Anapc2 (anaphase promoting complex subunit 2) - Rat Genome Database

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Gene: Anapc2 (anaphase promoting complex subunit 2) Rattus norvegicus
Analyze
Symbol: Anapc2
Name: anaphase promoting complex subunit 2
RGD ID: 1305546
Description: Predicted to enable ubiquitin protein ligase binding activity. Involved in negative regulation of gene expression; positive regulation of axon extension; and positive regulation of dendrite morphogenesis. Predicted to be part of anaphase-promoting complex. Orthologous to human ANAPC2 (anaphase promoting complex subunit 2); PARTICIPATES IN cell cycle pathway, mitotic; ubiquitin/proteasome degradation pathway; INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: anaphase-promoting complex subunit 2; LOC296558
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Arunc3
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8328,484,590 - 28,496,338 (+)NCBIGRCr8
mRatBN7.238,086,434 - 8,098,182 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl38,086,462 - 8,098,178 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx311,190,969 - 11,202,704 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0319,777,199 - 19,788,934 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0317,967,042 - 17,978,777 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.032,490,496 - 2,502,247 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,490,518 - 2,502,248 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.032,471,951 - 2,483,660 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.433,436,569 - 3,448,278 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.133,436,404 - 3,448,589 (+)NCBI
Celera32,913,015 - 2,924,724 (+)NCBICelera
Cytogenetic Map3p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Loss-of-Function Mutation in APC2 Causes Sotos Syndrome Features. Almuriekhi M, etal., Cell Rep. 2015 Mar 3. pii: S2211-1247(15)00139-4. doi: 10.1016/j.celrep.2015.02.011.
2. Molecular profiling of mouse lung tumors: association with tumor progression, lung development, and human lung adenocarcinomas. Bonner AE, etal., Oncogene. 2004 Feb 5;23(5):1166-76.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons. Gieffers C, etal., Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11317-22.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Liprinalpha1 degradation by calcium/calmodulin-dependent protein kinase II regulates LAR receptor tyrosine phosphatase distribution and dendrite development. Hoogenraad CC, etal., Dev Cell. 2007 Apr;12(4):587-602. doi: 10.1016/j.devcel.2007.02.006.
7. Comparative evaluation of the aqueous humor proteome of primary angle closure and primary open angle glaucomas and age-related cataract eyes. Kaur I, etal., Int Ophthalmol. 2019 Jan;39(1):69-104. doi: 10.1007/s10792-017-0791-0. Epub 2018 Jan 13.
8. A centrosomal Cdc20-APC pathway controls dendrite morphogenesis in postmitotic neurons. Kim AH, etal., Cell. 2009 Jan 23;136(2):322-36.
9. The anaphase promoting complex is required for memory function in mice. Kuczera T, etal., Learn Mem. 2010 Dec 22;18(1):49-57. doi: 10.1101/lm.1998411. Print 2011 Jan.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Laser capture microdissection and microarray expression analysis of lung adenocarcinoma reveals tobacco smoking- and prognosis-related molecular profiles. Miura K, etal., Cancer Res. 2002 Jun 1;62(11):3244-50.
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. The expression pattern of APC2 and APC7 in various cancer cell lines and AML patients. Rahimi H, etal., Adv Med Sci. 2015 Sep;60(2):259-63. doi: 10.1016/j.advms.2015.04.007. Epub 2015 May 13.
14. GOA pipeline RGD automated data pipeline
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Comprehensive gene review and curation RGD comprehensive gene curation
17. Alterations of protein expression in serum of infants with intrauterine growth restriction and different gestational ages. Ruis-González MD, etal., J Proteomics. 2015 Apr 24;119:169-82. doi: 10.1016/j.jprot.2015.02.003. Epub 2015 Feb 25.
18. APC/C is essential for hematopoiesis and impaired in aplastic anemia. Wang J, etal., Oncotarget. 2017 Jun 28;8(38):63360-63369. doi: 10.18632/oncotarget.18808. eCollection 2017 Sep 8.
Additional References at PubMed
PMID:12477932   PMID:16364912   PMID:18485873   PMID:19900895  


Genomics

Comparative Map Data
Anapc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8328,484,590 - 28,496,338 (+)NCBIGRCr8
mRatBN7.238,086,434 - 8,098,182 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl38,086,462 - 8,098,178 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx311,190,969 - 11,202,704 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0319,777,199 - 19,788,934 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0317,967,042 - 17,978,777 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.032,490,496 - 2,502,247 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,490,518 - 2,502,248 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.032,471,951 - 2,483,660 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.433,436,569 - 3,448,278 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.133,436,404 - 3,448,589 (+)NCBI
Celera32,913,015 - 2,924,724 (+)NCBICelera
Cytogenetic Map3p13NCBI
ANAPC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389137,174,784 - 137,188,560 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9137,174,784 - 137,188,560 (-)EnsemblGRCh38hg38GRCh38
GRCh379140,069,236 - 140,083,012 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369139,189,057 - 139,202,878 (-)NCBINCBI36Build 36hg18NCBI36
Build 349137,345,072 - 137,358,894NCBI
Celera9110,583,566 - 110,597,088 (-)NCBICelera
Cytogenetic Map9q34.3NCBI
HuRef9109,529,253 - 109,543,074 (-)NCBIHuRef
CHM1_19140,217,925 - 140,231,746 (-)NCBICHM1_1
T2T-CHM13v2.09149,412,464 - 149,426,223 (-)NCBIT2T-CHM13v2.0
Anapc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39225,162,469 - 25,175,928 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl225,162,490 - 25,175,927 (+)EnsemblGRCm39 Ensembl
GRCm38225,272,466 - 25,285,916 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl225,272,478 - 25,285,915 (+)EnsemblGRCm38mm10GRCm38
MGSCv37225,127,986 - 25,141,436 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36225,094,508 - 25,107,924 (+)NCBIMGSCv36mm8
Celera225,000,157 - 25,013,426 (+)NCBICelera
Cytogenetic Map2A3NCBI
cM Map217.12NCBI
Anapc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555135,183,472 - 5,194,253 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555135,183,472 - 5,194,253 (-)NCBIChiLan1.0ChiLan1.0
ANAPC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2112,210,577 - 2,224,304 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan192,213,159 - 2,226,638 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09108,234,949 - 108,248,227 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19137,204,356 - 137,217,652 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9137,204,356 - 137,217,652 (-)Ensemblpanpan1.1panPan2
ANAPC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1948,475,777 - 48,486,715 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl948,471,584 - 48,609,303 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha947,666,446 - 47,677,538 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0949,341,288 - 49,352,382 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl949,341,432 - 49,355,653 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1948,117,700 - 48,128,794 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0948,416,513 - 48,427,605 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0948,463,672 - 48,474,764 (+)NCBIUU_Cfam_GSD_1.0
Anapc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947202,566,104 - 202,577,692 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936669797,318 - 811,721 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936669797,475 - 808,952 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ANAPC2
(Sus scrofa - pig)
No map positions available.
ANAPC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1121,000,885 - 1,014,710 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl121,000,952 - 1,016,261 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660584,290,548 - 4,304,375 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Anapc2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624760760,749 - 772,855 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624760760,815 - 772,116 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Anapc2
7 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:83
Count of miRNA genes:67
Interacting mature miRNAs:70
Transcripts:ENSRNOT00000015099
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat

Markers in Region
RH128511  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.238,085,113 - 8,085,304 (+)MAPPERmRatBN7.2
Rnor_6.032,489,182 - 2,489,372NCBIRnor6.0
Rnor_5.032,470,595 - 2,470,785UniSTSRnor5.0
RGSC_v3.433,435,213 - 3,435,403UniSTSRGSC3.4
Celera32,911,659 - 2,911,849UniSTS
Cytogenetic Map3p13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000015099   ⟹   ENSRNOP00000015099
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl38,086,462 - 8,098,178 (+)Ensembl
Rnor_6.0 Ensembl32,490,518 - 2,502,248 (+)Ensembl
RefSeq Acc Id: NM_001100532   ⟹   NP_001094002
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,484,628 - 28,496,338 (+)NCBI
mRatBN7.238,086,470 - 8,098,181 (+)NCBI
Rnor_6.032,490,538 - 2,502,247 (+)NCBI
Rnor_5.032,471,951 - 2,483,660 (+)NCBI
RGSC_v3.433,436,569 - 3,448,278 (+)RGD
Celera32,913,015 - 2,924,724 (+)RGD
Sequence:
RefSeq Acc Id: XM_063283461   ⟹   XP_063139531
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,484,590 - 28,495,890 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001094002 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139531 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI07472 (Get FASTA)   NCBI Sequence Viewer  
  AAI66796 (Get FASTA)   NCBI Sequence Viewer  
  EDL93618 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000015099.6
RefSeq Acc Id: NP_001094002   ⟸   NM_001100532
- UniProtKB: B2RYJ1 (UniProtKB/TrEMBL),   F7EWF8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000015099   ⟸   ENSRNOT00000015099
RefSeq Acc Id: XP_063139531   ⟸   XM_063283461
- Peptide Label: isoform X1
Protein Domains
Cullin family profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B2RYJ1-F1-model_v2 AlphaFold B2RYJ1 1-836 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691867
Promoter ID:EPDNEW_R2392
Type:multiple initiation site
Name:Anapc2_1
Description:anaphase promoting complex subunit 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.032,490,528 - 2,490,588EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305546 AgrOrtholog
BioCyc Gene G2FUF-50465 BioCyc
Ensembl Genes ENSRNOG00000011295 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015099.8 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
  Cullin Repeats UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7446651 IMAGE-MGC_LOAD
  IMAGE:7938000 IMAGE-MGC_LOAD
InterPro APC2-like UniProtKB/TrEMBL
  APC_su2_C UniProtKB/TrEMBL
  Cullin_homology UniProtKB/TrEMBL
  Cullin_homology_sf UniProtKB/TrEMBL
  Cullin_N UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
KEGG Report rno:296558 UniProtKB/TrEMBL
MGC_CLONE MGC:125206 IMAGE-MGC_LOAD
  MGC:188593 IMAGE-MGC_LOAD
NCBI Gene 296558 ENTREZGENE
PANTHER ANAPHASE-PROMOTING COMPLEX SUBUNIT 2 UniProtKB/TrEMBL
  PTHR45957 UniProtKB/TrEMBL
Pfam APC2 UniProtKB/TrEMBL
  Cullin UniProtKB/TrEMBL
PhenoGen Anapc2 PhenoGen
PROSITE CULLIN_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011295 RatGTEx
SMART APC2 UniProtKB/TrEMBL
  CULLIN UniProtKB/TrEMBL
Superfamily-SCOP Cullin_homology UniProtKB/TrEMBL
  SSF46785 UniProtKB/TrEMBL
UniProt B2RYJ1 ENTREZGENE, UniProtKB/TrEMBL
  F7EWF8 ENTREZGENE, UniProtKB/TrEMBL
  Q3B7T7_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Anapc2  anaphase promoting complex subunit 2  Anapc2_predicted  anaphase promoting complex subunit 2 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Anapc2_predicted  anaphase promoting complex subunit 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED