Pax2 (paired box 2) - Rat Genome Database

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Gene: Pax2 (paired box 2) Rattus norvegicus
Analyze
Symbol: Pax2
Name: paired box 2
RGD ID: 1305568
Description: Predicted to enable C2H2 zinc finger domain binding activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cellular response to epidermal growth factor stimulus; positive regulation of cell population proliferation; and response to nutrient levels. Predicted to be located in centriolar satellite and nucleus. Predicted to be part of protein-DNA complex. Biomarker of nephroblastoma. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis 7; renal Wilms' tumor; and renal coloboma syndrome. Orthologous to human PAX2 (paired box 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; atrazine; bis(2-ethylhexyl) phthalate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC293992; paired box gene 2; paired box homeotic gene 2; paired box protein 2; paired box protein Pax-2; Pax-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81253,555,447 - 253,646,623 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1253,555,418 - 253,645,438 (+)EnsemblGRCr8
mRatBN7.21243,616,509 - 243,697,454 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1243,616,606 - 243,695,321 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1251,764,024 - 251,843,009 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01258,462,042 - 258,540,874 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01251,113,975 - 251,192,959 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01264,493,579 - 264,585,073 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1264,504,591 - 264,583,329 (+)Ensemblrn6Rnor6.0
Rnor_5.01271,936,269 - 272,027,514 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41249,804,055 - 249,895,306 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1239,428,164 - 239,506,765 (+)NCBICelera
RGSC_v3.11250,026,899 - 250,155,758 (+)NCBI
Cytogenetic Map1q54NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ development  (IEA)
brain morphogenesis  (ISO,ISS)
branching involved in ureteric bud morphogenesis  (ISO,ISS)
camera-type eye development  (ISO,ISS)
cell differentiation  (IEA)
cell fate determination  (ISO,ISS)
cellular response to epidermal growth factor stimulus  (IEP)
cellular response to glucose stimulus  (ISO,ISS)
cellular response to mechanical stimulus  (ISO)
cellular response to retinoic acid  (ISO,ISS)
central nervous system development  (ISO)
cochlea development  (ISO,ISS)
cochlea morphogenesis  (ISO,ISS)
glial cell differentiation  (ISO,ISS)
inner ear morphogenesis  (ISO,ISS)
kidney development  (ISO)
mesenchymal to epithelial transition  (ISO,ISS)
mesenchymal to epithelial transition involved in metanephros morphogenesis  (ISO,ISS)
mesodermal cell fate specification  (ISO,ISS)
mesonephric duct development  (ISO)
mesonephric tubule development  (ISO)
mesonephric tubule formation  (ISO)
mesonephros development  (ISO,ISS)
metanephric collecting duct development  (ISO,ISS)
metanephric distal convoluted tubule development  (ISO,ISS)
metanephric epithelium development  (ISO)
metanephric mesenchymal cell differentiation  (ISO,ISS)
metanephric mesenchyme development  (ISO,ISS)
metanephric nephron tubule formation  (ISO,ISS)
metanephros development  (ISO)
negative regulation of apoptotic process  (ISO,ISS)
negative regulation of apoptotic process involved in metanephric collecting duct development  (ISO,ISS)
negative regulation of apoptotic process involved in metanephric nephron tubule development  (ISO,ISS)
negative regulation of DNA-templated transcription  (ISO,ISS)
negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis  (ISO,ISS)
negative regulation of mesenchymal cell apoptotic process involved in metanephros development  (ISO,ISS)
negative regulation of programmed cell death  (ISO,ISS)
negative regulation of reactive oxygen species metabolic process  (ISO,ISS)
negative regulation of transcription by RNA polymerase II  (ISO)
nephric duct formation  (ISO,ISS)
nervous system development  (IBA)
neural tube closure  (ISO,ISS)
optic chiasma development  (ISO,ISS)
optic cup morphogenesis involved in camera-type eye development  (ISO,ISS)
optic nerve development  (ISO,ISS)
optic nerve morphogenesis  (ISO,ISS)
optic nerve structural organization  (ISO,ISS)
pancreas development  (ISO)
paramesonephric duct development  (ISO)
positive regulation of branching involved in ureteric bud morphogenesis  (ISO)
positive regulation of cell population proliferation  (IMP)
positive regulation of DNA-templated transcription  (ISO,ISS)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis  (ISO,ISS)
positive regulation of metanephric DCT cell differentiation  (ISO,ISS)
positive regulation of metanephric glomerulus development  (ISO,ISS)
positive regulation of optic nerve formation  (ISO,ISS)
positive regulation of transcription by RNA polymerase II  (ISO,ISS)
pronephric field specification  (ISO,ISS)
pronephros development  (ISO,ISS)
regulation of apoptotic process  (ISO)
regulation of DNA-templated transcription  (IEA)
regulation of metanephric nephron tubule epithelial cell differentiation  (ISO,ISS)
regulation of metanephros size  (ISO,ISS)
regulation of programmed cell death  (ISO)
regulation of transcription by RNA polymerase II  (IBA)
response to nutrient levels  (IEP)
retinal pigment epithelium development  (ISO,ISS)
sensory organ development  (IBA)
stem cell differentiation  (ISO,ISS)
system development  (IEA)
ureter development  (ISO,ISS)
ureter maturation  (ISO,ISS)
ureter morphogenesis  (ISO)
ureteric bud development  (ISO)
urogenital system development  (ISO,ISS)
vestibulocochlear nerve formation  (ISO,ISS)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Mechanisms of impaired nephrogenesis with fetal growth restriction: altered renal transcription and growth factor expression. Abdel-Hakeem AK, etal., Am J Obstet Gynecol. 2008 Sep;199(3):252.e1-7. Epub 2008 Jul 17.
2. A mechanism regulating proteolysis of specific proteins during renal tubular cell growth. Franch HA, etal., J Biol Chem. 2001 Jun 1;276(22):19126-31. Epub 2001 Mar 21.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Gene expression in Wilms' tumor mimics the earliest committed stage in the metanephric mesenchymal-epithelial transition. Li CM, etal., Am J Pathol. 2002 Jun;160(6):2181-90.
6. Involvement of Pax-2 in the action of activin A on tubular cell regeneration. Maeshima A, etal., J Am Soc Nephrol 2002 Dec;13(12):2850-9.
7. Aging-related changes in astrocytes in the rat retina: imbalance between cell proliferation and cell death reduces astrocyte availability. Mansour H, etal., Aging Cell. 2008 Aug;7(4):526-40. Epub 2008 Jun 28.
8. Accumulation of malignant renal stem cells is associated with epigenetic changes in normal renal progenitor genes. Metsuyanim S, etal., Stem Cells. 2008 Jul;26(7):1808-17. doi: 10.1634/stemcells.2007-0322. Epub 2008 May 8.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Therapeutic potential of human induced pluripotent stem cells and renal progenitor cells in experimental chronic kidney disease. Ribeiro PC, etal., Stem Cell Res Ther. 2020 Dec 9;11(1):530. doi: 10.1186/s13287-020-02060-4.
15. A rodent model for Wilms tumors: embryonal kidney neoplasms induced by N-nitroso-N'-methylurea. Sharma PM, etal., Proc Natl Acad Sci U S A. 1994 Oct 11;91(21):9931-5.
16. Suppression of chaperone-mediated autophagy in the renal cortex during acute diabetes mellitus. Sooparb S, etal., Kidney Int. 2004 Jun;65(6):2135-44.
17. Angiotensin II stimulates Pax-2 in rat kidney proximal tubular cells: impact on proliferation and apoptosis. Zhang SL, etal., Kidney Int. 2004 Dec;66(6):2181-92.
Additional References at PubMed
PMID:1337742   PMID:1723950   PMID:7720589   PMID:7856737   PMID:8413205   PMID:8575306   PMID:8951055   PMID:9178767   PMID:10322633   PMID:10536059   PMID:10980123   PMID:11731455  
PMID:11940591   PMID:12200151   PMID:12435636   PMID:12756174   PMID:14695376   PMID:15153556   PMID:15242798   PMID:15905411   PMID:16018995   PMID:16319112   PMID:16368682   PMID:16672320  
PMID:16735463   PMID:16916509   PMID:17047028   PMID:17164400   PMID:17166926   PMID:17300925   PMID:17314325   PMID:17357786   PMID:17513325   PMID:17538188   PMID:17785448   PMID:17881463  
PMID:18000879   PMID:18083586   PMID:18607644   PMID:19037705   PMID:19048125   PMID:19118900   PMID:20171952   PMID:20486844   PMID:20727173   PMID:21731775   PMID:21778682   PMID:23107969  
PMID:23503776   PMID:24471428   PMID:24676634   PMID:24710423   PMID:27939388   PMID:29280536   PMID:30117015  


Genomics

Comparative Map Data
Pax2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81253,555,447 - 253,646,623 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1253,555,418 - 253,645,438 (+)EnsemblGRCr8
mRatBN7.21243,616,509 - 243,697,454 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1243,616,606 - 243,695,321 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1251,764,024 - 251,843,009 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01258,462,042 - 258,540,874 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01251,113,975 - 251,192,959 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01264,493,579 - 264,585,073 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1264,504,591 - 264,583,329 (+)Ensemblrn6Rnor6.0
Rnor_5.01271,936,269 - 272,027,514 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41249,804,055 - 249,895,306 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1239,428,164 - 239,506,765 (+)NCBICelera
RGSC_v3.11250,026,899 - 250,155,758 (+)NCBI
Cytogenetic Map1q54NCBI
PAX2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810100,735,396 - 100,829,944 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10100,735,396 - 100,829,944 (+)Ensemblhg38GRCh38
GRCh3710102,495,153 - 102,589,701 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610102,495,458 - 102,579,688 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3410102,495,321 - 102,579,687NCBI
Celera1096,243,249 - 96,327,456 (+)NCBICelera
Cytogenetic Map10q24.31NCBI
HuRef1096,133,870 - 96,218,089 (+)NCBIHuRef
CHM1_110102,789,756 - 102,873,990 (+)NCBICHM1_1
T2T-CHM13v2.010101,618,753 - 101,713,301 (+)NCBIT2T-CHM13v2.0
Pax2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391944,735,040 - 44,826,708 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1944,735,057 - 44,826,310 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381944,746,601 - 44,838,269 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1944,756,045 - 44,837,871 (+)Ensemblmm10GRCm38
MGSCv371944,831,884 - 44,910,517 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361944,810,705 - 44,889,338 (+)NCBIMGSCv36mm8
Celera1945,528,146 - 45,605,640 (+)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1938.09NCBI
Pax2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554859,350,087 - 9,430,607 (-)Ensembl
ChiLan1.0NW_0049554859,351,913 - 9,430,607 (-)NCBIChiLan1.0ChiLan1.0
PAX2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28112,618,587 - 112,713,001 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110112,623,907 - 112,718,321 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01097,344,978 - 97,429,086 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110100,822,676 - 100,904,065 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10100,822,676 - 100,904,028 (+)EnsemblpanPan2panpan1.1
PAX2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12813,442,894 - 13,519,853 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2813,442,893 - 13,532,094 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2813,606,001 - 13,692,205 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02813,904,432 - 13,990,703 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2813,900,260 - 13,992,558 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12813,450,612 - 13,536,833 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02813,492,258 - 13,578,015 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02813,623,521 - 13,709,771 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pax2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721333,215,941 - 33,325,282 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366004,850,552 - 4,928,214 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366004,850,594 - 4,939,010 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PAX2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14111,823,308 - 111,913,969 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.114111,822,334 - 111,914,950 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214121,481,577 - 121,574,679 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PAX2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1993,763,975 - 93,847,180 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604854,813,496 - 54,880,591 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pax2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624831375,866 - 453,930 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624831375,851 - 453,968 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Pax2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1244,263,882 - 44,342,438 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pax2
611 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:70
Count of miRNA genes:65
Interacting mature miRNAs:69
Transcripts:ENSRNOT00000050076
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1210980612255980612Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1226175591270518180Rat
1578775Iddm21Insulin dependent diabetes mellitus QTL 214.13blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1245782829270518180Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1218829748263829748Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1248619887269633915Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631836Stl31Serum triglyceride level QTL 314.645e-06blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1247133834270518180Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1210980612255980612Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1237995023269633915Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1233480549270108840Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1200449456256003563Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1234540191270518180Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1233480549270108840Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1207163993269633915Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1210980612255980612Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1223134011262090599Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1210980612255980612Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2314011Gluco56Glucose level QTL 56blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1209203273254203273Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1225108840270108840Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1228180370266453608Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1208479811269633915Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1224633915269633915Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1232312773270518180Rat
2316896Gluco57Glucose level QTL 577.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1238398865255849249Rat
1358916Kidm22Kidney mass QTL 223.32kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1212738576257738576Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
2292218Kidm35Kidney mass QTL 35kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1208798288253798288Rat
61400Niddm1Non-insulin dependent diabetes mellitus QTL 111blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1228180243255849249Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1210980612255980612Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1210980612255980612Rat
7387289Uae45Urinary albumin excretion QTL 452.860.0021urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1233204160270518180Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1241569529269633915Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1210980612255980612Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1243953669270518180Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1226175591270518180Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233349180270518180Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1210980612255980612Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1228174566270518180Rat

Markers in Region
RH80285  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21243,695,192 - 243,695,410 (+)MAPPERmRatBN7.2
Rnor_6.01264,583,201 - 264,583,418NCBIRnor6.0
Rnor_5.01272,025,642 - 272,025,859UniSTSRnor5.0
RGSC_v3.41249,895,178 - 249,895,395UniSTSRGSC3.4
Celera1239,506,637 - 239,506,854UniSTS
Cytogenetic Map1q54UniSTS
PMC19453P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21243,649,921 - 243,650,009 (+)MAPPERmRatBN7.2
Rnor_6.01264,537,908 - 264,537,995NCBIRnor6.0
Rnor_5.01271,980,418 - 271,980,505UniSTSRnor5.0
RGSC_v3.41249,849,452 - 249,849,539UniSTSRGSC3.4
Celera1239,461,455 - 239,461,542UniSTS
Cytogenetic Map1q54UniSTS
D11Bir2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.237,207,455 - 7,207,593 (+)MAPPERmRatBN7.2
mRatBN7.21243,621,084 - 243,621,222 (+)MAPPERmRatBN7.2
Rnor_6.01264,508,928 - 264,509,065NCBIRnor6.0
Rnor_6.031,549,052 - 1,549,189NCBIRnor6.0
Rnor_5.031,541,880 - 1,542,017UniSTSRnor5.0
Rnor_5.01271,951,604 - 271,951,741UniSTSRnor5.0
RGSC_v3.41249,808,393 - 249,808,530UniSTSRGSC3.4
RGSC_v3.432,693,184 - 2,693,321UniSTSRGSC3.4
Celera32,044,635 - 2,044,772UniSTS
Celera1239,432,502 - 239,432,639UniSTS
Cytogenetic Map3p13UniSTS
Cytogenetic Map1q54UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
4 1 2 80 32 33 24 2 24 114 5 80 81 80 9 8 8

Sequence


Ensembl Acc Id: ENSRNOT00000050076   ⟹   ENSRNOP00000040130
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1253,555,418 - 253,644,490 (+)Ensembl
mRatBN7.2 Ensembl1243,616,745 - 243,695,321 (+)Ensembl
Rnor_6.0 Ensembl1264,504,591 - 264,583,329 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000085811   ⟹   ENSRNOP00000070907
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1253,555,462 - 253,644,490 (+)Ensembl
mRatBN7.2 Ensembl1243,616,606 - 243,695,321 (+)Ensembl
Rnor_6.0 Ensembl1264,507,985 - 264,538,070 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000129655   ⟹   ENSRNOP00000104618
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1253,565,755 - 253,645,438 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000138817   ⟹   ENSRNOP00000105134
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1253,565,922 - 253,645,438 (+)Ensembl
RefSeq Acc Id: NM_001106361   ⟹   NP_001099831
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81253,565,922 - 253,644,490 (+)NCBI
mRatBN7.21243,616,745 - 243,695,321 (+)NCBI
Rnor_6.01264,504,591 - 264,583,329 (+)NCBI
Rnor_5.01271,936,269 - 272,027,514 (+)NCBI
RGSC_v3.41249,804,055 - 249,895,306 (+)RGD
Celera1239,428,164 - 239,506,765 (+)RGD
Sequence:
RefSeq Acc Id: XM_006231443   ⟹   XP_006231505
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81253,565,686 - 253,646,623 (+)NCBI
mRatBN7.21243,616,509 - 243,697,454 (+)NCBI
Rnor_6.01264,493,579 - 264,585,073 (+)NCBI
Rnor_5.01271,936,269 - 272,027,514 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039109033   ⟹   XP_038964961
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81253,565,263 - 253,646,623 (+)NCBI
mRatBN7.21243,616,645 - 243,697,454 (+)NCBI
RefSeq Acc Id: XM_039109034   ⟹   XP_038964962
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81253,565,822 - 253,646,623 (+)NCBI
mRatBN7.21243,616,645 - 243,697,454 (+)NCBI
RefSeq Acc Id: XM_039109046   ⟹   XP_038964974
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81253,565,686 - 253,646,623 (+)NCBI
mRatBN7.21243,616,509 - 243,697,454 (+)NCBI
RefSeq Acc Id: XM_063287134   ⟹   XP_063143204
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81253,555,447 - 253,646,623 (+)NCBI
RefSeq Acc Id: XM_063287138   ⟹   XP_063143208
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81253,565,822 - 253,646,623 (+)NCBI
RefSeq Acc Id: NP_001099831   ⟸   NM_001106361
- UniProtKB: D4ACZ2 (UniProtKB/TrEMBL),   A6JHG7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231505   ⟸   XM_006231443
- Peptide Label: isoform X5
- Sequence:
Ensembl Acc Id: ENSRNOP00000070907   ⟸   ENSRNOT00000085811
Ensembl Acc Id: ENSRNOP00000040130   ⟸   ENSRNOT00000050076
RefSeq Acc Id: XP_038964974   ⟸   XM_039109046
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038964962   ⟸   XM_039109034
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038964961   ⟸   XM_039109033
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063143204   ⟸   XM_063287134
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063143208   ⟸   XM_063287138
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000104618   ⟸   ENSRNOT00000129655
Ensembl Acc Id: ENSRNOP00000105134   ⟸   ENSRNOT00000138817
Protein Domains
Paired

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4ACZ2-F1-model_v2 AlphaFold D4ACZ2 1-416 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305568 AgrOrtholog
BioCyc Gene G2FUF-55580 BioCyc
Ensembl Genes ENSRNOG00000014253 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000050076 ENTREZGENE
  ENSRNOT00000050076.6 UniProtKB/TrEMBL
  ENSRNOT00000085811 ENTREZGENE
  ENSRNOT00000085811.3 UniProtKB/TrEMBL
  ENSRNOT00000129655 ENTREZGENE
  ENSRNOT00000129655.1 UniProtKB/TrEMBL
  ENSRNOT00000138817 ENTREZGENE
  ENSRNOT00000138817.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
InterPro Homeodomain-like UniProtKB/TrEMBL
  Paired_box_N UniProtKB/TrEMBL
  PAIRED_DNA_bd_dom UniProtKB/TrEMBL
  Pax2_C UniProtKB/TrEMBL
  PAX_fam UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
KEGG Report rno:293992 UniProtKB/TrEMBL
NCBI Gene 293992 ENTREZGENE
PANTHER PAIRED BOX PROTEIN PAX-2 UniProtKB/TrEMBL
  PTHR45636 UniProtKB/TrEMBL
Pfam PAX UniProtKB/TrEMBL
  Pax2_C UniProtKB/TrEMBL
PharmGKB PAX2 RGD
PhenoGen Pax2 PhenoGen
PRINTS PAIREDBOX UniProtKB/TrEMBL
PROSITE PAIRED_1 UniProtKB/TrEMBL
  PAIRED_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014253 RatGTEx
SMART PAX UniProtKB/TrEMBL
Superfamily-SCOP Homeodomain_like UniProtKB/TrEMBL
UniProt A0A0G2JZ47_RAT UniProtKB/TrEMBL
  A0ABK0LQ26_RAT UniProtKB/TrEMBL
  A0ABK0LR90_RAT UniProtKB/TrEMBL
  A6JHG7 ENTREZGENE, UniProtKB/TrEMBL
  D4ACZ2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-30 Pax2  paired box 2  Pax2  paired box gene 2   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Pax2  paired box gene 2   Pax2_predicted  paired box gene 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Pax2_predicted  paired box gene 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED