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Gene: Lrrc66 (leucine rich repeat containing 66) Rattus norvegicus

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Symbol:

Lrrc66

Name:

leucine rich repeat containing 66

RGD ID:

1306094

Description:

Predicted to be located in membrane. Orthologous to human LRRC66 (leucine rich repeat containing 66); INTERACTS WITH 3-chloropropane-1,2-diol; bisphenol A; cadmium dichloride.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

leucine-rich repeat-containing protein 66; leucine-rich repeat-containing protein 66-like; liver regeneration-related protein LRRGT00044; LOC103693755; LOC289587; LRRGT00044; RGD1306094; similar to hypothetical protein MGC38937

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	34,932,814 - 34,959,046 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	14	34,933,161 - 34,959,044 (+)	Ensembl				GRCr8
mRatBN7.2	14	34,578,934 - 34,604,977 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	34,581,240 - 34,604,541 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	14	34,941,187 - 34,964,820 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	36,248,800 - 36,272,433 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	34,734,257 - 34,757,894 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	37,128,715 - 37,153,890 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	37,130,743 - 37,153,898 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	14	36,951,604 - 36,976,796 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	14	36,977,618 - 37,001,071 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	14	33,843,871 - 33,866,826 (+)	NCBI		Celera
RGSC_v3.1	14	36,980,052 - 37,003,506 (+)	NCBI
Cytogenetic Map	14	p11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

3-chloropropane-1,2-diol (EXP)

4,4'-sulfonyldiphenol (ISO)

aflatoxin B1 (ISO)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

cadmium dichloride (EXP,ISO)

cisplatin (ISO)

endosulfan (EXP)

epoxiconazole (ISO)

gentamycin (EXP)

hexadecanoic acid (ISO)

methoxychlor (EXP)

mono(2-ethylhexyl) phthalate (ISO)

propanal (ISO)

rotenone (ISO)

serpentine asbestos (ISO)

Theaflavin 3,3'-digallate (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Cellular Component

membrane (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data

Lrrc66
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	34,932,814 - 34,959,046 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	14	34,933,161 - 34,959,044 (+)	Ensembl				GRCr8
mRatBN7.2	14	34,578,934 - 34,604,977 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	34,581,240 - 34,604,541 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	14	34,941,187 - 34,964,820 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	36,248,800 - 36,272,433 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	34,734,257 - 34,757,894 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	37,128,715 - 37,153,890 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	37,130,743 - 37,153,898 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	14	36,951,604 - 36,976,796 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	14	36,977,618 - 37,001,071 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	14	33,843,871 - 33,866,826 (+)	NCBI		Celera
RGSC_v3.1	14	36,980,052 - 37,003,506 (+)	NCBI
Cytogenetic Map	14	p11	NCBI

LRRC66
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	51,993,652 - 52,020,363 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	51,993,614 - 52,020,363 (-)	Ensembl			hg38	GRCh38
GRCh37	4	52,859,818 - 52,886,529 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	52,554,621 - 52,581,234 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	4	50,354,945 - 50,381,556 (-)	NCBI		Celera
Cytogenetic Map	4	q12	NCBI
HuRef	4	48,801,374 - 48,827,987 (-)	NCBI		HuRef
CHM1_1	4	52,895,473 - 52,922,085 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	4	55,479,597 - 55,506,301 (-)	NCBI		T2T-CHM13v2.0

Lrrc66
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	73,763,985 - 73,789,771 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	73,763,985 - 73,789,869 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	5	73,606,642 - 73,632,421 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	73,606,642 - 73,632,526 (-)	Ensembl			mm10	GRCm38
MGSCv37	5	73,997,881 - 74,023,660 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	5	73,885,777 - 73,911,556 (-)	NCBI		MGSCv36	mm8
Celera	5	70,863,078 - 70,888,819 (-)	NCBI		Celera
Cytogenetic Map	5	C3.3	NCBI
cM Map	5	38.89	NCBI

Lrrc66
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955447	18,493,752 - 18,497,789 (+)	NCBI	ChiLan1.0	ChiLan1.0

LRRC66
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	77,796,528 - 77,822,311 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	78,000,475 - 78,026,422 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	71,943,241 - 71,968,520 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	78,497,523 - 78,521,457 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	78,497,523 - 78,521,445 (+)	Ensembl			panPan2	panpan1.1

