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Gene: Spire2 (spire-type actin nucleation factor 2) Rattus norvegicus

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Symbol:

Spire2

Name:

spire-type actin nucleation factor 2

RGD ID:

1305837

Description:

Predicted to enable microtubule binding activity. Predicted to be involved in several processes, including cytoskeleton organization; cytoskeleton-dependent cytokinesis; and positive regulation of double-strand break repair. Predicted to be located in cleavage furrow. Predicted to be active in cell cortex and cytoplasmic vesicle membrane. Orthologous to human SPIRE2 (spire type actin nucleation factor 2); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC307925; spire homolog 2; spire homolog 2 (Drosophila)

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SPIRE2 (spire type actin nucleation factor 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Spire2 (spire type actin nucleation factor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Spire2 (spire type actin nucleation factor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SPIRE2 (spire type actin nucleation factor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SPIRE2 (spire type actin nucleation factor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Spire2 (spire type actin nucleation factor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SPIRE2 (spire type actin nucleation factor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SPIRE2 (spire type actin nucleation factor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Spire2 (spire type actin nucleation factor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	SPIRE2 (spire type actin nucleation factor 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Spire2 (spire type actin nucleation factor 2)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	spire2 (spire-type actin nucleation factor 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	spir	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	spire2	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	68,281,878 - 68,320,427 (+)	NCBI		GRCr8
mRatBN7.2	19	51,373,368 - 51,411,920 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	51,373,228 - 51,411,920 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	19	58,167,669 - 58,206,422 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	58,848,133 - 58,886,950 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	61,066,277 - 61,105,022 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	56,136,904 - 56,175,500 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	56,136,904 - 56,175,500 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	19	66,847,850 - 66,886,402 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	19	67,143,780 - 67,144,041 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	19	53,658,621 - 53,697,285 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	19	53,663,401 - 53,691,149 (+)	NCBI
Celera	19	50,609,204 - 50,647,497 (+)	NCBI		Celera
Cytogenetic Map	19	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal recessive chronic granulomatous disease 4 (ISO)

familial melanoma (ISO)

Fanconi anemia (ISO)

KBG syndrome (ISO)

primary ciliary dyskinesia 33 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3,4-methylenedioxymethamphetamine (EXP)

4,4'-diaminodiphenylmethane (ISO)

acetamide (EXP)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

all-trans-retinoic acid (EXP)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP,ISO)

caffeine (ISO)

chlorpyrifos (ISO)

choline (ISO)

clothianidin (ISO)

copper atom (EXP)

copper(0) (EXP)

coumestrol (ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

endosulfan (EXP)

folic acid (ISO)

FR900359 (ISO)

inulin (ISO)

L-methionine (ISO)

methapyrilene (ISO)

nitrofen (EXP)

Nor-9-carboxy-delta9-THC (ISO)

paracetamol (EXP,ISO)

perfluorooctane-1-sulfonic acid (ISO)

quercetin (ISO)

resveratrol (ISO)

silicon dioxide (ISO)

sunitinib (ISO)

tetrachloromethane (EXP)

thioacetamide (EXP)

titanium dioxide (ISO)

trichloroethene (EXP)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin cytoskeleton organization (ISO)

actin filament network formation (IBA)

actin nucleation (IEA)

cleavage furrow formation (IBA,ISO)

establishment of meiotic spindle localization (IBA,ISO)

formin-nucleated actin cable assembly (ISO)

Golgi vesicle transport (IBA)

intracellular transport (IBA,ISO)

polar body extrusion after meiotic divisions (IBA,ISO)

positive regulation of double-strand break repair (ISO)

protein transport (IEA)

vesicle-mediated transport (ISO)

Cellular Component

cell cortex (IBA,ISO)

cleavage furrow (ISO)

cytoplasmic vesicle membrane (IBA,ISO)

cytoskeleton (IEA)

Molecular Function

actin binding (IEA)

microtubule binding (IBA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:21620703	PMID:21983562	PMID:26287480	PMID:31904090

