Ptprb (protein tyrosine phosphatase, receptor type, B) - Rat Genome Database

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Gene: Ptprb (protein tyrosine phosphatase, receptor type, B) Rattus norvegicus
Analyze
Symbol: Ptprb
Name: protein tyrosine phosphatase, receptor type, B
RGD ID: 1305922
Description: Predicted to enable cadherin binding activity. Involved in glial cell migration. Predicted to be located in membrane. Predicted to be part of receptor complex. Human ortholog(s) of this gene implicated in angiosarcoma; breast angiosarcoma; carcinoma (multiple); central nervous system cancer (multiple); and sarcoma. Orthologous to human PTPRB (protein tyrosine phosphatase receptor type B); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; atrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC688895; LOC102546841; LOC314843; LOC688895; receptor-type tyrosine-protein phosphatase beta; uncharacterized LOC102546841
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Kidm47
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8753,816,197 - 53,920,760 (+)NCBIGRCr8
mRatBN7.2751,953,375 - 52,034,751 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl751,930,015 - 52,034,748 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx753,860,095 - 53,941,469 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0756,063,182 - 56,144,564 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0755,841,176 - 55,922,540 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0759,326,484 - 59,431,114 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl759,326,518 - 59,425,718 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0759,358,899 - 59,441,068 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4755,613,557 - 55,714,216 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1755,634,330 - 55,732,082 (+)NCBI
Celera748,711,322 - 48,812,447 (+)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)
receptor complex  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Junctional protein MAGI-3 interacts with receptor tyrosine phosphatase beta (RPTPbeta) and tyrosine-phosphorylated proteins. Adamsky K, etal., J Cell Sci 2003 Apr 1;116(Pt 7):1279-89.
2. Primary mammary angiosarcomas harbor frequent mutations in KDR and PIK3CA and show evidence of distinct pathogenesis. Beca F, etal., Mod Pathol. 2020 Aug;33(8):1518-1526. doi: 10.1038/s41379-020-0511-6. Epub 2020 Mar 2.
3. Recurrent PTPRB and PLCG1 mutations in angiosarcoma. Behjati S, etal., Nat Genet. 2014 Apr;46(4):376-379. doi: 10.1038/ng.2921. Epub 2014 Mar 16.
4. Oncogenomics of c-Myc transgenic mice reveal novel regulators of extracellular signaling, angiogenesis and invasion with clinical significance for human lung adenocarcinoma. Ciribilli Y and Borlak J, Oncotarget. 2017 Oct 23;8(60):101808-101831. doi: 10.18632/oncotarget.21981. eCollection 2017 Nov 24.
5. Clinical biomarkers of pulmonary carcinoid tumors in never smokers via profiling miRNA and target mRNA. Deng B, etal., Cell Biosci. 2014 Jul 9;4:35. doi: 10.1186/2045-3701-4-35. eCollection 2014.
6. Targeting of the receptor protein tyrosine phosphatase beta with a monoclonal antibody delays tumor growth in a glioblastoma model. Foehr ED, etal., Cancer Res. 2006 Feb 15;66(4):2271-8. doi: 10.1158/0008-5472.CAN-05-1221.
7. Implication of a protein-tyrosine-phosphatase in human lung cancer. Gaits F, etal., Cell Mol Biol (Noisy-le-grand). 1994 Jul;40(5):677-85.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Effects of vascular-endothelial protein tyrosine phosphatase inhibition on breast cancer vasculature and metastatic progression. Goel S, etal., J Natl Cancer Inst. 2013 Aug 21;105(16):1188-201. doi: 10.1093/jnci/djt164. Epub 2013 Jul 30.
11. VE-PTP regulates VEGFR2 activity in stalk cells to establish endothelial cell polarity and lumen formation. Hayashi M, etal., Nat Commun. 2013;4:1672. doi: 10.1038/ncomms2683.
12. miR-665 promotes hepatocellular carcinoma cell migration, invasion, and proliferation by decreasing Hippo signaling through targeting PTPRB. Hu Y, etal., Cell Death Dis. 2018 Sep 20;9(10):954. doi: 10.1038/s41419-018-0978-y.
13. DCE-MRI in Glioma, Infiltration Zone and Healthy Brain to Assess Angiogenesis: A Biopsy Study. Keil VC, etal., Clin Neuroradiol. 2021 Dec;31(4):1049-1058. doi: 10.1007/s00062-021-01015-3. Epub 2021 Apr 26.
14. The VE-PTP Inhibitor AKB-9778 Improves Antitumor Activity and Diminishes the Toxicity of Interleukin 2 (IL-2) Administration. Li G, etal., J Immunother. 2019 Sep;42(7):237-243. doi: 10.1097/CJI.0000000000000290.
15. Functional comparison of long and short splice forms of RPTPbeta: implications for glioblastoma treatment. Lorente G, etal., Neuro Oncol. 2005 Apr;7(2):154-63. doi: 10.1215/S1152851704000547.
16. miR-624-5p promoted tumorigenesis and metastasis by suppressing hippo signaling through targeting PTPRB in osteosarcoma cells. Luo Y, etal., J Exp Clin Cancer Res. 2019 Dec 11;38(1):488. doi: 10.1186/s13046-019-1491-6.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. Targeted massively parallel sequencing of angiosarcomas reveals frequent activation of the mitogen activated protein kinase pathway. Murali R, etal., Oncotarget. 2015 Nov 3;6(34):36041-52. doi: 10.18632/oncotarget.5936.
19. Protein tyrosine phosphatase PTPRB regulates Src phosphorylation and tumour progression in NSCLC. Qi Y, etal., Clin Exp Pharmacol Physiol. 2016 Oct;43(10):1004-12. doi: 10.1111/1440-1681.12610.
20. GOA pipeline RGD automated data pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. PSMD11, PTPRM and PTPRB as novel biomarkers of pancreatic cancer progression. Sahni S, etal., Biochim Biophys Acta Gen Subj. 2020 Nov;1864(11):129682. doi: 10.1016/j.bbagen.2020.129682. Epub 2020 Jul 12.
24. Nine Genes Mediate the Therapeutic Effects of Iodine-131 Radiotherapy in Thyroid Carcinoma Patients. Shuwen H, etal., Dis Markers. 2020 Jun 16;2020:9369341. doi: 10.1155/2020/9369341. eCollection 2020.
25. RNA interference targeting protein tyrosine phosphatase zeta/receptor-type protein tyrosine phosphatase beta suppresses glioblastoma growth in vitro and in vivo. Ulbricht U, etal., J Neurochem. 2006 Sep;98(5):1497-506. doi: 10.1111/j.1471-4159.2006.04022.x.
26. Expression and function of the receptor protein tyrosine phosphatase zeta and its ligand pleiotrophin in human astrocytomas. Ulbricht U, etal., J Neuropathol Exp Neurol. 2003 Dec;62(12):1265-75. doi: 10.1093/jnen/62.12.1265.
27. A phase II study of ENMD-2076 in advanced soft tissue sarcoma (STS). Veitch Z, etal., Sci Rep. 2019 May 14;9(1):7390. doi: 10.1038/s41598-019-43222-6.
28. PTPRB promotes metastasis of colorectal carcinoma via inducing epithelial-mesenchymal transition. Weng X, etal., Cell Death Dis. 2019 Apr 30;10(5):352. doi: 10.1038/s41419-019-1554-9.
Additional References at PubMed
PMID:8889548   PMID:10557082   PMID:12234928   PMID:15708477   PMID:16028071   PMID:16514057   PMID:17360632   PMID:19116766   PMID:19136612   PMID:19451274   PMID:19751804   PMID:20014386  
PMID:21890632   PMID:23382219   PMID:26063811   PMID:28926625  


Genomics

Comparative Map Data
Ptprb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8753,816,197 - 53,920,760 (+)NCBIGRCr8
mRatBN7.2751,953,375 - 52,034,751 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl751,930,015 - 52,034,748 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx753,860,095 - 53,941,469 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0756,063,182 - 56,144,564 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0755,841,176 - 55,922,540 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0759,326,484 - 59,431,114 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl759,326,518 - 59,425,718 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0759,358,899 - 59,441,068 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4755,613,557 - 55,714,216 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1755,634,330 - 55,732,082 (+)NCBI
Celera748,711,322 - 48,812,447 (+)NCBICelera
Cytogenetic Map7q22NCBI
PTPRB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381270,515,870 - 70,637,429 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1270,515,870 - 70,637,440 (-)EnsemblGRCh38hg38GRCh38
GRCh371270,909,650 - 71,031,209 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361269,196,897 - 69,317,486 (-)NCBINCBI36Build 36hg18NCBI36
Build 341269,201,230 - 69,289,891NCBI
Celera1270,574,292 - 70,694,892 (-)NCBICelera
Cytogenetic Map12q15NCBI
HuRef1267,960,230 - 68,080,615 (-)NCBIHuRef
CHM1_11270,879,907 - 71,000,488 (-)NCBICHM1_1
T2T-CHM13v2.01270,495,299 - 70,616,833 (-)NCBIT2T-CHM13v2.0
Ptprb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910116,111,407 - 116,225,443 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10116,111,428 - 116,225,440 (+)EnsemblGRCm39 Ensembl
GRCm3810116,275,502 - 116,389,538 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10116,275,523 - 116,389,535 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710115,738,430 - 115,826,594 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610115,705,616 - 115,788,043 (+)NCBIMGSCv36mm8
Celera10118,242,005 - 118,330,326 (+)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1064.68NCBI
Ptprb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540510,648,818 - 10,766,993 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540510,647,777 - 10,766,909 (-)NCBIChiLan1.0ChiLan1.0
PTPRB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21078,531,420 - 78,653,114 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11278,527,819 - 78,649,494 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01268,025,973 - 68,147,613 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11270,797,843 - 70,915,318 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1270,797,843 - 70,915,308 (-)Ensemblpanpan1.1panPan2
PTPRB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11012,267,891 - 12,384,522 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1012,241,716 - 12,384,435 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1012,206,342 - 12,323,493 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01012,399,792 - 12,516,770 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1012,373,481 - 12,517,277 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11012,265,927 - 12,382,361 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01012,512,972 - 12,629,456 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01012,636,704 - 12,753,669 (-)NCBIUU_Cfam_GSD_1.0
Ptprb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494545,842,565 - 45,962,671 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365458,147,291 - 8,235,715 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365458,150,766 - 8,235,674 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTPRB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl534,659,964 - 34,794,289 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1534,656,460 - 34,794,838 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2537,232,103 - 37,330,419 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PTPRB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11166,095,445 - 66,222,402 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1166,101,038 - 66,221,982 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037179,455,085 - 179,582,365 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptprb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475027,188,729 - 27,316,150 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475027,188,858 - 27,320,470 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ptprb
