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Gene: Mtrex (Mtr4 exosome RNA helicase) Rattus norvegicus

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Symbol:

Mtrex

Name:

Mtr4 exosome RNA helicase

RGD ID:

1305984

Description:

Predicted to enable ATP binding activity and RNA helicase activity. Predicted to be involved in DNA damage response; RNA catabolic process; and maturation of 5.8S rRNA. Predicted to be located in nucleus. Predicted to be part of TRAMP complex; catalytic step 2 spliceosome; and nuclear exosome (RNase complex). Orthologous to human MTREX (Mtr4 exosome RNA helicase); PARTICIPATES IN ribosome biogenesis pathway; RNA degradation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; C60 fullerene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

exosome RNA helicase MTR4; LOC365668; MGC124848; RGD1305984; similar to RIKEN cDNA 2610528A15; Ski2 like RNA helicase 2; Skiv2l2; superkiller viralicidic activity 2-like 2; superkiller viralicidic activity 2-like 2 (S. cerevisiae)

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MTREX (Mtr4 exosome RNA helicase)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB
Mus musculus (house mouse):	Mtrex (Mtr4 exosome RNA helicase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Mtrex (Mtr4 exosome RNA helicase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MTREX (Mtr4 exosome RNA helicase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MTREX (Mtr4 exosome RNA helicase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Mtrex (Mtr4 exosome RNA helicase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MTREX (Mtr4 exosome RNA helicase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	MTREX (Mtr4 exosome RNA helicase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Mtrex (Mtr4 exosome RNA helicase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Mtrex (Mtr4 exosome RNA helicase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Mtrex (Mtr4 exosome RNA helicase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	MTREX (Mtr4 exosome RNA helicase)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	MTR4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	MTR4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Mtr4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Mtr4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	mtr-4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	mtr-4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	mtrex	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	mtrex	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	mtrex	Alliance	DIOPT (OMA\|OrthoFinder\|PANTHER)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	46,233,528 - 46,293,827 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	46,194,647 - 46,293,827 (-)	Ensembl				GRCr8
mRatBN7.2	2	44,500,326 - 44,560,624 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	44,461,444 - 44,560,627 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	51,613,289 - 51,673,599 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	49,671,649 - 49,731,959 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	44,546,896 - 44,607,345 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	44,726,716 - 44,787,013 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	44,717,781 - 44,786,963 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	63,766,773 - 63,827,191 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	44,247,683 - 44,306,293 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	40,278,641 - 40,339,354 (-)	NCBI		Celera
RGSC_v3.1	2	44,188,294 - 44,198,408 (-)	NCBI
Cytogenetic Map	2	q14	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

amyotrophic lateral sclerosis (ISO)

Marfanoid Mental Retardation Syndrome, Autosomal (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-hydroxypropanoic acid (ISO)

2-methylcholine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

5-azacytidine (ISO)

aflatoxin B1 (ISO)

aristolochic acid A (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

C60 fullerene (EXP)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

CU-O LINKAGE (ISO)

DDT (EXP)

deoxynivalenol (ISO)

dexamethasone (ISO)

diarsenic trioxide (ISO)

dicrotophos (ISO)

dioxygen (ISO)

diquat (ISO)

doxorubicin (ISO)

ethyl methanesulfonate (ISO)

folic acid (ISO)

formaldehyde (ISO)

indometacin (ISO)

kojic acid (ISO)

methoxychlor (EXP)

methyl methanesulfonate (ISO)

nitrates (ISO)

Nivalenol (ISO)

paracetamol (EXP,ISO)

perfluorooctanoic acid (ISO)

pirinixic acid (ISO)

poly(I:C) (EXP)

quercetin (ISO)

rac-lactic acid (ISO)

resveratrol (ISO)

Salinomycin (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

sodium fluoride (ISO)

succimer (ISO)

sulforaphane (ISO)

tetrachloroethene (ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

triphenyl phosphate (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

DNA damage response (IEA,ISO)

maturation of 5.8S rRNA (IEA,ISO)

mRNA processing (IEA)

RNA catabolic process (IEA,ISO)

RNA splicing (IEA)

rRNA processing (IEA,ISO)

Cellular Component

catalytic step 2 spliceosome (IEA,ISO)

exosome (RNase complex) (IEA,ISO)

nuclear exosome (RNase complex) (IEA,ISO)

nuclear speck (IEA)

nucleolus (IEA)

nucleoplasm (IEA,ISO)

nucleus (IEA,ISO)

spliceosomal complex (IEA)

TRAMP complex (IEA,ISO)

Molecular Function

ATP binding (IEA,ISO)

helicase activity (IEA)

hydrolase activity (IEA)

nucleic acid binding (IEA)

nucleotide binding (IEA)

protein binding (ISO)

RNA binding (IEA)

RNA helicase activity (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

ribosome biogenesis pathway (ISO)

RNA degradation pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	The LO-BaFL method and ALS microarray expression analysis.	Baciu C, etal., BMC Bioinformatics. 2012 Sep 24;13:244. doi: 10.1186/1471-2105-13-244.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
4.	GOA pipeline	RGD automated data pipeline
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	Comprehensive gene review and curation	RGD comprehensive gene curation
8.	The roles of SSU processome components and surveillance factors in the initial processing of human ribosomal RNA.	Sloan KE, etal., RNA. 2014 Apr;20(4):540-50. doi: 10.1261/rna.043471.113. Epub 2014 Feb 18.

Additional References at PubMed

PMID:8889548	PMID:11719186	PMID:11991638	PMID:12477932	PMID:14766980	PMID:15277470	PMID:16263084	PMID:16782053	PMID:17412707	PMID:21855801	PMID:22658674	PMID:26166824
PMID:29107693	PMID:29844170	PMID:29906447	PMID:31358741

Genomics

Comparative Map Data

Mtrex
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	46,233,528 - 46,293,827 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	46,194,647 - 46,293,827 (-)	Ensembl				GRCr8
mRatBN7.2	2	44,500,326 - 44,560,624 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	44,461,444 - 44,560,627 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	51,613,289 - 51,673,599 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	49,671,649 - 49,731,959 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	44,546,896 - 44,607,345 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	44,726,716 - 44,787,013 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	44,717,781 - 44,786,963 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	63,766,773 - 63,827,191 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	44,247,683 - 44,306,293 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	40,278,641 - 40,339,354 (-)	NCBI		Celera
RGSC_v3.1	2	44,188,294 - 44,198,408 (-)	NCBI
Cytogenetic Map	2	q14	NCBI

MTREX
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	55,307,989 - 55,425,579 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	55,307,736 - 55,426,065 (+)	Ensembl			hg38	GRCh38
GRCh37	5	54,603,817 - 54,721,407 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	54,639,373 - 54,756,562 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	5	51,556,391 - 51,674,226 (+)	NCBI		Celera
Cytogenetic Map	5	q11.2	NCBI
HuRef	5	51,576,539 - 51,694,389 (+)	NCBI		HuRef
CHM1_1	5	54,607,444 - 54,725,302 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	56,135,296 - 56,252,888 (+)	NCBI		T2T-CHM13v2.0

Mtrex
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	113,004,306 - 113,063,914 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	113,003,952 - 113,063,932 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	13	112,867,780 - 112,927,380 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	112,867,418 - 112,927,398 (-)	Ensembl			mm10	GRCm38
MGSCv37	13	113,657,988 - 113,717,588 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	13	113,988,658 - 114,048,258 (-)	NCBI		MGSCv36	mm8
Celera	13	117,183,410 - 117,243,861 (-)	NCBI		Celera
Cytogenetic Map	13	D2.2	NCBI
cM Map	13	63.93	NCBI

Mtrex
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955446	12,270,344 - 12,362,882 (-)	Ensembl
ChiLan1.0	NW_004955446	12,270,338 - 12,362,064 (-)	NCBI	ChiLan1.0	ChiLan1.0

MTREX
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	58,515,669 - 58,633,639 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	56,669,298 - 56,787,269 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	58,604,582 - 58,722,532 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	60,227,431 - 60,345,303 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	60,227,431 - 60,345,303 (-)	Ensembl			panPan2	panpan1.1

MTREX
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	42,660,448 - 42,763,133 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	42,660,653 - 42,763,133 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	39,706,168 - 39,808,488 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	43,124,168 - 43,226,960 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	43,124,357 - 43,226,946 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	40,202,710 - 40,305,343 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	41,004,493 - 41,107,204 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	41,824,794 - 41,927,622 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Mtrex
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	203,420,524 - 203,522,228 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936480	12,357,637 - 12,458,728 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936480	12,357,637 - 12,458,728 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MTREX
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	16	34,478,272 - 34,606,096 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	16	34,478,227 - 34,605,508 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	16	36,587,011 - 36,713,211 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MTREX
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	4	51,543,976 - 51,667,458 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	4	51,544,211 - 51,667,254 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666049	412,848 - 543,692 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mtrex
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624759	3,868,662 - 3,965,319 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624759	3,868,759 - 3,965,446 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Mtrex
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	3	183,866,245 - 183,925,789 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Mtrex
324 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	25
Count of miRNA genes:	23
Interacting mature miRNAs:	25
Transcripts:	ENSRNOT00000060695
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10755430	Coatc6	Coat color QTL 6		0.02576	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	2	13325041	58325041	Rat
7387318	Stl32	Serum triglyceride level QTL 32	3.2	0.0003	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	2	24117813	69117813	Rat
10755436	Coatc8	Coat color QTL 8		0.02431	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	2	36750344	81750344	Rat
1298074	Bp164	Blood pressure QTL 164		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	44537979	205135428	Rat
10755499	Bp389	Blood pressure QTL 389	2.61		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	20695736	231474293	Rat
1358917	Cm42	Cardiac mass QTL 42	2.82		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	206613235	Rat
9590080	Insglur4	Insulin/glucose ratio QTL 4	28.7	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	2	6152767	51152767	Rat
1300160	Hrtrt3	Heart rate QTL 3	3.62		heart pumping trait (VT:2000009)	absolute change in heart rate (CMO:0000534)	2	35614083	53462005	Rat
1579916	Bp270	Blood pressure QTL 270		0.003	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	16051883	61051883	Rat
731167	Glom4	Glomerulus QTL 4	2.4	0.0082	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	2	22038044	67038044	Rat
731166	Mamtr2	Mammary tumor resistance QTL 2		0.0001	mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	2	9623581	54623581	Rat
1358913	Cm41	Cardiac mass QTL 41	2.73		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	206613235	Rat
152025242	Bw191	Body weight QTL 191	3.62		body mass (VT:0001259)		2	40306867	124537199	Rat
1302794	Stl27	Serum triglyceride level QTL 27	4.4	0.0001	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	2	27148328	145807373	Rat
9685065	Swd6	Spike wave discharge measurement QTL 6	5.8	0.01	brain electrophysiology trait (VT:0010557)	brain spike-and-wave discharge rate (CMO:0001739)	2	40957423	50526673	Rat
9590095	Sffal3	Serum free fatty acids level QTL 3	6.78	0.001	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	2	28889991	73889991	Rat
70174	BpQTLCluster2	Blood pressure QTL cluster 2	4.24		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	2	41801363	104744824	Rat
1331764	Bp205	Blood pressure QTL 205	3.476		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	14368707	59368707	Rat
631208	Bw1	Body weight QTL1	5.09		mesenteric fat pad mass (VT:0010427)	mesenteric fat pad weight to body weight ratio (CMO:0000654)	2	44904355	85286097	Rat
1358901	Cm38	Cardiac mass QTL 38	2		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	159440891	Rat
1331760	Bp206	Blood pressure QTL 206	3.62454		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	4265106	205135428	Rat
1358899	Kidm23	Kidney mass QTL 23	3.88		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
2293835	Kiddil5	Kidney dilation QTL 5	3.8		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	44537979	159440891	Rat
1300155	Bp174	Blood pressure QTL 174	4.09		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	2	44537979	112567334	Rat
1358908	Bw49	Body weight QTL 49	3.36		body mass (VT:0001259)	body weight (CMO:0000012)	2	27148557	159440760	Rat
1358910	Kidm27	Kidney mass QTL 27	5.77		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
1358911	Kidm28	Kidney mass QTL 28	5.42		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
61355	Bp36	Blood pressure QTL 36	2.9		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	2	7605533	104774005	Rat
1358904	Cm39	Cardiac mass QTL 39	2.26		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	159440891	Rat
1354617	Bp240	Blood pressure QTL 240	4		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	28652666	83465677	Rat
2293843	Kiddil6	Kidney dilation QTL 6	3.1		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	44537979	184731399	Rat
1578664	Bmd9	Bone mineral QTL density 9	5		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	2	5736325	50736325	Rat
1358887	Bw50	Body weight QTL 50	2.39		body mass (VT:0001259)	body weight (CMO:0000012)	2	27148557	159440760	Rat
2306903	Bp336	Blood pressure QTL 336		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	38426449	111295694	Rat
1298085	Bp165	Blood pressure QTL 165		0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	44537979	205135428	Rat
2290453	Scl55	Serum cholesterol level QTL 55	2.83		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	2	28652666	139067443	Rat
152025206	Hrtrt23	Heart rate QTL 23	5.98		heart pumping trait (VT:2000009)		2	30219200	171802126	Rat
1358894	Kidm24	Kidney mass QTL 24	4.03		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
731184	Mamtr4	Mammary tumor resistance QTL 4		0.0003	mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	2	18227137	63227137	Rat
61371	Edpm1	Estrogen-dependent pituitary mass QTL 1	4	0.05	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	2	36868643	81868643	Rat
152025204	Hrtrt22	Heart rate QTL 22	5.6		heart pumping trait (VT:2000009)		2	30219200	171802126	Rat
1354601	Slep1	Serum leptin concentration QTL 1	5.39		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	2	44904355	89904355	Rat
1582246	Cm60	Cardiac mass QTL 60	5.8		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	33269996	78269996	Rat
1354603	Bp243	Blood pressure QTL 243	3.9		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	28652666	73652666	Rat

Markers in Region

BE115603

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	44,561,238 - 44,561,392 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	44,787,628 - 44,787,781	NCBI	Rnor6.0
Rnor_5.0	2	63,827,803 - 63,827,956	UniSTS	Rnor5.0
RGSC_v3.4	2	44,306,908 - 44,307,061	UniSTS	RGSC3.4
Celera	2	40,339,969 - 40,340,122	UniSTS
RH 3.4 Map	2	264.31	UniSTS
Cytogenetic Map	2	q14	UniSTS

RH127716

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	44,500,044 - 44,500,226 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	44,726,435 - 44,726,616	NCBI	Rnor6.0
Rnor_5.0	2	63,766,497 - 63,766,678	UniSTS	Rnor5.0
RGSC_v3.4	2	44,247,402 - 44,247,583	UniSTS	RGSC3.4
Celera	2	40,278,360 - 40,278,541	UniSTS
RH 3.4 Map	2	280.3	UniSTS
Cytogenetic Map	2	q14	UniSTS

RH131688

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	44,501,210 - 44,501,408 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	44,727,601 - 44,727,798	NCBI	Rnor6.0
Rnor_5.0	2	63,767,663 - 63,767,860	UniSTS	Rnor5.0
RGSC_v3.4	2	44,248,568 - 44,248,765	UniSTS	RGSC3.4
Celera	2	40,279,526 - 40,279,723	UniSTS
RH 3.4 Map	2	278.1	UniSTS
Cytogenetic Map	2	q14	UniSTS

BF398273

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	44,538,454 - 44,538,612 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	44,764,848 - 44,765,005	NCBI	Rnor6.0
Rnor_5.0	2	63,804,894 - 63,805,051	UniSTS	Rnor5.0
RGSC_v3.4	2	44,283,248 - 44,283,405	UniSTS	RGSC3.4
Celera	2	40,316,866 - 40,317,023	UniSTS
RH 3.4 Map	2	278.8	UniSTS
Cytogenetic Map	2	q14	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001034093	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC106510	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC091305	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CA510648	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB327646	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB576727	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB724841	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CF977889	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473955	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CO384799	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CO401332	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CO571909	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CV106248	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000060695 ⟹ ENSRNOP00000057426

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	46,223,791 - 46,293,827 (-)	Ensembl
mRatBN7.2 Ensembl	2	44,490,833 - 44,560,627 (-)	Ensembl
Rnor_6.0 Ensembl	2	44,717,781 - 44,786,963 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000095778 ⟹ ENSRNOP00000083727

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	46,194,647 - 46,293,827 (-)	Ensembl
mRatBN7.2 Ensembl	2	44,461,444 - 44,560,627 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000105374 ⟹ ENSRNOP00000088065

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	44,490,833 - 44,560,627 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000106550 ⟹ ENSRNOP00000077752

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	46,233,528 - 46,293,827 (-)	Ensembl
mRatBN7.2 Ensembl	2	44,501,634 - 44,560,602 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000111473 ⟹ ENSRNOP00000089400

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	44,500,321 - 44,560,627 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000117270 ⟹ ENSRNOP00000079685

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	44,499,586 - 44,560,627 (-)	Ensembl

RefSeq Acc Id:

NM_001034093 ⟹ NP_001029265

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	46,233,528 - 46,293,827 (-)	NCBI
mRatBN7.2	2	44,500,326 - 44,560,624 (-)	NCBI
Rnor_6.0	2	44,726,716 - 44,787,013 (-)	NCBI
Rnor_5.0	2	63,766,773 - 63,827,191 (-)	NCBI
RGSC_v3.4	2	44,247,683 - 44,306,293 (-)	RGD
Celera	2	40,278,641 - 40,339,354 (-)	RGD

Sequence:

show sequence

GGCGGCATGTCTGCCGTCGTGCGCCACTTGTCGCTAAGTTTTTAGTCATTGAACTGCCGGACTC
GCAGTGGTCTAAAAAGAAAAGGAACAAGACGCAGACGAGAAGGAGAAAAGTTACTCAGGCCTTA
AGGCTTGCTCACTTTTGATTCCTGCGGGCCACCGTAGAGTCCCTATTTGGCGTCACTGTAGGTG
CGATCCCGGGGCCTCTTGGGTAGGAGGGAGATTCAGTCTTAGAGTTCCGAAAGATGGCGGACGC
TTTCGGGGATGAGCTTTTCAGCGTTTTCGAGGATGATTCGACCACTGCAGCGGGAACCAAGAAA
GACAAAGAAAAGGAGAAAGATAAATGGAAGGGGCCACCGGGGCCTGCAGACAAGGCCGGGAAAC
GACTGGATACCAGATTACAGTCAGAACCAGCCAGTAGTGGGAAAAACAAGAGAGATCTAGATGT
TGAAGGCACAGATGAACCTATTTTTGGCAAGAAGCCCAGGATAGAAGACTCAATTAATGAAGAT
TTAAGCTTGGCGGACCTGATGCCCAGAGTCAAGGTACAGTCGGTTGAAACAGTTGAAGGCTGTA
CACACGAGGTCGCTCTTCCTGCAGATGAGGATTATATACCACTTAAGCCTCGAGTTGGGAAGGC
AGCAAAGGAATACCCGTTCATTCTTGATGCTTTCCAAAGAGAAGCCATTCAGTGTGTTGATAAC
AATCAGTCTGTGTTAGTATCTGCTCATACATCAGCGGGGAAAACCGTGTGCGCTGAGTATGCTA
TTGCACTGGCTTTAAGGGAAAAACAGCGTGTAATATTTACCAGCCCAATAAAGGCTCTAAGTAA
TCAGAAATACCGTGAAATGTATGAAGAATTTCAAGATGTTGGTCTGATGACTGGAGATGTTACT
ATTAATCCCACAGCATCTTGTCTGGTTATGACTACAGAGATTTTGAGAAGTATGCTGTACAGAG
GCTCTGAAGTTATGCGAGAAGTTGCGTGGGTCATATTTGATGAAATTCATTACATGAGAGATTC
AGAGCGTGGTGTAGTATGGGAAGAAACTATTATTTTGCTTCCAGACAATGTTCACTATGTCTTT
CTTTCGGCTACTATTCCCAATGCTCGACAGTTTGCTGAGTGGATCTGCCACCTACATAAACAGC
CCTGTCATGTAATTTATACTGATTATCGACCTACTCCATTGCAACACTACATATTTCCAGCAGG
GGGAGATGGCCTTCACCTTGTGGTTGATGAAAATGGTGACTTCAGAGAAGATAATTTTAACACT
GCAATGCAAGTACTTCGGGATGCAGGTGATTTGGCCAAAGGAGACCAGAAGGGACGGAAAGGAG
GAACAAAAGGTCCATCAAATGTGTTCAAGATTGTGAAGATGATTATGGAAAGAAATTTTCAACC
TGTGATTATCTTCAGTTTTAGTAAGAAGGATTGTGAAGCATACGCCCTTCAAATGACTAAACTA
GACTTCAACACAGATGAAGAAAAGAAGATGGTTGAAGAAGTTTTCAATAATGCAATTGACTGTT
TGTCTGATGAAGATAAAAAGCTCCCTCAGGTTGAACATGTACTTCCACTTTTGAAACGGGGGAT
TGGTATTCACCATGGTGGTTTGCTTCCTATTTTAAAGGAAACTATAGAGATTCTCTTTTCTGAA
GGATTGATAAAGGCCTTATTTGCCACAGAGACTTTTGCTATGGGAATTAACATGCCAGCTAGAA
CTGTTTTATTTACAAATGCCCGTAAATATGATGGGAAGGATTTTAGATGGATTTCCTCAGGTGA
GTACATCCAGATGTCTGGTCGTGCAGGAAGGAGGGGGATGGATGACAGAGGGATTGTGATTCTT
ATGGTCGATGAAAAGATGAGCCCAACAATTGGAAAACAACTGCTTAAGGGCTCAGCTGATCCTC
TGAATAGTGCTTTCCATCTAACGTACAACATGGTTTTGAACTTACTAAGAGTAGAAGAAATTAA
TCCCGAGTACATGCTTGAAAAATCCTTCTACCAGTTTCAGCATTATAGAGCAATTCCAGGAGTT
GTAGAAAAGGTAAAGAACTCGGAAGAACAGTATAATAAAATAGTAATTCCCAATGAAGAAAATG
TGGTCATCTATTACAAGATTAGACAGCAACTTGCCAAGCTGGGAAAAGAGATTGAAGAATATAT
TCATAAGCCAAAATACTGCTTACCCTTTCTACAACCAGGCCGTTTAGTAAAGGTGAAGAATGAA
GGTGATGATTTCGGCTGGGGAGTAGTGGTGAACTTCTCAAAAAAGTCAAACGTCAAGCCCAATT
CTGGCGAACTGGATCCCTTGTATGTGGTGGAAGTGCTCCTGCGCTGTAGCAAGGAAAGCCTGAA
AAACTCCGCCACAGAGGCAGCAAAGCCAGCAAAGCCGGATGAGAAGGGGGAGATGCAGGTTGTT
CCGGTTTTGGTGCATCTCCTGTCTGCCATCAGCACTGTTAGACTCTACATTCCAAAAGACCTCC
GCCCCGTGGACAACAGACAGAGTGTCCTAAAATCCATACAGGAAGTTCAAAAGCGGTTTCCCGA
TGGTGTTCCGTTGTTAGATCCTATCGATGATATGGGCATTCAAGATCAAGGACTGAAAAAAGTC
ATTCAGAAAGTAGAGGCTTTTGAGCATCGAATGTACTCGCACCCACTTCACAATGATCCTAATC
TGGAAACTGTGTATACCCTTTGTGAAAAAAAGGCACAGATTGCAATAGATATTAAGTCTGCAAA
GAGAGAACTGAAGAAAGCAAGAACTGTTCTGCAAATGGATGAACTCAAATGTCGTAAGCGTGTT
CTAAGAAGGCTGGGTTTTGCTACATCTTCTGATGTCATAGAGATGAAAGGACGGGTGGCTTGTG
AGATAAGCAGTGCTGACGAGCTCCTTCTAACAGAGATGATGTTTAATGGGCTCTTCAATGACCT
TTCTTCAGAACAGGCGACCGCACTGCTAAGCTGTTTTGTGTTTCAAGAGAATTCTAGTGAGATG
CCCAAATTAACAGAGCAGTTAGCTGGACCACTCCGACAAATGCAGGAATGTGCTAAAAGGATTG
CAAAGGTTTCTGCAGAGGCAAAACTGGAGATTGATGAAGAAACTTACTTAAGCTCATTCAAGCC
TCACCTGATGGATGTGGTGTACACCTGGGCAACTGGGGCCACATTTGCCCACATCTGCAAAATG
ACAGATGTCTTTGAAGGCAGTATAATCCGTTGTATGAGGCGCCTGGAAGAACTGCTTCGACAGA
TGTGTCAAGCAGCGAAAGCCATTGGAAACACAGAGCTGGAGAACAAGTTTGCTGAAGGAATCAC
CAAAATCAAGAGGGATATTGTATTTGCTGCCAGCCTCTACTTATAGAGTTCAATGTTAGTCACC
ACCTGTCTGATTGCAGTTGACTACAAATGCTTTTTCAAGTGTTCAAGTGGTTCTCCCAATTCAA
GAGTTGTTCGCAAGCATTTTTATTATATTTAAATCAAATATCATTCTGAGAAGGCATGTAACAT
ACACATTTGTACATAGCATCTTTCAATAAAAAAATGTACAGGTGAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001029265	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH91305	(Get FASTA)	NCBI Sequence Viewer
	EDM10360	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000057426.4
	ENSRNOP00000077752
	ENSRNOP00000077752.2
	ENSRNOP00000083727.1

RefSeq Acc Id:

NP_001029265 ⟸ NM_001034093

- UniProtKB:

A0A8I5ZN47 (UniProtKB/TrEMBL), A6I5Q2 (UniProtKB/TrEMBL), A0A8I6A840 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MADAFGDELFSVFEDDSTTAAGTKKDKEKEKDKWKGPPGPADKAGKRLDTRLQSEPASSGKNKR
DLDVEGTDEPIFGKKPRIEDSINEDLSLADLMPRVKVQSVETVEGCTHEVALPADEDYIPLKPR
VGKAAKEYPFILDAFQREAIQCVDNNQSVLVSAHTSAGKTVCAEYAIALALREKQRVIFTSPIK
ALSNQKYREMYEEFQDVGLMTGDVTINPTASCLVMTTEILRSMLYRGSEVMREVAWVIFDEIHY
MRDSERGVVWEETIILLPDNVHYVFLSATIPNARQFAEWICHLHKQPCHVIYTDYRPTPLQHYI
FPAGGDGLHLVVDENGDFREDNFNTAMQVLRDAGDLAKGDQKGRKGGTKGPSNVFKIVKMIMER
NFQPVIIFSFSKKDCEAYALQMTKLDFNTDEEKKMVEEVFNNAIDCLSDEDKKLPQVEHVLPLL
KRGIGIHHGGLLPILKETIEILFSEGLIKALFATETFAMGINMPARTVLFTNARKYDGKDFRWI
SSGEYIQMSGRAGRRGMDDRGIVILMVDEKMSPTIGKQLLKGSADPLNSAFHLTYNMVLNLLRV
EEINPEYMLEKSFYQFQHYRAIPGVVEKVKNSEEQYNKIVIPNEENVVIYYKIRQQLAKLGKEI
EEYIHKPKYCLPFLQPGRLVKVKNEGDDFGWGVVVNFSKKSNVKPNSGELDPLYVVEVLLRCSK
ESLKNSATEAAKPAKPDEKGEMQVVPVLVHLLSAISTVRLYIPKDLRPVDNRQSVLKSIQEVQK
RFPDGVPLLDPIDDMGIQDQGLKKVIQKVEAFEHRMYSHPLHNDPNLETVYTLCEKKAQIAIDI
KSAKRELKKARTVLQMDELKCRKRVLRRLGFATSSDVIEMKGRVACEISSADELLLTEMMFNGL
FNDLSSEQATALLSCFVFQENSSEMPKLTEQLAGPLRQMQECAKRIAKVSAEAKLEIDEETYLS
SFKPHLMDVVYTWATGATFAHICKMTDVFEGSIIRCMRRLEELLRQMCQAAKAIGNTELENKFA
EGITKIKRDIVFAASLYL

hide sequence

Ensembl Acc Id:

ENSRNOP00000057426 ⟸ ENSRNOT00000060695

Ensembl Acc Id:

ENSRNOP00000083727 ⟸ ENSRNOT00000095778

Ensembl Acc Id:

ENSRNOP00000088065 ⟸ ENSRNOT00000105374

Ensembl Acc Id:

ENSRNOP00000089400 ⟸ ENSRNOT00000111473

Ensembl Acc Id:

ENSRNOP00000077752 ⟸ ENSRNOT00000106550

Ensembl Acc Id:

ENSRNOP00000079685 ⟸ ENSRNOT00000117270

Protein Domains

Helicase ATP-binding Helicase C-terminal

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4AE49-F1-model_v2	AlphaFold	D4AE49	1-1066	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691138

Promoter ID:

EPDNEW_R1663

Type:

multiple initiation site

Name:

Mtrex_1

Description:

Mtr4 exosome RNA helicase

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	44,786,793 - 44,786,853	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305984	AgrOrtholog
BioCyc Gene	G2FUF-54387	BioCyc
Ensembl Genes	ENSRNOG00000010125	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000060695.6	UniProtKB/TrEMBL
	ENSRNOT00000095778.2	UniProtKB/TrEMBL
	ENSRNOT00000106550	ENTREZGENE
	ENSRNOT00000106550.2	UniProtKB/TrEMBL
Gene3D-CATH	1.10.3380.30	UniProtKB/TrEMBL
	2.40.30.300	UniProtKB/TrEMBL
	3.40.50.300	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7311286	IMAGE-MGC_LOAD
	IMAGE:7936557	IMAGE-MGC_LOAD
InterPro	DNA/RNA_helicase_DEAD/DEAH_N	UniProtKB/TrEMBL
	DSH_C	UniProtKB/TrEMBL
	Helicase_ATP-bd	UniProtKB/TrEMBL
	Helicase_C	UniProtKB/TrEMBL
	MTR4-like_stalk	UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/TrEMBL
	RNA-DNA_Helicase	UniProtKB/TrEMBL
	RNA_helicase_ATP-dep_SK12/DOB1	UniProtKB/TrEMBL
	rRNA_proc-arch_dom	UniProtKB/TrEMBL
KEGG Report	rno:365668	UniProtKB/TrEMBL
MGC_CLONE	MGC:109254	IMAGE-MGC_LOAD
	MGC:124848	IMAGE-MGC_LOAD
NCBI Gene	365668	ENTREZGENE
PANTHER	ATP-DEPENDENT RNA AND DNA HELICASE	UniProtKB/TrEMBL
	EXOSOME RNA HELICASE MTR4	UniProtKB/TrEMBL
Pfam	DEAD	UniProtKB/TrEMBL
	DSHCT	UniProtKB/TrEMBL
	Helicase_C	UniProtKB/TrEMBL
	MTR4-like_stalk	UniProtKB/TrEMBL
	rRNA_proc-arch	UniProtKB/TrEMBL
PhenoGen	Mtrex	PhenoGen
PIRSF	Antiviral_helicase_SKI2	UniProtKB/TrEMBL
PROSITE	HELICASE_ATP_BIND_1	UniProtKB/TrEMBL
	HELICASE_CTER	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000010125	RatGTEx
SMART	DEXDc	UniProtKB/TrEMBL
	DSHCT	UniProtKB/TrEMBL
	HELICc	UniProtKB/TrEMBL
Superfamily-SCOP	SSF52540	UniProtKB/TrEMBL
UniProt	A0A8I5Y1Z8_RAT	UniProtKB/TrEMBL
	A0A8I5ZN47	ENTREZGENE
	A0A8I5ZXU0_RAT	UniProtKB/TrEMBL
	A0A8I6A840	ENTREZGENE
	A6I5Q2	ENTREZGENE, UniProtKB/TrEMBL
	D4AE49_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-12-01	Mtrex	Mtr4 exosome RNA helicase	Skiv2l2	Ski2 like RNA helicase 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2016-01-13	Skiv2l2	Ski2 like RNA helicase 2	Skiv2l2	superkiller viralicidic activity 2-like 2 (S. cerevisiae)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-07	Skiv2l2	superkiller viralicidic activity 2-like 2 (S. cerevisiae)	RGD1305984	similar to RIKEN cDNA 2610528A15	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	RGD1305984	similar to RIKEN cDNA 2610528A15	RGD1305984_predicted	similar to RIKEN cDNA 2610528A15 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-20	RGD1305984_predicted	similar to RIKEN cDNA 2610528A15 (predicted)	LOC365668_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC365668_predicted	similar to RIKEN cDNA 2610528A15 (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - KEGG (archival)