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Gene: Slc35g2 (solute carrier family 35, member G2) Rattus norvegicus

Analyze

Symbol:

Slc35g2

Name:

solute carrier family 35, member G2

RGD ID:

1306109

Description:

Predicted to be located in synaptic vesicle membrane. Predicted to be active in plasma membrane. Orthologous to human SLC35G2 (solute carrier family 35 member G2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; amphetamine; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC315957; solute carrier family 35 member G2; Tmem22; transmembrane protein 22

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Allele / Splice:

Tmem22^{Tn(sb-T2/Bart3)2.332Mcwi}

Genetic Models:

F344-Tmem22^{Tn(sb-T2/Bart3)2.332Mcwi}

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	109,964,589 - 109,992,347 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	109,964,378 - 109,992,412 (-)	Ensembl				GRCr8
mRatBN7.2	8	101,085,579 - 101,113,339 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	101,085,545 - 101,113,349 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	106,750,098 - 106,777,876 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	104,949,432 - 104,977,210 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	102,791,979 - 102,819,757 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	108,854,134 - 108,881,519 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	108,854,146 - 108,880,879 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	8	108,269,643 - 108,297,339 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	8	105,416,072 - 105,443,969 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	8	100,482,828 - 100,509,840 (-)	NCBI		Celera
RGSC_v3.1	8	105,435,520 - 105,463,424 (-)	NCBI
Cytogenetic Map	8	q31	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

melanoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-methylcholine (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

amphetamine (EXP)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[b]fluoranthene (ISO)

beta-lapachone (ISO)

bisphenol A (EXP)

Butylbenzyl phthalate (ISO)

cadmium dichloride (EXP)

caffeine (ISO)

carbamazepine (ISO)

chrysene (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) chloride (ISO)

copper(II) sulfate (ISO)

coumarin (ISO)

cyclosporin A (ISO)

cylindrospermopsin (ISO)

Dibutyl phosphate (ISO)

diuron (EXP)

dorsomorphin (ISO)

entinostat (ISO)

FR900359 (ISO)

hydrogen peroxide (ISO)

lead(0) (ISO)

leflunomide (ISO)

mercury dibromide (ISO)

methylmercury chloride (ISO)

p-chloromercuribenzoic acid (ISO)

panobinostat (ISO)

perfluorohexanesulfonic acid (ISO)

phenylmercury acetate (ISO)

quercetin (ISO)

resveratrol (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

Soman (EXP)

sulforaphane (ISO)

tert-butyl hydroperoxide (ISO)

tetraphene (ISO)

thapsigargin (ISO)

titanium dioxide (ISO)

topotecan (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

triptonide (ISO)

valproic acid (ISO)

zalcitabine (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

Cellular Component

cytoplasmic vesicle (IEA)

Golgi apparatus (IEA,ISO)

membrane (IEA)

plasma membrane (IBA,IEA,ISO)

synaptic vesicle membrane (IEA,ISO)

Molecular Function

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
4.	Comprehensive gene review and curation	RGD comprehensive gene curation

Additional References at PubMed

PMID:12477932	PMID:15489334	PMID:19148500

Genomics

Comparative Map Data

Slc35g2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	109,964,589 - 109,992,347 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	109,964,378 - 109,992,412 (-)	Ensembl				GRCr8
mRatBN7.2	8	101,085,579 - 101,113,339 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	101,085,545 - 101,113,349 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	106,750,098 - 106,777,876 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	104,949,432 - 104,977,210 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	102,791,979 - 102,819,757 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	108,854,134 - 108,881,519 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	108,854,146 - 108,880,879 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	8	108,269,643 - 108,297,339 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	8	105,416,072 - 105,443,969 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	8	100,482,828 - 100,509,840 (-)	NCBI		Celera
RGSC_v3.1	8	105,435,520 - 105,463,424 (-)	NCBI
Cytogenetic Map	8	q31	NCBI

SLC35G2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	136,819,126 - 136,855,888 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	136,818,463 - 136,857,531 (+)	Ensembl			hg38	GRCh38
GRCh37	3	136,537,968 - 136,574,730 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	138,020,551 - 138,057,424 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	3	138,020,677 - 138,057,427	NCBI
Celera	3	134,964,163 - 135,001,036 (+)	NCBI		Celera
Cytogenetic Map	3	q22.3	NCBI
HuRef	3	133,914,042 - 133,950,844 (+)	NCBI		HuRef
CHM1_1	3	136,501,516 - 136,538,396 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	3	139,559,143 - 139,596,547 (+)	NCBI		T2T-CHM13v2.0

Slc35g2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	100,431,178 - 100,453,138 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	100,434,241 - 100,453,143 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	9	100,549,125 - 100,571,085 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	100,552,188 - 100,571,090 (-)	Ensembl			mm10	GRCm38
MGSCv37	9	100,452,607 - 100,471,504 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	9	100,361,540 - 100,390,593 (-)	NCBI		MGSCv36	mm8
Celera	9	100,090,867 - 100,109,646 (-)	NCBI		Celera
Cytogenetic Map	9	E3.3	NCBI
cM Map	9	52.74	NCBI

Slc35g2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955501	1,974,126 - 1,998,537 (-)	Ensembl
ChiLan1.0	NW_004955501	1,974,126 - 1,998,547 (-)	NCBI	ChiLan1.0	ChiLan1.0

SLC35G2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	134,738,246 - 134,773,058 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	134,742,852 - 134,777,610 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	133,861,781 - 133,897,920 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	141,322,549 - 141,356,119 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	141,354,685 - 141,355,923 (+)	Ensembl			panPan2	panpan1.1

SLC35G2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	23	33,250,767 - 33,294,015 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	23	33,290,960 - 33,292,198 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	23	33,235,176 - 33,276,565 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	23	33,780,440 - 33,822,088 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	23	33,780,464 - 33,823,608 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	23	33,462,687 - 33,504,305 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	23	33,528,585 - 33,569,969 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	23	33,773,182 - 33,814,599 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

SLC35G2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	77,825,178 - 77,861,774 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	13	77,825,191 - 77,858,537 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	85,352,174 - 85,385,557 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SLC35G2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	15	53,601,248 - 53,638,034 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	15	53,601,657 - 53,602,895 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666041	26,643,491 - 26,680,038 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Slc35g2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624730	13,234,213 - 13,261,175 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624730	13,226,369 - 13,261,239 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Slc35g2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	8	91,860,990 - 91,885,321 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Slc35g2
290 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	101
Count of miRNA genes:	85
Interacting mature miRNAs:	88
Transcripts:	ENSRNOT00000020610
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2303171	Bp331	Blood pressure QTL 331	5.57	0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	105462581	132782436	Rat
1549909	Stresp11	Stress response QTL 11	6.83	0.0019	stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	8	82352698	127352698	Rat
631210	Bw3	Body weight QTL3	5.9		mesenteric fat pad mass (VT:0010427)	mesenteric fat pad weight to body weight ratio (CMO:0000654)	8	61019838	121662124	Rat
1554321	Bmd3	Bone mineral density QTL 3	7.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	49849908	118871671	Rat
9590292	Uminl3	Urine mineral level QTL 3	3.62	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	8	80768445	125768445	Rat
8694446	Bw170	Body weight QTL 170	12.07	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	8	80768445	125768445	Rat
631650	Stl6	Serum triglyceride level QTL 6	4	0.0019	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	8	70041301	121080908	Rat
1581557	Eae16	Experimental allergic encephalomyelitis QTL 16	3.8		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	8	68690349	119799881	Rat
10450865	Bw175	Body weight QTL 175	4.1		total fat pad mass (VT:0015008)	adipose tissue molecular composition measurement (CMO:0000484)	8	84192326	129192326	Rat
724539	Cm19	Cardiac mass QTL 19	2.6		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	8	103375781	129871912	Rat
738011	Anxrr9	Anxiety related response QTL 9	6.1		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	8	102413464	132782436	Rat
71120	Niddm21	Non-insulin dependent diabetes mellitus QTL 21	3.73		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	8	66992095	111992095	Rat
8693654	Alc32	Alcohol consumption QTL 32	2	0.755	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	8	97492344	116428905	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	55428333	127966348	Rat
634332	Pia18	Pristane induced arthritis QTL 18	4		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	8	84192326	132782436	Rat
2316950	Scl66	Serum cholesterol level QTL 66	4.1		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	8	39106363	114525825	Rat
2300181	Bmd55	Bone mineral density QTL 55	5.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	85348065	130348065	Rat
1300171	Bp184	Blood pressure QTL 184	3.66		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	8	79394435	132782436	Rat
2313400	Anxrr25	Anxiety related response QTL 25			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	8	98145073	122898010	Rat
8694200	Abfw4	Abdominal fat weight QTL 4	9.07	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	8	80768445	125768445	Rat
8694392	Bw161	Body weight QTL 161	8.06	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	8	80768445	125768445	Rat
61437	Cia6	Collagen induced arthritis QTL 6			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	8	91340911	131690273	Rat

Genetic Models

This gene Slc35g2 is modified in the following models/strains:

F344-Tmem22^{Tn(sb-T2/Bart3)2.332Mcwi}

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
15	9	62	155	56	55	24	40	24	4	250	127	8	136	76	87	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001012126	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001393842	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017595679	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC088758	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473954	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000020610 ⟹ ENSRNOP00000020610

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	101,085,581 - 101,112,896 (-)	Ensembl
Rnor_6.0 Ensembl	8	108,854,146 - 108,880,879 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000110639 ⟹ ENSRNOP00000078957

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	109,964,378 - 109,992,412 (-)	Ensembl
mRatBN7.2 Ensembl	8	101,085,545 - 101,113,349 (-)	Ensembl

RefSeq Acc Id:

NM_001012126 ⟹ NP_001012126

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	109,964,589 - 109,991,904 (-)	NCBI
mRatBN7.2	8	101,085,579 - 101,112,896 (-)	NCBI
Rnor_6.0	8	108,854,146 - 108,880,879 (-)	NCBI
Rnor_5.0	8	108,269,643 - 108,297,339 (-)	NCBI
RGSC_v3.4	8	105,416,072 - 105,443,969 (-)	RGD
Celera	8	100,482,828 - 100,509,840 (-)	RGD

Sequence:

show sequence

GTCAAGCGCCCCGCCTACTTGACAGACCTGCACGGGGCGCGCATCTCTGCGGGGCGTCCGAAAG
GCCACCCAGTGCCCACTTCTCCCCGCTGCTGTCCTGGAGGACTGGAACAGAGGGTTGATAAAAA
TTTCTTATCTGAAGAAATGGATACTTCTCCATCCAAAAAATACCCAATTAAAAAACGGGTGAAA
ATACATCCCAATACAGTCATGGTGAAATATACCTCTCATTATCCCCAACCCGGGGAGGATGGGT
ATGAAGAAATCAACGAAGACTATGGTAGATTTATGGAAGAAAACCCAAAGAAAAGTCTGCTGAG
TGAAATGAGAAGAAAAGGAAGAACTCTGTTTGGAACCATGGACACTCAGCCTCCACGATCAGAA
GACCCAAGAGCCAGCAGCAGGGGACAGTTCCAGAGCTTTGCAGAAAAGAACATTTTTCAGTCCC
GAAAAATGTGGCTAGTGCTGTTTGGGTCTGCACTGGCGCATGGATGTGTGGCTCTCATCACGAG
GCTTGTTTCCGACCGTTCTAAAGTTCCGTCCTTAGAACTGATTTTTATCCGGTCTGTCTTGCAG
GTCTTATCCGTGATAGTTGTGTGTTATTACCAGGAAGCTCCCTTTGGGCCCAGCGGATACAGAT
TACGACTTTTCTTGTACGGTGTGTGCAACGTTATTTCCATCACCTGCGCTTACACCTCCTTTTC
AATAGTTCCTCCCAGCAATGGCACCACGATGTGGAGAGCCACCACCACCGTTTTCAGTGCTGTT
CTAGCCTTTCTTCTTGTAGATGAGAAAATGGCATATGTTGACATGGCTACAGTGGTCTGCAGCA
TCCTGGGTGTTTGTCTTGTCATGATCCCCAACATTGCTGATGAGGACAATTCTCTGTTAAATGT
CTGGAAGGAAGCCTTTGGGTATACAATGACTGTGATGGCTGGGCTGACCACTGCTCTTTCTATG
ATAGTGTACAGATCCATCAGGGAGAAGATCAGCATGTGGACCGCACTGTTTACCTTTGGTTGGA
CTGGAACAATCTGGGGGTTATCTACTATGTTTGTCCTTCAAGAACCCATCATTCCTTTAGATGG
AGAAACATGGAGCTATCTCATTGCTATATGCATCTGTTCTACTGTAGCATTCTTAGGCGTTTAT
TACGCCTTGGACAAATTCCACCCAGCTTTGGTCAGCACAGTACAACATCTGGAGATTGTGGTAG
CTATGGTCTTACAGCTTCTAGTGTTACACATATTTCCTAGTGTTTATGATGTTTTTGGAGGGGT
GATCATCATGATTAGTGTATTTGTCCTTGCTGGCTATAAACTTTACTGGAGGAATGTAAGGAGG
GAAGATTATCAGGAAATACTGGACTCTCCCATTAAATGAACACCTGGTTATTACTGTCATCTTG
TTAATGTCTAGTTATCAACACATACACTGCCATTTTAGCATTTACTTGTAGATGTCTTTTGTGT
TACATTATCAATAGAGTGCTATATAGTATAAATAATTATGCAGATGCAGAAAAATATACCAGAC
TAATATATTAAAGAATAAATATTAAATAGCAAAAAAAAAAAAAAAAAAAAAAAAAGG

hide sequence

RefSeq Acc Id:

NM_001393842 ⟹ NP_001380771

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	109,964,589 - 109,992,347 (-)	NCBI
mRatBN7.2	8	101,085,579 - 101,113,339 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001012126	(Get FASTA)	NCBI Sequence Viewer
	NP_001380771	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH88758	(Get FASTA)	NCBI Sequence Viewer
	EDL77421	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000020610.4
	ENSRNOP00000078957
	ENSRNOP00000078957.1
GenBank Protein	Q5M7A3	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001012126 ⟸ NM_001012126

- UniProtKB:

Q5M7A3 (UniProtKB/Swiss-Prot), A6I2F6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDTSPSKKYPIKKRVKIHPNTVMVKYTSHYPQPGEDGYEEINEDYGRFMEENPKKSLLSEMRRK
GRTLFGTMDTQPPRSEDPRASSRGQFQSFAEKNIFQSRKMWLVLFGSALAHGCVALITRLVSDR
SKVPSLELIFIRSVLQVLSVIVVCYYQEAPFGPSGYRLRLFLYGVCNVISITCAYTSFSIVPPS
NGTTMWRATTTVFSAVLAFLLVDEKMAYVDMATVVCSILGVCLVMIPNIADEDNSLLNVWKEAF
GYTMTVMAGLTTALSMIVYRSIREKISMWTALFTFGWTGTIWGLSTMFVLQEPIIPLDGETWSY
LIAICICSTVAFLGVYYALDKFHPALVSTVQHLEIVVAMVLQLLVLHIFPSVYDVFGGVIIMIS
VFVLAGYKLYWRNVRREDYQEILDSPIK

hide sequence

Ensembl Acc Id:

ENSRNOP00000020610 ⟸ ENSRNOT00000020610

Ensembl Acc Id:

ENSRNOP00000078957 ⟸ ENSRNOT00000110639

RefSeq Acc Id:	NP_001380771 ⟸ NM_001393842
- UniProtKB:	Q5M7A3 (UniProtKB/Swiss-Prot), A6I2F6 (UniProtKB/TrEMBL)

Protein Domains

EamA

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5M7A3-F1-model_v2	AlphaFold	Q5M7A3	1-412	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1306109	AgrOrtholog
BioCyc Gene	G2FUF-29372	BioCyc
Ensembl Genes	ENSRNOG00000015370	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000020610.8	UniProtKB/Swiss-Prot
	ENSRNOT00000110639	ENTREZGENE
	ENSRNOT00000110639.1	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7315776	IMAGE-MGC_LOAD
InterPro	EamA_dom	UniProtKB/Swiss-Prot
KEGG Report	rno:315957	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:105748	IMAGE-MGC_LOAD
NCBI Gene	315957	ENTREZGENE
PANTHER	ACYL-MALONYL CONDENSING ENZYME-RELATED	UniProtKB/Swiss-Prot
	SOLUTE CARRIER FAMILY 35 MEMBER G2	UniProtKB/Swiss-Prot
Pfam	EamA	UniProtKB/Swiss-Prot
PhenoGen	Slc35g2	PhenoGen
RatGTEx	ENSRNOG00000015370	RatGTEx
Superfamily-SCOP	Multidrug resistance efflux transporter EmrE	UniProtKB/Swiss-Prot
UniProt	A6I2F6	ENTREZGENE, UniProtKB/TrEMBL
	Q5M7A3	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-12-06	Tmem22	transmembrane protein 22	Tmem22_predicted	transmembrane protein 22 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Tmem22_predicted	transmembrane protein 22 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD