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Gene: Mkx (mohawk homeobox) Rattus norvegicus

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Symbol:

Mkx

Name:

mohawk homeobox

RGD ID:

1305652

Description:

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including cellular response to mechanical stimulus; intratendonous ossification; and negative regulation of cell differentiation. Predicted to be active in nucleus. Orthologous to human MKX (mohawk homeobox); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

homeobox protein Mohawk; iroquois homeobox protein-like 1; Irxl1; LOC100912277; LOC103694111; LOC291228; RGD1305652; similar to hypothetical protein MGC39616; uncharacterized LOC100912277; uncharacterized LOC103694111

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MKX (mohawk homeobox)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Mkx (mohawk homeobox)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Mkx (mohawk homeobox)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MKX (mohawk homeobox)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	LOC487079 (homeobox protein Mohawk)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Mkx (mohawk homeobox)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MKX (mohawk homeobox)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	MKX (mohawk homeobox)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Mkx (mohawk homeobox)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Mkx (mohawk homeobox)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	MKX (mohawk homeobox)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Mkx (mohawk homeobox)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	mkxa (mohawk homeobox a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	mkxa (mohawk homeobox a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	mkxb (mohawk homeobox b)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoInspector\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	mkxb (mohawk homeobox b)	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG11617	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG11617	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	mkx	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	mkx	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Allele / Splice:

Mkx^em1Asah

Genetic Models:

W-Mkx^em1Asah

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	59,772,113 - 59,851,160 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	17	59,773,570 - 59,850,345 (-)	Ensembl				GRCr8
mRatBN7.2	17	55,077,073 - 55,156,877 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	55,077,540 - 55,156,124 (-)	Ensembl				mRatBN7.2
Rnor_6.0	17	60,537,615 - 60,553,284 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	60,537,935 - 60,549,750 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	17	62,321,329 - 62,332,471 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	17	63,631,540 - 63,710,138 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	17	56,416,753 - 56,495,058 (-)	NCBI		Celera
RGSC_v3.1	17	63,642,477 - 63,722,172 (-)	NCBI
Cytogenetic Map	17	q12.1	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Heterotopic Ossification (IMP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

4,4'-sulfonyldiphenol (ISO)

5-fluorouracil (ISO)

aflatoxin B1 (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

cadmium dichloride (EXP)

choline (ISO)

chromium(6+) (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

dimethylarsinic acid (ISO)

folic acid (ISO)

genistein (ISO)

gentamycin (EXP)

GSK-J4 (ISO)

irinotecan (ISO)

L-methionine (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

methylarsonic acid (ISO)

N,N-diethyl-m-toluamide (EXP)

nickel atom (ISO)

nickel sulfate (ISO)

octadecanoic acid (ISO)

okadaic acid (ISO)

paracetamol (EXP)

perfluorononanoic acid (ISO)

permethrin (EXP)

potassium chromate (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

tetrachloromethane (EXP)

Theaflavin 3,3'-digallate (ISO)

titanium dioxide (ISO)

trichostatin A (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

animal organ development (IEA)

cell development (IBA)

cellular response to mechanical stimulus (IMP)

collagen fibril organization (ISO)

intratendonous ossification (IMP)

muscle organ development (IBA,ISO)

negative regulation of chondrocyte differentiation (IMP)

negative regulation of fat cell differentiation (IMP)

negative regulation of myoblast differentiation (ISO)

negative regulation of ossification (IMP)

negative regulation of transcription by RNA polymerase II (ISO)

positive regulation of collagen biosynthetic process (ISO)

positive regulation of gene expression (ISO)

positive regulation of transcription by RNA polymerase II (ISO)

regulation of DNA-templated transcription (IEA)

regulation of gene expression (ISO)

regulation of transcription by RNA polymerase II (IBA,IEA)

tendon cell differentiation (IMP,ISO)

tendon formation (ISO)

tendon sheath development (ISO)

Cellular Component

nucleus (IBA,IEA)

Molecular Function

DNA binding (IEA)

DNA-binding transcription activator activity, RNA polymerase II-specific (ISO)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA,IEA,ISO)

DNA-binding transcription repressor activity, RNA polymerase II-specific (ISO)

protein binding (ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA,ISO)

RNA polymerase II-specific DNA-binding transcription factor binding (ISO)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal gait (IMP)

abnormal tendon collagen fibril morphology (IMP)

abnormal tendon morphology (IMP)

decreased tendon stiffness (IMP)

increased bone ossification (IMP)

wavy tail (IMP)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
5.	Gene targeting of the transcription factor Mohawk in rats causes heterotopic ossification of Achilles tendon via failed tenogenesis.	Suzuki H, etal., Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):7840-5. doi: 10.1073/pnas.1522054113. Epub 2016 Jul 1.

Additional References at PubMed

PMID:16408284	PMID:19235719	PMID:20498044	PMID:20696843	PMID:21254332	PMID:22923612	PMID:28750046

Genomics

Comparative Map Data

Mkx
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	59,772,113 - 59,851,160 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	17	59,773,570 - 59,850,345 (-)	Ensembl				GRCr8
mRatBN7.2	17	55,077,073 - 55,156,877 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	55,077,540 - 55,156,124 (-)	Ensembl				mRatBN7.2
Rnor_6.0	17	60,537,615 - 60,553,284 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	60,537,935 - 60,549,750 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	17	62,321,329 - 62,332,471 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	17	63,631,540 - 63,710,138 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	17	56,416,753 - 56,495,058 (-)	NCBI		Celera
RGSC_v3.1	17	63,642,477 - 63,722,172 (-)	NCBI
Cytogenetic Map	17	q12.1	NCBI

MKX
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	27,672,874 - 27,745,819 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	27,672,874 - 27,746,060 (-)	Ensembl			hg38	GRCh38
GRCh37	10	27,961,803 - 28,034,748 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	28,001,809 - 28,074,753 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	10	28,001,811 - 28,074,753	NCBI
Celera	10	27,725,254 - 27,798,252 (-)	NCBI		Celera
Cytogenetic Map	10	p12.1	NCBI
HuRef	10	27,678,080 - 27,751,075 (-)	NCBI		HuRef
CHM1_1	10	27,961,725 - 28,034,733 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	10	27,703,607 - 27,776,565 (-)	NCBI		T2T-CHM13v2.0

Mkx
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	18	6,934,966 - 7,004,779 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	18	6,934,518 - 7,004,780 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	18	6,934,966 - 7,004,779 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	18	6,934,518 - 7,004,780 (-)	Ensembl			mm10	GRCm38
MGSCv37	18	6,934,964 - 7,004,777 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	18	6,934,998 - 7,004,754 (-)	NCBI		MGSCv36	mm8
Celera	18	6,980,394 - 7,049,750 (-)	NCBI		Celera
Cytogenetic Map	18	A1	NCBI
cM Map	18	4.53	NCBI

Mkx
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955462	1,564,191 - 1,631,951 (-)	Ensembl
ChiLan1.0	NW_004955462	1,564,739 - 1,631,613 (-)	NCBI	ChiLan1.0	ChiLan1.0

MKX
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	8	40,340,819 - 40,420,027 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	10	40,346,145 - 40,420,917 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	27,820,454 - 27,893,373 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	10	28,181,483 - 28,254,311 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	28,181,483 - 28,254,311 (-)	Ensembl			panPan2	panpan1.1

LOC487079
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	5,898,155 - 5,964,577 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	4,371,377 - 4,437,081 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	4,651,755 - 4,720,172 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
UNSW_CanFamBas_1.0	2	16,010,859 - 16,077,012 (+)	NCBI		UNSW_CanFamBas_1.0

Mkx
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	7,469,239 - 7,533,485 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936613	2,019,783 - 2,084,267 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936613	2,019,815 - 2,083,724 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MKX
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	39,096,782 - 39,172,198 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	10	39,096,778 - 39,173,384 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	53,679,406 - 53,744,157 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MKX
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	27,228,061 - 27,305,852 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666051	33,247,101 - 33,322,551 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mkx
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624805	6,061,635 - 6,121,926 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624805	6,060,131 - 6,122,305 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Mkx
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	14	28,896,083 - 28,968,728 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Mkx
650 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	18
Count of miRNA genes:	16
Interacting mature miRNAs:	18
Transcripts:	ENSRNOT00000025623
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631497	Bp98	Blood pressure QTL 98	3.66		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	49496932	65155015	Rat
70210	Cm15	Cardiac mass QTL 15	6.5		heart right ventricle mass (VT:0007033)	heart right ventricle wet weight (CMO:0000072)	17	30066472	75066472	Rat
152023626	Bp403	Blood pressure QTL 403	3.86		arterial blood pressure trait (VT:2000000)		17	24136127	84432719	Rat
2301412	Kidm40	Kidney mass QTL 40		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	17	42388164	87388164	Rat
1354588	Bvd4	Brain ventricular dilatation QTL 4	5.31	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	17	58194064	87388164	Rat
9590107	Sffal7	Serum free fatty acids level QTL 7	4.81	0.001	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	17	33104645	78104645	Rat
1354654	Spl7	Serum phospholipid level QTL 7	5.5		blood phospholipid amount (VT:0006084)	blood phospholipid level (CMO:0001169)	17	38031354	83031354	Rat
2317038	Ginf3	Gastrointestinal inflammation QTL 3	2.89	0.005	liver integrity trait (VT:0010547)	liver granuloma severity score (CMO:0002157)	17	54829503	93515804	Rat
1598871	Memor5	Memory QTL 5	5.3		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	17	40968017	89341781	Rat
1581512	Cm55	Cardiac mass QTL 55	2.8	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	17	27233445	83975845	Rat
1354629	Scl31	Serum cholesterol level QTL 31	4.1		blood cholesterol amount (VT:0000180)	blood total cholesterol level (CMO:0000051)	17	38031354	83031354	Rat
61394	Bp8	Blood pressure QTL 8	2.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	23286322	64246472	Rat
2317045	Aia11	Adjuvant induced arthritis QTL 11	4.06		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	17	26522051	71522051	Rat
1600398	Edcs5	Endometrial carcinoma susceptibility QTL 5	2.2		uterus morphology trait (VT:0001120)	percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)	17	35446949	75762341	Rat
10450503	Bp386	Blood pressure QTL 386		0.28	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	22019705	67019705	Rat
1559055	Bp278	Blood pressure QTL 278		0.04	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	23858926	68858926	Rat
152025238	Slep14	Serum leptin concentration QTL 14	4.62		blood leptin amount (VT:0005667)		17	24390595	84432719	Rat
1354638	Insul1	Insulin level QTL 1	4.8		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	17	38031354	83031354	Rat
1354635	Bp245	Blood pressure QTL 245	6		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	38031354	83031354	Rat
1331765	Hrtrt15	Heart rate QTL 15	4.094		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	17	15537025	60531414	Rat
8552928	Pigfal9	Plasma insulin-like growth factor 1 level QTL 9	9		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	17	33104645	78104645	Rat
12904736	Cm121	Cardiac mass QTL 121		0.043	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	17	42388164	87388164	Rat
1300148	Bp192	Blood pressure QTL 192	3.47		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	17	46050126	91050126	Rat
12903980	Cm120	Cardiac mass QTL 120		0.002	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	17	23858926	68858926	Rat
12903981	Am17	Aortic mass QTL 17		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	17	23858926	68858926	Rat
4889955	Bss93	Bone structure and strength QTL 93	4.4		tibia size trait (VT:0100001)	tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)	17	27233445	65155015	Rat
4889891	Eae32	Experimental allergic encephalomyelitis QTL 32	4.8	0.0002	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	17	27233445	72233445	Rat
12903982	Kidm70	Kidney mass QTL 70		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	17	23858926	68858926	Rat
4889894	Eae33	Experimental allergic encephalomyelitis QTL 33	5.2	0.0001	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	17	55604597	93006569	Rat
12903978	Cm118	Cardiac mass QTL 118		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	17	23858926	68858926	Rat
2324621	Coatc5	Coat color QTL 5			coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	17	42654895	87654895	Rat
12903979	Cm119	Cardiac mass QTL 119		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	17	23858926	68858926	Rat
1354619	Bp242	Blood pressure QTL 242	6.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	37687877	82687877	Rat
1300129	Rf25	Renal function QTL 25	3.03		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	17	41062352	86062352	Rat
152023740	Bp406	Blood pressure QTL 406	6.06		arterial blood pressure trait (VT:2000000)		17	24136127	84432719	Rat
1354663	Bvd5	Brain ventricular dilatation QTL 5	3.51	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	17	32199534	86201342	Rat
7488966	Bp370	Blood pressure QTL 370		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	23858926	68858926	Rat
152023737	Bp405	Blood pressure QTL 405	5.06		arterial blood pressure trait (VT:2000000)			24136127	84432719	Rat
152023736	Bp404	Blood pressure QTL 404	3.78		arterial blood pressure trait (VT:2000000)		17	24136127	84432719	Rat
724528	Uae4	Urinary albumin excretion QTL 4	4.9	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	17	36045537	81045537	Rat

Markers in Region

RH137808

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	55,126,021 - 55,126,197 (-)	MAPPER	mRatBN7.2
Rnor_6.0	17	60,573,754 - 60,573,929	NCBI	Rnor6.0
Rnor_5.0	17	62,354,027 - 62,354,202	UniSTS	Rnor5.0
RGSC_v3.4	17	63,678,182 - 63,678,357	UniSTS	RGSC3.4
RH 3.4 Map	17	557.0	UniSTS
Cytogenetic Map	17	q12.1	UniSTS

Genetic Models

This gene Mkx is modified in the following models/strains:

W-Mkx^em1Asah

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	62	139	59	57	27	37	27	6	260	131	11	118	78	92	30	10	10

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001432285	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001432286	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008771811	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008774009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017587744	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017600733	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039096145	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474080	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000017	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000025623 ⟹ ENSRNOP00000025623

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	17	59,773,570 - 59,850,345 (-)	Ensembl
mRatBN7.2 Ensembl	17	55,077,540 - 55,156,124 (-)	Ensembl
Rnor_6.0 Ensembl	17	60,537,935 - 60,549,750 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000157560 ⟹ ENSRNOP00000109485

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	17	59,774,027 - 59,849,076 (-)	Ensembl

RefSeq Acc Id:

XM_008771811 ⟹ XP_008770033

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	59,772,113 - 59,850,957 (-)	NCBI
mRatBN7.2	17	55,077,073 - 55,155,933 (-)	NCBI
Rnor_6.0	17	60,537,970 - 60,553,284 (+)	NCBI

Sequence:

show sequence

TTTGCTTTCGAATTATCCGCGGGGCAGTTCTGCAGGGATCGCGCTGGTCAGCACTGCTAAGAGC
GTATCTGGAACCCGAGCCCTGCTGCGGAGCTCCTGGTGGCCGGACTCTGAGGCGCTGCGGCAAG
GCCGCCGCGCGTCCCTGTCAGCCCTTACCATGAATACCATCGTCTTTAACAAGCTTGGGGGAGC
TGTGATTTTTGACGACCGAGGCACCCCAGATCGGGAACGTGGCAGCCGGCCATACGGCGGCGTC
CTGGACAATCCACATACAGGCCCGGAGGTGGGCATTCCAGACGGCCCGCCCCTCAAGGACAACC
TCAGCCTGAGACACCGGAGGACCGGGGCGAGGCCTGGAGGGAAGGTGAGGCACAAGCGACAGGC
CCTGCAAGACATGGCGCGGCCGCTTAAGCAGTGGCTTTACAAGCACCGTGACAACCCGTACCCT
ACGAAGACTGAGAAGATACTCTTGGCTCTAGGCTCGCAGATGACGCTAGTGCAGGTGTCAAATT
GGTTCGCTAATGCTAGACGACGGCTGAAGAACACTGTCCGGCAGCCGGATTTAAGTTGGGCCTT
AAGAATAAAGTTGTACAACAAGTATGTTCAGGGCAACGCCGAGCGGCTCAGTGTGAGCAGTGCG
GATGACTCCTGCTCTGAAGATGGAGAAAATCCCCCAAGAACTCACATGAACGAAGAGGGCTATA
GCACCCCTGCCCACCACACTGTGATTAAAGGGGAGAGCTCAGCGATAAAAGCTGGTGGGAGACC
GGAGTCAAGGGCAGCTGAGGACTATGTGTCACCGCCCAAGTATAAGAGCAGCTTGTTGAACCGT
TACCTTAACGACTCTTTGAGACATGTCATGGCCACCAGCACTGCCATGATGGGGAAAACAAGGC
GAAGGAACCATTCGGGGTCTTTTAGCTCGAACGAATTTGAAGAAGAACTGGTGTCTCCATCATC
ATCAGAAACTGAAGGCACCTTTGTCTATCGCACAGGTAAGCCCATGCTTTGTTCTTATTATGGT
GACGTGTGTAAGATAGATAAAAGCTGTGTCGTAGAGATTTACTGTAACAGATGGGAGAAACTGA
TACGTGGGTTGCTATAATTCTTGTGCAAAACTTTTAATTTGTTTTAAACCGGCAATAGGTACAT
TTGTTGGTAGATGATGGTCTCAGAGAGCCTTGAGACTTTTCTCTTTAAGCATCTTCATTCTCAC
TGACAATGTTAGTCATGATGACATGATGTCGGTACTTCTGTCTTTGCTGTGCATCTTGTGTGTG
TAGCCATGCATGGGCCCGTGTATGCAGATGCCTTCCCCTATGACTTTTGGCTTTATTCCCTTGA
GACTTGGTTTCTGCCTGAACCTAAATCTTAGCTTGTACCCAGTGAGACACAGAAATATTCATGG
CTCTGACACAGGAGCACTGGGTTATGGGCACAAGTCCCATCATGATTGACTCTTTTAATGTGGG
TGCTGGGGATTGGAACTCAGGTCTTCGGGCCTGTGCAGCTCATTTTCTTGCACTTGGAGCCATT
CTGCCTGCCTGATGTATTTAAAGTATTTAAAGGATGTCTATGTTCCCTTCATGAGTAATCCACA
TGGTGGAGAGATGAGCTGATCGTGGCCAGCCATGCAGATGTTTCCTGTTCTGTCTTTTCTTTCC
CATACTTTGATTGCTAGAAGTGATAGGAAATGAATACAAAGTAACACAAGGGCCAGAATTTTCA
GAGGGGAAGACACAAGCCTGGATCTCATGACTTTGAAATTTCTCTTTCATTCCTAGAAAGTACA
AGTAGGGCTGACCAATAGCTTTGAAGATTTTATATTCATTCCAGAGATAATGAGCTGGTTCTAC
CTGACCAAGGCATCCAGATGGCAAGTAGTAGTAATCTTGACTTTAGCACAGTGAGATTTGCATT
CAAGAAGTATTTGAGCAGGGCCACTTTGGAAGAAAGGATAGATGAGGTCTACATCTGGTATATT
TGCCGCCTGGCTCCTAAAAACTGACAGTGGATGAGTGTGAATGTTAGATCTGGAGACAAGAAAG
CACTCAATCTAACCAAGGTGAGAAAAAAAACCATGAACACACAATGGTTAATCCTTGTGTGAAC
AGCACAGCCTAACCTGCATAAGAGGTTCCAGAAGGGACACCTCTGCCAGAGCTATGATTGTATC
TACTGCCAACAGTCACTGCCTGTAGTTACTGTACCATTAATCAATGCCTAGAGCTATCCTGGTT
ATACTAGTACTACCAACCAGGATGCCTATAATCATCCTACAATCAACCAGTGCCTGTAGTTATC
CTACCACCATCAACCAGTGCCTGTAGTTATCCTACCACCACCAACCGTGGCTCTAGTTATCCTA
CCACCACCAACCAGTGCCTCTAGTTATCCTACCACCACCAACCAGTGCCTCTAGTTATCCTACC
ACCACCAACCAGTGCCTCTAGTTATCCCACTACCAACAATTATTTTCTATAGCTATGCTACTAC
CATTGACAATAATGGTATTTTCTCCAAGAATTTGTTGAGTACCATAAGGCCAACAACATGGCAG
TTGTGACAACTAAATTATATTTTTAAGGAAGAATGAGGTAGGAAATTCCCTGTTCCTGGAGACC
TTTTCAGTCAGATTTAGTTCAAGTCTCTTTTCATTATAAGACTCATTTTTCAAAGTATGTTATA
GGACAGGGACCAAGTCAGAAAGACCACAAGGTGGAACTTGTAGCTAAAATAAATGACCTAAGCG
ATCTAAGCATATCATGGCAGAAAGAGAAGATCGCAGTCAGGGATGCTACCTCTCCATCCACTGC
CATGACAAGGATGTAGCTTGTGTATGGAAGGCTCTTCTCTGTCTACTGGGCTCTTCTCCTTCTA
ATAATGATATCTGTTTAACTCTTAGTGACTGAGACTTTGTGAGTTACACTACTGCCACTCATTG
ACAAAGTAGCAACGAAACACTTGGCCCTGCTACCAGGACTGCAAACCTTTGCACAGCCTGGTGC
TACTGAGGGGGCCACATGGCAGCCACAGAGTGTGAGGAAGGAATCCAGTTAGCGCACTAACCTC
AGTCGTCACATTGGTTAGTCTGAAATCTCAAGTGTCTGCAGATATGAGCAGCGGTGCCTTTCTA
AAGTGTCAGGGCACCCTATAGACCCGAGTCAACTTTAGTTTGCATCTCTAGCTCCTACATGAAG
TAATGCCAAGCAAATGCAGAAACACCCTCAGAAGGAGGGACTGGATCTAGGAAGAAGTTAAAAT
AAAAAGCCACGTAGCCAATAATGAAAACGAAGGGACCAGGAGATGACTCTGTGGCGAGGGCATC
TGTTACACAAGCAGGAGGACCACAGTTCAGATCCTCAAGCCTACACGATGCCATTTGGGTTTGG
TGGCCCTCCTAAAATCCCAGCAACTGGAAGGCAGACAGCGAATCTCCAGGGAAAGCCAGCTAGT
GAGGCAAGCTGGATCAACAGGCTCCGGTTTCGATTGAGAAGCCTTTTCATAACAGATATGGAGG
CAAGTGATTGAGGGTGACTCCAAGTATTAACCTGTGGCTAATATATGCACATCCACATAGTGTA
AACACAGGGGAACATGTGTAATCACACACACAAGCACACACACATGTCACGAAGAGCCGTGAAC
AACTGTTTAACAGTGTACCACCTGTAACTGACTATGCACAGTACTTTTATATTAGTCTTAAAAT
GAATGATAAATTCATAAATAAGAAAGTCTGATCAGTGACAAATAACTCAGGGGAAAAAATCAGG
TTTTTAGTAAATCCGGTGCCCCAAAATTGTGAATCAGTGGAACCATTAGGTTTTGTTATTTAAA
ACTTTGAGTAAATAAGCCCTCTGTTTTCCACATTTTCTGGAACATTCAAAACCACAGAAAATGT
CTCCATTTAACAATCCTACTCTCACATCAGATTAAGGTAAAGTGAAAGTCTCTTTATGGTACAG
AACACTGAGCTAGCTGCAACAAACTGCAGAAACATGGAATGAAGCTATGATGATACAAATGAAT
GTTCATGCATGGGTACAGCAAAGGGTTTTCTGGAAGAGAAATGCAATTAGTGAGGTGAGTTAGG
AAGCAACTGTCTATTTAGAAAAAAATATGTTTCTTATAAATGTGTTTATGTTGACGGAAGTGTT
GAGTCTTTTGAAAATGCATGCTTTTTTCAAAGGTGACAAAACACACTGTCAGAAGAAATGCTGG
GCCTGCAGGTGATGCTTTTCAGACCTAGATATTTTGGCTGTTTGTGTTTCTTAAACCATCCCTA
ACGTCCTTGGTCCATATGAAGCGCTATCCATTGGCCAAGCTCTCTTTATAAATAAAGCCCACTT
TTCAGTTATTCAGCCAGTGAGAAAGCAACCTAGACATGTAAACTTTTTCATGCATGCATGTAAA
CTTCAAAAGAGCAATCTGATTTTTCCCTCTTAATGTTCAGGCTTGGAGAATTAAGAGAGGCTAA
GGGCCTAAAAGTGCTGTGCGAAGTTTTGAGCCAAACAATAGATGACTGTCTTCAGCAGGGAACT
GAGTGATAGCCCTGTCATAGCCAGGTTACCTTGTGTGGAAATAGAAGCACAGGAGGGCTTCCTG
AGTAGACACTGTGGCTTTCCTCAGCATCCGAGCCTCCTCCAGACTCCTTCATGTCCATCTGGCT
AAGTCTCTGTCCTCATTAGAACAGAAATGTTTAAAGTCAGCCATTCATTCATTCTCCTACCCCA
CCAGCTGTAGTTACAAAGACTTTAACTCCATTTTAAAAGACCACTTGTCCAGACTAAGCAATTA
TATCTCCCTGCCTCCTTCTCCCCTGCTAT

hide sequence

RefSeq Acc Id:

XM_017600733 ⟹ XP_017456222

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	59,772,113 - 59,851,160 (-)	NCBI
mRatBN7.2	17	55,077,073 - 55,156,877 (-)	NCBI
Rnor_6.0	17	60,537,615 - 60,553,284 (+)	NCBI

Sequence:

show sequence

CCTGTCTGGGTAAATAAAGCCGAGACGACGCCGGTGGCCGCGGTGAGCGCGTTGGAGCCTGCGC
CGAGAACATGCGGCGGGGATGGGAGTGTGCCTAGTCCTGAGACCGGACAACCAGCCACTGGCTG
AGGTCTTCGCGGCCATAGAACCCGAGCCCTGCTGCGGAGCTCCTGGTGGCCGGACTCTGAGGCG
CTGCGGCAAGGCCGCCGCGCGTCCCTGTCAGCCCTTACCATGAATACCATCGTCTTTAACAAGC
TTGGGGGAGCTGTGATTTTTGACGACCGAGGCACCCCAGATCGGGAACGTGGCAGCCGGCCATA
CGGCGGCGTCCTGGACAATCCACATACAGGCCCGGAGGTGGGCATTCCAGACGGCCCGCCCCTC
AAGGACAACCTCAGCCTGAGACACCGGAGGACCGGGGCGAGGCCTGGAGGGAAGGTGAGGCACA
AGCGACAGGCCCTGCAAGACATGGCGCGGCCGCTTAAGCAGTGGCTTTACAAGCACCGTGACAA
CCCGTACCCTACGAAGACTGAGAAGATACTCTTGGCTCTAGGCTCGCAGATGACGCTAGTGCAG
GTGTCAAATTGGTTCGCTAATGCTAGACGACGGCTGAAGAACACTGTCCGGCAGCCGGATTTAA
GTTGGGCCTTAAGAATAAAGTTGTACAACAAGTATGTTCAGGGCAACGCCGAGCGGCTCAGTGT
GAGCAGTGCGGATGACTCCTGCTCTGAAGATGGAGAAAATCCCCCAAGAACTCACATGAACGAA
GAGGGCTATAGCACCCCTGCCCACCACACTGTGATTAAAGGGGAGAGCTCAGCGATAAAAGCTG
GTGGGAGACCGGAGTCAAGGGCAGCTGAGGACTATGTGTCACCGCCCAAGTATAAGAGCAGCTT
GTTGAACCGTTACCTTAACGACTCTTTGAGACATGTCATGGCCACCAGCACTGCCATGATGGGG
AAAACAAGGCGAAGGAACCATTCGGGGTCTTTTAGCTCGAACGAATTTGAAGAAGAACTGGTGT
CTCCATCATCATCAGAAACTGAAGGCACCTTTGTCTATCGCACAGGTAAGCCCATGCTTTGTTC
TTATTATGGTGACGTGTGTAAGATAGATAAAAGCTGTGTCGTAGAGATTTACTGTAACAGATGG
GAGAAACTGATACGTGGGTTGCTATAATTCTTGTGCAAAACTTTTAATTTGTTTTAAACCGGCA
ATAGGTACATTTGTTGGTAGATGATGGTCTCAGAGAGCCTTGAGACTTTTCTCTTTAAGCATCT
TCATTCTCACTGACAATGTTAGTCATGATGACATGATGTCGGTACTTCTGTCTTTGCTGTGCAT
CTTGTGTGTGTAGCCATGCATGGGCCCGTGTATGCAGATGCCTTCCCCTATGACTTTTGGCTTT
ATTCCCTTGAGACTTGGTTTCTGCCTGAACCTAAATCTTAGCTTGTACCCAGTGAGACACAGAA
ATATTCATGGCTCTGACACAGGAGCACTGGGTTATGGGCACAAGTCCCATCATGATTGACTCTT
TTAATGTGGGTGCTGGGGATTGGAACTCAGGTCTTCGGGCCTGTGCAGCTCATTTTCTTGCACT
TGGAGCCATTCTGCCTGCCTGATGTATTTAAAGTATTTAAAGGATGTCTATGTTCCCTTCATGA
GTAATCCACATGGTGGAGAGATGAGCTGATCGTGGCCAGCCATGCAGATGTTTCCTGTTCTGTC
TTTTCTTTCCCATACTTTGATTGCTAGAAGTGATAGGAAATGAATACAAAGTAACACAAGGGCC
AGAATTTTCAGAGGGGAAGACACAAGCCTGGATCTCATGACTTTGAAATTTCTCTTTCATTCCT
AGAAAGTACAAGTAGGGCTGACCAATAGCTTTGAAGATTTTATATTCATTCCAGAGATAATGAG
CTGGTTCTACCTGACCAAGGCATCCAGATGGCAAGTAGTAGTAATCTTGACTTTAGCACAGTGA
GATTTGCATTCAAGAAGTATTTGAGCAGGGCCACTTTGGAAGAAAGGATAGATGAGGTCTACAT
CTGGTATATTTGCCGCCTGGCTCCTAAAAACTGACAGTGGATGAGTGTGAATGTTAGATCTGGA
GACAAGAAAGCACTCAATCTAACCAAGGTGAGAAAAAAAACCATGAACACACAATGGTTAATCC
TTGTGTGAACAGCACAGCCTAACCTGCATAAGAGGTTCCAGAAGGGACACCTCTGCCAGAGCTA
TGATTGTATCTACTGCCAACAGTCACTGCCTGTAGTTACTGTACCATTAATCAATGCCTAGAGC
TATCCTGGTTATACTAGTACTACCAACCAGGATGCCTATAATCATCCTACAATCAACCAGTGCC
TGTAGTTATCCTACCACCATCAACCAGTGCCTGTAGTTATCCTACCACCACCAACCGTGGCTCT
AGTTATCCTACCACCACCAACCAGTGCCTCTAGTTATCCTACCACCACCAACCAGTGCCTCTAG
TTATCCTACCACCACCAACCAGTGCCTCTAGTTATCCCACTACCAACAATTATTTTCTATAGCT
ATGCTACTACCATTGACAATAATGGTATTTTCTCCAAGAATTTGTTGAGTACCATAAGGCCAAC
AACATGGCAGTTGTGACAACTAAATTATATTTTTAAGGAAGAATGAGGTAGGAAATTCCCTGTT
CCTGGAGACCTTTTCAGTCAGATTTAGTTCAAGTCTCTTTTCATTATAAGACTCATTTTTCAAA
GTATGTTATAGGACAGGGACCAAGTCAGAAAGACCACAAGGTGGAACTTGTAGCTAAAATAAAT
GACCTAAGCGATCTAAGCATATCATGGCAGAAAGAGAAGATCGCAGTCAGGGATGCTACCTCTC
CATCCACTGCCATGACAAGGATGTAGCTTGTGTATGGAAGGCTCTTCTCTGTCTACTGGGCTCT
TCTCCTTCTAATAATGATATCTGTTTAACTCTTAGTGACTGAGACTTTGTGAGTTACACTACTG
CCACTCATTGACAAAGTAGCAACGAAACACTTGGCCCTGCTACCAGGACTGCAAACCTTTGCAC
AGCCTGGTGCTACTGAGGGGGCCACATGGCAGCCACAGAGTGTGAGGAAGGAATCCAGTTAGCG
CACTAACCTCAGTCGTCACATTGGTTAGTCTGAAATCTCAAGTGTCTGCAGATATGAGCAGCGG
TGCCTTTCTAAAGTGTCAGGGCACCCTATAGACCCGAGTCAACTTTAGTTTGCATCTCTAGCTC
CTACATGAAGTAATGCCAAGCAAATGCAGAAACACCCTCAGAAGGAGGGACTGGATCTAGGAAG
AAGTTAAAATAAAAAGCCACGTAGCCAATAATGAAAACGAAGGGACCAGGAGATGACTCTGTGG
CGAGGGCATCTGTTACACAAGCAGGAGGACCACAGTTCAGATCCTCAAGCCTACACGATGCCAT
TTGGGTTTGGTGGCCCTCCTAAAATCCCAGCAACTGGAAGGCAGACAGCGAATCTCCAGGGAAA
GCCAGCTAGTGAGGCAAGCTGGATCAACAGGCTCCGGTTTCGATTGAGAAGCCTTTTCATAACA
GATATGGAGGCAAGTGATTGAGGGTGACTCCAAGTATTAACCTGTGGCTAATATATGCACATCC
ACATAGTGTAAACACAGGGGAACATGTGTAATCACACACACAAGCACACACACATGTCACGAAG
AGCCGTGAACAACTGTTTAACAGTGTACCACCTGTAACTGACTATGCACAGTACTTTTATATTA
GTCTTAAAATGAATGATAAATTCATAAATAAGAAAGTCTGATCAGTGACAAATAACTCAGGGGA
AAAAATCAGGTTTTTAGTAAATCCGGTGCCCCAAAATTGTGAATCAGTGGAACCATTAGGTTTT
GTTATTTAAAACTTTGAGTAAATAAGCCCTCTGTTTTCCACATTTTCTGGAACATTCAAAACCA
CAGAAAATGTCTCCATTTAACAATCCTACTCTCACATCAGATTAAGGTAAAGTGAAAGTCTCTT
TATGGTACAGAACACTGAGCTAGCTGCAACAAACTGCAGAAACATGGAATGAAGCTATGATGAT
ACAAATGAATGTTCATGCATGGGTACAGCAAAGGGTTTTCTGGAAGAGAAATGCAATTAGTGAG
GTGAGTTAGGAAGCAACTGTCTATTTAGAAAAAAATATGTTTCTTATAAATGTGTTTATGTTGA
CGGAAGTGTTGAGTCTTTTGAAAATGCATGCTTTTTTCAAAGGTGACAAAACACACTGTCAGAA
GAAATGCTGGGCCTGCAGGTGATGCTTTTCAGACCTAGATATTTTGGCTGTTTGTGTTTCTTAA
ACCATCCCTAACGTCCTTGGTCCATATGAAGCGCTATCCATTGGCCAAGCTCTCTTTATAAATA
AAGCCCACTTTTCAGTTATTCAGCCAGTGAGAAAGCAACCTAGACATGTAAACTTTTTCATGCA
TGCATGTAAACTTCAAAAGAGCAATCTGATTTTTCCCTCTTAATGTTCAGGCTTGGAGAATTAA
GAGAGGCTAAGGGCCTAAAAGTGCTGTGCGAAGTTTTGAGCCAAACAATAGATGACTGTCTTCA
GCAGGGAACTGAGTGATAGCCCTGTCATAGCCAGGTTACCTTGTGTGGAAATAGAAGCACAGGA
GGGCTTCCTGAGTAGACACTGTGGCTTTCCTCAGCATCCGAGCCTCCTCCAGACTCCTTCATGT
CCATCTGGCTAAGTCTCTGTCCTCATTAGAACAGAAATGTTTAAAGTCAGCCATTCATTCATTC
TCCTACCCCACCAGCTGTAGTTACAAAGACTTTAACTCCATTTTAAAAGACCACTTGTCCAGAC
TAAGCAATTATATCTCCCTGCCTCCTTCTCCCCTGCTAT

hide sequence

RefSeq Acc Id:

XM_039096145 ⟹ XP_038952073

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	59,772,113 - 59,849,947 (-)	NCBI
mRatBN7.2	17	55,077,073 - 55,154,919 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001419214	(Get FASTA)	NCBI Sequence Viewer
	NP_001419215	(Get FASTA)	NCBI Sequence Viewer
	XP_008770033	(Get FASTA)	NCBI Sequence Viewer
	XP_017456222	(Get FASTA)	NCBI Sequence Viewer
	XP_038952073	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL83768	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000025623
	ENSRNOP00000025623.8
	ENSRNOP00000109485.1

RefSeq Acc Id:

XP_008770033 ⟸ XM_008771811

- Sequence:

show sequence

MNTIVFNKLGGAVIFDDRGTPDRERGSRPYGGVLDNPHTGPEVGIPDGPPLKDNLSLRHRRTGA
RPGGKVRHKRQALQDMARPLKQWLYKHRDNPYPTKTEKILLALGSQMTLVQVSNWFANARRRLK
NTVRQPDLSWALRIKLYNKYVQGNAERLSVSSADDSCSEDGENPPRTHMNEEGYSTPAHHTVIK
GESSAIKAGGRPESRAAEDYVSPPKYKSSLLNRYLNDSLRHVMATSTAMMGKTRRRNHSGSFSS
NEFEEELVSPSSSETEGTFVYRTGKPMLCSYYGDVCKIDKSCVVEIYCNRWEKLIRGLL

hide sequence

RefSeq Acc Id:

XP_017456222 ⟸ XM_017600733

- Sequence:

show sequence

MNTIVFNKLGGAVIFDDRGTPDRERGSRPYGGVLDNPHTGPEVGIPDGPPLKDNLSLRHRRTGA
RPGGKVRHKRQALQDMARPLKQWLYKHRDNPYPTKTEKILLALGSQMTLVQVSNWFANARRRLK
NTVRQPDLSWALRIKLYNKYVQGNAERLSVSSADDSCSEDGENPPRTHMNEEGYSTPAHHTVIK
GESSAIKAGGRPESRAAEDYVSPPKYKSSLLNRYLNDSLRHVMATSTAMMGKTRRRNHSGSFSS
NEFEEELVSPSSSETEGTFVYRTGKPMLCSYYGDVCKIDKSCVVEIYCNRWEKLIRGLL

hide sequence

Ensembl Acc Id:

ENSRNOP00000025623 ⟸ ENSRNOT00000025623

RefSeq Acc Id:	XP_038952073 ⟸ XM_039096145
- UniProtKB:	D3ZUL2 (UniProtKB/TrEMBL), A6KPM3 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000109485 ⟸ ENSRNOT00000157560

Protein Domains

Homeobox

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZUL2-F1-model_v2	AlphaFold	D3ZUL2	1-315	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305652	AgrOrtholog
BioCyc Gene	G2FUF-8970	BioCyc
Ensembl Genes	ENSRNOG00000018938	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000025623	ENTREZGENE
	ENSRNOT00000025623.9	UniProtKB/TrEMBL
	ENSRNOT00000157560.1	UniProtKB/TrEMBL
Gene3D-CATH	Homeodomain-like	UniProtKB/TrEMBL
InterPro	Homeobox	UniProtKB/TrEMBL
	Homeobox_CS	UniProtKB/TrEMBL
	Homeobox_KN_domain	UniProtKB/TrEMBL
	Homeodomain-like	UniProtKB/TrEMBL
NCBI Gene	291228	ENTREZGENE
PANTHER	HOMEOBOX PROTEIN MOHAWK	UniProtKB/TrEMBL
	IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX	UniProtKB/TrEMBL
Pfam	Homeobox_KN	UniProtKB/TrEMBL
PhenoGen	Mkx	PhenoGen
PROSITE	HOMEOBOX_1	UniProtKB/TrEMBL
	HOMEOBOX_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000018938	RatGTEx
SMART	HOX	UniProtKB/TrEMBL
Superfamily-SCOP	Homeodomain_like	UniProtKB/TrEMBL
UniProt	A0ABK0LYB9_RAT	UniProtKB/TrEMBL
	A6KPM3	ENTREZGENE, UniProtKB/TrEMBL
	D3ZUL2	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Mkx	mohawk homeobox	LOC103694111	uncharacterized LOC103694111	Data merged from RGD:9392383	737654	PROVISIONAL
2015-07-29	LOC103694111	uncharacterized LOC103694111	LOC100912277	uncharacterized LOC100912277	Data merged from RGD:6488159	737654	PROVISIONAL
2014-08-25	LOC103694111	uncharacterized LOC103694111			Symbol and Name status set to provisional	70820	PROVISIONAL
2012-07-05	LOC100912277	uncharacterized LOC100912277			Symbol and Name status set to provisional	70820	PROVISIONAL
2008-03-04	Mkx	mohawk homeobox	Irxl1_predicted	iroquois homeobox protein-like 1 (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Irxl1_predicted	iroquois homeobox protein-like 1 (predicted)	RGD1305652_predicted	similar to hypothetical protein MGC39616 (predicted)	Symbol and Name updated	1299863	APPROVED
2005-01-20	RGD1305652_predicted	similar to hypothetical protein MGC39616 (predicted)	LOC291228_predicted	similar to hypothetical protein MGC39616 (predicted)	Symbol and Name status set to approved	1331353	APPROVED
2005-01-20	RGD1305652_predicted	similar to hypothetical protein MGC39616 (predicted)	LOC291228_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC291228_predicted	similar to hypothetical protein MGC39616 (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
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InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

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MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Mammalian Phenotype