TIA1 (TIA1 cytotoxic granule-associated RNA binding protein)

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Keyword

Gene: TIA1 (TIA1 cytotoxic granule-associated RNA binding protein) Homo sapiens

Symbol:

TIA1

Name:

TIA1 cytotoxic granule-associated RNA binding protein

Description:

The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms of this gene product has been described in the literature. [provided by RefSeq, Jul 2008]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

cytotoxic granule-associated RNA-binding protein; nucleolysin TIA-1 isoform p40; OTTHUMP00000160046; OTTHUMP00000160047; OTTHUMP00000204010; OTTHUMP00000204044; p40-TIA-1 (containing p15-TIA-1); RNA-binding protein TIA-1; T-cell-restricted intracellular antigen-1; TIA-1; TIA1 cytotoxic granule-associated RNA-binding protein; WDM

Orthologs:

Mus musculus : Tia1 (cytotoxic granule-associated RNA binding protein 1) MGI
Rattus norvegicus : Tia1 (TIA1 cytotoxic granule-associated RNA binding protein)

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	2	70,303,651 - 70,342,854	-	NCBI
Human Genome Assembly HuRef	2	70,173,346 - 70,212,582	-	NCBI
Human Genome Assembly GRCh37	2	70,436,576 - 70,475,779	-	NCBI
Human Genome Assembly Build 36	2	70,292,318 - 70,329,251	-	NCBI
Human Cytogenetic Map	2	p13		NCBI
Human Genome Assembly	2	70,350,466 - 70,387,398		NCBI