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Gene: Slc7a4 (solute carrier family 7, member 4) Rattus norvegicus

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Symbol:

Slc7a4

Name:

solute carrier family 7, member 4

RGD ID:

1305905

Description:

Predicted to enable amino acid transmembrane transporter activity. Predicted to be involved in amino acid transport. Predicted to be active in plasma membrane. Orthologous to human SLC7A4 (solute carrier family 7 member 4); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; acetamide.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

cationic amino acid transporter 4; LOC303787; solute carrier family 7 (cationic amino acid transporter, y+ system), member 4; solute carrier family 7 (orphan transporter), member 4

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SLC7A4 (solute carrier family 7 member 4)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Slc7a4 (solute carrier family 7 (cationic amino acid transporter, y+ system), member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Slc7a4 (solute carrier family 7 member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SLC7A4 (solute carrier family 7 member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SLC7A4 (solute carrier family 7 member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Slc7a4 (solute carrier family 7 member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SLC7A4 (solute carrier family 7 member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SLC7A4 (solute carrier family 7 member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Slc7a4 (solute carrier family 7 member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	SLC7A4 (solute carrier family 7 member 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Slc7a4 (solute carrier family 7 (cationic amino acid transporter, y+ system), member 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	slc7a4 (solute carrier family 7 member 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	BAP3	Alliance	DIOPT (Ensembl Compara\|InParanoid)
Saccharomyces cerevisiae (baker's yeast):	GNP1	Alliance	DIOPT (Ensembl Compara\|InParanoid)
Saccharomyces cerevisiae (baker's yeast):	MMP1	Alliance	DIOPT (Ensembl Compara\|InParanoid)
Drosophila melanogaster (fruit fly):	CG13248	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	AGP3	Alliance	DIOPT (Ensembl Compara\|InParanoid)
Caenorhabditis elegans (roundworm):	B0454.6	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	C50D2.2	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	F23F1.6	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	GAP1	Alliance	DIOPT (Ensembl Compara\|InParanoid)
Saccharomyces cerevisiae (baker's yeast):	HIP1	Alliance	DIOPT (InParanoid\|OrthoInspector)
Saccharomyces cerevisiae (baker's yeast):	AGP1	Alliance	DIOPT (Ensembl Compara\|InParanoid)
Saccharomyces cerevisiae (baker's yeast):	ALP1	Alliance	DIOPT (Ensembl Compara\|InParanoid)
Saccharomyces cerevisiae (baker's yeast):	BAP2	Alliance	DIOPT (Ensembl Compara\|InParanoid)
Saccharomyces cerevisiae (baker's yeast):	CAN1	Alliance	DIOPT (Ensembl Compara\|InParanoid)
Saccharomyces cerevisiae (baker's yeast):	PUT4	Alliance	DIOPT (Ensembl Compara\|InParanoid)
Saccharomyces cerevisiae (baker's yeast):	SAM3	Alliance	DIOPT (Ensembl Compara\|InParanoid)
Xenopus tropicalis (tropical clawed frog):	slc7a4	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	96,939,456 - 96,943,127 (+)	NCBI		GRCr8
mRatBN7.2	11	83,435,093 - 83,439,078 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	83,435,211 - 83,438,881 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	92,162,835 - 92,166,513 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	84,824,000 - 84,827,677 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	83,877,609 - 83,881,285 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	87,445,585 - 87,450,008 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	87,446,382 - 87,449,940 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	90,496,879 - 90,501,299 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	85,426,546 - 85,430,217 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	11	85,467,826 - 85,470,502 (+)	NCBI
Celera	11	82,203,782 - 82,207,453 (+)	NCBI		Celera
Cytogenetic Map	11	q23	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

chromosome 22q11.2 deletion syndrome, distal (ISO)

chromosome 22q11.2 microduplication syndrome (ISO)

DiGeorge syndrome (ISO)

epilepsy (ISO)

intellectual disability (ISO)

megacolon (ISO)

Neurodevelopmental Disorders (ISO)

primary immunodeficiency disease (ISO)

schizophrenia (ISO)

velocardiofacial syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP,ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-hydroxypropanoic acid (ISO)

4-hydroxyphenyl retinamide (ISO)

acetamide (EXP)

aflatoxin B1 (ISO)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP)

cadmium dichloride (EXP,ISO)

carbon nanotube (ISO)

decabromodiphenyl ether (EXP,ISO)

dibutyl phthalate (ISO)

diclofenac (ISO)

endosulfan (EXP)

folic acid (ISO)

FR900359 (ISO)

furan (EXP)

gentamycin (EXP)

inulin (ISO)

lead(0) (ISO)

mifepristone (ISO)

Monobutylphthalate (EXP)

orphenadrine (EXP)

paracetamol (EXP)

paraquat (EXP)

perfluorooctane-1-sulfonic acid (ISO)

progesterone (ISO)

rac-lactic acid (ISO)

raloxifene (EXP)

resveratrol (ISO)

Soman (EXP)

testosterone (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trichloroethene (EXP)

triclosan (ISO)

Triptolide (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

amino acid transmembrane transport (IEA)

amino acid transport (IBA)

carboxylic acid transmembrane transport (IEA)

Cellular Component

plasma membrane (IBA)

Molecular Function

amino acid transmembrane transporter activity (IBA)

carboxylic acid transmembrane transporter activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932

Genomics

Comparative Map Data

Slc7a4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	96,939,456 - 96,943,127 (+)	NCBI		GRCr8
mRatBN7.2	11	83,435,093 - 83,439,078 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	83,435,211 - 83,438,881 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	92,162,835 - 92,166,513 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	84,824,000 - 84,827,677 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	83,877,609 - 83,881,285 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	87,445,585 - 87,450,008 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	87,446,382 - 87,449,940 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	90,496,879 - 90,501,299 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	85,426,546 - 85,430,217 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	11	85,467,826 - 85,470,502 (+)	NCBI
Celera	11	82,203,782 - 82,207,453 (+)	NCBI		Celera
Cytogenetic Map	11	q23	NCBI

SLC7A4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	22	21,028,718 - 21,032,561 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	22	21,028,718 - 21,032,840 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	22	21,383,007 - 21,386,850 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	22	19,713,007 - 19,716,847 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	22	19,707,561 - 19,711,396	NCBI
Celera	22	4,874,309 - 4,878,149 (-)	NCBI		Celera
Cytogenetic Map	22	q11.21	NCBI
HuRef	22	4,651,291 - 4,655,131 (-)	NCBI		HuRef
CHM1_1	22	21,383,208 - 21,387,048 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	22	21,437,477 - 21,441,320 (-)	NCBI		T2T-CHM13v2.0

Slc7a4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	17,389,882 - 17,394,619 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	17,389,882 - 17,401,078 (-)	Ensembl		GRCm39 Ensembl
GRCm38	16	17,572,018 - 17,576,890 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	17,572,018 - 17,583,214 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	16	17,572,111 - 17,576,764 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	16	17,485,581 - 17,490,234 (-)	NCBI		MGSCv36	mm8
Celera	16	18,145,336 - 18,149,989 (-)	NCBI		Celera
Cytogenetic Map	16	A3	NCBI
cM Map	16	10.89	NCBI

Slc7a4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955442	19,258,796 - 19,263,317 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955442	19,258,901 - 19,263,317 (+)	NCBI	ChiLan1.0	ChiLan1.0

SLC7A4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	23	30,735,466 - 30,739,356 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	22	33,284,389 - 33,288,279 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	22	3,252,667 - 3,256,561 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	22	19,741,779 - 19,744,931 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	22	19,738,025 - 19,744,931 (-)	Ensembl	panpan1.1		panPan2

SLC7A4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	30,467,817 - 30,472,806 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	30,468,789 - 30,471,458 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	30,412,703 - 30,416,576 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	31,863,133 - 31,867,016 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	31,863,173 - 31,870,985 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	29,908,968 - 29,912,841 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	29,533,160 - 29,537,028 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	30,622,131 - 30,626,006 (+)	NCBI		UU_Cfam_GSD_1.0

Slc7a4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	140,181,595 - 140,185,740 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936619	2,567,887 - 2,572,394 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936619	2,568,322 - 2,572,391 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLC7A4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	50,633,878 - 50,637,404 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	50,631,693 - 50,638,381 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	54,082,608 - 54,086,111 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SLC7A4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	19	4,970,147 - 4,973,603 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	19	4,970,483 - 4,973,230 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666085	1,997,653 - 2,001,171 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Slc7a4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624945	642,432 - 646,231 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624945	642,082 - 646,247 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Slc7a4
14 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	45
Count of miRNA genes:	42
Interacting mature miRNAs:	44
Transcripts:	ENSRNOT00000002560
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
724554	Iddm17	Insulin dependent diabetes mellitus QTL 17		0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	11	18976208	86241447	Rat
10058954	Gmadr7	Adrenal mass QTL 7	2.49	0.0049	adrenal gland mass (VT:0010420)	both adrenal glands wet weight to body weight ratio (CMO:0002411)	11	60346590	86241447	Rat
1354593	Stl12	Serum triglyceride level QTL 12	3.36		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	11	66422148	86241447	Rat
2302043	Pia27	Pristane induced arthritis QTL 27	18.6	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)	11	82566545	83440803	Rat
724561	Plsm4	Polydactyly-luxate syndrome (PLS) morphotypes QTL 4		0.0003	forelimb integrity trait (VT:0010562)	front foot phalanges count (CMO:0001947)	11	54457534	86241447	Rat
634339	Niddm50	Non-insulin dependent diabetes mellitus QTL 50	3.32		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	11	66422148	86241447	Rat
7411658	Foco27	Food consumption QTL 27	16.2	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	11	56351424	86241447	Rat

Markers in Region

RH138046

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	11	96,943,012 - 96,943,201 (+)	Marker Load Pipeline
mRatBN7.2	11	83,438,767 - 83,438,956 (-)	MAPPER	mRatBN7.2
Rnor_6.0	11	87,446,187 - 87,446,375	NCBI	Rnor6.0
Rnor_5.0	11	90,497,481 - 90,497,669	UniSTS	Rnor5.0
RGSC_v3.4	11	85,430,103 - 85,430,291	UniSTS	RGSC3.4
Celera	11	82,207,339 - 82,207,527	UniSTS
RH 3.4 Map	11	713.8	UniSTS
Cytogenetic Map	11	q23	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001107078	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017597952	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017597953	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC169079	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473999	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ214252	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HB903937	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HB918328	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HB925497	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HB942285	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HC961346	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HC975737	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HC982906	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HC999694	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000011	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000002560 ⟹ ENSRNOP00000002560

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	11	83,435,211 - 83,438,881 (+)	Ensembl
Rnor_6.0 Ensembl	11	87,446,382 - 87,449,940 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000097648 ⟹ ENSRNOP00000089345

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	11	83,435,211 - 83,438,881 (+)	Ensembl

RefSeq Acc Id:

NM_001107078 ⟹ NP_001100548

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	96,939,456 - 96,943,127 (+)	NCBI
mRatBN7.2	11	83,435,211 - 83,438,882 (+)	NCBI
Rnor_6.0	11	87,446,261 - 87,449,932 (-)	NCBI
Rnor_5.0	11	90,496,879 - 90,501,299 (-)	NCBI
RGSC_v3.4	11	85,426,546 - 85,430,217 (+)	RGD
Celera	11	82,203,782 - 82,207,453 (+)	RGD

Sequence:

show sequence

AGCGACGGCGACAGCAGGTTCCTGAGGCTGGCTCAGTACTCTGTCTGCCATGGCCCGGGGACTG
CCCAGCACTGCCCGCTTGGCACGCTTTTGCCAGAAACTGAACCGTCTGAAGCCACTGGAAGAGT
CTAGCACAGAGACATCACTGCGGCGTTGCCTGTCCACACTGGACTTGACCCTACTGGGTGTGGG
TGGCATGGTGGGATCTGGGCTCTATGTACTCACAGGCACAGTGGCTAAGGACATGGCTGGCCCT
GCTGTGCTCTTGTCCTTTTTGGTGGCCGCTGTAGCCTCCCTGCTGGCAGCACTATGCTATGCAG
AGTTTGGAGCCCGCGTGCCCCGTACTGGCTCTGCATACCTATTCACCTACGTGTCCATGGGGGA
AATATGGGCATTTCTCATAGGCTGGAATGTGCTTCTGGAATACCTCATTGGAGGTGCTGCTGTG
GCCCGTGCCTGGAGTGGCTATTTGGATGCCATCTTTAACCACAGCATTCGCAACTTCACAGAAT
CTCACATGGGTGTCTGGCAGATGCCCTTCCTAGCCCACTATCCAGATTTTCTGGCTGCTGGCAT
TTTGCTTGTGGCTTCTGCCTTTGTCTCCTGTGGCGCCCGAGTCTCCTCCTGGCTCAACCACACA
TTCTCAGCCATCAGTCTGATTGTGATCCTCTTCATCATCGTCCTGGGTTTCATCCTGGCCCGTC
CTCACAATTGGAGTGCAGAAGAAGGTGGCTTTGCACCCTTCGGCTTCTCTGGCATCCTCGCTGG
CACAGCCACCTGTTTCTATGCCTTTGTGGGCTTCGATGTCATTGCCGCCTCCAGTGAGGAGGCC
AAAAACCCACGGTGGGCCGTGCCCATGGCCATTGCCATCTCGCTTGGCCTGGCAGCTGGTGCCT
ATATTCTGGTCTCCACTGTGCTGACCCTCATGGTGCCTTGGCATAGCCTGGACCCTGACTCGGC
ACTTGCTGATGCCTTCTACAGGCGGGGCTACGGCTGGGCTGGCTTCATTGTGGCAGTTGGTTCT
ATCTGTGCCATGAACACGGTCCTGCTCAGCAACCTCTTCTCCCTGCCGCGCATTGTCTACGCCA
TGGCTGCCGACGGGCTCTTCTTCCAGGTGTTCGCCCGTGTACACCCCCGGACACAGGTGCCTGT
GGTGGGAATCCTGGTGTTTGGGGTCCTTATGGCTCTCCTGGCACTGCTGATGGACCTCGAGGCA
CTGGTCCAGTTCCTATCCATCGGCACCCTGCTGGCCTATACCTTTGTCGCCACCAGCATCATTG
TGCTGCGTTTCCAGAAAGCTTCCCCACCCAGTTCCCCTTGCCCAGCCAGCCCCGGCCCCACAGT
TAAGAAGTACGACTCCTTCTCGGACCATATACAGCTAGTAGATGCTGTACAGGCTTCGATGTCT
GAGCCTGGGCAGCTGCGACCAGCCCTGAAGCCCTTCCTGGGCTTCCTGGATGGACTCAGCCCTG
GAACTGCTGTGACCTGGGCGCTGGGCATCTTGATAGCCTCAGCTATTTCCCTGGCGTGTGTGCT
AGTCTTCGGGAACTCAGCCCTGCACCTCCCACGGTGGGGCTATGTCTTGCTGCTGGTCGTCAGT
GGTGCTGTCTTTCTGTCCAGCCTCCTGGTCCTGGGGGCTCACCAGCAGCAAAAGAAACAAGACA
CTTTCCAGATCCCTTTGGTGCCCCTGACTCCAGCCCTGAGCATCCTCCTCAACCTTTGCCTCAT
GCTGAAGCTCAGCTACCTGACCTGGCTGCGTTTTATCTTCTGGCTGCTGGTCGGACTCGTCGTG
TATTTTGGCTACGGCATCTGGCACAGCAAGGAGAACCAGAGGGAGCCATTGGAGCTGACTACTG
CACACTACGTGGTATTCCCCAGCGGCAGCCTGGAGGAAACCGTGCAAGCTGTGCAGCCTGATAG
CCAGACACCAGTCCAGGGACCAGGCTGTACCGAGTAGCTGGCCATGGAGTCTGGCTCATGGAGG
CCCCCCACAACCCTAACATCCAGAGGCTGAAAGAATTGGCAGCTGCCTACTCAAGGAAGCTTGG
GTCTGAAGCCTGCCCAGACTGGGCTGGGAGTGTTCTCAGAGCCTAAACACAGGAACTGAGTCTT
CAGCTATCAATAGGCCATGGCTAGAGCTGGGGCGCACTCTTCGTCCGCTGCCTTCCTGTTTATG
ATTAACTCTGGATACCTGGGCAGGTGGGGCAGAGTGAGCAGGGAAGCGGCTTCAGCCCCTGAGA
CGCAGAATAATAACTAATCAGCTAGTTTGTGAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001100548	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI69079	(Get FASTA)	NCBI Sequence Viewer
	CBF83047	(Get FASTA)	NCBI Sequence Viewer
	CBF94176	(Get FASTA)	NCBI Sequence Viewer
	CBF97696	(Get FASTA)	NCBI Sequence Viewer
	CBG05915	(Get FASTA)	NCBI Sequence Viewer
	CBV00656	(Get FASTA)	NCBI Sequence Viewer
	CBV07696	(Get FASTA)	NCBI Sequence Viewer
	CBV11216	(Get FASTA)	NCBI Sequence Viewer
	CBV19437	(Get FASTA)	NCBI Sequence Viewer
	EDL77897	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000002560.3
	ENSRNOP00000089345.1

RefSeq Acc Id:

NP_001100548 ⟸ NM_001107078

- UniProtKB:

B5DFJ0 (UniProtKB/TrEMBL), F7FP86 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MARGLPSTARLARFCQKLNRLKPLEESSTETSLRRCLSTLDLTLLGVGGMVGSGLYVLTGTVAK
DMAGPAVLLSFLVAAVASLLAALCYAEFGARVPRTGSAYLFTYVSMGEIWAFLIGWNVLLEYLI
GGAAVARAWSGYLDAIFNHSIRNFTESHMGVWQMPFLAHYPDFLAAGILLVASAFVSCGARVSS
WLNHTFSAISLIVILFIIVLGFILARPHNWSAEEGGFAPFGFSGILAGTATCFYAFVGFDVIAA
SSEEAKNPRWAVPMAIAISLGLAAGAYILVSTVLTLMVPWHSLDPDSALADAFYRRGYGWAGFI
VAVGSICAMNTVLLSNLFSLPRIVYAMAADGLFFQVFARVHPRTQVPVVGILVFGVLMALLALL
MDLEALVQFLSIGTLLAYTFVATSIIVLRFQKASPPSSPCPASPGPTVKKYDSFSDHIQLVDAV
QASMSEPGQLRPALKPFLGFLDGLSPGTAVTWALGILIASAISLACVLVFGNSALHLPRWGYVL
LLVVSGAVFLSSLLVLGAHQQQKKQDTFQIPLVPLTPALSILLNLCLMLKLSYLTWLRFIFWLL
VGLVVYFGYGIWHSKENQREPLELTTAHYVVFPSGSLEETVQAVQPDSQTPVQGPGCTE

hide sequence

Ensembl Acc Id:

ENSRNOP00000002560 ⟸ ENSRNOT00000002560

Ensembl Acc Id:

ENSRNOP00000089345 ⟸ ENSRNOT00000097648

Protein Domains

Cationic amino acid transporter C-terminal

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-B5DFJ0-F1-model_v2	AlphaFold	B5DFJ0	1-635	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698321

Promoter ID:

EPDNEW_R8845

Type:

single initiation site

Name:

Slc7a4_1

Description:

solute carrier family 7, member 4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	11	87,449,944 - 87,450,004	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305905	AgrOrtholog
BioCyc Gene	G2FUF-20596	BioCyc
Ensembl Genes	ENSRNOG00000001874	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000002560.6	UniProtKB/TrEMBL
	ENSRNOT00000097648.1	UniProtKB/TrEMBL
Gene3D-CATH	Amino acid/polyamine transporter I	UniProtKB/TrEMBL
InterPro	AA/rel_permease1	UniProtKB/TrEMBL
	CAT_C	UniProtKB/TrEMBL
KEGG Report	rno:303787	UniProtKB/TrEMBL
NCBI Gene	303787	ENTREZGENE
PANTHER	CATIONIC AMINO ACID TRANSPORTER 4	UniProtKB/TrEMBL
	INNER MEMBRANE TRANSPORTER YGJI-RELATED	UniProtKB/TrEMBL
Pfam	AA_permease_2	UniProtKB/TrEMBL
	AA_permease_C	UniProtKB/TrEMBL
PhenoGen	Slc7a4	PhenoGen
PIRSF	AA_transporter	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000001874	RatGTEx
UniProt	A0A8I6ABQ8_RAT	UniProtKB/TrEMBL
	B5DFJ0	ENTREZGENE, UniProtKB/TrEMBL
	F7FP86	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-08-02	Slc7a4	solute carrier family 7, member 4	Slc7a4	solute carrier family 7 (orphan transporter), member 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-10-16	Slc7a4	solute carrier family 7 (orphan transporter), member 4	Slc7a4	solute carrier family 7 (cationic amino acid transporter, y+ system), member 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Slc7a4	solute carrier family 7 (cationic amino acid transporter, y+ system), member 4	Slc7a4_predicted	solute carrier family 7 (cationic amino acid transporter, y+ system), member 4 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Slc7a4_predicted	solute carrier family 7 (cationic amino acid transporter, y+ system), member 4 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar