Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17alpha-ethynylestradiol | affects expression | ISO | Klk8 (Mus musculus) | 6480464 | Ethinyl Estradiol affects the expression of KLK8 mRNA | CTD | PMID:17555576 | 17alpha-ethynylestradiol | multiple interactions | ISO | Klk8 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of KLK8 mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | decreases expression | ISO | Klk8 (Mus musculus) | 6480464 | Ethinyl Estradiol results in decreased expression of KLK8 mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Klk8 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of KLK8 mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Klk8 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of KLK8 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Klk8 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of KLK8 mRNA | CTD | PMID:17035482 | 2-hydroxypropanoic acid | decreases expression | ISO | KLK8 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of KLK8 mRNA | CTD | PMID:30851411 | 4,4'-sulfonyldiphenol | increases expression | ISO | Klk8 (Mus musculus) | 6480464 | bisphenol S results in increased expression of KLK8 mRNA | CTD | PMID:30951980 | acrylamide | decreases expression | EXP | | 6480464 | Acrylamide results in decreased expression of KLK8 mRNA | CTD | PMID:28959563 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of KLK8 mRNA | CTD | PMID:16483693 | arsane | multiple interactions | ISO | KLK8 (Homo sapiens) | 6480464 | [sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of KLK8 mRNA | CTD | PMID:32525701 | arsenic atom | multiple interactions | ISO | KLK8 (Homo sapiens) | 6480464 | [sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of KLK8 mRNA | CTD | PMID:32525701 | benzalkonium chloride | increases expression | ISO | Klk8 (Mus musculus) | 6480464 | Benzalkonium Compounds results in increased expression of KLK8 mRNA | CTD | PMID:30171875 | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of KLK8 mRNA | CTD | PMID:21839799 | benzo[a]pyrene | affects methylation | ISO | KLK8 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of KLK8 5' UTR and Benzo(a)pyrene affects the methylation of KLK8 promoter | CTD | PMID:27901495 | benzo[a]pyrene | decreases methylation | ISO | KLK8 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of KLK8 exon | CTD | PMID:27901495 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of KLK8 mRNA | CTD | PMID:25181051 | bisphenol A | increases expression | ISO | Klk8 (Mus musculus) | 6480464 | bisphenol A results in increased expression of KLK8 mRNA | CTD | PMID:32156529 | butanal | increases expression | ISO | KLK8 (Homo sapiens) | 6480464 | butyraldehyde results in increased expression of KLK8 mRNA | CTD | PMID:26079696 | cadmium atom | increases expression | ISO | KLK8 (Homo sapiens) | 6480464 | Cadmium results in increased expression of KLK8 mRNA | CTD | PMID:21120746 | cadmium dichloride | increases expression | EXP | | 6480464 | Cadmium Chloride results in increased expression of KLK8 mRNA | CTD | PMID:33453195 | calcitriol | increases expression | ISO | KLK8 (Homo sapiens) | 6480464 | Calcitriol results in increased expression of KLK8 mRNA | CTD | PMID:26485663 | calcium atom | increases activity | ISO | KLK8 (Homo sapiens) | 6480464 | Calcium results in increased activity of KLK8 protein | CTD | PMID:16800733 | calcium dichloride | increases activity | ISO | KLK8 (Homo sapiens) | 6480464 | Calcium Chloride results in increased activity of KLK8 protein | CTD | PMID:16800733 | calcium(0) | increases activity | ISO | KLK8 (Homo sapiens) | 6480464 | Calcium results in increased activity of KLK8 protein | CTD | PMID:16800733 | carbon nanotube | decreases expression | ISO | Klk8 (Mus musculus) | 6480464 | Nanotubes and Carbon results in decreased expression of KLK8 mRNA | CTD | PMID:25554681 | chymostatin | decreases activity | ISO | KLK8 (Homo sapiens) | 6480464 | chymostatin results in decreased activity of KLK8 protein | CTD | PMID:16800733 | cisplatin | multiple interactions | ISO | KLK8 (Homo sapiens) | 6480464 | [Cisplatin co-treated with panobinostat] affects the expression of KLK8 mRNA | CTD | PMID:21791302 | cisplatin | affects response to substance | ISO | KLK8 (Homo sapiens) | 6480464 | KLK8 protein affects the susceptibility to Cisplatin | CTD | PMID:16217747 | Cuprizon | decreases expression | EXP | | 6480464 | Cuprizone results in decreased expression of KLK8 mRNA | CTD | PMID:26577399 | decabromodiphenyl ether | decreases expression | EXP | | 6480464 | decabromobiphenyl ether results in decreased expression of KLK8 mRNA | CTD | PMID:23640034 | diazinon | increases methylation | ISO | KLK8 (Homo sapiens) | 6480464 | Diazinon results in increased methylation of KLK8 gene | CTD | PMID:22964155 | dibenz[a,h]anthracene | increases expression | ISO | Klk8 (Mus musculus) | 6480464 | 1 more ... | CTD | PMID:26377693 | diethylstilbestrol | increases expression | ISO | Klk8 (Mus musculus) | 6480464 | Diethylstilbestrol results in increased expression of KLK8 mRNA | CTD | PMID:15171707 | dorsomorphin | multiple interactions | ISO | KLK8 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | entinostat | increases expression | ISO | KLK8 (Homo sapiens) | 6480464 | entinostat results in increased expression of KLK8 mRNA | CTD | PMID:26272509 and PMID:27188386 | entinostat | multiple interactions | ISO | KLK8 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLK8 mRNA | CTD | PMID:27188386 | fenvalerate | increases expression | EXP | | 6480464 | fenvalerate results in increased expression of KLK8 mRNA | CTD | PMID:30307764 | folic acid | decreases expression | ISO | Klk8 (Mus musculus) | 6480464 | Folic Acid results in decreased expression of KLK8 mRNA | CTD | PMID:25629700 | leupeptin | decreases activity | ISO | KLK8 (Homo sapiens) | 6480464 | leupeptin results in decreased activity of KLK8 protein | CTD | PMID:16800733 | linsidomine | increases oxidation | EXP | | 6480464 | linsidomine results in increased oxidation of KLK8 protein | CTD | PMID:28086193 | magnesium atom | increases activity | ISO | KLK8 (Homo sapiens) | 6480464 | Magnesium results in increased activity of KLK8 protein | CTD | PMID:16800733 | magnesium dichloride | increases activity | ISO | KLK8 (Homo sapiens) | 6480464 | Magnesium Chloride results in increased activity of KLK8 protein | CTD | PMID:16800733 | magnesium sulfate | increases activity | ISO | KLK8 (Homo sapiens) | 6480464 | Magnesium Sulfate results in increased activity of KLK8 protein | CTD | PMID:16800733 | mercury dibromide | decreases expression | ISO | KLK8 (Homo sapiens) | 6480464 | mercuric bromide results in decreased expression of KLK8 mRNA | CTD | PMID:26272509 | mercury dibromide | multiple interactions | ISO | KLK8 (Homo sapiens) | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KLK8 mRNA | CTD | PMID:27188386 | methylmercury chloride | decreases expression | ISO | KLK8 (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of KLK8 mRNA | CTD | PMID:28001369 | N-ethyl-N-nitrosourea | increases mutagenesis | ISO | Klk8 (Mus musculus) | 6480464 | Ethylnitrosourea results in increased mutagenesis of KLK8 mRNA | CTD | PMID:27776689 | nickel sulfate | decreases activity | ISO | KLK8 (Homo sapiens) | 6480464 | nickel sulfate results in decreased activity of KLK8 protein | CTD | PMID:16800733 | ozone | decreases expression | ISO | Klk8 (Mus musculus) | 6480464 | Ozone results in decreased expression of KLK8 mRNA | CTD | PMID:12763052 and PMID:33026818 | panobinostat | multiple interactions | ISO | KLK8 (Homo sapiens) | 6480464 | [Cisplatin