPCR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2116,228,786 - 16,256,987 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1116,435,012 - 16,463,205 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01208,488,080 - 208,521,291 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11213,514,986 - 213,543,680 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1213,514,986 - 213,543,680 (+)EnsemblpanPan2panpan1.1
NTPCR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.146,704,571 - 6,733,820 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha46,693,240 - 6,722,006 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.046,726,875 - 6,755,692 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl46,725,334 - 6,756,323 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.146,736,907 - 6,765,707 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.046,857,165 - 6,885,962 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.047,081,335 - 7,110,107 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ntpcr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934442,392,764 - 42,407,048 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648418,557,958 - 18,571,254 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648418,557,999 - 18,571,236 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NTPCR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1457,802,565 - 57,833,151 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11457,802,564 - 57,833,155 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
NTPCR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12570,162,533 - 70,190,936 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2570,162,571 - 70,190,517 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605572,116,323 - 72,149,590 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ntpcr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477517,006,662 - 17,033,740 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462477516,996,658 - 17,033,745 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Ntpcr
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11745,250,405 - 45,264,361 (+)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:270
Count of miRNA genes:177
Interacting mature miRNAs:203
Transcripts:ENSRNOT00000026965
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)194438513474246245Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)193253961574246245Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)196124916174246245Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)193177788874246245Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032907674246245Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)194622677874246245Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)193236531174246245Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)194172254674246245Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191083361874246245Rat

Markers in Region
AU028904  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81970,604,559 - 70,604,648 (+)Marker Load Pipeline
mRatBN7.21953,707,239 - 53,707,328 (+)MAPPERmRatBN7.2
Rnor_6.01958,571,320 - 58,571,408NCBIRnor6.0
Rnor_5.01969,268,562 - 69,268,650UniSTSRnor5.0
RGSC_v3.41955,944,789 - 55,944,877UniSTSRGSC3.4
Celera1953,068,319 - 53,068,407UniSTS
Cytogenetic Map19q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 91 59 6 355 191 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000026965   ⟹   ENSRNOP00000026965
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1970,593,274 - 70,612,578 (+)Ensembl
mRatBN7.2 Ensembl1953,695,976 - 53,715,202 (+)Ensembl
Rnor_6.0 Ensembl1958,565,576 - 58,579,265 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099966   ⟹   ENSRNOP00000086708
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1970,600,304 - 70,610,173 (+)Ensembl
mRatBN7.2 Ensembl1953,702,984 - 53,712,853 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000111023   ⟹   ENSRNOP00000085117
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1970,593,274 - 70,612,578 (+)Ensembl
mRatBN7.2 Ensembl1953,702,000 - 53,715,202 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000111221   ⟹   ENSRNOP00000090123
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1970,600,424 - 70,613,197 (+)Ensembl
mRatBN7.2 Ensembl1953,702,971 - 53,715,202 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114770   ⟹   ENSRNOP00000083457
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1953,701,469 - 53,713,215 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000116565   ⟹   ENSRNOP00000096985
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1970,598,774 - 70,602,347 (+)Ensembl
mRatBN7.2 Ensembl1953,701,469 - 53,705,027 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000121649   ⟹   ENSRNOP00000107016
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1970,599,532 - 70,613,197 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000141375   ⟹   ENSRNOP00000105264
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1970,598,784 - 70,613,197 (+)Ensembl
RefSeq Acc Id: NM_001134573   ⟹   NP_001128045
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81970,598,816 - 70,612,516 (+)NCBI
mRatBN7.21953,701,496 - 53,715,196 (+)NCBI
Rnor_6.01958,565,576 - 58,579,276 (+)NCBI
Rnor_5.01969,262,818 - 69,276,518 (+)NCBI
RGSC_v3.41955,939,045 - 55,952,745 (+)RGD
Celera1953,062,575 - 53,076,275 (+)RGD
Sequence:
RefSeq Acc Id: XM_039097902   ⟹   XP_038953830
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81970,600,638 - 70,612,580 (+)NCBI
mRatBN7.21953,701,515 - 53,715,260 (+)NCBI
RefSeq Acc Id: NP_001128045   ⟸   NM_001134573
- UniProtKB: A6KJ39 (UniProtKB/TrEMBL),   A0A8I6A3A7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000026965   ⟸   ENSRNOT00000026965
RefSeq Acc Id: XP_038953830   ⟸   XM_039097902
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000085117   ⟸   ENSRNOT00000111023
Ensembl Acc Id: ENSRNOP00000096985   ⟸   ENSRNOT00000116565
Ensembl Acc Id: ENSRNOP00000090123   ⟸   ENSRNOT00000111221
Ensembl Acc Id: ENSRNOP00000083457   ⟸   ENSRNOT00000114770
Ensembl Acc Id: ENSRNOP00000086708   ⟸   ENSRNOT00000099966
Ensembl Acc Id: ENSRNOP00000105264   ⟸   ENSRNOT00000141375
Ensembl Acc Id: ENSRNOP00000107016   ⟸   ENSRNOT00000121649
Protein Domains
AAA+ ATPase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A478-F1-model_v2 AlphaFold D4A478 1-192 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701250
Promoter ID:EPDNEW_R11773
Type:initiation region
Name:Ntpcr_1
Description:nucleoside-triphosphatase, cancer-related
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01958,565,612 - 58,565,672EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306192 AgrOrtholog
BioCyc Gene G2FUF-5203 BioCyc
Ensembl Genes ENSRNOG00000019922 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026965.9 UniProtKB/TrEMBL
  ENSRNOT00000099966.2 UniProtKB/TrEMBL
  ENSRNOT00000111023.2 UniProtKB/TrEMBL
  ENSRNOT00000111221.2 UniProtKB/TrEMBL
  ENSRNOT00000116565.2 UniProtKB/TrEMBL
  ENSRNOT00000121649.1 UniProtKB/TrEMBL
  ENSRNOT00000141375 ENTREZGENE
  ENSRNOT00000141375.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
InterPro ATPase_AAA+_core UniProtKB/TrEMBL
  DUF265 UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
KEGG Report rno:361443 UniProtKB/TrEMBL
NCBI Gene 361443 ENTREZGENE
PANTHER CANCER-RELATED NUCLEOSIDE-TRIPHOSPHATASE UniProtKB/TrEMBL
  PTHR43146 UniProtKB/TrEMBL
Pfam DUF265 UniProtKB/TrEMBL
PhenoGen Ntpcr PhenoGen
RatGTEx ENSRNOG00000019922 RatGTEx
SMART AAA UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A8I6A3A7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AMZ9_RAT UniProtKB/TrEMBL
  A0A8I6GF87_RAT UniProtKB/TrEMBL
  A0A8I6GIM3_RAT UniProtKB/TrEMBL
  A0ABK0LQ12_RAT UniProtKB/TrEMBL
  A0ABK0LU42_RAT UniProtKB/TrEMBL
  A6KJ39 ENTREZGENE, UniProtKB/TrEMBL
  D4A478_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-05-26 Ntpcr  nucleoside-triphosphatase, cancer-related  RGD1306192  similar to RIKEN cDNA 2310079N02  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1306192  similar to RIKEN cDNA 2310079N02   RGD1306192_predicted  similar to RIKEN cDNA 2310079N02 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1306192_predicted  similar to RIKEN cDNA 2310079N02 (predicted)  LOC361443_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC361443_predicted  similar to RIKEN cDNA 2310079N02 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL