Ttk (Ttk protein kinase) - Rat Genome Database

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Gene: Ttk (Ttk protein kinase) Rattus norvegicus
Analyze
Symbol: Ttk
Name: Ttk protein kinase
RGD ID: 1305558
Description: Predicted to enable identical protein binding activity; kinetochore binding activity; and protein kinase activity. Predicted to be involved in negative regulation of metaphase/anaphase transition of cell cycle; protein localization to kinetochore; and repair of mitotic kinetochore microtubule attachment defect. Predicted to act upstream of or within female meiosis chromosome segregation; protein localization to chromosome; and protein localization to meiotic spindle midzone. Predicted to be located in cytoplasm. Predicted to be active in kinetochore and nucleus. Orthologous to human TTK (TTK protein kinase); PARTICIPATES IN cell cycle pathway, mitotic; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: dual specificity protein kinase TTK; LOC315852; Monopolar spindle 1; Mps1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8893,632,678 - 93,672,664 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl893,634,319 - 93,672,664 (+)EnsemblGRCr8
mRatBN7.2884,754,329 - 84,792,653 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl884,754,315 - 84,792,651 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx890,359,283 - 90,404,092 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0888,583,852 - 88,622,109 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0886,456,985 - 86,494,976 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0891,368,065 - 91,405,995 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl891,368,111 - 91,405,993 (+)Ensemblrn6Rnor6.0
Rnor_5.0890,886,724 - 90,924,327 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4888,906,665 - 88,944,613 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera884,402,963 - 84,441,218 (+)NCBICelera
Cytogenetic Map8q31NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2-methylcholine  (ISO)
2-palmitoylglycerol  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-azacytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
acetamide  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
aflatoxin M1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
aristolochic acid A  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (EXP)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
choline  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
cryptolepine  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
D-glucose  (ISO)
DDE  (ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
diallyl trisulfide  (ISO)
diazinon  (EXP)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
dicrotophos  (ISO)
dieldrin  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
etoposide  (ISO)
folic acid  (ISO)
FR900359  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (ISO)
geraniol  (ISO)
glucose  (ISO)
GW 4064  (ISO)
irinotecan  (ISO)
kojic acid  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
lidocaine  (EXP)
lithium atom  (EXP)
lithium hydride  (EXP)
lucanthone  (ISO)
methamphetamine  (EXP)
methoxychlor  (EXP)
methylseleninic acid  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
palbociclib  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
PhIP  (ISO)
phytoestrogen  (ISO)
picoxystrobin  (ISO)
piroxicam  (ISO)
potassium chromate  (ISO)
propanal  (ISO)
pyrimidifen  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
senecionine  (EXP)
Senkirkine  (EXP)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
temozolomide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
thalidomide  (ISO)
thapsigargin  (ISO)
thifluzamide  (ISO)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
topotecan  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
Triptolide  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
vincaleukoblastine  (ISO)
vinclozolin  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO)
kinetochore  (IBA,IEA,ISO)
nucleus  (IBA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive Molecular Analyses of a Macrophage-Related Gene Signature With Regard to Prognosis, Immune Features, and Biomarkers for Immunotherapy in Hepatocellular Carcinoma Based on WGCNA and the LASSO Algorithm. Wang T, etal., Front Immunol. 2022 May 27;13:843408. doi: 10.3389/fimmu.2022.843408. eCollection 2022.
Additional References at PubMed
PMID:1375325   PMID:19946888   PMID:21558374   PMID:25197064   PMID:25468996  


Genomics

Comparative Map Data
Ttk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8893,632,678 - 93,672,664 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl893,634,319 - 93,672,664 (+)EnsemblGRCr8
mRatBN7.2884,754,329 - 84,792,653 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl884,754,315 - 84,792,651 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx890,359,283 - 90,404,092 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0888,583,852 - 88,622,109 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0886,456,985 - 86,494,976 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0891,368,065 - 91,405,995 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl891,368,111 - 91,405,993 (+)Ensemblrn6Rnor6.0
Rnor_5.0890,886,724 - 90,924,327 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4888,906,665 - 88,944,613 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera884,402,963 - 84,441,218 (+)NCBICelera
Cytogenetic Map8q31NCBI
TTK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38680,004,649 - 80,042,527 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl680,003,887 - 80,043,580 (+)Ensemblhg38GRCh38
GRCh37680,714,366 - 80,752,244 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36680,771,078 - 80,808,958 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34680,771,077 - 80,808,956NCBI
Celera681,132,293 - 81,170,226 (+)NCBICelera
Cytogenetic Map6q14.1NCBI
HuRef677,937,044 - 77,974,979 (+)NCBIHuRef
CHM1_1680,811,776 - 80,849,705 (+)NCBICHM1_1
T2T-CHM13v2.0681,213,044 - 81,250,924 (+)NCBIT2T-CHM13v2.0
Ttk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39983,716,704 - 83,754,442 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl983,716,742 - 83,754,442 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38983,834,651 - 83,872,390 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl983,834,689 - 83,872,389 (+)Ensemblmm10GRCm38
MGSCv37983,728,296 - 83,765,997 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36983,631,459 - 83,669,102 (+)NCBIMGSCv36mm8
Celera980,934,680 - 80,972,688 (+)NCBICelera
Cytogenetic Map9E2NCBI
cM Map945.61NCBI
Ttk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555027,824,194 - 7,866,879 (+)NCBIChiLan1.0ChiLan1.0
TTK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25100,089,805 - 100,129,839 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1697,969,110 - 98,010,196 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0677,887,382 - 77,925,737 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1681,158,143 - 81,196,478 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl681,158,143 - 81,196,478 (+)EnsemblpanPan2panpan1.1
TTK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11240,915,733 - 40,959,423 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1240,915,439 - 40,957,279 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1240,787,409 - 40,829,802 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01241,678,975 - 41,721,444 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1241,679,025 - 41,720,658 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11240,992,362 - 41,034,814 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01240,969,244 - 41,011,626 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01241,120,015 - 41,162,453 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ttk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494676,256,203 - 76,303,738 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493651010,176,968 - 10,213,483 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TTK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl186,076,583 - 86,125,718 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1186,076,576 - 86,125,334 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2196,781,685 - 96,828,277 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TTK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1134,738,849 - 4,779,563 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl134,738,959 - 4,780,627 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666040180,959,238 - 181,026,938 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ttk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248196,631,697 - 6,682,181 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ttk
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1877,965,343 - 78,002,941 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ttk
797 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:32
Count of miRNA genes:25
Interacting mature miRNAs:31
Transcripts:ENSRNOT00000051612
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)862848139107848139Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)863141536109261840Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)882352698127352698Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)858337123103337123Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)862848139107848139Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)880768445125768445Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)862970527107970527Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)839106363103375781Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)85076395195763951Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)862848139107848139Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)862848139107848139Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)862848139107848139Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)862848139107848139Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)85158969999045312Rat
71120Niddm21Non-insulin dependent diabetes mellitus QTL 213.73blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)866992095111992095Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)860248093105248093Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)839106363103375781Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)884192326132782436Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)879394435132782436Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)839106258103375958Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)862848139107848139Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)863404444108404444Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)855428416107963099Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)862963099107963099Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)880768445125768445Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)870041301121080908Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)850763951107970527Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)868690349119799881Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84961020494610204Rat
10450865Bw175Body weight QTL 1754.1total fat pad mass (VT:0015008)adipose tissue molecular composition measurement (CMO:0000484)884192326129192326Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)84924517894245178Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)885348065130348065Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)839106258103375958Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)862982864107982864Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)84924517894245178Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)880768445125768445Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)880768445125768445Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)891340911131690273Rat

Markers in Region
BQ193649  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8893,634,187 - 93,634,361 (+)Marker Load Pipeline
mRatBN7.2884,754,170 - 84,754,344 (+)MAPPERmRatBN7.2
Rnor_6.0891,367,979 - 91,368,152NCBIRnor6.0
Rnor_5.0890,886,311 - 90,886,484UniSTSRnor5.0
RGSC_v3.4888,906,214 - 88,906,387UniSTSRGSC3.4
Celera884,402,512 - 84,402,685UniSTS
RH 3.4 Map8969.09UniSTS
Cytogenetic Map8q31UniSTS
RH143537  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2884,790,323 - 84,790,480 (+)MAPPERmRatBN7.2
Rnor_6.0891,403,666 - 91,403,822NCBIRnor6.0
Rnor_5.0890,921,998 - 90,922,154UniSTSRnor5.0
RGSC_v3.4888,942,286 - 88,942,442UniSTSRGSC3.4
Celera884,438,891 - 84,439,047UniSTS
RH 3.4 Map8977.6UniSTS
Cytogenetic Map8q31UniSTS
RH137297  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2884,792,409 - 84,792,609 (+)MAPPERmRatBN7.2
Rnor_6.0891,405,752 - 91,405,951NCBIRnor6.0
Rnor_5.0890,924,084 - 90,924,283UniSTSRnor5.0
RGSC_v3.4888,944,372 - 88,944,571UniSTSRGSC3.4
Celera884,440,977 - 84,441,176UniSTS
RH 3.4 Map8978.3UniSTS
Cytogenetic Map8q31UniSTS
BM383386  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8893,644,705 - 93,645,353 (+)Marker Load Pipeline
mRatBN7.2884,764,692 - 84,765,340 (+)MAPPERmRatBN7.2
Rnor_6.0891,378,034 - 91,378,681NCBIRnor6.0
Rnor_5.0890,896,366 - 90,897,013UniSTSRnor5.0
RGSC_v3.4888,916,655 - 88,917,302UniSTSRGSC3.4
Celera884,413,261 - 84,413,908UniSTS
RH 3.4 Map8978.5UniSTS
Cytogenetic Map8q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 66 165 91 90 59 85 59 6 346 184 11 144 79 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001108172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001401052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006243460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006243461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006243462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006243463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006243464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006243465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006243466 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039081526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039081527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039081528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000051612   ⟹   ENSRNOP00000042156
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl893,634,596 - 93,672,664 (+)Ensembl
mRatBN7.2 Ensembl884,754,588 - 84,792,647 (+)Ensembl
Rnor_6.0 Ensembl891,368,430 - 91,405,993 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000083151   ⟹   ENSRNOP00000072355
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl893,634,319 - 93,672,664 (+)Ensembl
mRatBN7.2 Ensembl884,754,315 - 84,792,647 (+)Ensembl
Rnor_6.0 Ensembl891,368,111 - 91,405,988 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114297   ⟹   ENSRNOP00000079704
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl893,634,639 - 93,672,664 (+)Ensembl
mRatBN7.2 Ensembl884,754,622 - 84,792,651 (+)Ensembl
RefSeq Acc Id: NM_001108172   ⟹   NP_001101642
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8893,634,639 - 93,672,664 (+)NCBI
mRatBN7.2884,754,622 - 84,792,651 (+)NCBI
Rnor_6.0891,368,430 - 91,405,993 (+)NCBI
Rnor_5.0890,886,724 - 90,924,327 (+)NCBI
RGSC_v3.4888,906,665 - 88,944,613 (+)RGD
Celera884,402,963 - 84,441,218 (+)RGD
Sequence:
RefSeq Acc Id: NM_001401052   ⟹   NP_001387981
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8893,634,639 - 93,672,663 (+)NCBI
mRatBN7.2884,754,622 - 84,792,650 (+)NCBI
RefSeq Acc Id: XM_006243460   ⟹   XP_006243522
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8893,632,678 - 93,672,660 (+)NCBI
mRatBN7.2884,754,342 - 84,792,653 (+)NCBI
Rnor_6.0891,368,065 - 91,405,995 (+)NCBI
Rnor_5.0890,886,724 - 90,924,327 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006243461   ⟹   XP_006243523
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8893,632,678 - 93,672,660 (+)NCBI
mRatBN7.2884,754,344 - 84,792,653 (+)NCBI
Rnor_6.0891,368,095 - 91,405,995 (+)NCBI
Rnor_5.0890,886,724 - 90,924,327 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006243462   ⟹   XP_006243524
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8893,632,678 - 93,672,660 (+)NCBI
mRatBN7.2884,754,343 - 84,792,653 (+)NCBI
Rnor_6.0891,368,066 - 91,405,995 (+)NCBI
Rnor_5.0890,886,724 - 90,924,327 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006243463   ⟹   XP_006243525
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8893,632,678 - 93,672,660 (+)NCBI
mRatBN7.2884,754,343 - 84,792,653 (+)NCBI
Rnor_6.0891,368,066 - 91,405,995 (+)NCBI
Rnor_5.0890,886,724 - 90,924,327 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006243464   ⟹   XP_006243526
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8893,635,013 - 93,672,660 (+)NCBI
mRatBN7.2884,754,976 - 84,792,653 (+)NCBI
Rnor_6.0891,368,066 - 91,405,995 (+)NCBI
Rnor_5.0890,886,724 - 90,924,327 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006243465   ⟹   XP_006243527
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8893,632,678 - 93,672,660 (+)NCBI
mRatBN7.2884,754,343 - 84,792,653 (+)NCBI
Rnor_6.0891,368,066 - 91,405,995 (+)NCBI
Rnor_5.0890,886,724 - 90,924,327 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006243466   ⟹   XP_006243528
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8893,635,116 - 93,672,660 (+)NCBI
mRatBN7.2884,755,098 - 84,792,653 (+)NCBI
Rnor_6.0891,368,893 - 91,405,995 (+)NCBI
Rnor_5.0890,886,724 - 90,924,327 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039081526   ⟹   XP_038937454
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8893,632,678 - 93,672,660 (+)NCBI
mRatBN7.2884,754,344 - 84,792,653 (+)NCBI
RefSeq Acc Id: XM_039081527   ⟹   XP_038937455
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8893,632,678 - 93,672,660 (+)NCBI
mRatBN7.2884,754,342 - 84,792,653 (+)NCBI
RefSeq Acc Id: XM_039081528   ⟹   XP_038937456
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8893,632,678 - 93,672,660 (+)NCBI
mRatBN7.2884,754,342 - 84,792,653 (+)NCBI
RefSeq Acc Id: XM_063265555   ⟹   XP_063121625
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8893,632,678 - 93,672,660 (+)NCBI
RefSeq Acc Id: XM_063265557   ⟹   XP_063121627
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8893,632,678 - 93,672,660 (+)NCBI
RefSeq Acc Id: NP_001101642   ⟸   NM_001108172
- Peptide Label: isoform 2
- UniProtKB: A6I1S0 (UniProtKB/TrEMBL),   A6I1S3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243526   ⟸   XM_006243464
- Peptide Label: isoform X3
- UniProtKB: A6I1S3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243522   ⟸   XM_006243460
- Peptide Label: isoform X1
- UniProtKB: A6I1S3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243525   ⟸   XM_006243463
- Peptide Label: isoform X3
- UniProtKB: A6I1S3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243527   ⟸   XM_006243465
- Peptide Label: isoform X3
- UniProtKB: A6I1S3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243524   ⟸   XM_006243462
- Peptide Label: isoform X3
- UniProtKB: A6I1S3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243523   ⟸   XM_006243461
- Peptide Label: isoform X2
- UniProtKB: A0A0G2K2S5 (UniProtKB/TrEMBL),   A6I1S3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243528   ⟸   XM_006243466
- Peptide Label: isoform X3
- UniProtKB: A6I1S3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000042156   ⟸   ENSRNOT00000051612
Ensembl Acc Id: ENSRNOP00000072355   ⟸   ENSRNOT00000083151
RefSeq Acc Id: XP_038937455   ⟸   XM_039081527
- Peptide Label: isoform X5
- UniProtKB: A6I1S3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038937456   ⟸   XM_039081528
- Peptide Label: isoform X6
- UniProtKB: A6I1S3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038937454   ⟸   XM_039081526
- Peptide Label: isoform X4
- UniProtKB: D4A4S7 (UniProtKB/TrEMBL),   A6I1S3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000079704   ⟸   ENSRNOT00000114297
RefSeq Acc Id: NP_001387981   ⟸   NM_001401052
- Peptide Label: isoform 1
- UniProtKB: A6I1S3 (UniProtKB/TrEMBL),   D4A4S7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121625   ⟸   XM_063265555
- Peptide Label: isoform X4
- UniProtKB: A6I1S3 (UniProtKB/TrEMBL),   D4A4S7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121627   ⟸   XM_063265557
- Peptide Label: isoform X4
- UniProtKB: A6I1S3 (UniProtKB/TrEMBL),   D4A4S7 (UniProtKB/TrEMBL)
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K2S5-F1-model_v2 AlphaFold A0A0G2K2S5 1-863 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696154
Promoter ID:EPDNEW_R6679
Type:multiple initiation site
Name:Ttk_1
Description:Ttk protein kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0891,368,437 - 91,368,497EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305558 AgrOrtholog
BioCyc Gene G2FUF-29676 BioCyc
Ensembl Genes ENSRNOG00000029055 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000051612 ENTREZGENE
  ENSRNOT00000051612.4 UniProtKB/TrEMBL
  ENSRNOT00000083151 ENTREZGENE
  ENSRNOT00000083151.3 UniProtKB/TrEMBL
  ENSRNOT00000114297 ENTREZGENE
  ENSRNOT00000114297.2 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.10 UniProtKB/TrEMBL
  Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Dual_sp_prot_kinse_Ttk UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Ser/Thr_prot_kinase_AS UniProtKB/TrEMBL
  TPR-like_helical UniProtKB/TrEMBL
NCBI Gene 315852 ENTREZGENE
PANTHER MIXED LINEAGE PROTEIN KINASE UniProtKB/TrEMBL
  PTHR22974:SF21 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PhenoGen Ttk PhenoGen
PROSITE PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
RatGTEx ENSRNOG00000029055 RatGTEx
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
UniProt A0A0G2K2S5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZNI6_RAT UniProtKB/TrEMBL
  A6I1S0 ENTREZGENE, UniProtKB/TrEMBL
  A6I1S3 ENTREZGENE, UniProtKB/TrEMBL
  D4A4S7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Ttk  Ttk protein kinase   Ttk_predicted  Ttk protein kinase (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Ttk_predicted  Ttk protein kinase (predicted)      Symbol and Name status set to approved 70820 APPROVED