Tcf7 (transcription factor 7) - Rat Genome Database

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Gene: Tcf7 (transcription factor 7) Rattus norvegicus
Analyze
Symbol: Tcf7
Name: transcription factor 7
RGD ID: 1305894
Description: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and beta-catenin binding activity. Predicted to be involved in several processes, including canonical Wnt signaling pathway involved in negative regulation of apoptotic process; cellular response to interleukin-4; and regulation of gamma-delta T cell differentiation. Predicted to act upstream of or within several processes, including T cell differentiation; embryonic morphogenesis; and neural tube development. Predicted to be located in euchromatin and nucleus. Predicted to be part of beta-catenin-TCF complex. Predicted to be active in chromatin. Orthologous to human TCF7 (transcription factor 7); PARTICIPATES IN Wnt signaling, canonical pathway; acute myeloid leukemia pathway; arrhythmogenic right ventricular cardiomyopathy pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; alpha-Zearalanol; amphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC363595; transcription factor 7 (T-cell specific, HMG-box); transcription factor 7, T-cell specific
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81036,924,363 - 36,954,279 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1036,924,363 - 36,954,279 (-)EnsemblGRCr8
mRatBN7.21036,423,443 - 36,454,350 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1036,423,445 - 36,453,535 (-)EnsemblmRatBN7.2
Rnor_6.01037,616,033 - 37,646,027 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1037,617,279 - 37,645,802 (-)Ensemblrn6Rnor6.0
Rnor_5.01037,389,506 - 37,419,457 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41037,686,862 - 37,716,831 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1035,778,033 - 35,807,975 (-)NCBICelera
RGSC_v3.11037,693,621 - 37,723,030 (-)NCBI
Cytogenetic Map10q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-bromoindirubin-3'-oxime  (ISO)
acetaldehyde  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
AH23848  (ISO)
alpha-naphthoflavone  (ISO)
alpha-Zearalanol  (EXP)
amiodarone  (ISO)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (ISO)
bortezomib  (ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
casticin  (ISO)
celastrol  (ISO)
CGP 52608  (ISO)
choline  (ISO)
cisplatin  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclophosphamide  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP,ISO)
dieldrin  (EXP)
diethylstilbestrol  (ISO)
disodium selenite  (ISO)
endosulfan  (EXP)
flavonoids  (ISO)
flusilazole  (ISO)
folic acid  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
GSK-J4  (ISO)
indometacin  (ISO)
inulin  (ISO)
iron dichloride  (ISO)
isoorientin  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
methapyrilene  (ISO)
methoxychlor  (EXP)
naphthalene  (ISO)
neohesperidin  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP)
niclosamide  (ISO)
nitrofen  (EXP)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentanal  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
poly(I:C)  (ISO)
propanal  (ISO)
quercetin  (ISO)
quercitrin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
selenic acid  (ISO)
sodium arsenite  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
tibolone  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
beta-catenin-TCF complex  (IBA)
chromatin  (IBA)
euchromatin  (ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Comprehensive gene review and curation RGD comprehensive gene curation
7. TCF transcription factors: molecular switches in carcinogenesis. Roose J and Clevers H, Biochim Biophys Acta. 1999 Oct 29;1424(2-3):M23-37.
8. TCF7 is suppressed by the androgen receptor via microRNA-1-mediated downregulation and is involved in the development of resistance to androgen deprivation in prostate cancer. Siu MK, etal., Prostate Cancer Prostatic Dis. 2017 Jun;20(2):172-178. doi: 10.1038/pcan.2017.2. Epub 2017 Feb 21.
Additional References at PubMed
PMID:1827138   PMID:9462507   PMID:9488439   PMID:12235125   PMID:15057272   PMID:17218525   PMID:18158920   PMID:18579517   PMID:20128911   PMID:22723415   PMID:23562159  


Genomics

Comparative Map Data
Tcf7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81036,924,363 - 36,954,279 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1036,924,363 - 36,954,279 (-)EnsemblGRCr8
mRatBN7.21036,423,443 - 36,454,350 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1036,423,445 - 36,453,535 (-)EnsemblmRatBN7.2
Rnor_6.01037,616,033 - 37,646,027 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1037,617,279 - 37,645,802 (-)Ensemblrn6Rnor6.0
Rnor_5.01037,389,506 - 37,419,457 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41037,686,862 - 37,716,831 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1035,778,033 - 35,807,975 (-)NCBICelera
RGSC_v3.11037,693,621 - 37,723,030 (-)NCBI
Cytogenetic Map10q22NCBI
TCF7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385134,108,218 - 134,148,210 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5134,114,681 - 134,151,865 (+)Ensemblhg38GRCh38
GRCh375133,450,372 - 133,483,901 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365133,478,301 - 133,511,819 (+)NCBIBuild 36Build 36hg18NCBI36
Celera5129,574,095 - 129,607,613 (+)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5128,635,317 - 128,668,890 (+)NCBIHuRef
CHM1_15132,882,980 - 132,916,497 (+)NCBICHM1_1
T2T-CHM13v2.05134,630,059 - 134,671,840 (+)NCBIT2T-CHM13v2.0
Tcf7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391152,137,347 - 52,174,211 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1152,143,198 - 52,174,158 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381152,246,527 - 52,283,383 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1152,252,371 - 52,283,331 (-)Ensemblmm10GRCm38
MGSCv371152,066,106 - 52,096,073 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361152,096,027 - 52,125,994 (-)NCBIMGSCv36mm8
Celera1156,821,774 - 56,852,195 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1131.86NCBI
Tcf7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554085,362,084 - 5,388,527 (+)Ensembl
ChiLan1.0NW_0049554085,362,423 - 5,388,684 (+)NCBIChiLan1.0ChiLan1.0
TCF7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24129,407,016 - 129,446,603 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15127,546,618 - 127,586,165 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05129,518,134 - 129,549,972 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15135,671,630 - 135,704,417 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5135,671,095 - 135,702,734 (+)EnsemblpanPan2panpan1.1
TCF7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11122,313,113 - 22,346,221 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1122,313,105 - 22,344,004 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1121,059,022 - 21,092,131 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01123,113,932 - 23,147,114 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1123,113,518 - 23,164,886 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11121,814,042 - 21,847,134 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01121,679,173 - 21,712,308 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01122,321,753 - 22,354,875 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tcf7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213114,092,704 - 114,122,991 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366471,097,019 - 1,125,729 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366471,096,726 - 1,125,753 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TCF7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2136,422,940 - 136,457,910 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.12136,422,740 - 136,456,323 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22142,042,088 - 142,051,487 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TCF7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12336,919,648 - 36,953,088 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2336,919,745 - 36,951,192 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603440,979,669 - 41,016,821 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tcf7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473338,076,410 - 38,104,173 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473338,076,800 - 38,104,265 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Tcf7
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1934,748,775 - 34,779,099 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tcf7
86 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:190
Count of miRNA genes:135
Interacting mature miRNAs:150
Transcripts:ENSRNOT00000008022, ENSRNOT00000064865
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103589345164140567Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103621155669161158Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102183375861843633Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103589326364653589Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102980091064653589Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102702353561843633Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138832698Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103589326352293000Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102937704652699134Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
BF392792  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21036,430,435 - 36,430,608 (+)MAPPERmRatBN7.2
Rnor_6.01037,623,024 - 37,623,196NCBIRnor6.0
Rnor_5.01037,396,496 - 37,396,668UniSTSRnor5.0
RGSC_v3.41037,693,864 - 37,694,036UniSTSRGSC3.4
Celera1035,785,024 - 35,785,196UniSTS
RH 3.4 Map10389.8UniSTS
Cytogenetic Map10q22UniSTS
PMC126018P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21036,427,772 - 36,428,998 (+)MAPPERmRatBN7.2
Rnor_6.01037,620,363 - 37,621,586NCBIRnor6.0
Rnor_5.01037,393,836 - 37,395,058UniSTSRnor5.0
RGSC_v3.41037,691,203 - 37,692,426UniSTSRGSC3.4
Celera1035,782,363 - 35,783,586UniSTS
Cytogenetic Map10q22UniSTS
UniSTS:498411  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21036,424,434 - 36,425,095 (+)MAPPERmRatBN7.2
Rnor_6.01037,617,025 - 37,617,685NCBIRnor6.0
Rnor_5.01037,390,498 - 37,391,158UniSTSRnor5.0
RGSC_v3.41037,687,865 - 37,688,525UniSTSRGSC3.4
Celera1035,779,025 - 35,779,685UniSTS
Cytogenetic Map10q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 92 59 6 356 192 11 140 81 92 31 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000008022   ⟹   ENSRNOP00000008022
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1036,924,716 - 36,954,279 (-)Ensembl
mRatBN7.2 Ensembl1036,424,888 - 36,453,535 (-)Ensembl
Rnor_6.0 Ensembl1037,617,279 - 37,645,802 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097186   ⟹   ENSRNOP00000097383
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1036,924,363 - 36,954,279 (-)Ensembl
mRatBN7.2 Ensembl1036,423,445 - 36,453,535 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108192   ⟹   ENSRNOP00000088372
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1036,924,363 - 36,954,279 (-)Ensembl
mRatBN7.2 Ensembl1036,423,445 - 36,453,535 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116080   ⟹   ENSRNOP00000079588
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1036,425,970 - 36,453,535 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118654   ⟹   ENSRNOP00000078370
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1036,924,684 - 36,954,279 (-)Ensembl
mRatBN7.2 Ensembl1036,423,764 - 36,453,535 (-)Ensembl
RefSeq Acc Id: NM_001427430   ⟹   NP_001414359
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,924,363 - 36,954,279 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001414359 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABP57803 (Get FASTA)   NCBI Sequence Viewer  
  EDM04359 (Get FASTA)   NCBI Sequence Viewer  
  EDM04360 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000008022.6
  ENSRNOP00000078370.1
  ENSRNOP00000088372.1
  ENSRNOP00000097383
  ENSRNOP00000097383.1
Ensembl Acc Id: ENSRNOP00000008022   ⟸   ENSRNOT00000008022
Ensembl Acc Id: ENSRNOP00000088372   ⟸   ENSRNOT00000108192
Ensembl Acc Id: ENSRNOP00000078370   ⟸   ENSRNOT00000118654
Ensembl Acc Id: ENSRNOP00000097383   ⟸   ENSRNOT00000097186
Ensembl Acc Id: ENSRNOP00000079588   ⟸   ENSRNOT00000116080
RefSeq Acc Id: NP_001414359   ⟸   NM_001427430
- UniProtKB: A0A8I6ASU6 (UniProtKB/TrEMBL),   A0A8I6A7R1 (UniProtKB/TrEMBL),   A6HEA4 (UniProtKB/TrEMBL)
Protein Domains
HMG box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZLD0-F1-model_v2 AlphaFold D3ZLD0 1-449 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305894 AgrOrtholog
BioCyc Gene G2FUF-25172 BioCyc
Ensembl Genes ENSRNOG00000005872 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000008022.9 UniProtKB/TrEMBL
  ENSRNOT00000097186 ENTREZGENE
  ENSRNOT00000097186.2 UniProtKB/TrEMBL
  ENSRNOT00000108192.2 UniProtKB/TrEMBL
  ENSRNOT00000118654.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.30.10 UniProtKB/TrEMBL
  4.10.900.10 UniProtKB/TrEMBL
InterPro Catenin_binding_dom UniProtKB/TrEMBL
  CTNNB1-bd_N UniProtKB/TrEMBL
  HMG_box_dom_sf UniProtKB/TrEMBL
  HMG_superfamily UniProtKB/TrEMBL
  TCF/LEF UniProtKB/TrEMBL
NCBI Gene 363595 ENTREZGENE
PANTHER PTHR10373 UniProtKB/TrEMBL
  PTHR10373:SF33 UniProtKB/TrEMBL
Pfam CTNNB1_binding UniProtKB/TrEMBL
  HMG_box UniProtKB/TrEMBL
PhenoGen Tcf7 PhenoGen
PROSITE HMG_BOX_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005872 RatGTEx
SMART c-clamp UniProtKB/TrEMBL
  HMG UniProtKB/TrEMBL
Superfamily-SCOP HMG-box UniProtKB/TrEMBL
UniProt A0A8I5ZLY3_RAT UniProtKB/TrEMBL
  A0A8I6A7R1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ASU6 ENTREZGENE, UniProtKB/TrEMBL
  A6HEA4 ENTREZGENE, UniProtKB/TrEMBL
  A6HEA5_RAT UniProtKB/TrEMBL
  D3ZLD0_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-05-18 Tcf7  transcription factor 7  Tcf7  transcription factor 7 (T-cell specific, HMG-box)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-02-02 Tcf7  transcription factor 7 (T-cell specific, HMG-box)  Tcf7  transcription factor 7, T-cell specific  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Tcf7  transcription factor 7, T-cell specific   Tcf7_predicted  transcription factor 7, T-cell specific (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Tcf7_predicted  transcription factor 7, T-cell specific (predicted)      Symbol and Name status set to approved 70820 APPROVED