LRRC66
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	13	44,943,556 - 44,969,350 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	13	44,942,441 - 44,966,861 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	13	44,893,538 - 44,922,231 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	13	45,551,987 - 45,577,717 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	13	45,550,882 - 45,575,736 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	13	45,217,572 - 45,246,126 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	13	44,752,598 - 44,781,229 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	13	45,632,593 - 45,658,381 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Lrrc66
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405285	31,150,170 - 31,187,917 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936482	15,112,877 - 15,148,006 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936482	15,112,189 - 15,148,015 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LRRC66
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	39,106,912 - 39,148,747 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	8	39,104,727 - 39,127,021 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	41,282,878 - 41,305,693 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LRRC66
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	16,420,697 - 16,453,510 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	16,422,008 - 16,452,139 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666066	17,490,738 - 17,522,936 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Lrrc66
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624761	17,690,699 - 17,736,467 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Lrrc66
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	11	30,395,322 - 30,420,986 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Lrrc66
95 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	82
Count of miRNA genes:	71
Interacting mature miRNAs:	75
Transcripts:	ENSRNOT00000031756
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631528	Scl11	Serum cholesterol level QTL 11	4.9		blood cholesterol amount (VT:0000180)	blood total cholesterol level (CMO:0000051)	14	17875645	36079022	Rat
731183	Pia20	Pristane induced arthritis QTL 20	3.55		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	14	9393298	39411170	Rat
9589814	Gluco67	Glucose level QTL 67	4.54	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	14	1	40068101	Rat
7411573	Bw139	Body weight QTL 139	4.7	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	14	1	40068101	Rat
1300154	Bp189	Blood pressure QTL 189	3.04		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	14	31238080	72970315	Rat
70187	Pancm5	Pancreatic morphology QTL 5	16.7		pancreas mass (VT:0010144)	pancreas weight to body weight ratio (CMO:0000630)	14	30674469	85041098	Rat
2324617	Coatc2	Coat color QTL 2		0.001	coat/hair pigmentation trait (VT:0010463)	pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)	14	31121333	39507682	Rat
631523	Pia13	Pristane induced arthritis QTL 13	3.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	14	33424686	102238540	Rat
1358296	Ael3	Aortic elastin QTL 3	3.7	0.00051	aorta elastin amount (VT:0003905)	aortic elastin	14	8621398	53621398	Rat
61420	Pia6	Pristane induced arthritis QTL 6	4.9		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	14	18915454	42433608	Rat
7387267	Uae42	Urinary albumin excretion QTL 42		0.61	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	14	22521517	67521517	Rat
631839	Niddm37	Non-insulin dependent diabetes mellitus QTL 37	3.37		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	11334716	100078267	Rat
2313397	Coatc1	Coat color QTL1			coat/hair pigmentation trait (VT:0010463)	coat/hair color measurement (CMO:0001808)	14	18895192	63895192	Rat
631262	Tcas4	Tongue tumor susceptibility QTL 4	7.29		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	14	17906726	54251504	Rat
634352	Apr6	Acute phase response QTL 6	3.7		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	14	1	41415516	Rat
2302045	Pia39	Pristane induced arthritis QTL 39	4.9	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G2a level (CMO:0002116)	14	8621398	53621398	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	11	65	148	61	60	29	76	29	6	307	173	9	127	81	92	31	16	16

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001008763	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008770138	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017599101	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017599102	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017599103	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063272911	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063272912	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063272914	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063272915	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063272916	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AY383699	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473981	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000031756 ⟹ ENSRNOP00000030477

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	14	34,933,161 - 34,959,044 (+)	Ensembl
mRatBN7.2 Ensembl	14	34,581,240 - 34,604,541 (+)	Ensembl
Rnor_6.0 Ensembl	14	37,130,743 - 37,153,898 (+)	Ensembl

RefSeq Acc Id:

NM_001008763 ⟹ NP_001008763

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	34,932,981 - 34,959,046 (+)	NCBI
mRatBN7.2	14	34,578,934 - 34,604,977 (+)	NCBI
Rnor_6.0	14	37,131,325 - 37,153,600 (+)	NCBI
Rnor_5.0	14	36,951,604 - 36,976,796 (+)	NCBI
RGSC_v3.4	14	36,977,618 - 37,001,071 (+)	RGD
Celera	14	33,843,871 - 33,866,826 (+)	RGD

Sequence:

show sequence

ATGAAAGACTTCTACGCCAGAGTTACTGTCATGGTTACAGGTCTTTGCTTTGTGGGAACAGTGA
CAAACCCATCAAGAAAAAGCAGTCTTTCCCTCCATCAGCAGGATGGGGATCTTCTGGCAAACTG
GTCTTCTACAAGACACACGTCCCAGAAAACAGACACCGTGGACAGGAACTCCTATTTCTTTAGA
GTTCTCTTCCAGCCGCACACAAAAGAACGGCACACAAACCATCTGGACCGCACTAATCATCGCT
TGTCAAAAGTGACCCTCAGCTGTCTCGCGCATTTGCGTGCTTTGGAGATGTTAAACCTTGGCGA
CGATGTTATCCACTCCCTCTGCCTGGATCTGTCCCTGCCTTCTTCCTCACGGCAAAAGCGCCAC
AGAAGTCGCTTCCGTGGCCGACATCCCCGGCTAAAGGTGCTGCTACTTCAAAGGAATCAACTCG
GTCCTACTCCTAAAGGACTGTGGAAGCTGAAGCCACTGTGCAGTCTGGATCTGTCATTCAACAG
GAGAGTCGGCATTGGGCTGTCTGGTTTTCATGGCTGCCTGCAGCTGAAGAGCATCTATTTAAAG
AACAACAAGATCCTCACGATTCACCCAGAAGCTTTCAAAGGGCTCAAAAAATTACAGGTGGTAG
ACCTCAGAAGCAGTGCACTGACCATGCTTGTACCAATTGTGACCATTGCTCTAGAATGGCCCAA
CCTGGAACTTGGCTTGGCTGATAACCAGTGGCAGTGTAATGAGAGTGACGCCAACTTCCAAAAC
ATCGCCTCTGTATCCTGGGGGGAAATATGGAAAGCCGTCTGCAACACGCCTGTGGAGAATGAGA
AACCATATGTGGAGGCTTCCCAGATCAGAATTTCCAGGGATATACACCTTCCTCGCTCTCCTTC
CAGTGACTTGCAGAGCCTCATCCAGAGCAAAGCAGAGAAGCCCCGGGCAGGAATGGACGTGCAC
CTTTCCGCTCTGGAGAAGAAGGCACAGGTTGGCTATGGTGATCTCAAAGGGATATGGCTGCAGT
CCCCGATGGAGCTCAGAGACTCCCAGGGTGGCCCTGTCACTGACAGAAAGGATGACAAACCCCC
AGACCTTGCCCTGGCCGTCTGCCTGTCAGTGTTCATCACATTTGTGGTGGCTTTCTGCCTGGGG
GCTTTTGCAAGACCCTACATCGACAGACTACGGCAACAAAGATGCTTGAACAAAAGGCCTGGCT
CAGAGAATGCCTACTCAAACGAGGGTTTCCATGACGACGTGGAAGCTGCCCAACATGTACAGCA
CCAAGGGACAGATCTATGCCAAACTACCCACCACCTAAATCTTTTTGAGAACCAGGATCCTTCC
TGGGGGACAGAGGCAATCCCACATGGTGCTGTCCTATCAGAACGGATGCTGGGAAGCAACGGGA
TGGACCCCAGTAGTCAGCAGAGCCCAGGACAATTCGAGGACAGCGGTGAGGCAAGAAGTGGAGA
TGGCAACATGTTTCCAAATGGCCGTGTAGTCCACCCTGCAGTCCACGGGCTTCCAAGCGCTGAC
GCTCAGAAGCCGATTTCACCAGGGCAGCATCACTATGACGTTCCTGAAGAATCACTTTATGACA
CAGTGGCCCAGGAATATTCTCTCCTTGACAATGCAATGGATAGGTCTTCTGTTGCTGGCTGTCT
GGGAACTTTCCCCAACTCTATCAATAGTGGTCGGGATGAATTGTGCCCTTCACAGCCAAGGGAT
GTTGTGGCTTCCTTCTCCAAAACCCTAGCACATATGAGCACTCGAGAGGCTGAGGAGAGTGTGG
AAAGGGGCTTCCCTGAACCTTTGGGAGCCATGGGCTCCCAGATAGAATCTTCTGAGGAAAGGCA
AGTGAGCAATTCCATTAGAGAGCTGGCCACACAACAGGCAAGCTTCCAAGAAGTTGATGTTGAG
GAAAGACTTGCCCATGTCTACAGTGAGGCCCTATACAATGACACACCCTCCCACATGCCAAGAC
ACAGCAGTGGCCATGATGTCGCCTCTGCTACTGAGGAGGCTGTGCAGAGAGATGCTTCCTTTGA
CCCTCATGATGACTTGGTGACCAACTACGAGTCTGATTCTGACGAGGGCTCTTTGTTTACCCTT
AGTTCTGAGGGTTCTCAGGACACAAGGAGCTTGACTGAAGAACAGGCATTTGTGGAGAGTGGTG
GGGACAGCCAGCCCCTCCCGAGCAGGAACTTGGGGGAATACAAGGACAGTGTGACATCAGCAGA
AAGTGTTGAAGACATCACGTCACAACAGACTCTAGAGAAGCGTGAAGCGCAAGAAGCTCACCTC
GGAAACACTCTCATTTCTGGTCCAGACTCTTGTGTGCATGAAACACATCTGGAAAATGACTCTA
GCCCCCTTGACCCTGAGAATGTACCAACATGGACCCAACCCCCAGACCATAAGCTAGCACACCA
TGAGACTCTAGGCACATTTGTGTATGGTGACATAGGGCCCCAGTCTGAGGCAGTAGACTGGCTC
TACTCCCTTAGAGACCTGGAATTCCCAAATATAGATAGTTCACCATCACCACCATGTTCTGATC
AAGATCCCTCAGATCCTGAGGAGCATGACACCAAATAG

hide sequence

RefSeq Acc Id:

XM_063272911 ⟹ XP_063128981

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	34,932,814 - 34,959,046 (+)	NCBI

RefSeq Acc Id:

XM_063272912 ⟹ XP_063128982

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	34,933,673 - 34,959,046 (+)	NCBI

RefSeq Acc Id:

XM_063272914 ⟹ XP_063128984

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	34,932,814 - 34,959,046 (+)	NCBI

RefSeq Acc Id:

XM_063272915 ⟹ XP_063128985

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	34,933,673 - 34,959,046 (+)	NCBI

RefSeq Acc Id:

XM_063272916 ⟹ XP_063128986

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	34,933,603 - 34,959,046 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001008763	(Get FASTA)	NCBI Sequence Viewer
	XP_063128981	(Get FASTA)	NCBI Sequence Viewer
	XP_063128982	(Get FASTA)	NCBI Sequence Viewer
	XP_063128984	(Get FASTA)	NCBI Sequence Viewer
	XP_063128985	(Get FASTA)	NCBI Sequence Viewer
	XP_063128986	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAQ96257	(Get FASTA)	NCBI Sequence Viewer
	EDL89952	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000030477
GenBank Protein	Q6TXF5	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001008763 ⟸ NM_001008763

- UniProtKB:

Q6TXF5 (UniProtKB/Swiss-Prot), A6JD30 (UniProtKB/TrEMBL), A0A8L2UKS8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MKDFYARVTVMVTGLCFVGTVTNPSRKSSLSLHQQDGDLLANWSSTRHTSQKTDTVDRNSYFFR
VLFQPHTKERHTNHLDRTNHRLSKVTLSCLAHLRALEMLNLGDDVIHSLCLDLSLPSSSRQKRH
RSRFRGRHPRLKVLLLQRNQLGPTPKGLWKLKPLCSLDLSFNRRVGIGLSGFHGCLQLKSIYLK
NNKILTIHPEAFKGLKKLQVVDLRSSALTMLVPIVTIALEWPNLELGLADNQWQCNESDANFQN
IASVSWGEIWKAVCNTPVENEKPYVEASQIRISRDIHLPRSPSSDLQSLIQSKAEKPRAGMDVH
LSALEKKAQVGYGDLKGIWLQSPMELRDSQGGPVTDRKDDKPPDLALAVCLSVFITFVVAFCLG
AFARPYIDRLRQQRCLNKRPGSENAYSNEGFHDDVEAAQHVQHQGTDLCQTTHHLNLFENQDPS
WGTEAIPHGAVLSERMLGSNGMDPSSQQSPGQFEDSGEARSGDGNMFPNGRVVHPAVHGLPSAD
AQKPISPGQHHYDVPEESLYDTVAQEYSLLDNAMDRSSVAGCLGTFPNSINSGRDELCPSQPRD
VVASFSKTLAHMSTREAEESVERGFPEPLGAMGSQIESSEERQVSNSIRELATQQASFQEVDVE
ERLAHVYSEALYNDTPSHMPRHSSGHDVASATEEAVQRDASFDPHDDLVTNYESDSDEGSLFTL
SSEGSQDTRSLTEEQAFVESGGDSQPLPSRNLGEYKDSVTSAESVEDITSQQTLEKREAQEAHL
GNTLISGPDSCVHETHLENDSSPLDPENVPTWTQPPDHKLAHHETLGTFVYGDIGPQSEAVDWL
YSLRDLEFPNIDSSPSPPCSDQDPSDPEEHDTK

hide sequence

Ensembl Acc Id:

ENSRNOP00000030477 ⟸ ENSRNOT00000031756

RefSeq Acc Id:	XP_063128981 ⟸ XM_063272911
- Peptide Label:	isoform X1
- UniProtKB:	A0A8L2UKS8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063128984 ⟸ XM_063272914
- Peptide Label:	isoform X2
- UniProtKB:	Q6TXF5 (UniProtKB/Swiss-Prot), A6JD30 (UniProtKB/TrEMBL), A0A8L2UKS8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063128986 ⟸ XM_063272916
- Peptide Label:	isoform X2
- UniProtKB:	Q6TXF5 (UniProtKB/Swiss-Prot), A6JD30 (UniProtKB/TrEMBL), A0A8L2UKS8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063128982 ⟸ XM_063272912
- Peptide Label:	isoform X1
- UniProtKB:	A0A8L2UKS8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063128985 ⟸ XM_063272915
- Peptide Label:	isoform X2
- UniProtKB:	Q6TXF5 (UniProtKB/Swiss-Prot), A6JD30 (UniProtKB/TrEMBL), A0A8L2UKS8 (UniProtKB/TrEMBL)

Protein Domains

LRRNT

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q6TXF5-F1-model_v2	AlphaFold	Q6TXF5	1-865	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1306094	AgrOrtholog
BioCyc Gene	G2FUF-15870	BioCyc
Ensembl Genes	ENSRNOG00000026585	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000031756	ENTREZGENE
Gene3D-CATH	3.80.10.10	UniProtKB/Swiss-Prot
InterPro	Leu-rich_rpt	UniProtKB/Swiss-Prot
	LRR_dom_sf	UniProtKB/Swiss-Prot
	LRR_TM_domain-containing	UniProtKB/Swiss-Prot
KEGG Report	rno:289587	UniProtKB/Swiss-Prot
NCBI Gene	289587	ENTREZGENE
PANTHER	ANTIGEN BSP, PUTATIVE-RELATED	UniProtKB/Swiss-Prot
	INSULIN LIKE GROWTH FACTOR BINDING PROTEIN ACID LABILE SUBUNIT	UniProtKB/Swiss-Prot
Pfam	LRR_8	UniProtKB/Swiss-Prot
PhenoGen	Lrrc66	PhenoGen
RatGTEx	ENSRNOG00000026585	RatGTEx
Superfamily-SCOP	L domain-like	UniProtKB/Swiss-Prot
UniProt	A0A8L2UKS8	ENTREZGENE, UniProtKB/TrEMBL
	A6JD30	ENTREZGENE, UniProtKB/TrEMBL
	LRC66_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Lrrc66	leucine rich repeat containing 66	LOC103693755	leucine-rich repeat-containing protein 66-like	Data merged from RGD:9071312	737654	PROVISIONAL
2014-08-25	LOC103693755	leucine-rich repeat-containing protein 66-like			Symbol and Name status set to provisional	70820	PROVISIONAL
2008-09-09	Lrrc66	leucine rich repeat containing 66	RGD1306094	similar to hypothetical protein MGC38937	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	RGD1306094	similar to hypothetical protein MGC38937	RGD1306094_predicted	similar to hypothetical protein MGC38937 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-20	RGD1306094_predicted	similar to hypothetical protein MGC38937 (predicted)	LOC289587_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC289587_predicted	similar to hypothetical protein MGC38937 (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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