co-treated with Panobinostat] affects the expression of KLK8 mRNA more ... | CTD | PMID:21791302 and PMID:27188386 | panobinostat | increases expression | ISO | KLK8 (Homo sapiens) | 6480464 | panobinostat results in increased expression of KLK8 mRNA | CTD | PMID:26272509 | pentanal | increases expression | ISO | KLK8 (Homo sapiens) | 6480464 | pentanal results in increased expression of KLK8 mRNA | CTD | PMID:26079696 | perfluorohexanesulfonic acid | increases expression | ISO | Klk8 (Mus musculus) | 6480464 | perfluorohexanesulfonic acid results in increased expression of KLK8 mRNA | CTD | PMID:37995155 | permethrin | increases expression | ISO | KLK8 (Homo sapiens) | 6480464 | Permethrin results in increased expression of KLK8 mRNA | CTD | PMID:37047231 | phenylmercury acetate | decreases expression | ISO | KLK8 (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in decreased expression of KLK8 mRNA | CTD | PMID:26272509 | phenylmercury acetate | multiple interactions | ISO | KLK8 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KLK8 mRNA | CTD | PMID:27188386 | potassium atom | increases activity | ISO | KLK8 (Homo sapiens) | 6480464 | Potassium results in increased activity of KLK8 protein | CTD | PMID:16800733 | potassium chloride | increases activity | ISO | KLK8 (Homo sapiens) | 6480464 | Potassium Chloride results in increased activity of KLK8 protein | CTD | PMID:16800733 | propanal | increases expression | ISO | KLK8 (Homo sapiens) | 6480464 | propionaldehyde results in increased expression of KLK8 mRNA | CTD | PMID:26079696 | rac-lactic acid | decreases expression | ISO | KLK8 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of KLK8 mRNA | CTD | PMID:30851411 | SB 431542 | multiple interactions | ISO | KLK8 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | sodium arsenate | multiple interactions | ISO | KLK8 (Homo sapiens) | 6480464 | [sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of KLK8 mRNA | CTD | PMID:32525701 | sodium arsenite | affects methylation | ISO | KLK8 (Homo sapiens) | 6480464 | sodium arsenite affects the methylation of KLK8 gene | CTD | PMID:28589171 | sodium arsenite | increases expression | ISO | Klk8 (Mus musculus) | 6480464 | sodium arsenite results in increased expression of KLK8 mRNA | CTD | PMID:37682722 | tamoxifen | affects expression | ISO | Klk8 (Mus musculus) | 6480464 | Tamoxifen affects the expression of KLK8 mRNA | CTD | PMID:17555576 | titanium dioxide | decreases expression | ISO | Klk8 (Mus musculus) | 6480464 | titanium dioxide results in decreased expression of KLK8 mRNA | CTD | PMID:23557971 and PMID:29264374 | trichostatin A | increases expression | ISO | KLK8 (Homo sapiens) | 6480464 | trichostatin A results in increased expression of KLK8 mRNA | CTD | PMID:24935251 | triclosan | increases expression | ISO | KLK8 (Homo sapiens) | 6480464 | Triclosan results in increased expression of KLK8 mRNA | CTD | PMID:30510588 | valproic acid | affects expression | ISO | KLK8 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of KLK8 mRNA | CTD | PMID:25979313 | valproic acid | decreases expression | ISO | KLK8 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of KLK8 mRNA | CTD | PMID:28001369 | valproic acid | increases methylation | ISO | KLK8 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of KLK8 gene | CTD | PMID:29154799 | zinc atom | decreases activity | ISO | KLK8 (Homo sapiens) | 6480464 | Zinc results in decreased activity of KLK8 protein | CTD | PMID:16800733 | zinc sulfate | decreases activity | ISO | KLK8 (Homo sapiens) | 6480464 | Zinc Sulfate results in decreased activity of KLK8 protein | CTD | PMID:16800733 | zinc(0) | decreases activity | ISO | KLK8 (Homo sapiens) | 6480464 | Zinc results in decreased activity of KLK8 protein | CTD | PMID:16800733 | |