Genomics

Comparative Map Data

Spire2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	68,281,878 - 68,320,427 (+)	NCBI		GRCr8
mRatBN7.2	19	51,373,368 - 51,411,920 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	51,373,228 - 51,411,920 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	19	58,167,669 - 58,206,422 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	58,848,133 - 58,886,950 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	61,066,277 - 61,105,022 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	56,136,904 - 56,175,500 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	56,136,904 - 56,175,500 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	19	66,847,850 - 66,886,402 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	19	67,143,780 - 67,144,041 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	19	53,658,621 - 53,697,285 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	19	53,663,401 - 53,691,149 (+)	NCBI
Celera	19	50,609,204 - 50,647,497 (+)	NCBI		Celera
Cytogenetic Map	19	q12	NCBI

SPIRE2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	89,828,475 - 89,871,319 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	89,818,179 - 89,871,319 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	89,894,883 - 89,937,727 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	88,422,408 - 88,465,228 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	16	74,959,135 - 75,003,098 (+)	NCBI		Celera
Cytogenetic Map	16	q24.3	NCBI
HuRef	16	75,589,058 - 75,631,446 (+)	NCBI		HuRef
CHM1_1	16	91,306,174 - 91,348,994 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	16	95,913,065 - 95,956,358 (+)	NCBI		T2T-CHM13v2.0

Spire2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	124,059,452 - 124,096,257 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	124,059,452 - 124,096,254 (+)	Ensembl		GRCm39 Ensembl
GRCm38	8	123,332,713 - 123,369,518 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	123,332,713 - 123,369,515 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	125,856,613 - 125,893,418 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	126,218,803 - 126,255,608 (+)	NCBI		MGSCv36	mm8
Celera	8	127,573,872 - 127,611,690 (+)	NCBI		Celera
Cytogenetic Map	8	E1	NCBI
cM Map	8	72.1	NCBI

Spire2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955541	3,341,702 - 3,361,320 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955541	3,341,705 - 3,359,646 (+)	NCBI	ChiLan1.0	ChiLan1.0

SPIRE2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	99,670,328 - 99,723,881 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	105,557,415 - 105,611,338 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	70,580,030 - 70,634,143 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	90,247,214 - 90,300,104 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	90,273,160 - 90,299,061 (+)	Ensembl	panpan1.1		panPan2

SPIRE2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	63,732,855 - 63,765,162 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	63,732,842 - 63,753,419 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	63,745,844 - 63,778,279 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	63,961,037 - 63,993,491 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	63,961,857 - 63,993,497 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	63,981,142 - 64,013,579 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	63,818,643 - 63,850,783 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	64,225,009 - 64,257,453 (-)	NCBI		UU_Cfam_GSD_1.0

Spire2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	24,482,586 - 24,501,634 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936641	236,135 - 245,916 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936641	236,135 - 246,004 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SPIRE2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	211,487 - 243,561 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	211,480 - 246,109 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	337,123 - 369,176 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SPIRE2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	75,160,728 - 75,200,417 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	75,177,082 - 75,201,581 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666047	222,896 - 273,567 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Spire2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624746	164,712 - 193,346 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624746	164,712 - 193,346 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Spire2
325 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	63
Count of miRNA genes:	55
Interacting mature miRNAs:	56
Transcripts:	ENSRNOT00000022823
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2313395	Anxrr26	Anxiety related response QTL 26			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	19	49976481	53225766	Rat
1578764	Stresp19	Stress response QTL 19	3.6	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	19	15630201	57337602	Rat
61350	Bp32	Blood pressure QTL 32		0.012	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	19	20483575	57337602	Rat
5135224	Leukc1	Leukocyte quantity QTL 1			eosinophil quantity (VT:0002602)	blood eosinophil count (CMO:0000033)	19	44340214	55283277	Rat
724546	Kidm3	Kidney mass QTL 3	3.1		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	19	29322490	57337602	Rat
7411549	Bw130	Body weight QTL 130	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	19	15455860	57337602	Rat
1358200	Insglur2	Insulin/glucose ratio QTL 2	4.1		blood glucose amount (VT:0000188)	serum glucose level (CMO:0000543)	19	33838214	55283146	Rat
724566	Uae12	Urinary albumin excretion QTL 12	5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	19	2187927	56457239	Rat
1331737	Uae29	Urinary albumin excretion QTL 29	5.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	19	4096155	55283277	Rat
2298478	Eau8	Experimental allergic uveoretinitis QTL 8		0.0163	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	19	17154433	57337602	Rat

Markers in Region

D19Rat105

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	19	51,372,833 - 51,373,046 (+)	MAPPER	mRatBN7.2
Rnor_6.0	19	56,431,247 - 56,431,459	NCBI	Rnor6.0
Rnor_6.0	19	56,136,370 - 56,136,582	NCBI	Rnor6.0
Rnor_5.0	19	67,143,246 - 67,143,458	UniSTS	Rnor5.0
Rnor_5.0	19	66,847,374 - 66,847,586	UniSTS	Rnor5.0
RGSC_v3.4	19	53,658,086 - 53,658,298	RGD	RGSC3.4
RGSC_v3.4	19	53,658,087 - 53,658,299	UniSTS	RGSC3.4
RGSC_v3.1	19	53,662,967 - 53,663,179	RGD
Celera	19	50,608,678 - 50,608,882	UniSTS
SHRSP x BN Map	19	43.8499	UniSTS
SHRSP x BN Map	19	43.8499	RGD
Cytogenetic Map	19	q12	UniSTS

RH141514

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	19	68,319,510 - 68,320,209 (+)	Marker Load Pipeline
mRatBN7.2	19	51,411,003 - 51,411,702 (+)	MAPPER	mRatBN7.2
Rnor_6.0	19	56,174,584 - 56,175,282	NCBI	Rnor6.0
Rnor_5.0	19	66,885,299 - 66,886,176	UniSTS	Rnor5.0
RGSC_v3.4	19	53,696,369 - 53,697,067	UniSTS	RGSC3.4
Celera	19	50,646,581 - 50,647,279	UniSTS
RH 3.4 Map	19	713.51	UniSTS
Cytogenetic Map	19	q12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	8	24	113	82	81	50	16	50	6	171	60	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001127538	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC115273	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC132057	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC166756	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473972	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000019	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000022823 ⟹ ENSRNOP00000022823

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	19	51,373,368 - 51,411,920 (+)	Ensembl
Rnor_6.0 Ensembl	19	56,136,904 - 56,175,500 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000105637 ⟹ ENSRNOP00000087442

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	19	51,373,228 - 51,411,920 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000116216 ⟹ ENSRNOP00000086553

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	19	51,373,368 - 51,411,920 (+)	Ensembl

RefSeq Acc Id:

NM_001127538 ⟹ NP_001121010

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	68,281,878 - 68,320,427 (+)	NCBI
mRatBN7.2	19	51,373,368 - 51,411,920 (+)	NCBI
Rnor_6.0	19	56,136,904 - 56,175,500 (+)	NCBI
Rnor_5.0	19	67,143,780 - 67,144,041 (+)	NCBI
RGSC_v3.4	19	53,658,621 - 53,697,285 (+)	RGD
Celera	19	50,609,204 - 50,647,497 (+)	RGD

Sequence:

show sequence

GCGGCCATGGCCCGGGCGGGCGGCGGCGGCGCAGCAGCTCCCGAACGCGCGGGGGGCGCGGCGC
GGCCCGAGCCGTGGGAGCTGTCCCTGGAGGAAGTGCTGAAGGTGTACGAGCAGCCCATCAACGA
GGAGCAGGCCTGGGCGGTGTGCTTCCAGGGCTGCCGCGGGCTGCGGGGCGAGCCGGGCGGCGTG
CGGCGCATCCGGGACACGGCAGACATCCTCCTGCGTAGGGACGGCTCGGTTGGCGCGCGGCTGG
AGCCCGAGCCTTCGACCATGGTGGTCCCACCCGCCAACTCAGAAGCCCAGATGGTGCAGTCACT
GGGCTTTGCCATCTACCGTGCGCTGGACTGGGGGTTAGACGAGAATGAGGAGCGAGAGCTCAGC
CCGCAGCTGGAGAGGCTCATCGACCTCATGGCCAACAGCGACTGTGAAGACAGCAGCTGCGGGG
CAGCAGATGAGGGCTACGGGGGTCCAGAAGAGGAGGAGGAGGCTGAGGGCGGCCCCCGAGCTGT
GCGCACCTTTGCTCAGGCCATGCGGCTGTGTGCCTCACGCCTGACGGATCCCCACGGTGCGCAG
GCCCACTACCAGGCAGTGTGCCGAGCTCTCTTTGTGGAGACGCTCGAGCTCCGTGCCTTCCTGG
CCCGGGTGAGGGAGGCCAAAGAGATGCTGCAGAAGCTAGGAGAGGATGAGCCACGGGTAGAGAA
GCCGCTGGCCGAGCTCGACCACCTGGGACACACAGACTGGGCCCGGCTGTGGGTCCAGCTCATG
CGGGAGCTCCGTCACGGGGTGAAGCTGAAGAAGGTGCAAGAGAAGGAGTTCAACCCCCTGCCCA
CCGAGTTCCAGCTCACGCCCTTCGAGATGCTGATGCAGGATATCCGTGCCAGGAACTATAAGCT
GCGAAAGGTCATGGTCGATGGCGACATCCCTCCCCGAGTGAAGAAAGACGCCCATGAGCTCATC
CTGGACTTCATCCGTTCACGGCCTCCACTGAAGCAGGTCTCAGAGAGACGGCTTCGCCCTGTGC
CACAGAAGCAAAGAACACTGCACGAGAAGATCCTGGAGGAAATCAAACAGGAGCGGAGGCTTCG
TCCAGTAGGGGCCCAGCACTTGGGAGCCCGTGGGTTTGGTTCTCTGCCCTGCATCCTCAACGCC
TGCTCCGGGGACATCAAGTCCACTTCCTGCATCAACCTGTCTGTCACAGATGCTGGGAGTGGGA
GTCAGCGCCCACGGCCCCGGGTCCTGCTGAAAGCCCCGACCTTAGCAGAGATGGAAGAGATGAG
CACGCCTGAGGAAGAAGAGTCCCCATGTGGTGAGGTGGCGCTGAAGCGGGACCGCTCTTTTTCG
GAACACGACCTGGCCCAGCTTCGGAGTGAGATGGGATCTGGCCTTCAGTCAGCCACTCAGCCCC
CAGGAGGGACAGAGCCTCCTCGGGTCAGAGCAGGCAGCATGCACTCCTGGAGGCCCAGCACCCG
AGACCAGGGTCTCTGTTCTGTGAGTGGCCAGTCTCAGCCTCACCCCAGCAACTTGAGCTCAGCG
GATGGACCTGAGGCTTCTGCACCAGATGCCAGACATCTATGGCTGGAGTTCAGCCATCCTGTGG
AGAGCCTGGCTCTGACTGTAGAAGAGGTGGTAGATGTGCGGAGGGTGCTGGTGAAGGCAGAGAT
GGAGAAGTTTCTGCAGGACAAGGAGCTCTTCAGCAGCCTTAAGAGGGGGAAGATTTGTTGCTGC
TGCCGAACCAAGTTTCCCCTATTTTCCTGGCCACCTACCTGTCTCTTCTGCAAGAGAGCCGTGT
GCACTTCCTGTAGCGTAAAGATGAAGATGCCTTCCAAGAAGCATGGACACATCCCTGTGTACAC
ACTTGGTTTCGAGAGTCTCCAGAGGGTGCCAACTACCAAAGCCTCGCCAGCACTGAGGAGAGAC
GCCTTCCAATGCCTGCAGGGACCGAAGTGGCGGAGCGTGGAGGAGGAGTTCCCCCACATCTATG
CCCACGGCTGTGTCCTCAAGGACGTCTGCAGTGACTGCACCAGCTTTGTGGCTGACGTAGTGTG
CTCCAGCCGCAAGAGCGTGGATGTCCTCAATGCCACGCCACGGCGCAGCCACCAGACGCAGTCC
CTCTATGTCCCCAACACCAGGACTCTCAACTTCCAATGACTGTTTGATGGCCTCCCTGCACCCC
ACCCTGGAACACAGCTGCCATCAGCCCCCCCTCGCGCATGTACATATATACATATATAGATACA
TTTATAATATATATATGGCCTATATTTATTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001121010	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI66756	(Get FASTA)	NCBI Sequence Viewer
	EDL92806	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000022823.4
	ENSRNOP00000086553.1
	ENSRNOP00000087442.1

RefSeq Acc Id:

NP_001121010 ⟸ NM_001127538

- UniProtKB:

G3V870 (UniProtKB/TrEMBL), A6IZX8 (UniProtKB/TrEMBL), B2RYF2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MARAGGGGAAAPERAGGAARPEPWELSLEEVLKVYEQPINEEQAWAVCFQGCRGLRGEPGGVRR
IRDTADILLRRDGSVGARLEPEPSTMVVPPANSEAQMVQSLGFAIYRALDWGLDENEERELSPQ
LERLIDLMANSDCEDSSCGAADEGYGGPEEEEEAEGGPRAVRTFAQAMRLCASRLTDPHGAQAH
YQAVCRALFVETLELRAFLARVREAKEMLQKLGEDEPRVEKPLAELDHLGHTDWARLWVQLMRE
LRHGVKLKKVQEKEFNPLPTEFQLTPFEMLMQDIRARNYKLRKVMVDGDIPPRVKKDAHELILD
FIRSRPPLKQVSERRLRPVPQKQRTLHEKILEEIKQERRLRPVGAQHLGARGFGSLPCILNACS
GDIKSTSCINLSVTDAGSGSQRPRPRVLLKAPTLAEMEEMSTPEEEESPCGEVALKRDRSFSEH
DLAQLRSEMGSGLQSATQPPGGTEPPRVRAGSMHSWRPSTRDQGLCSVSGQSQPHPSNLSSADG
PEASAPDARHLWLEFSHPVESLALTVEEVVDVRRVLVKAEMEKFLQDKELFSSLKRGKICCCCR
TKFPLFSWPPTCLFCKRAVCTSCSVKMKMPSKKHGHIPVYTLGFESLQRVPTTKASPALRRDAF
QCLQGPKWRSVEEEFPHIYAHGCVLKDVCSDCTSFVADVVCSSRKSVDVLNATPRRSHQTQSLY
VPNTRTLNFQ

hide sequence

Ensembl Acc Id:

ENSRNOP00000022823 ⟸ ENSRNOT00000022823

Ensembl Acc Id:

ENSRNOP00000087442 ⟸ ENSRNOT00000105637

Ensembl Acc Id:

ENSRNOP00000086553 ⟸ ENSRNOT00000116216

Protein Domains

KIND

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-G3V870-F1-model_v2	AlphaFold	G3V870	1-714	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305837	AgrOrtholog
BioCyc Gene	G2FUF-5328	BioCyc
Ensembl Genes	ENSRNOG00000016920	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000022823.7	UniProtKB/TrEMBL
	ENSRNOT00000105637.1	UniProtKB/TrEMBL
	ENSRNOT00000116216.1	UniProtKB/TrEMBL
Gene3D-CATH	Transferase(Phosphotransferase) domain 1	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7930322	IMAGE-MGC_LOAD
InterPro	KIND	UniProtKB/TrEMBL
	Spire	UniProtKB/TrEMBL
	Znf_FYVE_PHD	UniProtKB/TrEMBL
KEGG Report	rno:307925	UniProtKB/TrEMBL
MGC_CLONE	MGC:188506	IMAGE-MGC_LOAD
NCBI Gene	307925	ENTREZGENE
PANTHER	PTHR21345	UniProtKB/TrEMBL
	PTHR21345:SF5	UniProtKB/TrEMBL
Pfam	KIND	UniProtKB/TrEMBL
PhenoGen	Spire2	PhenoGen
PROSITE	KIND	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000016920	RatGTEx
SMART	KIND	UniProtKB/TrEMBL
Superfamily-SCOP	FYVE_PHD_ZnF	UniProtKB/TrEMBL
UniProt	A0A8I6A365_RAT	UniProtKB/TrEMBL
	A0A8I6GF30_RAT	UniProtKB/TrEMBL
	A6IZX8	ENTREZGENE, UniProtKB/TrEMBL
	B2RYF2	ENTREZGENE, UniProtKB/TrEMBL
	G3V870	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-09-17	Spire2	spire-type actin nucleation factor 2	Spire2	spire homolog 2 (Drosophila)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Spire2	spire homolog 2 (Drosophila)	Spire2_predicted	spire homolog 2 (Drosophila) (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Spire2_predicted	spire homolog 2 (Drosophila) (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar