Ptprb (protein tyrosine phosphatase, receptor type, B) - Rat Genome Database

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Gene: Ptprb (protein tyrosine phosphatase, receptor type, B) Rattus norvegicus
Analyze
Symbol: Ptprb
Name: protein tyrosine phosphatase, receptor type, B
RGD ID: 1305922
Description: Predicted to enable cadherin binding activity and protein tyrosine phosphatase activity. Involved in glial cell migration. Predicted to be located in membrane. Predicted to be part of receptor complex. Human ortholog(s) of this gene implicated in angiosarcoma; breast angiosarcoma; carcinoma (multiple); central nervous system cancer (multiple); and sarcoma. Orthologous to human PTPRB (protein tyrosine phosphatase receptor type B); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; alpha-Zearalanol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC688895; LOC102546841; LOC314843; LOC688895; receptor-type tyrosine-protein phosphatase beta; uncharacterized LOC102546841
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Kidm47
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8753,816,197 - 53,920,760 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl753,816,097 - 53,920,760 (+)EnsemblGRCr8
mRatBN7.2751,953,375 - 52,034,751 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl751,930,015 - 52,034,748 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx753,860,095 - 53,941,469 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0756,063,182 - 56,144,564 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0755,841,176 - 55,922,540 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0759,326,484 - 59,431,114 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl759,326,518 - 59,425,718 (+)Ensemblrn6Rnor6.0
Rnor_5.0759,358,899 - 59,441,068 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4755,613,557 - 55,714,216 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera748,711,322 - 48,812,447 (+)NCBICelera
RGSC_v3.1755,634,330 - 55,732,082 (+)NCBI
Cytogenetic Map7q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)
receptor complex  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Junctional protein MAGI-3 interacts with receptor tyrosine phosphatase beta (RPTPbeta) and tyrosine-phosphorylated proteins. Adamsky K, etal., J Cell Sci 2003 Apr 1;116(Pt 7):1279-89.
2. Primary mammary angiosarcomas harbor frequent mutations in KDR and PIK3CA and show evidence of distinct pathogenesis. Beca F, etal., Mod Pathol. 2020 Aug;33(8):1518-1526. doi: 10.1038/s41379-020-0511-6. Epub 2020 Mar 2.
3. Recurrent PTPRB and PLCG1 mutations in angiosarcoma. Behjati S, etal., Nat Genet. 2014 Apr;46(4):376-379. doi: 10.1038/ng.2921. Epub 2014 Mar 16.
4. Oncogenomics of c-Myc transgenic mice reveal novel regulators of extracellular signaling, angiogenesis and invasion with clinical significance for human lung adenocarcinoma. Ciribilli Y and Borlak J, Oncotarget. 2017 Oct 23;8(60):101808-101831. doi: 10.18632/oncotarget.21981. eCollection 2017 Nov 24.
5. Clinical biomarkers of pulmonary carcinoid tumors in never smokers via profiling miRNA and target mRNA. Deng B, etal., Cell Biosci. 2014 Jul 9;4:35. doi: 10.1186/2045-3701-4-35. eCollection 2014.
6. Targeting of the receptor protein tyrosine phosphatase beta with a monoclonal antibody delays tumor growth in a glioblastoma model. Foehr ED, etal., Cancer Res. 2006 Feb 15;66(4):2271-8. doi: 10.1158/0008-5472.CAN-05-1221.
7. Implication of a protein-tyrosine-phosphatase in human lung cancer. Gaits F, etal., Cell Mol Biol (Noisy-le-grand). 1994 Jul;40(5):677-85.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Effects of vascular-endothelial protein tyrosine phosphatase inhibition on breast cancer vasculature and metastatic progression. Goel S, etal., J Natl Cancer Inst. 2013 Aug 21;105(16):1188-201. doi: 10.1093/jnci/djt164. Epub 2013 Jul 30.
11. VE-PTP regulates VEGFR2 activity in stalk cells to establish endothelial cell polarity and lumen formation. Hayashi M, etal., Nat Commun. 2013;4:1672. doi: 10.1038/ncomms2683.
12. miR-665 promotes hepatocellular carcinoma cell migration, invasion, and proliferation by decreasing Hippo signaling through targeting PTPRB. Hu Y, etal., Cell Death Dis. 2018 Sep 20;9(10):954. doi: 10.1038/s41419-018-0978-y.
13. DCE-MRI in Glioma, Infiltration Zone and Healthy Brain to Assess Angiogenesis: A Biopsy Study. Keil VC, etal., Clin Neuroradiol. 2021 Dec;31(4):1049-1058. doi: 10.1007/s00062-021-01015-3. Epub 2021 Apr 26.
14. The VE-PTP Inhibitor AKB-9778 Improves Antitumor Activity and Diminishes the Toxicity of Interleukin 2 (IL-2) Administration. Li G, etal., J Immunother. 2019 Sep;42(7):237-243. doi: 10.1097/CJI.0000000000000290.
15. Functional comparison of long and short splice forms of RPTPbeta: implications for glioblastoma treatment. Lorente G, etal., Neuro Oncol. 2005 Apr;7(2):154-63. doi: 10.1215/S1152851704000547.
16. miR-624-5p promoted tumorigenesis and metastasis by suppressing hippo signaling through targeting PTPRB in osteosarcoma cells. Luo Y, etal., J Exp Clin Cancer Res. 2019 Dec 11;38(1):488. doi: 10.1186/s13046-019-1491-6.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. Targeted massively parallel sequencing of angiosarcomas reveals frequent activation of the mitogen activated protein kinase pathway. Murali R, etal., Oncotarget. 2015 Nov 3;6(34):36041-52. doi: 10.18632/oncotarget.5936.
19. Protein tyrosine phosphatase PTPRB regulates Src phosphorylation and tumour progression in NSCLC. Qi Y, etal., Clin Exp Pharmacol Physiol. 2016 Oct;43(10):1004-12. doi: 10.1111/1440-1681.12610.
20. GOA pipeline RGD automated data pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. PSMD11, PTPRM and PTPRB as novel biomarkers of pancreatic cancer progression. Sahni S, etal., Biochim Biophys Acta Gen Subj. 2020 Nov;1864(11):129682. doi: 10.1016/j.bbagen.2020.129682. Epub 2020 Jul 12.
24. Nine Genes Mediate the Therapeutic Effects of Iodine-131 Radiotherapy in Thyroid Carcinoma Patients. Shuwen H, etal., Dis Markers. 2020 Jun 16;2020:9369341. doi: 10.1155/2020/9369341. eCollection 2020.
25. RNA interference targeting protein tyrosine phosphatase zeta/receptor-type protein tyrosine phosphatase beta suppresses glioblastoma growth in vitro and in vivo. Ulbricht U, etal., J Neurochem. 2006 Sep;98(5):1497-506. doi: 10.1111/j.1471-4159.2006.04022.x.
26. Expression and function of the receptor protein tyrosine phosphatase zeta and its ligand pleiotrophin in human astrocytomas. Ulbricht U, etal., J Neuropathol Exp Neurol. 2003 Dec;62(12):1265-75. doi: 10.1093/jnen/62.12.1265.
27. A phase II study of ENMD-2076 in advanced soft tissue sarcoma (STS). Veitch Z, etal., Sci Rep. 2019 May 14;9(1):7390. doi: 10.1038/s41598-019-43222-6.
28. PTPRB promotes metastasis of colorectal carcinoma via inducing epithelial-mesenchymal transition. Weng X, etal., Cell Death Dis. 2019 Apr 30;10(5):352. doi: 10.1038/s41419-019-1554-9.
Additional References at PubMed
PMID:8889548   PMID:10557082   PMID:12234928   PMID:15708477   PMID:16028071   PMID:16514057   PMID:17360632   PMID:19116766   PMID:19136612   PMID:19451274   PMID:19751804   PMID:20014386  
PMID:21890632   PMID:23382219   PMID:26063811   PMID:28926625  


Genomics

Comparative Map Data
Ptprb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8753,816,197 - 53,920,760 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl753,816,097 - 53,920,760 (+)EnsemblGRCr8
mRatBN7.2751,953,375 - 52,034,751 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl751,930,015 - 52,034,748 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx753,860,095 - 53,941,469 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0756,063,182 - 56,144,564 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0755,841,176 - 55,922,540 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0759,326,484 - 59,431,114 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl759,326,518 - 59,425,718 (+)Ensemblrn6Rnor6.0
Rnor_5.0759,358,899 - 59,441,068 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4755,613,557 - 55,714,216 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera748,711,322 - 48,812,447 (+)NCBICelera
RGSC_v3.1755,634,330 - 55,732,082 (+)NCBI
Cytogenetic Map7q22NCBI
PTPRB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381270,515,870 - 70,637,429 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1270,515,870 - 70,637,440 (-)Ensemblhg38GRCh38
GRCh371270,909,650 - 71,031,209 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361269,196,897 - 69,317,486 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341269,201,230 - 69,289,891NCBI
Celera1270,574,292 - 70,694,892 (-)NCBICelera
Cytogenetic Map12q15NCBI
HuRef1267,960,230 - 68,080,615 (-)NCBIHuRef
CHM1_11270,879,907 - 71,000,488 (-)NCBICHM1_1
T2T-CHM13v2.01270,495,299 - 70,616,833 (-)NCBIT2T-CHM13v2.0
Ptprb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910116,111,407 - 116,225,443 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10116,111,428 - 116,225,440 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3810116,275,502 - 116,389,538 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10116,275,523 - 116,389,535 (+)Ensemblmm10GRCm38
MGSCv3710115,738,430 - 115,826,594 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3610115,705,616 - 115,788,043 (+)NCBIMGSCv36mm8
Celera10118,242,005 - 118,330,326 (+)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1064.68NCBI
Ptprb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540510,648,818 - 10,766,993 (-)Ensembl
ChiLan1.0NW_00495540510,647,777 - 10,766,909 (-)NCBIChiLan1.0ChiLan1.0
PTPRB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21078,531,420 - 78,653,114 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11278,527,819 - 78,649,494 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01268,025,973 - 68,147,613 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11270,797,843 - 70,915,318 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1270,797,843 - 70,915,308 (-)EnsemblpanPan2panpan1.1
PTPRB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11012,267,891 - 12,384,522 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1012,241,716 - 12,384,435 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1012,206,342 - 12,323,493 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01012,399,792 - 12,516,770 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1012,373,481 - 12,517,277 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11012,265,927 - 12,382,361 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01012,512,972 - 12,629,456 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01012,636,704 - 12,753,669 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ptprb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494545,842,565 - 45,962,671 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365458,147,291 - 8,235,715 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365458,150,766 - 8,235,674 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTPRB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl534,659,964 - 34,794,289 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1534,656,460 - 34,794,838 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2537,232,103 - 37,330,419 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PTPRB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11166,095,445 - 66,222,402 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1166,101,038 - 66,221,982 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037179,455,085 - 179,582,365 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptprb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475027,188,729 - 27,316,150 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475027,188,858 - 27,320,470 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ptprb
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11194,433,120 - 194,534,815 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ptprb
571 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:69
Count of miRNA genes:65
Interacting mature miRNAs:67
Transcripts:ENSRNOT00000006501
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72380760668807606Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74511390390113903Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)71051708662346019Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72663805771638057Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)75170064396700643Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72417947886817926Rat
10059605Kidm47Kidney mass QTL 472.910.05kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)74913799967614020Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)731770293110435881Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)71011291660150541Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73984590284845902Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7946087754460877Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73299870277998702Rat
2317059Aia15Adjuvant induced arthritis QTL 152.46joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)74968283263890004Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73617876481178764Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74847504993475049Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73617876481178764Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
2303629Vencon3Ventilatory control QTL 37.25respiration trait (VT:0001943)respiration rate (CMO:0000289)74299622658678836Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72862457565788017Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)72154197786817926Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
1300138Hrtrt9Heart rate QTL 94.72heart pumping trait (VT:2000009)heart rate (CMO:0000002)71049882055498820Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71746044762460447Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
2303582Gluco53Glucose level QTL 533blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)74860308793603087Rat
70207Niddm31Non-insulin dependent diabetes mellitus QTL 313.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)72005723265057232Rat
61439Cia8Collagen induced arthritis QTL 85.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)72718291472182914Rat

Markers in Region
RH131513  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2751,929,395 - 51,929,575 (+)MAPPERmRatBN7.2
Rnor_6.0759,325,716 - 59,325,895NCBIRnor6.0
Rnor_5.0759,335,167 - 59,335,346UniSTSRnor5.0
RGSC_v3.4755,612,736 - 55,612,915UniSTSRGSC3.4
Celera748,710,554 - 48,710,733UniSTS
RH 3.4 Map7476.0UniSTS
Cytogenetic Map7q22UniSTS
RH128899  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2751,939,511 - 51,939,691 (+)MAPPERmRatBN7.2
Rnor_6.0759,335,832 - 59,336,011NCBIRnor6.0
Rnor_5.0759,345,283 - 59,345,462UniSTSRnor5.0
RGSC_v3.4755,622,852 - 55,623,031UniSTSRGSC3.4
Celera748,720,670 - 48,720,849UniSTS
RH 3.4 Map13173.8UniSTS
Cytogenetic Map7q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 48 59 6 312 148 11 143 81 92 31 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000085231   ⟹   ENSRNOP00000072398
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl753,816,097 - 53,912,644 (+)Ensembl
mRatBN7.2 Ensembl751,930,015 - 52,026,635 (+)Ensembl
Rnor_6.0 Ensembl759,326,518 - 59,425,718 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000085334   ⟹   ENSRNOP00000070093
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl753,839,402 - 53,913,297 (+)Ensembl
mRatBN7.2 Ensembl751,953,375 - 52,027,288 (+)Ensembl
Rnor_6.0 Ensembl759,349,745 - 59,422,694 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000094476   ⟹   ENSRNOP00000082351
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl753,839,402 - 53,920,760 (+)Ensembl
mRatBN7.2 Ensembl751,930,015 - 52,034,748 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000119174   ⟹   ENSRNOP00000081477
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl753,839,402 - 53,920,760 (+)Ensembl
mRatBN7.2 Ensembl751,953,375 - 52,034,748 (+)Ensembl
RefSeq Acc Id: NM_001372134   ⟹   NP_001359063
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8753,839,402 - 53,920,760 (+)NCBI
mRatBN7.2751,953,375 - 52,034,751 (+)NCBI
RefSeq Acc Id: XM_063263482   ⟹   XP_063119552
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8753,816,197 - 53,920,760 (+)NCBI
RefSeq Acc Id: XM_063263483   ⟹   XP_063119553
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8753,839,811 - 53,920,760 (+)NCBI
Ensembl Acc Id: ENSRNOP00000072398   ⟸   ENSRNOT00000085231
Ensembl Acc Id: ENSRNOP00000070093   ⟸   ENSRNOT00000085334
RefSeq Acc Id: NP_001359063   ⟸   NM_001372134
- Peptide Label: precursor
- UniProtKB: A0A8I5ZV35 (UniProtKB/TrEMBL),   A6IGM6 (UniProtKB/TrEMBL),   D3ZTG5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000081477   ⟸   ENSRNOT00000119174
Ensembl Acc Id: ENSRNOP00000082351   ⟸   ENSRNOT00000094476
RefSeq Acc Id: XP_063119552   ⟸   XM_063263482
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063119553   ⟸   XM_063263483
- Peptide Label: isoform X2
- UniProtKB: A6IGM7 (UniProtKB/TrEMBL),   D3ZTG5 (UniProtKB/TrEMBL)
Protein Domains
Fibronectin type-III   Tyrosine specific protein phosphatases   Tyrosine-protein phosphatase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K2W0-F1-model_v2 AlphaFold A0A0G2K2W0 1-2238 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695203
Promoter ID:EPDNEW_R5727
Type:multiple initiation site
Name:Ptprb_2
Description:protein tyrosine phosphatase, receptor type, B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R5728  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0759,326,562 - 59,326,622EPDNEW
RGD ID:13695206
Promoter ID:EPDNEW_R5728
Type:single initiation site
Name:Ptprb_1
Description:protein tyrosine phosphatase, receptor type, B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R5727  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0759,349,690 - 59,349,750EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305922 AgrOrtholog
BioCyc Gene G2FUF-34035 BioCyc
Ensembl Genes ENSRNOG00000055293 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000085231 ENTREZGENE
  ENSRNOT00000085231.3 UniProtKB/TrEMBL
  ENSRNOT00000085334.3 UniProtKB/TrEMBL
  ENSRNOT00000094476.2 UniProtKB/TrEMBL
  ENSRNOT00000119174 ENTREZGENE
  ENSRNOT00000119174.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  2.80.10.50 UniProtKB/TrEMBL
  3.90.190.10 UniProtKB/TrEMBL
InterPro Dual-sp/Tyr_phosphatase UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  FN_III UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/TrEMBL
  PTPRJ_TM UniProtKB/TrEMBL
  Ricin_B-like_lectins UniProtKB/TrEMBL
  Ricin_B_lectin UniProtKB/TrEMBL
  RTP_Phos/Ushers UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/TrEMBL
  Tyr_Pase_rcpt/non-rcpt UniProtKB/TrEMBL
NCBI Gene 314843 ENTREZGENE
PANTHER CYTOKINE RECEPTOR UniProtKB/TrEMBL
  RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE BETA UniProtKB/TrEMBL
Pfam fn3 UniProtKB/TrEMBL
  PTP_tm UniProtKB/TrEMBL
  Ricin_B_lectin UniProtKB/TrEMBL
  Y_phosphatase UniProtKB/TrEMBL
PhenoGen Ptprb PhenoGen
PRINTS PRTYPHPHTASE UniProtKB/TrEMBL
PROSITE FN3 UniProtKB/TrEMBL
  RICIN_B_LECTIN UniProtKB/TrEMBL
  TYR_PHOSPHATASE_1 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_PTP UniProtKB/TrEMBL
RatGTEx ENSRNOG00000055293 RatGTEx
SMART FN3 UniProtKB/TrEMBL
  PTPc UniProtKB/TrEMBL
  PTPc_motif UniProtKB/TrEMBL
Superfamily-SCOP FN_III-like UniProtKB/TrEMBL
  SSF50370 UniProtKB/TrEMBL
  SSF52799 UniProtKB/TrEMBL
UniProt A0A0G2K2W0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZV35 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZXS1 ENTREZGENE, UniProtKB/TrEMBL
  A6IGM6 ENTREZGENE, UniProtKB/TrEMBL
  A6IGM7 ENTREZGENE, UniProtKB/TrEMBL
  D3ZTG5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-29 Ptprb  protein tyrosine phosphatase, receptor type, B  LOC102546841  uncharacterized LOC102546841  Data merged from RGD:7586698 737654 PROVISIONAL
2015-07-29 Ptprb  protein tyrosine phosphatase, receptor type, B  LOC688895  hypothetical protein LOC688895  Data merged from RGD:1584071 737654 PROVISIONAL
2013-12-18 LOC102546841  uncharacterized LOC102546841      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 Ptprb  protein tyrosine phosphatase, receptor type, B   Ptprb_predicted  protein tyrosine phosphatase, receptor type, B (predicted)  'predicted' is removed 2292626 APPROVED
2006-11-19 LOC688895  hypothetical protein LOC688895      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-12 Ptprb_predicted  protein tyrosine phosphatase, receptor type, B (predicted)      Symbol and Name status set to approved 70820 APPROVED