Aifm3 (apoptosis inducing factor, mitochondria associated 3) - Rat Genome Database

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Gene: Aifm3 (apoptosis inducing factor, mitochondria associated 3) Rattus norvegicus
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Symbol: Aifm3
Name: apoptosis inducing factor, mitochondria associated 3
RGD ID: 1306028
Description: Predicted to enable oxidoreductase activity, acting on NAD(P)H. Predicted to be involved in execution phase of apoptosis. Predicted to be located in cytosol; endoplasmic reticulum; and mitochondrial inner membrane. Predicted to be active in mitochondrion. Orthologous to human AIFM3 (apoptosis inducing factor mitochondria associated 3); INTERACTS WITH 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: apoptosis-inducing factor 3; apoptosis-inducing factor, mitochondrion-associated 3; LOC303786; MGC109275; RGD1306028; similar to hypothetical protein FLJ30473
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81197,009,100 - 97,030,601 (-)NCBIGRCr8
mRatBN7.21183,504,859 - 83,523,630 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1183,504,861 - 83,521,248 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1192,232,276 - 92,247,077 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01184,893,435 - 84,908,236 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01183,947,043 - 83,961,844 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01187,364,452 - 87,380,705 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1187,366,621 - 87,380,704 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01190,417,097 - 90,431,999 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41185,496,302 - 85,512,831 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11185,544,286 - 85,551,637 (-)NCBI
Celera1182,273,467 - 82,288,125 (-)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15764604   PMID:18614015   PMID:21447364   PMID:22085972   PMID:22871113  


Genomics

Comparative Map Data
Aifm3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81197,009,100 - 97,030,601 (-)NCBIGRCr8
mRatBN7.21183,504,859 - 83,523,630 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1183,504,861 - 83,521,248 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1192,232,276 - 92,247,077 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01184,893,435 - 84,908,236 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01183,947,043 - 83,961,844 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01187,364,452 - 87,380,705 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1187,366,621 - 87,380,704 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01190,417,097 - 90,431,999 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41185,496,302 - 85,512,831 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11185,544,286 - 85,551,637 (-)NCBI
Celera1182,273,467 - 82,288,125 (-)NCBICelera
Cytogenetic Map11q23NCBI
AIFM3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382220,965,172 - 20,981,358 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2220,965,108 - 20,981,360 (+)EnsemblGRCh38hg38GRCh38
GRCh372221,319,460 - 21,335,647 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362219,649,434 - 19,665,649 (+)NCBINCBI36Build 36hg18NCBI36
Celera224,810,763 - 4,826,996 (+)NCBICelera
Cytogenetic Map22q11.21NCBI
HuRef224,589,741 - 4,603,945 (+)NCBIHuRef
CHM1_12221,319,619 - 21,335,846 (+)NCBICHM1_1
T2T-CHM13v2.02221,373,992 - 21,390,168 (+)NCBIT2T-CHM13v2.0
Aifm3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391617,307,418 - 17,325,349 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1617,307,475 - 17,325,349 (+)EnsemblGRCm39 Ensembl
GRCm381617,489,624 - 17,507,485 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1617,489,611 - 17,507,485 (+)EnsemblGRCm38mm10GRCm38
MGSCv371617,489,784 - 17,507,575 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361617,403,254 - 17,421,045 (+)NCBIMGSCv36mm8
Celera1618,062,758 - 18,080,551 (+)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1610.84NCBI
Aifm3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544219,333,591 - 19,346,438 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544219,334,217 - 19,346,438 (-)NCBIChiLan1.0ChiLan1.0
AIFM3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22330,663,078 - 30,688,168 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12233,220,882 - 33,237,106 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0223,189,169 - 3,205,394 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12219,679,872 - 19,695,349 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2219,679,873 - 19,695,349 (+)Ensemblpanpan1.1panPan2
AIFM3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12630,520,542 - 30,533,256 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2630,519,872 - 30,532,796 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2630,478,323 - 30,492,711 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02631,928,867 - 31,943,261 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2631,910,811 - 31,943,250 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12629,974,681 - 29,989,031 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02629,598,646 - 29,613,004 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02630,687,693 - 30,702,093 (-)NCBIUU_Cfam_GSD_1.0
Aifm3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118140,249,410 - 140,263,534 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366192,493,256 - 2,504,322 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366192,485,840 - 2,505,075 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AIFM3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1450,562,776 - 50,576,275 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11450,562,611 - 50,576,273 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21454,011,363 - 54,025,438 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AIFM3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1194,901,118 - 4,917,290 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl194,904,050 - 4,918,224 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660852,052,891 - 2,068,955 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aifm3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624945710,820 - 722,621 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624945710,562 - 724,699 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Aifm3
44 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:166
Count of miRNA genes:113
Interacting mature miRNAs:118
Transcripts:ENSRNOT00000040978
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116642214886241447Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 38
Low 3 34 54 38 19 38 7 10 36 35 41 11 7
Below cutoff 9 3 3 3 1 1 1

Sequence


RefSeq Acc Id: ENSRNOT00000040978   ⟹   ENSRNOP00000048427
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1183,504,861 - 83,519,593 (-)Ensembl
Rnor_6.0 Ensembl1187,366,621 - 87,380,378 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000086117   ⟹   ENSRNOP00000073999
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1183,504,862 - 83,510,876 (-)Ensembl
Rnor_6.0 Ensembl1187,374,690 - 87,380,704 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000112032   ⟹   ENSRNOP00000088997
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1183,504,925 - 83,521,248 (-)Ensembl
RefSeq Acc Id: NM_001013977   ⟹   NP_001013999
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81197,009,100 - 97,023,832 (-)NCBI
mRatBN7.21183,504,861 - 83,519,593 (-)NCBI
Rnor_6.01187,365,973 - 87,380,705 (+)NCBI
Rnor_5.01190,417,097 - 90,431,999 (+)NCBI
RGSC_v3.41185,496,302 - 85,512,831 (-)RGD
Celera1182,273,467 - 82,288,125 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008768875   ⟹   XP_008767097
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81197,009,100 - 97,030,601 (-)NCBI
mRatBN7.21183,505,181 - 83,523,627 (-)NCBI
Rnor_6.01187,364,452 - 87,380,431 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039088259   ⟹   XP_038944187
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81197,009,100 - 97,030,601 (-)NCBI
mRatBN7.21183,505,181 - 83,523,627 (-)NCBI
RefSeq Acc Id: XM_039088260   ⟹   XP_038944188
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81197,009,100 - 97,030,601 (-)NCBI
mRatBN7.21183,505,181 - 83,523,627 (-)NCBI
RefSeq Acc Id: XM_063270454   ⟹   XP_063126524
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81197,009,100 - 97,030,601 (-)NCBI
RefSeq Acc Id: XM_063270455   ⟹   XP_063126525
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81197,009,100 - 97,030,601 (-)NCBI
RefSeq Acc Id: XM_063270456   ⟹   XP_063126526
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81197,009,100 - 97,016,021 (-)NCBI
RefSeq Acc Id: XR_010055949
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81197,011,537 - 97,030,601 (-)NCBI
RefSeq Acc Id: NP_001013999   ⟸   NM_001013977
- UniProtKB: D3ZF03 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008767097   ⟸   XM_008768875
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000048427   ⟸   ENSRNOT00000040978
RefSeq Acc Id: ENSRNOP00000073999   ⟸   ENSRNOT00000086117
RefSeq Acc Id: XP_038944188   ⟸   XM_039088260
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038944187   ⟸   XM_039088259
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000088997   ⟸   ENSRNOT00000112032
RefSeq Acc Id: XP_063126525   ⟸   XM_063270455
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063126524   ⟸   XM_063270454
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063126526   ⟸   XM_063270456
- Peptide Label: isoform X3
Protein Domains
FAD/NAD(P)-binding   Rieske

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZF03-F1-model_v2 AlphaFold D3ZF03 1-604 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306028 AgrOrtholog
BioCyc Gene G2FUF-20590 BioCyc
Ensembl Genes ENSRNOG00000037957 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000040978 ENTREZGENE
  ENSRNOT00000040978.5 UniProtKB/TrEMBL
  ENSRNOT00000086117.2 UniProtKB/TrEMBL
  ENSRNOT00000112032.1 UniProtKB/TrEMBL
Gene3D-CATH 2.102.10.10 UniProtKB/TrEMBL
  3.30.390.30 UniProtKB/TrEMBL
  3.50.50.60 UniProtKB/TrEMBL
InterPro FAD/NAD-bd_sf UniProtKB/TrEMBL
  FAD/NAD-linked_Rdtase_dimer UniProtKB/TrEMBL
  Pyr_nucl-diS_OxRdtase_FAD/NAD UniProtKB/TrEMBL
  Reductase_C UniProtKB/TrEMBL
  Rieske_2Fe-2S UniProtKB/TrEMBL
  Rieske_2Fe-2S_sf UniProtKB/TrEMBL
KEGG Report rno:303786 UniProtKB/TrEMBL
NCBI Gene 303786 ENTREZGENE
PANTHER APOPTOSIS-INDUCING FACTOR 1 UniProtKB/TrEMBL
  APOPTOSIS-INDUCING FACTOR 3 UniProtKB/TrEMBL
Pfam Pyr_redox_2 UniProtKB/TrEMBL
  Reductase_C UniProtKB/TrEMBL
  Rieske UniProtKB/TrEMBL
PhenoGen Aifm3 PhenoGen
PRINTS FADPNR UniProtKB/TrEMBL
  PNDRDTASEI UniProtKB/TrEMBL
  PNDRDTASEII UniProtKB/TrEMBL
PROSITE RIESKE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000037957 RatGTEx
Superfamily-SCOP FAD/NAD-linked_reductase_dimer UniProtKB/TrEMBL
  Rieske_dom UniProtKB/TrEMBL
  SSF51905 UniProtKB/TrEMBL
UniProt A0A8I6A793_RAT UniProtKB/TrEMBL
  D3ZF03 ENTREZGENE, UniProtKB/TrEMBL
  Q5FVJ2_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-25 Aifm3  apoptosis inducing factor, mitochondria associated 3  Aifm3  apoptosis-inducing factor, mitochondrion-associated 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Aifm3  apoptosis-inducing factor, mitochondrion-associated 3  RGD1306028  similar to hypothetical protein FLJ30473  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1306028  similar to hypothetical protein FLJ30473  RGD1306028_predicted  similar to hypothetical protein FLJ30473 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1306028_predicted  similar to hypothetical protein FLJ30473 (predicted)  LOC303786_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC303786_predicted  similar to hypothetical protein FLJ30473 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL