Bod1 (biorientation of chromosomes in cell division 1) - Rat Genome Database

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Gene: Bod1 (biorientation of chromosomes in cell division 1) Rattus norvegicus
Analyze
Symbol: Bod1
Name: biorientation of chromosomes in cell division 1
RGD ID: 1305622
Description: Predicted to enable protein phosphatase 2A binding activity and protein phosphatase inhibitor activity. Predicted to be involved in mitotic sister chromatid biorientation; mitotic sister chromatid cohesion, centromeric; and protein localization to chromosome, centromeric region. Predicted to be located in centrosome; spindle microtubule; and spindle pole. Predicted to be part of Set1C/COMPASS complex and outer kinetochore. Orthologous to several human genes including BOD1 (biorientation of chromosomes in cell division 1); INTERACTS WITH (+)-schisandrin B; bisphenol A; cadmium dichloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: biorientation defective protein 1; biorientation of chromosomes in cell division protein 1; Fam44b; family with sequence similarity 44, member B; hypothetical LOC287173; LOC287173; RGD1305622
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81016,497,918 - 16,504,259 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1016,497,876 - 16,504,253 (+)EnsemblGRCr8
mRatBN7.21015,993,454 - 15,999,795 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1015,993,454 - 15,999,787 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1020,740,896 - 20,747,237 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01020,229,826 - 20,236,167 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01015,719,433 - 15,725,773 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01016,259,728 - 16,266,069 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1016,259,728 - 16,266,061 (+)Ensemblrn6Rnor6.0
Rnor_5.01016,152,118 - 16,158,459 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41016,255,404 - 16,261,741 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1015,659,266 - 15,665,607 (+)NCBICelera
RGSC_v3.11016,256,452 - 16,262,788 (+)NCBI
Cytogenetic Map10q12NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:15489334   PMID:17938248   PMID:24157919  


Genomics

Comparative Map Data
Bod1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81016,497,918 - 16,504,259 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1016,497,876 - 16,504,253 (+)EnsemblGRCr8
mRatBN7.21015,993,454 - 15,999,795 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1015,993,454 - 15,999,787 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1020,740,896 - 20,747,237 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01020,229,826 - 20,236,167 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01015,719,433 - 15,725,773 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01016,259,728 - 16,266,069 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1016,259,728 - 16,266,061 (+)Ensemblrn6Rnor6.0
Rnor_5.01016,152,118 - 16,158,459 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41016,255,404 - 16,261,741 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1015,659,266 - 15,665,607 (+)NCBICelera
RGSC_v3.11016,256,452 - 16,262,788 (+)NCBI
Cytogenetic Map10q12NCBI
BOD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385173,607,145 - 173,616,650 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5173,607,145 - 173,616,659 (-)Ensemblhg38GRCh38
GRCh375173,034,148 - 173,043,653 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365172,967,146 - 172,976,262 (-)NCBIBuild 36Build 36hg18NCBI36
Build 345172,967,149 - 172,976,262NCBI
Celera5169,066,406 - 169,075,924 (-)NCBICelera
Cytogenetic Map5q35.2NCBI
HuRef5168,129,859 - 168,139,374 (-)NCBIHuRef
CHM1_15172,466,671 - 172,476,189 (-)NCBICHM1_1
T2T-CHM13v2.05174,147,207 - 174,156,712 (-)NCBIT2T-CHM13v2.0
Bod1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391131,615,150 - 31,621,862 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1131,615,181 - 31,621,885 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381131,665,150 - 31,671,862 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1131,665,181 - 31,671,885 (-)Ensemblmm10GRCm38
MGSCv371131,565,150 - 31,571,862 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361131,565,150 - 31,571,862 (-)NCBIMGSCv36mm8
Celera1134,080,907 - 34,087,599 (-)NCBICelera
Cytogenetic Map11A4NCBI
cM Map1118.55NCBI
Bod1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540826,236,941 - 26,242,570 (-)Ensembl
ChiLan1.0NW_00495540826,235,229 - 26,242,576 (-)NCBIChiLan1.0ChiLan1.0
BOD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24168,734,263 - 168,743,408 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15166,873,789 - 166,882,948 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05168,951,787 - 168,960,934 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15175,857,814 - 175,866,951 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5175,857,814 - 175,866,951 (-)EnsemblpanPan2panpan1.1
BOD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1438,888,096 - 38,895,539 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha438,834,963 - 38,842,274 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0439,259,503 - 39,266,976 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl439,259,295 - 39,266,394 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1439,077,779 - 39,085,242 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0439,266,320 - 39,273,785 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0439,774,971 - 39,782,432 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Bod1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721393,357,695 - 93,425,351 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366092,080,374 - 2,092,310 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366092,034,271 - 2,096,274 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BOD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11650,734,510 - 50,743,417 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21654,988,365 - 54,996,776 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BOD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12375,761,476 - 75,771,205 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660342,834,544 - 2,844,425 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bod1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473316,459,383 - 16,469,343 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Bod1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v194,276,964 - 4,283,260 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Bod1
32 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:466
Count of miRNA genes:263
Interacting mature miRNAs:316
Transcripts:ENSRNOT00000028115
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10666111835509383Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135730538Rat
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10130004247Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
737820Alc9Alcohol consumption QTL 92.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)101576223019737486Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10117749933Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138832698Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 91 59 6 355 191 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000028115   ⟹   ENSRNOP00000028115
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1016,497,876 - 16,504,253 (+)Ensembl
mRatBN7.2 Ensembl1015,993,454 - 15,999,787 (+)Ensembl
Rnor_6.0 Ensembl1016,259,728 - 16,266,061 (+)Ensembl
RefSeq Acc Id: NM_001013854   ⟹   NP_001013876
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81016,497,918 - 16,504,255 (+)NCBI
mRatBN7.21015,993,454 - 15,999,791 (+)NCBI
Rnor_6.01016,259,728 - 16,266,065 (+)NCBI
Rnor_5.01016,152,118 - 16,158,459 (+)NCBI
RGSC_v3.41016,255,404 - 16,261,741 (+)RGD
Celera1015,659,266 - 15,665,603 (+)NCBI
Sequence:
RefSeq Acc Id: NR_073160
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81016,497,921 - 16,504,259 (+)NCBI
mRatBN7.21015,993,457 - 15,999,795 (+)NCBI
Rnor_6.01016,259,731 - 16,266,069 (+)NCBI
Rnor_5.01016,152,118 - 16,158,459 (+)NCBI
Celera1015,659,269 - 15,665,607 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001013876 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH79025 (Get FASTA)   NCBI Sequence Viewer  
  EDM04034 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000028115
GenBank Protein Q6AYJ2 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001013876   ⟸   NM_001013854
- UniProtKB: A0A0H2UHS5 (UniProtKB/TrEMBL),   A6HDC9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000028115   ⟸   ENSRNOT00000028115
Protein Domains
BOD1/SHG1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6AYJ2-F1-model_v2 AlphaFold Q6AYJ2 1-173 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697085
Promoter ID:EPDNEW_R7609
Type:initiation region
Name:Bod1_1
Description:biorientation of chromosomes in cell division 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01016,259,809 - 16,259,869EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305622 AgrOrtholog
BioCyc Gene G2FUF-25671 BioCyc
Ensembl Genes ENSRNOG00000020717 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000028115 ENTREZGENE
IMAGE_CLONE IMAGE:7113945 IMAGE-MGC_LOAD
InterPro BOD1/SHG1_dom UniProtKB/Swiss-Prot
  BOD1L1 UniProtKB/Swiss-Prot
KEGG Report rno:287173 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93951 IMAGE-MGC_LOAD
NCBI Gene 287173 ENTREZGENE
PANTHER BIORIENTATION OF CHROMOSOMES IN CELL DIVISION 1 LIKE 1 UniProtKB/Swiss-Prot
  BIORIENTATION OF CHROMOSOMES IN CELL DIVISION 1 LIKE 1 UniProtKB/Swiss-Prot
Pfam COMPASS-Shg1 UniProtKB/Swiss-Prot
PhenoGen Bod1 PhenoGen
RatGTEx ENSRNOG00000020717 RatGTEx
UniProt A0A0H2UHS5 ENTREZGENE, UniProtKB/TrEMBL
  A6HDC9 ENTREZGENE, UniProtKB/TrEMBL
  BOD1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-03-24 Bod1  biorientation of chromosomes in cell division 1  Fam44b  family with sequence similarity 44, member B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Fam44b  family with sequence similarity 44, member B  RGD1305622  hypothetical LOC287173  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1305622  hypothetical LOC287173  RGD1305622_predicted  hypothetical LOC287173 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1305622_predicted  hypothetical LOC287173 (predicted)  LOC287173_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC287173_predicted  hypothetical LOC287173 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL