Tia1 (TIA1 cytotoxic granule-associated RNA binding protein) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Tia1 (TIA1 cytotoxic granule-associated RNA binding protein) Rattus norvegicus
Analyze
Symbol: Tia1
Name: TIA1 cytotoxic granule-associated RNA binding protein
RGD ID: 1305742
Description: Predicted to enable mRNA 3'-UTR AU-rich region binding activity. Involved in positive regulation of epithelial cell apoptotic process. Located in cytoplasmic stress granule. Part of ribonucleoprotein complex. Biomarker of transient cerebral ischemia. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 26. Orthologous to human TIA1 (TIA1 cytotoxic granule associated RNA binding protein); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cytotoxic granule associated RNA binding protein TIA1; cytotoxic granule-associated RNA binding protein 1; LOC312510; nucleolysin TIA-1; nucleolysin TIA-1 isoform p40
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84120,410,180 - 120,440,676 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4120,410,251 - 120,440,665 (+)EnsemblGRCr8
mRatBN7.24118,852,765 - 118,883,252 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4118,852,837 - 118,880,586 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4124,325,699 - 124,353,034 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04120,100,446 - 120,127,785 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04118,724,703 - 118,752,035 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04118,207,845 - 118,238,246 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4118,207,862 - 118,235,218 (+)Ensemblrn6Rnor6.0
Rnor_5.04182,779,104 - 182,809,496 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44120,590,164 - 120,617,530 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4107,824,561 - 107,851,859 (+)NCBICelera
RGSC_v3.14120,834,644 - 120,862,010 (+)NCBI
Cytogenetic Map4q34NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,4'-trichlorobiphenyl  (ISO)
2-butoxyethanol  (ISO)
2-methylcholine  (ISO)
3',5'-cyclic UMP  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetazolamide  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
clobetasol  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
cycloheximide  (EXP)
cyclosporin A  (ISO)
DDE  (ISO)
depsipeptide  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
disodium selenite  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
emetine  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
genistein  (ISO)
gentamycin  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
lead(0)  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
miconazole  (ISO)
mitoxantrone  (ISO)
N-[2-amino-6-[(4-fluorophenyl)methylamino]-3-pyridinyl]carbamic acid ethyl ester  (ISO)
nickel dichloride  (EXP,ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (ISO)
phenobarbital  (ISO)
potassium chromate  (ISO)
putrescine  (EXP)
quercetin  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
selenic acid  (ISO)
selenium atom  (ISO)
selenomethionine  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
Soman  (EXP)
spermidine  (EXP)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
thiram  (ISO)
topotecan  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO)
cytoplasmic stress granule  (IDA,IEA,ISO)
cytosol  (IEA,ISO)
nuclear stress granule  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IEA,ISO)
ribonucleoprotein complex  (IDA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. The proximal region of the 3'-untranslated region of cyclooxygenase-2 is recognized by a multimeric protein complex containing HuR, TIA-1, TIAR, and the heterogeneous nuclear ribonucleoprotein U. Cok SJ, etal., J Biol Chem. 2003 Sep 19;278(38):36157-62. Epub 2003 Jul 9.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Prolonged translation arrest in reperfused hippocampal cornu Ammonis 1 is mediated by stress granules. Kayali F, etal., Neuroscience. 2005;134(4):1223-45.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Polyamines inhibit the assembly of stress granules in normal intestinal epithelial cells regulating apoptosis. Zou T, etal., Am J Physiol Cell Physiol. 2012 Jul 1;303(1):C102-11. doi: 10.1152/ajpcell.00009.2012. Epub 2012 May 2.
Additional References at PubMed
PMID:10921895   PMID:11106748   PMID:12388085   PMID:12477932   PMID:16278295   PMID:17488725   PMID:21933836   PMID:21984414   PMID:22022532   PMID:22658674   PMID:22681889   PMID:24965446  
PMID:27430620   PMID:28131823  


Genomics

Comparative Map Data
Tia1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84120,410,180 - 120,440,676 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4120,410,251 - 120,440,665 (+)EnsemblGRCr8
mRatBN7.24118,852,765 - 118,883,252 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4118,852,837 - 118,880,586 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4124,325,699 - 124,353,034 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04120,100,446 - 120,127,785 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04118,724,703 - 118,752,035 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04118,207,845 - 118,238,246 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4118,207,862 - 118,235,218 (+)Ensemblrn6Rnor6.0
Rnor_5.04182,779,104 - 182,809,496 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44120,590,164 - 120,617,530 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4107,824,561 - 107,851,859 (+)NCBICelera
RGSC_v3.14120,834,644 - 120,862,010 (+)NCBI
Cytogenetic Map4q34NCBI
TIA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38270,209,444 - 70,248,793 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl270,209,444 - 70,248,761 (-)Ensemblhg38GRCh38
GRCh37270,436,576 - 70,475,925 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36270,292,318 - 70,329,251 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34270,350,466 - 70,387,398NCBI
Celera270,287,270 - 70,326,467 (-)NCBICelera
Cytogenetic Map2p13.3NCBI
HuRef270,173,346 - 70,212,582 (-)NCBIHuRef
CHM1_1270,366,164 - 70,405,367 (-)NCBICHM1_1
T2T-CHM13v2.0270,221,187 - 70,260,535 (-)NCBIT2T-CHM13v2.0
Tia1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39686,381,001 - 86,410,387 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl686,381,201 - 86,410,387 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38686,404,203 - 86,433,405 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl686,404,219 - 86,433,405 (+)Ensemblmm10GRCm38
MGSCv37686,354,213 - 86,383,399 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36686,369,948 - 86,399,039 (+)NCBIMGSCv36mm8
Celera688,341,646 - 88,371,036 (+)NCBICelera
Cytogenetic Map6D1NCBI
cM Map637.69NCBI
Tia1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542414,887,659 - 14,921,588 (+)Ensembl
ChiLan1.0NW_00495542414,887,722 - 14,920,844 (+)NCBIChiLan1.0ChiLan1.0
TIA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21256,147,686 - 56,188,133 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A56,151,623 - 56,191,324 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A70,264,568 - 70,303,913 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A71,381,348 - 71,420,208 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A71,380,881 - 71,420,533 (-)EnsemblpanPan2panpan1.1
TIA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11068,768,080 - 68,798,869 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1068,770,647 - 68,798,799 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1068,656,350 - 68,687,391 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01069,789,663 - 69,820,732 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1069,789,668 - 69,820,708 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11069,507,331 - 69,538,538 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01069,770,004 - 69,801,064 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01070,069,253 - 70,100,318 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tia1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629214,159,436 - 14,190,584 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649114,380,195 - 14,411,868 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493649114,381,107 - 14,411,931 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TIA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl372,240,600 - 72,277,296 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1372,240,535 - 72,281,811 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2375,704,293 - 75,718,683 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TIA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11436,866,379 - 36,902,683 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1436,866,414 - 36,903,246 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604575,109,659 - 75,143,962 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tia1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247623,184,985 - 3,221,183 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247623,185,632 - 3,220,406 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Tia1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1659,867,471 - 59,896,629 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tia1
95 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:81
Count of miRNA genes:74
Interacting mature miRNAs:78
Transcripts:ENSRNOT00000023103
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)496731383141731383Rat
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)486583980149763391Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4107346299152346299Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)439431983123203361Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)492406430137406430Rat
1300116Hrtrt5Heart rate QTL 53.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)4117737142152833657Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4112427331157427331Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4112427331157427331Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4117559384162559384Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
2306545Iddm39Insulin dependent diabetes mellitus QTL 39blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)478687630123687630Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)426234499134199155Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4111383604156383604Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4108206096153206096Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4106848959168870974Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)494638356168870820Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)474169813134199155Rat
634334Xhs3X-ray hypersensitivity QTL 310intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)486058928131411333Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)475939858140508796Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4111383604156383604Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482944895154403548Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)427862204126119996Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)475939858140508796Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)4100752691179366077Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)465060960127749483Rat
631662Hcar2Hepatocarcinoma resistance QTL 23.10.0003liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)484349032129349032Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463245026129846354Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)486709649168870974Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)457664252127749483Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
2306899Bp338Blood pressure QTL 3380.071arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)482336765127336765Rat
2293840Kiddil9Kidney dilation QTL 92.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)4113634167149763391Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)465495851159259805Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4116184844161184844Rat
1578670Bss14Bone structure and strength QTL 1416.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)488883695133883695Rat
70201Gcr1Gastric cancer resistance QTL 12.7stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)4103834277148834277Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)486583980131583980Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)457613339151163960Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
1578662Bss15Bone structure and strength QTL 1519.6femur width (VT:1000666)femoral neck width (CMO:0001695)488883695133883695Rat

Markers in Region
RH138064  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24118,871,491 - 118,871,686 (+)MAPPERmRatBN7.2
Rnor_6.04118,226,621 - 118,226,815NCBIRnor6.0
Rnor_5.04182,797,871 - 182,798,065UniSTSRnor5.0
RGSC_v3.44120,608,810 - 120,609,004UniSTSRGSC3.4
Celera4107,843,198 - 107,843,392UniSTS
RH 3.4 Map4694.3UniSTS
Cytogenetic Map4q34UniSTS
RH136064  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24118,872,930 - 118,873,076 (+)MAPPERmRatBN7.2
Rnor_6.04118,228,058 - 118,228,203NCBIRnor6.0
Rnor_5.04182,799,308 - 182,799,453UniSTSRnor5.0
RGSC_v3.44120,610,247 - 120,610,392UniSTSRGSC3.4
Celera4107,844,635 - 107,844,780UniSTS
Cytogenetic Map4q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001012096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001443678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001443679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001443680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001443681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006236828 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006236829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006236830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006236831 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286070 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005503216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005503217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005503218 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005503219 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005503220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005503221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC087064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000023103   ⟹   ENSRNOP00000023102
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4120,410,251 - 120,439,388 (+)Ensembl
mRatBN7.2 Ensembl4118,852,843 - 118,880,214 (+)Ensembl
Rnor_6.0 Ensembl4118,207,920 - 118,235,218 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000085787   ⟹   ENSRNOP00000071859
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4118,852,837 - 118,873,475 (+)Ensembl
Rnor_6.0 Ensembl4118,207,862 - 118,228,613 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000097697   ⟹   ENSRNOP00000095113
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4118,852,837 - 118,870,259 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107832   ⟹   ENSRNOP00000094527
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4120,410,268 - 120,438,010 (+)Ensembl
mRatBN7.2 Ensembl4118,852,837 - 118,880,586 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110929   ⟹   ENSRNOP00000096950
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4120,410,268 - 120,440,665 (+)Ensembl
mRatBN7.2 Ensembl4118,862,571 - 118,880,214 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112790   ⟹   ENSRNOP00000097874
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4120,410,273 - 120,437,547 (+)Ensembl
mRatBN7.2 Ensembl4118,852,837 - 118,880,123 (+)Ensembl
RefSeq Acc Id: NM_001012096   ⟹   NP_001012096
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84120,410,273 - 120,437,639 (+)NCBI
mRatBN7.24118,852,843 - 118,880,215 (+)NCBI
Rnor_6.04118,207,920 - 118,235,219 (+)NCBI
Rnor_5.04182,779,104 - 182,809,496 (+)NCBI
RGSC_v3.44120,590,164 - 120,617,530 (+)RGD
Celera4107,824,561 - 107,851,859 (+)RGD
Sequence:
RefSeq Acc Id: XM_006236828   ⟹   XP_006236890
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84120,410,180 - 120,440,676 (+)NCBI
mRatBN7.24118,852,771 - 118,883,242 (+)NCBI
Rnor_6.04118,207,846 - 118,238,246 (+)NCBI
Rnor_5.04182,779,104 - 182,809,496 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006236829   ⟹   XP_006236891
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84120,410,195 - 120,440,676 (+)NCBI
mRatBN7.24118,852,771 - 118,883,242 (+)NCBI
Rnor_6.04118,207,845 - 118,238,246 (+)NCBI
Rnor_5.04182,779,104 - 182,809,496 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006236830   ⟹   XP_006236892
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84120,410,180 - 120,440,676 (+)NCBI
mRatBN7.24118,852,771 - 118,883,242 (+)NCBI
Rnor_6.04118,207,847 - 118,238,246 (+)NCBI
Rnor_5.04182,779,104 - 182,809,496 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039107613   ⟹   XP_038963541
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84120,410,180 - 120,432,024 (+)NCBI
mRatBN7.24118,852,766 - 118,874,031 (+)NCBI
RefSeq Acc Id: XM_063286065   ⟹   XP_063142135
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84120,410,180 - 120,436,761 (+)NCBI
RefSeq Acc Id: XM_063286066   ⟹   XP_063142136
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84120,410,195 - 120,436,761 (+)NCBI
RefSeq Acc Id: XM_063286067   ⟹   XP_063142137
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84120,410,180 - 120,436,761 (+)NCBI
RefSeq Acc Id: XM_063286068   ⟹   XP_063142138
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84120,410,195 - 120,436,761 (+)NCBI
RefSeq Acc Id: XM_063286069   ⟹   XP_063142139
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84120,423,189 - 120,436,761 (+)NCBI
RefSeq Acc Id: XM_063286070   ⟹   XP_063142140
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84120,423,191 - 120,436,761 (+)NCBI
RefSeq Acc Id: XM_063286071   ⟹   XP_063142141
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84120,423,189 - 120,436,761 (+)NCBI
RefSeq Acc Id: XM_063286072   ⟹   XP_063142142
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84120,423,191 - 120,436,761 (+)NCBI
RefSeq Acc Id: XR_005503216
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84120,410,180 - 120,440,676 (+)NCBI
mRatBN7.24118,852,771 - 118,883,252 (+)NCBI
RefSeq Acc Id: XR_005503217
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84120,410,180 - 120,432,766 (+)NCBI
mRatBN7.24118,852,767 - 118,876,251 (+)NCBI
RefSeq Acc Id: XR_005503218
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84120,410,189 - 120,432,766 (+)NCBI
mRatBN7.24118,852,766 - 118,876,251 (+)NCBI
RefSeq Acc Id: XR_005503219
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84120,410,180 - 120,432,139 (+)NCBI
mRatBN7.24118,852,766 - 118,874,715 (+)NCBI
RefSeq Acc Id: XR_005503220
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84120,410,180 - 120,431,513 (+)NCBI
mRatBN7.24118,852,766 - 118,874,088 (+)NCBI
RefSeq Acc Id: XR_005503221
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84120,410,186 - 120,432,094 (+)NCBI
mRatBN7.24118,852,765 - 118,874,673 (+)NCBI
RefSeq Acc Id: NP_001012096   ⟸   NM_001012096
- UniProtKB: Q5PQR7 (UniProtKB/TrEMBL),   F7FKD5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236890   ⟸   XM_006236828
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AKZ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236891   ⟸   XM_006236829
- Peptide Label: isoform X5
- UniProtKB: A6IAW7 (UniProtKB/TrEMBL),   A0A8I6AKZ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236892   ⟸   XM_006236830
- Peptide Label: isoform X7
- UniProtKB: F7FKD5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071859   ⟸   ENSRNOT00000085787
Ensembl Acc Id: ENSRNOP00000023102   ⟸   ENSRNOT00000023103
RefSeq Acc Id: XP_038963541   ⟸   XM_039107613
- Peptide Label: isoform X10
- UniProtKB: A0A8I6ASW3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000094527   ⟸   ENSRNOT00000107832
Ensembl Acc Id: ENSRNOP00000095113   ⟸   ENSRNOT00000097697
Ensembl Acc Id: ENSRNOP00000097874   ⟸   ENSRNOT00000112790
Ensembl Acc Id: ENSRNOP00000096950   ⟸   ENSRNOT00000110929
RefSeq Acc Id: XP_063142135   ⟸   XM_063286065
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AKZ8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063142137   ⟸   XM_063286067
- Peptide Label: isoform X4
- UniProtKB: F7FKD5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063142136   ⟸   XM_063286066
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AKZ8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063142138   ⟸   XM_063286068
- Peptide Label: isoform X6
- UniProtKB: F7FKD5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063142139   ⟸   XM_063286069
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063142141   ⟸   XM_063286071
- Peptide Label: isoform X9
RefSeq Acc Id: XP_063142140   ⟸   XM_063286070
- Peptide Label: isoform X9
RefSeq Acc Id: XP_063142142   ⟸   XM_063286072
- Peptide Label: isoform X9
Protein Domains
RRM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5PQR7-F1-model_v2 AlphaFold Q5PQR7 1-375 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693213
Promoter ID:EPDNEW_R3733
Type:initiation region
Name:Tia1_1
Description:TIA1 cytotoxic granule-associated RNA binding protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04118,207,872 - 118,207,932EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305742 AgrOrtholog
BioCyc Gene G2FUF-43898 BioCyc
Ensembl Genes ENSRNOG00000016813 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023103 ENTREZGENE
  ENSRNOT00000023103.6 UniProtKB/TrEMBL
  ENSRNOT00000107832 ENTREZGENE
  ENSRNOT00000107832.2 UniProtKB/TrEMBL
  ENSRNOT00000110929 ENTREZGENE
  ENSRNOT00000110929.2 UniProtKB/TrEMBL
  ENSRNOT00000112790 ENTREZGENE
  ENSRNOT00000112790.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.330 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7132038 IMAGE-MGC_LOAD
InterPro Nucleotide-bd_a/b_plait_sf UniProtKB/TrEMBL
  RBD_domain_sf UniProtKB/TrEMBL
  RRM_dom_euk UniProtKB/TrEMBL
  RRM_RNP1 UniProtKB/TrEMBL
  TIA-1_RRM1 UniProtKB/TrEMBL
  TIA1_RRM2 UniProtKB/TrEMBL
  TIAR_RRM3 UniProtKB/TrEMBL
KEGG Report rno:312510 UniProtKB/TrEMBL
MGC_CLONE MGC:94287 IMAGE-MGC_LOAD
NCBI Gene 312510 ENTREZGENE
PANTHER EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G UniProtKB/TrEMBL
Pfam RRM_1 UniProtKB/TrEMBL
PhenoGen Tia1 PhenoGen
PROSITE RRM UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016813 RatGTEx
SMART RRM UniProtKB/TrEMBL
  RRM_1 UniProtKB/TrEMBL
Superfamily-SCOP SSF54928 UniProtKB/TrEMBL
UniProt A0A8I6AKZ8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AQH6_RAT UniProtKB/TrEMBL
  A0A8I6AS00_RAT UniProtKB/TrEMBL
  A0A8I6ASW3 ENTREZGENE
  A6IAW7 ENTREZGENE, UniProtKB/TrEMBL
  F7FKD5 ENTREZGENE, UniProtKB/TrEMBL
  Q5PQR7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-23 Tia1  TIA1 cytotoxic granule-associated RNA binding protein  Tia1  cytotoxic granule-associated RNA binding protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Tia1  cytotoxic granule-associated RNA binding protein 1  Tia1_predicted  cytotoxic granule-associated RNA binding protein 1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Tia1_predicted  cytotoxic granule-associated RNA binding protein 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED