Imported Disease Annotations - ClinVarTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | genetic disease | | ISO | CADM2 (Homo sapiens) | 8554872 | ClinVar Annotator: match by term: Inborn genetic diseases | ClinVar | | |
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Imported Disease Annotations - ClinVarTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | genetic disease | | ISO | CADM2 (Homo sapiens) | 8554872 | ClinVar Annotator: match by term: Inborn genetic diseases | ClinVar | | |
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# | Reference Title | Reference Citation |
1. | A novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder. | Casey JP, etal., Hum Genet. 2012 Apr;131(4):565-79. doi: 10.1007/s00439-011-1094-6. Epub 2011 Oct 14. |
2. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
3. | A novel splicing variant of CADM2 as a protective transcript of psoriasis. | Hiruma A, etal., Biochem Biophys Res Commun. 2011 Sep 9;412(4):626-32. doi: 10.1016/j.bbrc.2011.08.013. Epub 2011 Aug 11. |
4. | Downregulation of microRNA‑182 inhibits cell viability, invasion and angiogenesis in retinoblastoma through inhibition of the PI3K/AKT pathway and CADM2 upregulation. | Huang YX, etal., Int J Oncol. 2018 Dec;53(6):2615-2626. doi: 10.3892/ijo.2018.4587. Epub 2018 Oct 9. |
5. | Genetic predictors of weight loss in overweight and obese subjects. | Lamiquiz-Moneo I, etal., Sci Rep. 2019 Jul 24;9(1):10770. doi: 10.1038/s41598-019-47283-5. |
6. | CADM2 inhibits human glioma proliferation, migration and invasion. | Liu N, etal., Oncol Rep. 2019 Apr;41(4):2273-2280. doi: 10.3892/or.2019.7010. Epub 2019 Feb 13. |
7. | Nectin-like proteins mediate axon Schwann cell interactions along the internode and are essential for myelination. | Maurel P, etal., J Cell Biol. 2007 Aug 27;178(5):861-74. |
8. | Rat ISS GO annotations from MGI mouse gene data--August 2006 | MGD data from the GO Consortium |
9. | Exploring single nucleotide polymorphisms previously related to obesity and metabolic traits in pediatric-onset type 2 diabetes. | Miranda-Lora AL, etal., Acta Diabetol. 2017 Jul;54(7):653-662. doi: 10.1007/s00592-017-0987-9. Epub 2017 Apr 12. |
10. | The adhesion molecule Necl-3/SynCAM-2 localizes to myelinated axons, binds to oligodendrocytes and promotes cell adhesion. | Pellissier F, etal., BMC Neurosci. 2007 Oct 29;8:90. |
11. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
12. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
13. | Low CADM2 expression predicts high recurrence risk of hepatocellular carcinoma patients after hepatectomy. | Yang S, etal., J Cancer Res Clin Oncol. 2014 Jan;140(1):109-16. doi: 10.1007/s00432-013-1536-8. Epub 2013 Nov 17. |
Cadm2 (Rattus norvegicus - Norway rat) |
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CADM2 (Homo sapiens - human) |
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Cadm2 (Mus musculus - house mouse) |
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Cadm2 (Chinchilla lanigera - long-tailed chinchilla) |
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CADM2 (Pan paniscus - bonobo/pygmy chimpanzee) |
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CADM2 (Canis lupus familiaris - dog) |
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Cadm2 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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CADM2 (Sus scrofa - pig) |
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CADM2 (Chlorocebus sabaeus - green monkey) |
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Cadm2 (Heterocephalus glaber - naked mole-rat) |
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Variants in Cadm2
3142 total Variants |
The detailed report is available here: | Full Report | CSV | TAB | Printer | ||||
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
The following QTLs overlap with this region. | Full Report | CSV | TAB | Printer | Gviewer |
D11Got5 |
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D11Got1 |
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D11Mco8 |
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BF386655 |
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BF387017 |
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BF387497 |
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AU047486 |
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RH137821 |
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AU048452 |
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alimentary part of gastrointestinal system | circulatory system | endocrine system | exocrine system | hemolymphoid system | hepatobiliary system | integumental system | musculoskeletal system | nervous system | renal system | reproductive system | respiratory system | appendage | |
High | |||||||||||||
Medium | 58 | 4 | |||||||||||
Low | 1 | 20 | 6 | 1 | 1 | 1 | 14 | 10 | 25 | 6 | 1 | ||
Below cutoff | 2 | 21 | 20 | 10 | 18 | 10 | 7 | 9 | 2 | 24 | 11 | 4 | 7 |
RefSeq Acc Id: | ENSRNOT00000046370 ⟹ ENSRNOP00000040899 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000087133 ⟹ ENSRNOP00000073563 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000095471 ⟹ ENSRNOP00000093597 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000099827 ⟹ ENSRNOP00000088953 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000108768 ⟹ ENSRNOP00000082922 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000111554 ⟹ ENSRNOP00000088030 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000115818 ⟹ ENSRNOP00000081968 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | NM_001047102 ⟹ NP_001040567 | ||||||||||||||||||||||||||||
RefSeq Status: | VALIDATED | ||||||||||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_039088451 ⟹ XP_038944379 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | XM_039088453 ⟹ XP_038944381 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | XM_039088454 ⟹ XP_038944382 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | XM_039088455 ⟹ XP_038944383 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | XM_039088456 ⟹ XP_038944384 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | XM_063270608 ⟹ XP_063126678 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | NP_001040567 ⟸ NM_001047102 |
- Peptide Label: | precursor |
- UniProtKB: | Q1WIM2 (UniProtKB/Swiss-Prot), A0A8I6A950 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | ENSRNOP00000073563 ⟸ ENSRNOT00000087133 |
RefSeq Acc Id: | ENSRNOP00000040899 ⟸ ENSRNOT00000046370 |
RefSeq Acc Id: | XP_038944381 ⟸ XM_039088453 |
- Peptide Label: | isoform X2 |
- UniProtKB: | Q1WIM2 (UniProtKB/Swiss-Prot), A0A8I5ZY73 (UniProtKB/TrEMBL) |
RefSeq Acc Id: | XP_038944382 ⟸ XM_039088454 |
- Peptide Label: | isoform X3 |
- UniProtKB: | Q1WIM2 (UniProtKB/Swiss-Prot), A0A0A0MY16 (UniProtKB/TrEMBL) |
RefSeq Acc Id: | XP_038944379 ⟸ XM_039088451 |
- Peptide Label: | isoform X1 |
- UniProtKB: | Q1WIM2 (UniProtKB/Swiss-Prot) |
RefSeq Acc Id: | XP_038944384 ⟸ XM_039088456 |
- Peptide Label: | isoform X4 |
- UniProtKB: | A0A0G2K5U6 (UniProtKB/TrEMBL) |
RefSeq Acc Id: | XP_038944383 ⟸ XM_039088455 |
- Peptide Label: | isoform X4 |
- UniProtKB: | A0A0G2K5U6 (UniProtKB/TrEMBL) |
RefSeq Acc Id: | ENSRNOP00000088030 ⟸ ENSRNOT00000111554 |
RefSeq Acc Id: | ENSRNOP00000093597 ⟸ ENSRNOT00000095471 |
RefSeq Acc Id: | ENSRNOP00000088953 ⟸ ENSRNOT00000099827 |
RefSeq Acc Id: | ENSRNOP00000081968 ⟸ ENSRNOT00000115818 |
RefSeq Acc Id: | ENSRNOP00000082922 ⟸ ENSRNOT00000108768 |
RefSeq Acc Id: | XP_063126678 ⟸ XM_063270608 |
- Peptide Label: | isoform X5 |
Name | Modeler | Protein Id | AA Range | Protein Structure |
AF-Q1WIM2-F1-model_v2 | AlphaFold | Q1WIM2 | 1-435 | view protein structure |
eQTL | View at Phenogen | |
WGCNA | View at Phenogen | |
Tissue/Strain Expression | View at Phenogen |
Database | Acc Id | Source(s) |
AGR Gene | RGD:1305678 | AgrOrtholog |
BioCyc Gene | G2FUF-22296 | BioCyc |
Ensembl Genes | ENSRNOG00000030840 | Ensembl, ENTREZGENE, UniProtKB/TrEMBL |
Ensembl Transcript | ENSRNOT00000046370 | ENTREZGENE |
ENSRNOT00000046370.6 | UniProtKB/TrEMBL | |
ENSRNOT00000087133.2 | UniProtKB/TrEMBL | |
ENSRNOT00000095471.1 | UniProtKB/TrEMBL | |
ENSRNOT00000099827.1 | UniProtKB/TrEMBL | |
ENSRNOT00000108768.1 | UniProtKB/TrEMBL | |
ENSRNOT00000111554 | ENTREZGENE | |
ENSRNOT00000111554.1 | UniProtKB/TrEMBL | |
ENSRNOT00000115818.1 | UniProtKB/TrEMBL | |
Gene3D-CATH | 2.60.40.10 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
InterPro | CD80_C2-set | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
Ig-like_dom | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Ig-like_dom_sf | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Ig-like_fold | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Ig_sub | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Ig_sub2 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Ig_V-set | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Neurexin-like | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
KEGG Report | rno:360687 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
NCBI Gene | 360687 | ENTREZGENE |
PANTHER | CELL ADHESION MOLECULE 2 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
IG-LIKE DOMAIN-CONTAINING PROTEIN | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Pfam | C2-set_2 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
Ig_3 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
V-set | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PhenoGen | Cadm2 | PhenoGen |
PIRSF | TyrPK_CSF1-R | UniProtKB/TrEMBL |
PROSITE | IG_LIKE | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
RatGTEx | ENSRNOG00000030840 | RatGTEx |
SMART | 4.1m | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
IGc2 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
SM00409 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Superfamily-SCOP | SSF48726 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
UniProt | A0A0A0MY16 | ENTREZGENE, UniProtKB/TrEMBL |
A0A0G2K5U6 | ENTREZGENE, UniProtKB/TrEMBL | |
A0A8I5ZU16_RAT | UniProtKB/TrEMBL | |
A0A8I5ZY73 | ENTREZGENE, UniProtKB/TrEMBL | |
A0A8I6A666_RAT | UniProtKB/TrEMBL | |
A0A8I6A950 | ENTREZGENE, UniProtKB/TrEMBL | |
A0A8I6GKD0_RAT | UniProtKB/TrEMBL | |
CADM2_RAT | UniProtKB/Swiss-Prot, ENTREZGENE |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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2008-03-04 | Cadm2 | cell adhesion molecule 2 | Igsf4d_predicted | immunoglobulin superfamily, member 4 (predicted) | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2005-01-12 | Igsf4d_predicted | immunoglobulin superfamily, member 4 (predicted) | Symbol and Name status set to approved | 70820 | APPROVED |