241 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:69
Count of miRNA genes:65
Interacting mature miRNAs:67
Transcripts:ENSRNOT00000006501
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71557388960573889Rat
2317059Aia15Adjuvant induced arthritis QTL 152.46joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)71700459862004598Rat
10755451Coatc11Coat color QTL 110coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)71794435762944357Rat
1354639Spl5Serum phospholipid level QTL 53.9blood LDL phospholipid amount (VT:0010505)blood low density lipoprotein phospholipid level (CMO:0001568)71965431752888450Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72192119566921195Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)72409960669099606Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72673740163902784Rat
1300138Hrtrt9Heart rate QTL 94.72heart pumping trait (VT:2000009)heart rate (CMO:0000002)72940968353612950Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)72940968374409683Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73111283276112832Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73429328279293282Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73429328279293282Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73796056982960569Rat
2303629Vencon3Ventilatory control QTL 37.25respiration trait (VT:0001943)respiration rate (CMO:0000289)74110969256793354Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
634326Hc3Hypercalciuria QTL 32.1urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)74278731487787314Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74322875088228750Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)743747099102228765Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)74486753389867533Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74659007091590070Rat
10059605Kidm47Kidney mass QTL 472.910.05kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)74725178365728867Rat
2293696Bmd32Bone mineral density QTL 325.10.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)74765143992651439Rat
2293707Bss32Bone structure and strength QTL 327.640.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)74765143992651439Rat
2300178Bmd54Bone mineral density QTL 545.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)74765143992651439Rat
2293644Bmd29Bone mineral density QTL 295.40.0001femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)74765143992651439Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)74765143992651439Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)74765143992651439Rat
2293685Bmd21Bone mineral density QTL 214.20.0003femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)74765143992651439Rat

Markers in Region
RH131513  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2751,929,395 - 51,929,575 (+)MAPPERmRatBN7.2
Rnor_6.0759,325,716 - 59,325,895NCBIRnor6.0
Rnor_5.0759,335,167 - 59,335,346UniSTSRnor5.0
RGSC_v3.4755,612,736 - 55,612,915UniSTSRGSC3.4
Celera748,710,554 - 48,710,733UniSTS
RH 3.4 Map7476.0UniSTS
Cytogenetic Map7q22UniSTS
RH128899  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2751,939,511 - 51,939,691 (+)MAPPERmRatBN7.2
Rnor_6.0759,335,832 - 59,336,011NCBIRnor6.0
Rnor_5.0759,345,283 - 59,345,462UniSTSRnor5.0
RGSC_v3.4755,622,852 - 55,623,031UniSTSRGSC3.4
Celera748,720,670 - 48,720,849UniSTS
RH 3.4 Map13173.8UniSTS
Cytogenetic Map7q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 28 19 8 12 8 8 8 10 25 13 11 8
Low 3 15 38 33 7 33 3 64 10 28
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000085231   ⟹   ENSRNOP00000072398
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl751,930,015 - 52,026,635 (+)Ensembl
Rnor_6.0 Ensembl759,326,518 - 59,425,718 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000085334   ⟹   ENSRNOP00000070093
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl751,953,375 - 52,027,288 (+)Ensembl
Rnor_6.0 Ensembl759,349,745 - 59,422,694 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000094476   ⟹   ENSRNOP00000082351
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl751,930,015 - 52,034,748 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000119174   ⟹   ENSRNOP00000081477
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl751,953,375 - 52,034,748 (+)Ensembl
RefSeq Acc Id: NM_001372134   ⟹   NP_001359063
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8753,839,402 - 53,920,760 (+)NCBI
mRatBN7.2751,953,375 - 52,034,751 (+)NCBI
RefSeq Acc Id: XM_063263482   ⟹   XP_063119552
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8753,816,197 - 53,920,760 (+)NCBI
RefSeq Acc Id: XM_063263483   ⟹   XP_063119553
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8753,839,811 - 53,920,760 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000072398   ⟸   ENSRNOT00000085231
RefSeq Acc Id: ENSRNOP00000070093   ⟸   ENSRNOT00000085334
RefSeq Acc Id: NP_001359063   ⟸   NM_001372134
- Peptide Label: precursor
- UniProtKB: A0A8I5ZV35 (UniProtKB/TrEMBL),   A6IGM6 (UniProtKB/TrEMBL),   D3ZTG5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000081477   ⟸   ENSRNOT00000119174
RefSeq Acc Id: ENSRNOP00000082351   ⟸   ENSRNOT00000094476
RefSeq Acc Id: XP_063119552   ⟸   XM_063263482
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063119553   ⟸   XM_063263483
- Peptide Label: isoform X2
Protein Domains
Fibronectin type-III   Tyrosine specific protein phosphatases   Tyrosine-protein phosphatase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K2W0-F1-model_v2 AlphaFold A0A0G2K2W0 1-2238 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695203
Promoter ID:EPDNEW_R5727
Type:multiple initiation site
Name:Ptprb_2
Description:protein tyrosine phosphatase, receptor type, B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R5728  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0759,326,562 - 59,326,622EPDNEW
RGD ID:13695206
Promoter ID:EPDNEW_R5728
Type:single initiation site
Name:Ptprb_1
Description:protein tyrosine phosphatase, receptor type, B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R5727  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0759,349,690 - 59,349,750EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305922 AgrOrtholog
BioCyc Gene G2FUF-34035 BioCyc
Ensembl Genes ENSRNOG00000055293 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000085231.2 UniProtKB/TrEMBL
  ENSRNOT00000085334.2 UniProtKB/TrEMBL
  ENSRNOT00000094476.1 UniProtKB/TrEMBL
  ENSRNOT00000119174 ENTREZGENE
  ENSRNOT00000119174.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  2.80.10.50 UniProtKB/TrEMBL
  3.90.190.10 UniProtKB/TrEMBL
InterPro Dual-sp/Tyr_phosphatase UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  FN_III UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/TrEMBL
  PTPRJ_TM UniProtKB/TrEMBL
  Ricin_B-like_lectins UniProtKB/TrEMBL
  Ricin_B_lectin UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/TrEMBL
  Tyr_Pase_rcpt/non-rcpt UniProtKB/TrEMBL
NCBI Gene 314843 ENTREZGENE
PANTHER CYTOKINE RECEPTOR UniProtKB/TrEMBL
  RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE BETA UniProtKB/TrEMBL
Pfam fn3 UniProtKB/TrEMBL
  PTP_tm UniProtKB/TrEMBL
  Ricin_B_lectin UniProtKB/TrEMBL
  Y_phosphatase UniProtKB/TrEMBL
PhenoGen Ptprb PhenoGen
PRINTS PRTYPHPHTASE UniProtKB/TrEMBL
PROSITE FN3 UniProtKB/TrEMBL
  RICIN_B_LECTIN UniProtKB/TrEMBL
  TYR_PHOSPHATASE_1 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_PTP UniProtKB/TrEMBL
RatGTEx ENSRNOG00000055293 RatGTEx
SMART FN3 UniProtKB/TrEMBL
  PTPc UniProtKB/TrEMBL
  PTPc_motif UniProtKB/TrEMBL
Superfamily-SCOP FN_III-like UniProtKB/TrEMBL
  SSF50370 UniProtKB/TrEMBL
  SSF52799 UniProtKB/TrEMBL
UniProt A0A0G2K2W0_RAT UniProtKB/TrEMBL
  A0A8I5ZV35 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZXS1_RAT UniProtKB/TrEMBL
  A6IGM6 ENTREZGENE, UniProtKB/TrEMBL
  D3ZTG5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-29 Ptprb  protein tyrosine phosphatase, receptor type, B  LOC102546841  uncharacterized LOC102546841  Data merged from RGD:7586698 737654 PROVISIONAL
2015-07-29 Ptprb  protein tyrosine phosphatase, receptor type, B  LOC688895  hypothetical protein LOC688895  Data merged from RGD:1584071 737654 PROVISIONAL
2013-12-18 LOC102546841  uncharacterized LOC102546841      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 Ptprb  protein tyrosine phosphatase, receptor type, B   Ptprb_predicted  protein tyrosine phosphatase, receptor type, B (predicted)  'predicted' is removed 2292626 APPROVED
2006-11-19 LOC688895  hypothetical protein LOC688895      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-12 Ptprb_predicted  protein tyrosine phosphatase, receptor type, B (predicted)      Symbol and Name status set to approved 70820 APPROVED