Dhrs3 (dehydrogenase/reductase 3) - Rat Genome Database

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Gene: Dhrs3 (dehydrogenase/reductase 3) Rattus norvegicus
Analyze
Symbol: Dhrs3
Name: dehydrogenase/reductase 3
RGD ID: 1305584
Description: Predicted to enable all-trans-retinol dehydrogenase (NAD+) activity and all-trans-retinol dehydrogenase (NADP+) activity. Predicted to be involved in regulation of retinoic acid receptor signaling pathway and retinoid metabolic process. Predicted to act upstream of or within several processes, including heart morphogenesis; negative regulation of retinoic acid receptor signaling pathway; and regulation of ossification. Predicted to be located in membrane. Predicted to be active in lipid droplet. Orthologous to human DHRS3 (dehydrogenase/reductase 3); PARTICIPATES IN retinol metabolic pathway; vitamin A deficiency pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: dehydrogenase/reductase (SDR family) member 3; dehydrogenase/reductase member 2; LOC313689; MGC125166; retinal dehydrogenase/reductase family member 3; short-chain dehydrogenase/reductase 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85162,031,853 - 162,065,655 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5162,031,386 - 162,065,653 (+)EnsemblGRCr8
mRatBN7.25156,747,939 - 156,782,420 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5156,747,962 - 156,782,417 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5159,442,883 - 159,476,659 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05161,216,178 - 161,249,955 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05161,172,504 - 161,206,285 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05162,809,090 - 162,843,385 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5162,808,646 - 162,843,383 (+)Ensemblrn6Rnor6.0
Rnor_5.05166,490,669 - 166,524,735 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45163,341,856 - 163,375,604 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5155,037,838 - 155,072,177 (+)NCBICelera
RGSC_v3.15163,351,897 - 163,386,360 (+)NCBI
Cytogenetic Map5q36NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(S)-nicotine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,1-dichloroethene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitroacetophenone  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetohexamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldosterone  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (ISO)
androst-4-ene-3,17-dione  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
benzil  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzoates  (ISO)
bexarotene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
clofibric acid  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
corosolic acid  (ISO)
cyclosporin A  (ISO)
cyproconazole  (EXP)
D-glyceraldehyde  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
diethyl malate  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (ISO)
disulfiram  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
estrone  (ISO)
fenarimol  (EXP)
flusilazole  (EXP,ISO)
flutamide  (EXP)
fulvestrant  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glyceraldehyde  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
iron dichloride  (ISO)
isoprenaline  (ISO)
isotretinoin  (ISO)
ketoconazole  (EXP)
lead diacetate  (EXP,ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP)
methylmercury chloride  (ISO)
miconazole  (ISO)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
Muraglitazar  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
niclosamide  (ISO)
nicotine  (ISO)
nitrofen  (EXP)
okadaic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
triadimefon  (EXP)
trichloroethene  (EXP,ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
zearalenone  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:22790594   PMID:24005908  


Genomics

Comparative Map Data
Dhrs3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85162,031,853 - 162,065,655 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5162,031,386 - 162,065,653 (+)EnsemblGRCr8
mRatBN7.25156,747,939 - 156,782,420 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5156,747,962 - 156,782,417 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5159,442,883 - 159,476,659 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05161,216,178 - 161,249,955 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05161,172,504 - 161,206,285 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05162,809,090 - 162,843,385 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5162,808,646 - 162,843,383 (+)Ensemblrn6Rnor6.0
Rnor_5.05166,490,669 - 166,524,735 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45163,341,856 - 163,375,604 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5155,037,838 - 155,072,177 (+)NCBICelera
RGSC_v3.15163,351,897 - 163,386,360 (+)NCBI
Cytogenetic Map5q36NCBI
DHRS3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38112,567,910 - 12,618,210 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl112,567,909 - 12,620,133 (-)Ensemblhg38GRCh38
GRCh37112,627,939 - 12,678,216 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36112,550,526 - 12,600,407 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34112,562,205 - 12,611,734NCBI
Celera111,739,647 - 11,790,328 (-)NCBICelera
Cytogenetic Map1p36.21NCBI
HuRef111,780,861 - 11,830,631 (-)NCBIHuRef
CHM1_1112,615,961 - 12,665,873 (-)NCBICHM1_1
T2T-CHM13v2.0112,112,042 - 12,164,110 (-)NCBIT2T-CHM13v2.0
Dhrs3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394144,618,712 - 144,654,214 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4144,619,397 - 144,654,779 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm384144,892,534 - 144,928,209 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4144,892,827 - 144,928,209 (+)Ensemblmm10GRCm38
MGSCv374144,482,730 - 144,517,548 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364144,159,764 - 144,194,896 (+)NCBIMGSCv36mm8
Celera4146,478,723 - 146,513,572 (+)NCBICelera
Cytogenetic Map4E1NCBI
cM Map478.14NCBI
Dhrs3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554861,439,179 - 1,474,130 (+)Ensembl
ChiLan1.0NW_0049554861,439,179 - 1,473,476 (+)NCBIChiLan1.0ChiLan1.0
DHRS3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21215,613,024 - 215,666,906 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11214,262,703 - 214,313,799 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0111,319,109 - 11,370,463 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1112,533,696 - 12,584,381 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl112,533,696 - 12,584,381 (-)EnsemblpanPan2panpan1.1
DHRS3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1283,826,361 - 83,865,412 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl283,826,374 - 83,865,426 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha280,360,613 - 80,399,101 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0284,466,959 - 84,505,451 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl284,469,339 - 84,505,448 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1281,237,580 - 81,276,024 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0282,236,372 - 82,274,800 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0283,302,792 - 83,341,302 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dhrs3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505835,412,395 - 35,445,492 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364741,235,962 - 1,269,510 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364741,237,177 - 1,270,299 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DHRS3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl672,556,236 - 72,598,815 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1672,556,234 - 72,599,233 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2666,685,233 - 66,695,568 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DHRS3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120119,183,453 - 119,236,953 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20119,184,996 - 119,237,015 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605422,986,171 - 23,040,105 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dhrs3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624818557,409 - 590,872 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624818557,399 - 590,872 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Dhrs3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1113,901,169 - 13,936,918 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Dhrs3
239 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:44
Count of miRNA genes:39
Interacting mature miRNAs:43
Transcripts:ENSRNOT00000021155
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
1354583Despr3Despair related QTL34.980.0002locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)5132930505172190305Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5141212838172190305Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5149642129171146538Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5160111176171146538Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5133789363172190305Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5134369199172190305Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136631198172190305Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5156396728172190305Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133081618172190305Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
631263Cm24Cardiac mass QTL 243.5heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)5149805999162987697Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5138002522170842766Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133270647172190305Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5160071170172129029Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)5141764300172190305Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5133789363172190305Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5148093485172129029Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5156396728167181764Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5131708216172190305Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5149661912166600247Rat
1298090Bp155Blood pressure QTL 1553.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)5156289283171137955Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133081618172190305Rat

Markers in Region
D5Rat47  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr85162,039,559 - 162,039,678 (+)Marker Load Pipeline
mRatBN7.25156,756,326 - 156,756,443 (+)MAPPERmRatBN7.2
Rnor_6.05162,817,289 - 162,817,407NCBIRnor6.0
Rnor_5.05166,498,868 - 166,498,986UniSTSRnor5.0
RGSC_v3.45163,349,562 - 163,349,681RGDRGSC3.4
RGSC_v3.45163,349,563 - 163,349,681UniSTSRGSC3.4
Celera5155,045,557 - 155,045,675UniSTS
RGSC_v3.15163,359,751 - 163,359,869RGD
RH 3.4 Map51061.7RGD
RH 3.4 Map51061.7UniSTS
RH 2.0 Map51086.7RGD
SHRSP x BN Map594.3499RGD
FHH x ACI Map591.9599RGD
Cytogenetic Map5q36UniSTS
AU049431  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25156,766,572 - 156,766,753 (+)MAPPERmRatBN7.2
Rnor_6.05162,827,538 - 162,827,718NCBIRnor6.0
Rnor_5.05166,508,888 - 166,509,068UniSTSRnor5.0
RGSC_v3.45163,359,757 - 163,359,937UniSTSRGSC3.4
Celera5155,056,330 - 155,056,510UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
23 13 82 208 91 90 59 140 59 6 462 264 21 187 108 121 31 33 33

Sequence


Ensembl Acc Id: ENSRNOT00000021155   ⟹   ENSRNOP00000021155
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5162,031,386 - 162,065,653 (+)Ensembl
mRatBN7.2 Ensembl5156,747,962 - 156,782,417 (+)Ensembl
Rnor_6.0 Ensembl5162,808,646 - 162,843,383 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000097510   ⟹   ENSRNOP00000092929
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5162,031,471 - 162,065,653 (+)Ensembl
mRatBN7.2 Ensembl5156,747,962 - 156,782,417 (+)Ensembl
RefSeq Acc Id: NM_001037199   ⟹   NP_001032276
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85162,031,853 - 162,065,655 (+)NCBI
mRatBN7.25156,748,619 - 156,782,420 (+)NCBI
Rnor_6.05162,809,090 - 162,843,385 (+)NCBI
Rnor_5.05166,490,669 - 166,524,735 (+)NCBI
RGSC_v3.45163,341,856 - 163,375,604 (+)RGD
Celera5155,037,838 - 155,072,177 (+)RGD
Sequence:
RefSeq Acc Id: NP_001032276   ⟸   NM_001037199
- UniProtKB: Q3B7V0 (UniProtKB/TrEMBL),   A6IU09 (UniProtKB/TrEMBL),   A1YR15 (UniProtKB/TrEMBL),   F7FCZ4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000021155   ⟸   ENSRNOT00000021155
Ensembl Acc Id: ENSRNOP00000092929   ⟸   ENSRNOT00000097510
Protein Domains
Ketoreductase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q3B7V0-F1-model_v2 AlphaFold Q3B7V0 1-302 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694245
Promoter ID:EPDNEW_R4770
Type:multiple initiation site
Name:Dhrs3_1
Description:dehydrogenase/reductase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R4771  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05162,808,644 - 162,808,704EPDNEW
RGD ID:13694246
Promoter ID:EPDNEW_R4771
Type:initiation region
Name:Dhrs3_2
Description:dehydrogenase/reductase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R4770  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05162,809,000 - 162,809,060EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305584 AgrOrtholog
BioCyc Gene G2FUF-39256 BioCyc
BioCyc Pathway PWY-6857 [retinol biosynthesis] BioCyc
  PWY-6861 [the visual cycle I (vertebrates)] BioCyc
BioCyc Pathway Image PWY-6857 BioCyc
  PWY-6861 BioCyc
Ensembl Genes ENSRNOG00000015736 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000021155 ENTREZGENE
  ENSRNOT00000021155.7 UniProtKB/TrEMBL
  ENSRNOT00000097510.2 UniProtKB/TrEMBL
Gene3D-CATH NAD(P)-binding Rossmann-like Domain UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7322355 IMAGE-MGC_LOAD
InterPro Glc/ribitol_DH UniProtKB/TrEMBL
  KR_dom UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/TrEMBL
  PKS_KR UniProtKB/TrEMBL
KEGG Report rno:313689 UniProtKB/TrEMBL
MGC_CLONE MGC:125166 IMAGE-MGC_LOAD
NCBI Gene 313689 ENTREZGENE
PANTHER PKSB UniProtKB/TrEMBL
  PTHR24322:SF483 UniProtKB/TrEMBL
Pfam adh_short UniProtKB/TrEMBL
  PF08659 UniProtKB/TrEMBL
PhenoGen Dhrs3 PhenoGen
PRINTS GDHRDH UniProtKB/TrEMBL
  SDRFAMILY UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015736 RatGTEx
SMART PKS_KR UniProtKB/TrEMBL
Superfamily-SCOP SSF51735 UniProtKB/TrEMBL
UniProt A0A8A1UIA7_RAT UniProtKB/TrEMBL
  A0A8I6AIX3_RAT UniProtKB/TrEMBL
  A0ABZ3NNF2_RAT UniProtKB/TrEMBL
  A1YR15 ENTREZGENE, UniProtKB/TrEMBL
  A6IU09 ENTREZGENE, UniProtKB/TrEMBL
  A6IU10_RAT UniProtKB/TrEMBL
  A6IU11_RAT UniProtKB/TrEMBL
  F7FCZ4 ENTREZGENE, UniProtKB/TrEMBL
  Q3B7V0 ENTREZGENE
UniProt Secondary Q3B7V0 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-01 Dhrs3  dehydrogenase/reductase 3  Dhrs3  dehydrogenase/reductase (SDR family) member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Dhrs3  dehydrogenase/reductase (SDR family) member 3  Dhrs3_predicted  dehydrogenase/reductase (SDR family) member 3 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Dhrs3_predicted  dehydrogenase/reductase (SDR family) member 3 (predicted)      Symbol and Name status set to approved 70820 APPROVED