Pfdn1 (prefoldin subunit 1) - Rat Genome Database

Name: Pfdn1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Pfdn1 (prefoldin subunit 1) Rattus norvegicus

Analyze

Symbol:

Pfdn1

Name:

prefoldin subunit 1

RGD ID:

1305603

Description:

Predicted to enable amyloid-beta binding activity; protein folding chaperone; and unfolded protein binding activity. Predicted to be involved in negative regulation of amyloid fibril formation and protein folding. Predicted to act upstream of or within B cell activation; actin cytoskeleton organization; and brain development. Predicted to be part of prefoldin complex. Predicted to be active in cytoplasm. Orthologous to human PFDN1 (prefoldin subunit 1); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC361310; prefoldin 1

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PFDN1 (prefoldin subunit 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Pfdn1 (prefoldin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Pfdn1 (prefoldin subunit 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PFDN1 (prefoldin subunit 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PFDN1 (prefoldin subunit 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Pfdn1 (prefoldin subunit 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PFDN1 (prefoldin subunit 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PFDN1 (prefoldin subunit 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Pfdn1 (prefoldin subunit 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	ENOX1 (ecto-NOX disulfide-thiol exchanger 1)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	PFDN1 (prefoldin subunit 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Mus musculus (house mouse):	Pfdn1 (prefoldin 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	pfdn1 (prefoldin subunit 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	PFD1	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Pfdn1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	pfd-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	pfdn1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	28,288,210 - 28,341,198 (-)	NCBI		GRCr8
mRatBN7.2	18	28,014,145 - 28,067,148 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	28,014,145 - 28,067,064 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	18	28,141,323 - 28,194,236 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	28,903,409 - 28,956,326 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	28,238,656 - 28,291,565 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	29,233,987 - 29,290,447 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	29,233,987 - 29,290,447 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	18	28,940,034 - 28,997,334 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	18	29,043,386 - 29,096,475 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	18	29,070,391 - 29,138,459 (-)	NCBI
Celera	18	27,742,853 - 27,795,443 (-)	NCBI		Celera
Cytogenetic Map	18	p11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant intellectual developmental disorder 31 (ISO)

familial adenomatous polyposis 1 (ISO)

genetic disease (ISO)

Hereditary Neoplastic Syndromes (ISO)

Neurodevelopmental Disorders (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

(S)-nicotine (ISO)

1,2-dimethylhydrazine (ISO)

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

4,4'-diaminodiphenylmethane (ISO)

acrolein (ISO)

aflatoxin B1 (ISO)

alpha-pinene (ISO)

aristolochic acid A (ISO)

bisphenol A (EXP,ISO)

Brodifacoum (EXP)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

caffeine (ISO)

CGP 52608 (ISO)

crocidolite asbestos (ISO)

cylindrospermopsin (ISO)

dibutyl phthalate (ISO)

diuron (EXP,ISO)

epoxiconazole (ISO)

ethanol (ISO)

finasteride (EXP)

flutamide (EXP)

gentamycin (EXP)

ivermectin (ISO)

methidathion (ISO)

miconazole (ISO)

N,N-diethyl-m-toluamide (EXP)

nicotine (ISO)

ozone (ISO)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

permethrin (EXP)

pyrogallol (ISO)

SB 431542 (ISO)

sunitinib (ISO)

tetrachloromethane (ISO)

tolcapone (EXP)

toluene (EXP)

tungsten (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin cytoskeleton organization (ISO)

B cell activation (ISO)

cerebellum development (ISO)

negative regulation of amyloid fibril formation (ISO)

protein folding (IBA,ISO)

telencephalon development (ISO)

Cellular Component

cytoplasm (IBA)

prefoldin complex (ISO)

Molecular Function

amyloid-beta binding (ISO)

protein binding (ISO)

protein folding chaperone (IBA,ISO)

unfolded protein binding (IBA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:16876117	PMID:18566413

Genomics

Comparative Map Data

Pfdn1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	28,288,210 - 28,341,198 (-)	NCBI		GRCr8
mRatBN7.2	18	28,014,145 - 28,067,148 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	28,014,145 - 28,067,064 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	18	28,141,323 - 28,194,236 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	28,903,409 - 28,956,326 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	28,238,656 - 28,291,565 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	29,233,987 - 29,290,447 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	29,233,987 - 29,290,447 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	18	28,940,034 - 28,997,334 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	18	29,043,386 - 29,096,475 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	18	29,070,391 - 29,138,459 (-)	NCBI
Celera	18	27,742,853 - 27,795,443 (-)	NCBI		Celera
Cytogenetic Map	18	p11	NCBI

PFDN1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	140,245,035 - 140,303,101 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	140,245,035 - 140,303,113 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	139,624,620 - 139,682,686 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	139,604,819 - 139,662,873 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	139,604,835 - 139,662,847	NCBI
Celera	5	135,701,310 - 135,759,316 (-)	NCBI		Celera
Cytogenetic Map	5	q31.3	NCBI
HuRef	5	134,769,914 - 134,827,849 (-)	NCBI		HuRef
CHM1_1	5	139,057,759 - 139,115,827 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	5	140,770,478 - 140,828,531 (-)	NCBI		T2T-CHM13v2.0

Pfdn1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	18	36,536,732 - 36,587,548 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	18	36,536,729 - 36,587,577 (-)	Ensembl		GRCm39 Ensembl
GRCm38	18	36,403,679 - 36,454,495 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	18	36,403,676 - 36,454,524 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	18	36,563,333 - 36,614,149 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	18	36,529,653 - 36,580,469 (-)	NCBI		MGSCv36	mm8
Celera	18	36,859,471 - 36,910,850 (-)	NCBI		Celera
Cytogenetic Map	18	B2	NCBI
cM Map	18	19.46	NCBI

Pfdn1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955418	351,078 - 414,292 (+)	NCBI	ChiLan1.0	ChiLan1.0

PFDN1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	135,504,946 - 135,564,989 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	133,644,503 - 133,702,578 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	135,611,791 - 135,669,895 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	141,729,128 - 141,786,822 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	141,729,128 - 141,786,822 (-)	Ensembl	panpan1.1		panPan2

PFDN1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	35,454,139 - 35,519,818 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	35,454,404 - 35,519,725 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	32,557,224 - 32,588,680 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	35,909,878 - 35,975,476 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	35,907,816 - 35,975,361 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	32,961,926 - 33,027,195 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	33,829,331 - 33,894,632 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	34,582,250 - 34,647,518 (-)	NCBI		UU_Cfam_GSD_1.0

Pfdn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	152,296,230 - 152,359,310 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936531	9,252,216 - 9,311,581 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936531	9,252,195 - 9,311,531 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PFDN1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	142,011,063 - 142,077,925 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	142,011,568 - 142,078,000 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	147,954,676 - 148,021,374 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PFDN1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	42,892,818 - 42,953,540 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	42,892,401 - 42,953,491 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666034	34,931,427 - 34,992,605 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pfdn1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624743	33,012,922 - 33,083,654 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624743	33,012,920 - 33,083,776 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Pfdn1
335 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	132
Count of miRNA genes:	96
Interacting mature miRNAs:	123
Transcripts:	ENSRNOT00000025353
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2312598	Bp340	Blood pressure QTL 340		0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	1	30558703	Rat
2300180	Bmd67	Bone mineral density QTL 67	4.8	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	18	1	34291613	Rat
2293661	Bss50	Bone structure and strength QTL 50	4.64	0.0003	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	18	1	34291613	Rat
61388	Bp2	Blood pressure QTL 2	3.23		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	1	35374722	Rat
9589153	Insul31	Insulin level QTL 31	7.15	0.05	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	18	1	42547119	Rat
2299160	Iddm35	Insulin dependent diabetes mellitus QTL 35	2.79		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	18	4207941	60377792	Rat
2312568	Glom21	Glomerulus QTL 21	2	0.005	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	18	5185858	40503530	Rat
2293708	Bss46	Bone structure and strength QTL 46	8.8	0.0001	lumbar vertebra morphology trait (VT:0010494)	lumbar vertebra cortical cross-sectional area (CMO:0001690)	18	11791518	63636873	Rat
1578661	Bss20	Bone structure and strength QTL 20	3.7		femur morphology trait (VT:0000559)	femoral neck cross-sectional area (CMO:0001697)	18	11791518	83218561	Rat
1578667	Bss21	Bone structure and strength QTL 21	3.5		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	18	11791518	83218561	Rat
61382	Bp46	Blood pressure QTL 46	18.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	11941791	31393320	Rat
631264	Scl22	Serum cholesterol level QTL 22	6.2		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	18	11941791	31393320	Rat
1331766	Bp236	Blood pressure QTL 236	3.022		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	11944299	31359530	Rat
61375	Bp41	Blood pressure QTL 41	2.4		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	18	11944299	41122201	Rat
1331753	Bp231	Blood pressure QTL 231	3.643		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	11944299	52293055	Rat
1358358	Sradr6	Stress Responsive Adrenal Weight QTL 6	2.49		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	18	11944299	59330563	Rat
6903359	Bp355	Blood pressure QTL 355	3.6		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	11944544	59796478	Rat
2313082	Bss85	Bone structure and strength QTL 85	0.8	0.0001	long bone metaphysis morphology trait (VT:0000133)	tibia midshaft total cross-sectional area (CMO:0001715)	18	14951337	59951337	Rat
1358193	Emca2	Estrogen-induced mammary cancer QTL 2	1.6		mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	18	18007599	63571040	Rat
1331735	Rf44	Renal function QTL 44	2.981		urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	18	18234564	31359530	Rat
1331775	Bp235	Blood pressure QTL 235	3.201		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	18234564	31359530	Rat
1600373	Mamtr6	Mammary tumor resistance QTL 6			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	18	19278901	83218561	Rat
1331741	Bp232	Blood pressure QTL 232	3.59112		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	21372893	83213037	Rat
1641923	Colcr8	Colorectal carcinoma resistance QTL 8	3.1	0.0014	intestine integrity trait (VT:0010554)	poorly differentiated malignant colorectal tumor number (CMO:0002076)	18	22066242	52293055	Rat
1331733	Bp233	Blood pressure QTL 233	3.97196		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	24796977	79788953	Rat
2325839	Bp348	Blood pressure QTL 348		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	25570985	70570985	Rat
12904673	Cm127	Cardiac mass QTL 127		0.005	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	18	26548082	46969551	Rat
12904675	Am19	Aortic mass QTL 19		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	18	26548082	46969551	Rat
12904677	Kidm72	Kidney mass QTL 72		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	18	26548082	46969551	Rat
12904668	Bw188	Body weight QTL 188		0.03	body mass (VT:0001259)	body weight (CMO:0000012)	18	26548082	46969551	Rat
12904669	Cm125	Cardiac mass QTL 125		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	18	26548082	46969551	Rat
12904670	Cm126	Cardiac mass QTL 126		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	18	26548082	46969551	Rat
2301413	Bp318	Blood pressure QTL 318		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	26548082	46969551	Rat

Markers in Region

D18Rat35

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	28,026,021 - 28,026,196 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	29,245,863 - 29,246,037	NCBI	Rnor6.0
Rnor_5.0	18	28,951,910 - 28,952,084	UniSTS	Rnor5.0
RGSC_v3.4	18	29,055,261 - 29,055,436	RGD	RGSC3.4
RGSC_v3.4	18	29,055,262 - 29,055,436	UniSTS	RGSC3.4
RGSC_v3.1	18	29,081,908 - 29,082,082	RGD
Celera	18	27,754,729 - 27,754,909	UniSTS
RH 3.4 Map	18	390.1	RGD
RH 3.4 Map	18	390.1	UniSTS
RH 2.0 Map	18	521.3	RGD
FHH x ACI Map	18	19.38	RGD
Cytogenetic Map	18	p11	UniSTS

D18Rat59

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	28,050,464 - 28,050,665 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	29,270,520 - 29,270,720	NCBI	Rnor6.0
Rnor_5.0	18	28,976,567 - 28,976,767	UniSTS	Rnor5.0
RGSC_v3.4	18	29,079,671 - 29,079,990	RGD	RGSC3.4
RGSC_v3.4	18	29,079,703 - 29,079,903	UniSTS	RGSC3.4
RGSC_v3.1	18	29,106,349 - 29,106,549	RGD
Celera	18	27,778,941 - 27,779,141	UniSTS
RH 3.4 Map	18	390.2	RGD
RH 3.4 Map	18	390.2	UniSTS
RH 2.0 Map	18	520.9	RGD
SHRSP x BN Map	18	12.6699	RGD
Cytogenetic Map	18	p11	UniSTS

RH128014

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	28,014,635 - 28,014,819 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	29,234,478 - 29,234,661	NCBI	Rnor6.0
Rnor_5.0	18	28,940,525 - 28,940,708	UniSTS	Rnor5.0
RGSC_v3.4	18	29,043,877 - 29,044,060	UniSTS	RGSC3.4
Celera	18	27,743,344 - 27,743,527	UniSTS
RH 3.4 Map	18	390.0	UniSTS
Cytogenetic Map	18	p11	UniSTS

PMC18810P1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_5.0	1	206,487,422 - 206,487,559	NCBI	Rnor5.0
RGSC_v3.4	1	187,303,086 - 187,303,222	UniSTS	RGSC3.4
Celera	1	180,278,983 - 180,279,119	UniSTS
Cytogenetic Map	18	p11	UniSTS
Cytogenetic Map	3	q35	UniSTS
Cytogenetic Map	1	q22	UniSTS
Cytogenetic Map	8	q24	UniSTS

PMC350564P1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_5.0	1	206,487,427 - 206,487,551	NCBI	Rnor5.0
RGSC_v3.4	1	187,303,091 - 187,303,214	UniSTS	RGSC3.4
Celera	1	180,278,988 - 180,279,111	UniSTS
Cytogenetic Map	18	p11	UniSTS
Cytogenetic Map	3	q35	UniSTS
Cytogenetic Map	1	q22	UniSTS
Cytogenetic Map	8	q24	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	57	41	19	41	8	11	74	35	41	11	8
Low
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001108427	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039096961	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473974	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ227006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ234841	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000025353 ⟹ ENSRNOP00000025353

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	18	28,014,145 - 28,067,064 (-)	Ensembl
Rnor_6.0 Ensembl	18	29,233,987 - 29,290,447 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000099632 ⟹ ENSRNOP00000085908

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	18	28,014,547 - 28,067,064 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000099811 ⟹ ENSRNOP00000086719

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	18	28,028,463 - 28,067,064 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000102443 ⟹ ENSRNOP00000087707

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	18	28,029,783 - 28,067,064 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000115511 ⟹ ENSRNOP00000085736

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	18	28,014,145 - 28,064,166 (-)	Ensembl

RefSeq Acc Id:

NM_001108427 ⟹ NP_001101897

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	28,288,210 - 28,341,123 (-)	NCBI
mRatBN7.2	18	28,014,145 - 28,067,064 (-)	NCBI
Rnor_6.0	18	29,233,987 - 29,290,447 (-)	NCBI
Rnor_5.0	18	28,940,034 - 28,997,334 (-)	NCBI
RGSC_v3.4	18	29,043,386 - 29,096,475 (-)	RGD
Celera	18	27,742,853 - 27,795,443 (-)	RGD

Sequence:

show sequence

TAGCGCAGGCGCATAGTGTCCTTCAATATGGCCGCCTCCGTGGATCTGGAGTTGAAGAAGGCCT
TCACAGAGCTTCAAGCCAAAGTTATTGATACTCAACAGAAGGTGAAGCTTGCAGACATACAGAT
TGAACAGCTAAACAGGACAAAAAAGCACGCACACCTTACGGACACGGAGATCATGACACTGGTG
GATGAGACTAACATGTATGAAGGTGTAGGAAGAATGTTTATTCTACAGTCCAAGGAAGTAATTC
ACAACCAGCTGTTAGAAAAACAGAAAATAGCAGAAGAAAAAATTAAAGAGCTGGAGCAGAAAAA
GTCCTACCTGGAACGGAGTGTTAAGGAAGCTGAAGACAACATCCGAGAAATGCTGATGGCTCGA
AGGGCACAGTAGGAGCTGCTGGGAAAGTTCTTCCTTTCTGATCCCTCTCATCCTGTGTCAAGAC
AGGGGTTGTGCAGGGCACTGCCCTCCCTCTGCCCTGTGGCCCCATCTCTCTGTCACCCTGAGGC
CCTTCAGGTCCCAACTGAATGTCTGCCAACCACTGCCCAGGACACTCTTCTTTCCTGGGGCAAG
CCAGGAGCTCTCAACAGAGGGAAGAAATGGAGGGCAGAGGGAGAAAGCTGCCCAAGCCTGTCAC
TAGGCATGTGGGTTAGACCAGGTTAGACCAATAAAAAACTATGTCTCACTCTATGACATCTGCT
TTTCTCCAACTGAGGAGAGAGAGGCAAGTGTCTACCTCAGCTCGCGTCCCTTTTTTCTCCTCCT
TCTGTCCCTTGACAGGTGACACATGGGCCTCCCTGTAGAGCATAGAAGAAGGAAGACAAGTTGA
TAGGTGAGGTGAACAGAGCCACAGTTGGCGTCAGGGTTCCTTCCCTGTTTTCTCCTCAGAATTC
CAAAACAAAGTTCAATAGCAAGCAGCATCTCTGGCTCTGTCTGGCCATGGTGCCACCTCTGAGC
TCCCCTTCGTTTTCTCAGAACAGCCCGTTCACCGCGCAGCTTTCAGGAATTTACTGCAGGTCAG
CTGAACACAACTGTTCTTGAAAACTAGATGTAAACTAAGTATTTCGAAAAAACTACTAGTGAAT
ACTCAGAACACC

hide sequence

RefSeq Acc Id:

XM_039096961 ⟹ XP_038952889

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	28,288,617 - 28,341,198 (-)	NCBI
mRatBN7.2	18	28,014,549 - 28,067,148 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001101897	(Get FASTA)	NCBI Sequence Viewer
	XP_038952889	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL76293	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000025353
	ENSRNOP00000025353.4
	ENSRNOP00000085736.1
	ENSRNOP00000085908
	ENSRNOP00000085908.1
	ENSRNOP00000086719.1
	ENSRNOP00000087707.1

RefSeq Acc Id:	NP_001101897 ⟸ NM_001108427
- UniProtKB:	D3ZX38 (UniProtKB/TrEMBL), A6J311 (UniProtKB/TrEMBL), A0A8I6A4I0 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAASVDLELKKAFTELQAKVIDTQQKVKLADIQIEQLNRTKKHAHLTDTEIMTLVDETNMYEGV GRMFILQSKEVIHNQLLEKQKIAEEKIKELEQKKSYLERSVKEAEDNIREMLMARRAQ hide sequence

RefSeq Acc Id:

ENSRNOP00000025353 ⟸ ENSRNOT00000025353

RefSeq Acc Id:	XP_038952889 ⟸ XM_039096961
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6A3F6 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSRNOP00000085736 ⟸ ENSRNOT00000115511

RefSeq Acc Id:

ENSRNOP00000087707 ⟸ ENSRNOT00000102443

RefSeq Acc Id:

ENSRNOP00000086719 ⟸ ENSRNOT00000099811

RefSeq Acc Id:

ENSRNOP00000085908 ⟸ ENSRNOT00000099632

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZX38-F1-model_v2	AlphaFold	D3ZX38	1-122	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700719

Promoter ID:

EPDNEW_R11242

Type:

initiation region

Name:

Pfdn1_1

Description:

prefoldin subunit 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	18	29,290,427 - 29,290,487	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305603	AgrOrtholog
BioCyc Gene	G2FUF-7876	BioCyc
Ensembl Genes	ENSRNOG00000018653	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000025353	ENTREZGENE
	ENSRNOT00000025353.6	UniProtKB/TrEMBL
	ENSRNOT00000099632.1	UniProtKB/TrEMBL
	ENSRNOT00000099811.1	UniProtKB/TrEMBL
	ENSRNOT00000102443.1	UniProtKB/TrEMBL
	ENSRNOT00000115511.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.287.370	UniProtKB/TrEMBL
InterPro	PFD_beta-like	UniProtKB/TrEMBL
	Prefoldin	UniProtKB/TrEMBL
KEGG Report	rno:361310	UniProtKB/TrEMBL
NCBI Gene	361310	ENTREZGENE
PANTHER	PREFOLDIN SUBUNIT 1	UniProtKB/TrEMBL
	PREFOLDIN SUBUNIT 1-RELATED	UniProtKB/TrEMBL
Pfam	Prefoldin_2	UniProtKB/TrEMBL
PhenoGen	Pfdn1	PhenoGen
RatGTEx	ENSRNOG00000018653	RatGTEx
Superfamily-SCOP	Prefoldin	UniProtKB/TrEMBL
UniProt	A0A8I6A3F6	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6A4I0	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6A6J4_RAT	UniProtKB/TrEMBL
	A0A8I6A8A6_RAT	UniProtKB/TrEMBL
	A6J311	ENTREZGENE, UniProtKB/TrEMBL
	D3ZX38	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2009-02-26	Pfdn1	prefoldin subunit 1	Pfdn1	prefoldin 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Pfdn1	prefoldin 1	Pfdn1_predicted	prefoldin 1 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Pfdn1_predicted	prefoldin 1 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar