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Gene: Cadm2 (cell adhesion molecule 2) Rattus norvegicus

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Symbol:

Cadm2

Name:

cell adhesion molecule 2

RGD ID:

1305678

Description:

Involved in synaptic membrane adhesion. Located in axon and neuronal cell body membrane. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynaptic membrane. Human ortholog(s) of this gene implicated in autism spectrum disorder; malignant astrocytoma; obesity; psoriasis; and type 2 diabetes mellitus. Orthologous to human CADM2 (cell adhesion molecule 2); INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Igsf4d; immunoglobulin superfamily member 4D; immunoglobulin superfamily, member 4; LOC360687; Necl-3; nectin-like protein 3; synaptic cell adhesion molecule 2; SynCAM 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CADM2 (cell adhesion molecule 2)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Cadm2 (cell adhesion molecule 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Cadm2 (cell adhesion molecule 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CADM2 (cell adhesion molecule 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CADM2 (cell adhesion molecule 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Cadm2 (cell adhesion molecule 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CADM2 (cell adhesion molecule 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CADM2 (cell adhesion molecule 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Cadm2 (cell adhesion molecule 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Cadm2 (cell adhesion molecule 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	EPHA3 (EPH receptor A3)	HGNC	OMA
Homo sapiens (human):	STX19 (syntaxin 19)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	CADM2 (cell adhesion molecule 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Cadm2 (cell adhesion molecule 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	cadm2b (cell adhesion molecule 2b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	cadm2a (cell adhesion molecule 2a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	cadm2a (cell adhesion molecule 2a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	dpr16	Alliance	DIOPT (InParanoid\|SonicParanoid)
Drosophila melanogaster (fruit fly):	dpr19	Alliance	DIOPT (InParanoid\|SonicParanoid)
Drosophila melanogaster (fruit fly):	dpr15	Alliance	DIOPT (InParanoid\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	cadm2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	cadm2	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Fas3	Alliance	DIOPT (Ensembl Compara\|Hieranoid)

Allele / Splice:

Cadm2^{Tn(sb-T2/Bart3)2.180Mcwi}

Genetic Models:

F344-Cadm2^{Tn(sb-T2/Bart3)2.180Mcwi}

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	17,994,856 - 18,971,895 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	11	17,994,856 - 18,971,448 (-)	Ensembl				GRCr8
mRatBN7.2	11	4,548,367 - 5,525,420 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	4,555,159 - 5,525,400 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	11	13,151,919 - 14,120,737 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	5,945,843 - 6,914,696 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	5,050,918 - 6,019,774 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	4,175,078 - 4,397,335 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	4,174,881 - 4,397,361 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	11	7,871,257 - 8,090,100 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	11	4,273,771 - 5,330,393 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	11	4,517,639 - 5,495,475 (-)	NCBI		Celera
RGSC_v3.1	11	4,273,770 - 4,503,107 (-)	NCBI
Cytogenetic Map	11	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autism spectrum disorder (ISO)

hepatocellular carcinoma (ISO)

malignant astrocytoma (ISO)

obesity (ISO)

psoriasis (ISO)

retinoblastoma (ISO)

type 2 diabetes mellitus (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (EXP)

17alpha-ethynylestradiol (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

8-Br-cAMP (ISO)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

all-trans-retinoic acid (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP,ISO)

chlordecone (ISO)

cyclosporin A (ISO)

dioxygen (ISO)

dorsomorphin (ISO)

ethanol (ISO)

folic acid (ISO)

fulvestrant (ISO)

lead(0) (ISO)

mercury atom (ISO)

mercury dibromide (ISO)

mercury(0) (ISO)

methapyrilene (ISO)

methylmercury chloride (ISO)

nickel atom (ISO)

O-methyleugenol (ISO)

okadaic acid (ISO)

ozone (ISO)

paracetamol (EXP)

phenylmercury acetate (ISO)

pioglitazone (ISO)

propanal (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sodium fluoride (EXP)

thimerosal (ISO)

thiram (ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

valproic acid (EXP,ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell adhesion (IEA)

homophilic cell-cell adhesion (IBA)

synaptic membrane adhesion (IDA,IEP,IMP)

Cellular Component

axon (IDA)

GABA-ergic synapse (IDA,IEP,IMP)

glutamatergic synapse (IDA,IEP,IMP)

membrane (IEA)

neuronal cell body membrane (IBA,IDA)

plasma membrane (IEA)

postsynaptic membrane (IDA,IEP,IMP)

synapse (IEA)

Molecular Function

protein binding (IPI,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	A novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder.	Casey JP, etal., Hum Genet. 2012 Apr;131(4):565-79. doi: 10.1007/s00439-011-1094-6. Epub 2011 Oct 14.
2.	SynCAMs organize synapses through heterophilic adhesion.	Fogel AI, etal., J Neurosci. 2007 Nov 14;27(46):12516-30.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	A novel splicing variant of CADM2 as a protective transcript of psoriasis.	Hiruma A, etal., Biochem Biophys Res Commun. 2011 Sep 9;412(4):626-32. doi: 10.1016/j.bbrc.2011.08.013. Epub 2011 Aug 11.
5.	Downregulation of microRNA‑182 inhibits cell viability, invasion and angiogenesis in retinoblastoma through inhibition of the PI3K/AKT pathway and CADM2 upregulation.	Huang YX, etal., Int J Oncol. 2018 Dec;53(6):2615-2626. doi: 10.3892/ijo.2018.4587. Epub 2018 Oct 9.
6.	Genetic predictors of weight loss in overweight and obese subjects.	Lamiquiz-Moneo I, etal., Sci Rep. 2019 Jul 24;9(1):10770. doi: 10.1038/s41598-019-47283-5.
7.	CADM2 inhibits human glioma proliferation, migration and invasion.	Liu N, etal., Oncol Rep. 2019 Apr;41(4):2273-2280. doi: 10.3892/or.2019.7010. Epub 2019 Feb 13.
8.	Nectin-like proteins mediate axon Schwann cell interactions along the internode and are essential for myelination.	Maurel P, etal., J Cell Biol. 2007 Aug 27;178(5):861-74.
9.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
10.	Exploring single nucleotide polymorphisms previously related to obesity and metabolic traits in pediatric-onset type 2 diabetes.	Miranda-Lora AL, etal., Acta Diabetol. 2017 Jul;54(7):653-662. doi: 10.1007/s00592-017-0987-9. Epub 2017 Apr 12.
11.	The adhesion molecule Necl-3/SynCAM-2 localizes to myelinated axons, binds to oligodendrocytes and promotes cell adhesion.	Pellissier F, etal., BMC Neurosci. 2007 Oct 29;8:90.
12.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
14.	Low CADM2 expression predicts high recurrence risk of hepatocellular carcinoma patients after hepatectomy.	Yang S, etal., J Cancer Res Clin Oncol. 2014 Jan;140(1):109-16. doi: 10.1007/s00432-013-1536-8. Epub 2013 Nov 17.

Additional References at PubMed

PMID:22871113	PMID:29039453

Genomics

Comparative Map Data

Cadm2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	17,994,856 - 18,971,895 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	11	17,994,856 - 18,971,448 (-)	Ensembl				GRCr8
mRatBN7.2	11	4,548,367 - 5,525,420 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	4,555,159 - 5,525,400 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	11	13,151,919 - 14,120,737 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	5,945,843 - 6,914,696 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	5,050,918 - 6,019,774 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	4,175,078 - 4,397,335 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	4,174,881 - 4,397,361 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	11	7,871,257 - 8,090,100 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	11	4,273,771 - 5,330,393 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	11	4,517,639 - 5,495,475 (-)	NCBI		Celera
RGSC_v3.1	11	4,273,770 - 4,503,107 (-)	NCBI
Cytogenetic Map	11	p12	NCBI

CADM2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	84,958,989 - 86,074,429 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	84,958,989 - 86,074,429 (+)	Ensembl			hg38	GRCh38
GRCh37	3	85,008,140 - 86,123,579 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	85,858,322 - 86,200,641 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	3	85,858,321 - 86,200,638	NCBI
Celera	3	85,754,715 - 86,870,332 (+)	NCBI		Celera
Cytogenetic Map	3	p12.1	NCBI
HuRef	3	85,021,486 - 86,137,517 (+)	NCBI		HuRef
CHM1_1	3	84,960,228 - 86,075,698 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	3	85,024,005 - 86,146,272 (+)	NCBI		T2T-CHM13v2.0

Cadm2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	66,452,302 - 67,417,825 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	66,452,307 - 67,417,796 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	16	66,655,416 - 67,620,917 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	66,655,421 - 67,620,908 (-)	Ensembl			mm10	GRCm38
MGSCv37	16	66,655,666 - 67,621,153 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	16	66,579,334 - 67,539,146 (-)	NCBI		MGSCv36	mm8
Celera	16	66,933,305 - 67,895,289 (-)	NCBI		Celera
Cytogenetic Map	16	C1.3- C2	NCBI
cM Map	16	37.96	NCBI

Cadm2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955407	7,077,887 - 7,355,853 (-)	Ensembl
ChiLan1.0	NW_004955407	7,070,355 - 7,355,841 (-)	NCBI	ChiLan1.0	ChiLan1.0

CADM2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	85,096,880 - 86,213,586 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	85,869,821 - 86,218,375 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	85,076,738 - 86,200,515 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	87,200,283 - 88,318,087 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	87,200,482 - 88,310,438 (+)	Ensembl			panPan2	panpan1.1

CADM2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	31	1,872,005 - 2,931,942 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	31	1,879,585 - 2,931,452 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	31	1,923,826 - 2,990,923 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	31	1,868,368 - 2,932,068 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	31	1,869,206 - 2,931,641 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	31	1,838,209 - 2,904,288 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	31	1,892,951 - 2,955,130 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	31	2,224,471 - 3,287,100 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Cadm2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404971	3,300,333 - 4,297,753 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936610	3,305,551 - 3,598,837 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936610	3,304,556 - 4,297,745 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CADM2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	169,688,958 - 170,014,005 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	13	169,681,947 - 170,753,114 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	180,745,385 - 180,922,682 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CADM2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	90,879,537 - 91,994,144 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666041	74,824,798 - 75,904,006 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cadm2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624789	1,245,304 - 2,314,562 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624789	1,245,224 - 2,316,519 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Cadm2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	4	74,638,662 - 75,576,865 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Cadm2
8100 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	157
Count of miRNA genes:	125
Interacting mature miRNAs:	131
Transcripts:	ENSRNOT00000046370
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1598842	Glom10	Glomerulus QTL 10	3.4		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	11	3818154	48818154	Rat
1600394	Edcs1	Endometrial carcinoma susceptibility QTL1	2.9	0.04	uterus morphology trait (VT:0001120)	percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)	11	12823152	57823152	Rat
634339	Niddm50	Non-insulin dependent diabetes mellitus QTL 50	3.32		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	11	10806125	55806125	Rat

Markers in Region

D11Got5

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	5,094,127 - 5,094,363 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	12,960,913 - 12,961,148	NCBI	Rnor6.0
Rnor_5.0	11	16,620,702 - 16,620,937	UniSTS	Rnor5.0
RGSC_v3.4	11	4,815,879 - 4,816,115	RGD	RGSC3.4
RGSC_v3.4	11	4,815,880 - 4,816,115	UniSTS	RGSC3.4
Celera	11	5,066,743 - 5,066,978	UniSTS
RGSC_v3.1	11	4,815,880 - 4,816,115	RGD
RH 3.4 Map	11	0.0	RGD
RH 3.4 Map	11	0.0	UniSTS
RH 2.0 Map	11	775.5	RGD
Cytogenetic Map	11	p12	UniSTS

D11Got1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	5,094,166 - 5,094,350 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	12,960,952 - 12,961,135	NCBI	Rnor6.0
Rnor_5.0	11	16,620,741 - 16,620,924	UniSTS	Rnor5.0
RGSC_v3.4	11	4,815,918 - 4,816,102	RGD	RGSC3.4
RGSC_v3.4	11	4,815,919 - 4,816,102	UniSTS	RGSC3.4
Celera	11	5,066,782 - 5,066,965	UniSTS
RGSC_v3.1	11	4,815,918 - 4,816,102	RGD
RH 2.0 Map	11	803.6	RGD
Cytogenetic Map	11	p12	UniSTS

D11Mco8

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	4,728,703 - 4,728,950 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	4,349,717 - 4,349,963	NCBI	Rnor6.0
Rnor_5.0	11	8,043,362 - 8,043,608	UniSTS	Rnor5.0
Celera	11	4,701,802 - 4,702,048	UniSTS
Cytogenetic Map	11	p12	UniSTS

BF386655

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	4,569,659 - 4,569,834 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	4,188,829 - 4,189,003	NCBI	Rnor6.0
Rnor_5.0	11	7,885,091 - 7,885,265	UniSTS	Rnor5.0
RGSC_v3.4	11	4,288,166 - 4,288,340	UniSTS	RGSC3.4
Celera	11	4,543,279 - 4,543,453	UniSTS
Cytogenetic Map	11	p12	UniSTS

BF387017

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	4,907,960 - 4,908,141 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	12,760,789 - 12,760,969	NCBI	Rnor6.0
Rnor_5.0	11	16,421,247 - 16,421,427	UniSTS	Rnor5.0
RGSC_v3.4	11	4,628,760 - 4,628,940	UniSTS	RGSC3.4
Celera	11	4,880,105 - 4,880,285	UniSTS
Cytogenetic Map	11	p12	UniSTS

BF387497

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	5,474,121 - 5,474,271 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	13,346,949 - 13,347,098	NCBI	Rnor6.0
Rnor_5.0	11	17,000,642 - 17,000,791	UniSTS	Rnor5.0
RGSC_v3.4	11	5,277,567 - 5,277,716	UniSTS	RGSC3.4
Celera	11	5,444,945 - 5,445,094	UniSTS
Cytogenetic Map	11	p12	UniSTS

AU047486

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Celera	11	5,443,105 - 5,443,379	UniSTS
Cytogenetic Map	11	p12	UniSTS

RH137821

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	4,958,286 - 4,958,408 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	12,824,848 - 12,824,969	NCBI	Rnor6.0
Rnor_5.0	11	16,484,637 - 16,484,758	UniSTS	Rnor5.0
RGSC_v3.4	11	4,680,219 - 4,680,340	UniSTS	RGSC3.4
Celera	11	4,931,153 - 4,931,274	UniSTS
Cytogenetic Map	11	p12	UniSTS

AU048452

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	4,662,018 - 4,662,192 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	4,280,946 - 4,281,119	NCBI	Rnor6.0
Rnor_5.0	11	7,977,193 - 7,977,366	UniSTS	Rnor5.0
RGSC_v3.4	11	4,383,860 - 4,384,033	UniSTS	RGSC3.4
Celera	11	4,635,599 - 4,635,772	UniSTS
Cytogenetic Map	11	p12	UniSTS

Genetic Models

This gene Cadm2 is modified in the following models/strains:

F344-Cadm2^{Tn(sb-T2/Bart3)2.180Mcwi}

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
9	11	65	164	56	54	24	31	24	6	245	127	11	143	77	89	30	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001047102	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039088451	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039088453	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039088454	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039088455	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039088456	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063270608	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DQ272744	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000011	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000046370 ⟹ ENSRNOP00000040899

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	11	4,555,159 - 5,524,775 (-)	Ensembl
Rnor_6.0 Ensembl	11	4,175,078 - 4,397,361 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000087133 ⟹ ENSRNOP00000073563

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	11	4,555,159 - 4,711,060 (-)	Ensembl
Rnor_6.0 Ensembl	11	4,174,881 - 4,332,255 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000095471 ⟹ ENSRNOP00000093597

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	11	4,555,159 - 4,780,494 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000099827 ⟹ ENSRNOP00000088953

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	11	4,555,159 - 4,869,533 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000108768 ⟹ ENSRNOP00000082922

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	11	4,555,159 - 5,525,400 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000111554 ⟹ ENSRNOP00000088030

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	11	4,555,159 - 5,525,400 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000115818 ⟹ ENSRNOP00000081968

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	11	4,555,159 - 4,707,043 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000124799 ⟹ ENSRNOP00000109645

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	11	17,994,856 - 18,157,227 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000144814 ⟹ ENSRNOP00000108195

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	11	17,994,856 - 18,226,988 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000148613 ⟹ ENSRNOP00000099794

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	11	17,994,856 - 18,971,448 (-)	Ensembl

RefSeq Acc Id:

NM_001047102 ⟹ NP_001040567

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	17,994,856 - 18,971,886 (-)	NCBI
mRatBN7.2	11	4,548,367 - 5,525,412 (-)	NCBI
Rnor_6.0	11	4,175,078 - 4,397,335 (-)	NCBI
Rnor_5.0	11	7,871,257 - 8,090,100 (-)	NCBI
RGSC_v3.4	11	4,273,771 - 5,330,393 (-)	RGD
Celera	11	4,517,639 - 5,495,475 (-)	RGD

Sequence:

show sequence

ATGATTTGGAAACGCAGCGCGGTTCTCCGCTTCTACAGTGTCTGCGGGCTCCTGTTACAAGGCA
GCCAAGGGCAGTTTCCACTAACTCAGAATGTCACGGTTGTTGAAGGCGGAACTGCAATTCTGAC
CTGCAGAGTTGATCAAAATGATAACACCTCCCTCCAGTGGTCGAATCCAGCTCAGCAGACTCTG
TACTTCGATGACAAGAAAGCTTTGAGGGACAATCGGATCGAGCTGGTTCGCGCTTCTTGGCATG
AGTTGAGCATCAGTGTCAGTGACGTGTCTCTCTCTGATGAAGGACAGTACACCTGTTCCTTATT
TACAATGCCTGTCAAAACCTCCAAGGCCTATCTCACTGTCCTGGGTGTTCCAGAGAAGCCTCAG
ATTAGTGGATTTTCATCCCCAGTCATGGAGGGAGACCTGATGCAGCTGACTTGCAAGACGTCAG
GCAGTAAGCCTGCGGCTGATATAAGATGGTTCAAAAATGACAAAGAGATCAAAGATGTGAAGTA
CTTGAAGGAAGAGGATGCTAACCGCAAGACCTTCACCGTCAGCAGCACACTGGATTTCCGAGTG
GACCGTAGCGATGATGGAGTGGCGGTCATCTGCAGAGTAGACCACGAGTCCCTCAATGCCACCC
CTCAGGTAGCCATGCAGGTGCTAGAAATACACTATACACCATCAGTGAAGATTATACCATCCAC
TCCTTTTCCACAAGAAGGACAGGCTTTAACATTGACTTGTGAATCTAAAGGAAAACCACTGCCA
GAACCTGTTTTGTGGACGAAGGATGGGGCAGAATTACCAGATCCTGATCGAATGGTTGTGAGTG
GTAGGGAACTCAACATTCTCTTCCTGAACAAAACGGACAATGGCACTTATCGATGCGAAGCCAC
TAACACCATTGGTCAAAGCAGCGCAGAGTACGTCCTCATTGTACACGATCCCAATTCTCTGGCT
GGTCAGAATGGCCCTGACCATGCTCTCATAGGCGGCATAGTGGCTGTGGTTGTATTTGTTACCC
TGTGCTCCATATTCCTGCTTGGCCGATATCTGGCAAGACATAAAGGAACATATCTCACAAACGA
AGCTAAAGGAGCCGAAGACGCACCAGATGCCGACACAGCCATTATCAATGCTGAAGGCAGCCAA
GTCAATGCCGAAGAGAAAAAAGAGTATTTCATTTAA

hide sequence

RefSeq Acc Id:

XM_039088451 ⟹ XP_038944379

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	17,994,856 - 18,971,895 (-)	NCBI
mRatBN7.2	11	4,548,367 - 5,525,420 (-)	NCBI

RefSeq Acc Id:

XM_039088453 ⟹ XP_038944381

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	17,994,856 - 18,971,895 (-)	NCBI
mRatBN7.2	11	4,548,367 - 5,525,420 (-)	NCBI

RefSeq Acc Id:

XM_039088454 ⟹ XP_038944382

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	17,994,856 - 18,971,894 (-)	NCBI
mRatBN7.2	11	4,548,367 - 5,525,420 (-)	NCBI

RefSeq Acc Id:

XM_039088455 ⟹ XP_038944383

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	17,994,856 - 18,153,563 (-)	NCBI
mRatBN7.2	11	4,548,367 - 4,707,055 (-)	NCBI

RefSeq Acc Id:

XM_039088456 ⟹ XP_038944384

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	17,994,856 - 18,154,039 (-)	NCBI
mRatBN7.2	11	4,548,367 - 4,707,548 (-)	NCBI

RefSeq Acc Id:

XM_063270608 ⟹ XP_063126678

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	17,994,856 - 18,153,574 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001040567	(Get FASTA)	NCBI Sequence Viewer
	XP_038944379	(Get FASTA)	NCBI Sequence Viewer
	XP_038944381	(Get FASTA)	NCBI Sequence Viewer
	XP_038944382	(Get FASTA)	NCBI Sequence Viewer
	XP_038944383	(Get FASTA)	NCBI Sequence Viewer
	XP_038944384	(Get FASTA)	NCBI Sequence Viewer
	XP_063126678	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	ABB85363	(Get FASTA)	NCBI Sequence Viewer
	EDL75913	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000099794
	ENSRNOP00000108195
	ENSRNOP00000109645
GenBank Protein	Q1WIM2	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001040567 ⟸ NM_001047102
- Peptide Label:	precursor
- UniProtKB:	Q1WIM2 (UniProtKB/Swiss-Prot), A0A8I6A950 (UniProtKB/TrEMBL)
- Sequence:	show sequence MIWKRSAVLRFYSVCGLLLQGSQGQFPLTQNVTVVEGGTAILTCRVDQNDNTSLQWSNPAQQTL YFDDKKALRDNRIELVRASWHELSISVSDVSLSDEGQYTCSLFTMPVKTSKAYLTVLGVPEKPQ ISGFSSPVMEGDLMQLTCKTSGSKPAADIRWFKNDKEIKDVKYLKEEDANRKTFTVSSTLDFRV DRSDDGVAVICRVDHESLNATPQVAMQVLEIHYTPSVKIIPSTPFPQEGQALTLTCESKGKPLP EPVLWTKDGAELPDPDRMVVSGRELNILFLNKTDNGTYRCEATNTIGQSSAEYVLIVHDPNSLA GQNGPDHALIGGIVAVVVFVTLCSIFLLGRYLARHKGTYLTNEAKGAEDAPDADTAIINAEGSQ VNAEEKKEYFI hide sequence

Ensembl Acc Id:

ENSRNOP00000073563 ⟸ ENSRNOT00000087133

Ensembl Acc Id:

ENSRNOP00000040899 ⟸ ENSRNOT00000046370

RefSeq Acc Id:	XP_038944381 ⟸ XM_039088453
- Peptide Label:	isoform X2
- UniProtKB:	Q1WIM2 (UniProtKB/Swiss-Prot), A0A8I5ZY73 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038944382 ⟸ XM_039088454
- Peptide Label:	isoform X3
- UniProtKB:	Q1WIM2 (UniProtKB/Swiss-Prot), A0A0A0MY16 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038944379 ⟸ XM_039088451
- Peptide Label:	isoform X1
- UniProtKB:	Q1WIM2 (UniProtKB/Swiss-Prot)

RefSeq Acc Id:	XP_038944384 ⟸ XM_039088456
- Peptide Label:	isoform X4
- UniProtKB:	A0A0G2K5U6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038944383 ⟸ XM_039088455
- Peptide Label:	isoform X4
- UniProtKB:	A0A0G2K5U6 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000088030 ⟸ ENSRNOT00000111554

Ensembl Acc Id:

ENSRNOP00000093597 ⟸ ENSRNOT00000095471

Ensembl Acc Id:

ENSRNOP00000088953 ⟸ ENSRNOT00000099827

Ensembl Acc Id:

ENSRNOP00000081968 ⟸ ENSRNOT00000115818

Ensembl Acc Id:

ENSRNOP00000082922 ⟸ ENSRNOT00000108768

RefSeq Acc Id:	XP_063126678 ⟸ XM_063270608
- Peptide Label:	isoform X5

Ensembl Acc Id:

ENSRNOP00000109645 ⟸ ENSRNOT00000124799

Ensembl Acc Id:

ENSRNOP00000099794 ⟸ ENSRNOT00000148613

Ensembl Acc Id:

ENSRNOP00000108195 ⟸ ENSRNOT00000144814

Protein Domains

Ig-like C2-type Ig-like V-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q1WIM2-F1-model_v2	AlphaFold	Q1WIM2	1-435	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305678	AgrOrtholog
BioCyc Gene	G2FUF-22296	BioCyc
Ensembl Genes	ENSRNOG00000030840	Ensembl
	ENSRNOG00000074750	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000124799	ENTREZGENE
	ENSRNOT00000144814	ENTREZGENE
	ENSRNOT00000148613	ENTREZGENE
Gene3D-CATH	2.60.40.10	UniProtKB/Swiss-Prot
InterPro	CD80_C2-set	UniProtKB/Swiss-Prot
	Ig-like_dom	UniProtKB/Swiss-Prot
	Ig-like_dom_sf	UniProtKB/Swiss-Prot
	Ig-like_fold	UniProtKB/Swiss-Prot
	Ig_sub	UniProtKB/Swiss-Prot
	Ig_sub2	UniProtKB/Swiss-Prot
	Ig_V-set	UniProtKB/Swiss-Prot
	Neurexin-like	UniProtKB/Swiss-Prot
KEGG Report	rno:360687	UniProtKB/Swiss-Prot
NCBI Gene	360687	ENTREZGENE
PANTHER	CELL ADHESION MOLECULE 2	UniProtKB/Swiss-Prot
	IG-LIKE DOMAIN-CONTAINING PROTEIN	UniProtKB/Swiss-Prot
Pfam	C2-set_2	UniProtKB/Swiss-Prot
	Ig_3	UniProtKB/Swiss-Prot
	V-set	UniProtKB/Swiss-Prot
PhenoGen	Cadm2	PhenoGen
PROSITE	IG_LIKE	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000030840	RatGTEx
	ENSRNOG00000074750	RatGTEx
SMART	4.1m	UniProtKB/Swiss-Prot
	IGc2	UniProtKB/Swiss-Prot
	SM00409	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF48726	UniProtKB/Swiss-Prot
UniProt	A0A0A0MY16	ENTREZGENE
	A0A0G2K5U6	ENTREZGENE
	A0A8I5ZY73	ENTREZGENE
	A0A8I6A950	ENTREZGENE
	A0ABK0LBX7_RAT	UniProtKB/TrEMBL
	A0ABK0LG21_RAT	UniProtKB/TrEMBL
	A0ABK0LYP2_RAT	UniProtKB/TrEMBL
	CADM2_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-03-04	Cadm2	cell adhesion molecule 2	Igsf4d_predicted	immunoglobulin superfamily, member 4 (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-12	Igsf4d_predicted	immunoglobulin superfamily, member 4 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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