Fbxl14 (F-box and leucine-rich repeat protein 14) - Rat Genome Database

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Gene: Fbxl14 (F-box and leucine-rich repeat protein 14) Rattus norvegicus
Analyze
Symbol: Fbxl14
Name: F-box and leucine-rich repeat protein 14
RGD ID: 1305523
Description: Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm. Orthologous to human FBXL14 (F-box and leucine rich repeat protein 14); INTERACTS WITH ammonium chloride; bisphenol A; ketoconazole.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: F-box/LRR-repeat protein 14; LOC312675
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84154,334,820 - 154,338,638 (+)NCBIGRCr8
mRatBN7.24152,662,542 - 152,666,360 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4152,662,542 - 152,666,360 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4158,924,548 - 158,928,366 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04154,708,264 - 154,712,082 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04153,331,612 - 153,335,430 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04151,986,890 - 151,990,706 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04219,072,836 - 219,076,652 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44155,824,662 - 155,826,479 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14156,069,826 - 156,072,546 (+)NCBI
Celera4141,517,575 - 141,521,393 (+)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOA pipeline RGD automated data pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:19028597   PMID:19955572  


Genomics

Comparative Map Data
Fbxl14
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84154,334,820 - 154,338,638 (+)NCBIGRCr8
mRatBN7.24152,662,542 - 152,666,360 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4152,662,542 - 152,666,360 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4158,924,548 - 158,928,366 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04154,708,264 - 154,712,082 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04153,331,612 - 153,335,430 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04151,986,890 - 151,990,706 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04219,072,836 - 219,076,652 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44155,824,662 - 155,826,479 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14156,069,826 - 156,072,546 (+)NCBI
Celera4141,517,575 - 141,521,393 (+)NCBICelera
Cytogenetic Map4q42NCBI
FBXL14
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38121,565,993 - 1,594,842 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl121,565,993 - 1,594,581 (-)EnsemblGRCh38hg38GRCh38
GRCh37121,675,159 - 1,703,747 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36121,545,420 - 1,573,592 (-)NCBINCBI36Build 36hg18NCBI36
Build 34121,545,420 - 1,573,592NCBI
Celera123,282,418 - 3,311,437 (-)NCBICelera
Cytogenetic Map12p13.33NCBI
HuRef121,528,764 - 1,557,372 (-)NCBIHuRef
CHM1_1121,674,606 - 1,702,775 (-)NCBICHM1_1
T2T-CHM13v2.0121,560,304 - 1,591,264 (-)NCBIT2T-CHM13v2.0
Fbxl14
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396119,456,629 - 119,460,847 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6119,456,629 - 119,459,591 (+)EnsemblGRCm39 Ensembl
GRCm386119,479,668 - 119,483,886 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6119,479,668 - 119,482,630 (+)EnsemblGRCm38mm10GRCm38
MGSCv376119,429,686 - 119,433,904 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366119,445,398 - 119,448,241 (+)NCBIMGSCv36mm8
Celera6121,313,339 - 121,317,557 (+)NCBICelera
Cytogenetic Map6F1NCBI
cM Map656.86NCBI
Fbxl14
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554544,133,718 - 4,137,363 (-)NCBIChiLan1.0ChiLan1.0
FBXL14
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2107,092,551 - 7,131,288 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1127,098,633 - 7,128,044 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0121,674,046 - 1,703,414 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1121,626,056 - 1,653,656 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl121,626,802 - 1,655,056 (-)Ensemblpanpan1.1panPan2
FBXL14
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12743,617,087 - 43,625,269 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2743,618,301 - 43,625,126 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha273,059,620 - 3,067,802 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02743,984,462 - 43,992,650 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2743,985,676 - 43,992,609 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12743,915,558 - 43,923,746 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02743,888,062 - 43,896,238 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0272,417,535 - 2,425,933 (+)NCBIUU_Cfam_GSD_1.0
Fbxl14
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945107,377,231 - 107,381,495 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366061,805,827 - 1,806,870 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366061,802,833 - 1,806,870 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FBXL14
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl568,675,531 - 68,678,296 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1568,675,071 - 68,678,219 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2570,936,905 - 70,942,682 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FBXL14
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1111,632,858 - 1,636,225 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660636,693,562 - 6,723,982 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fbxl14
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473511,273,798 - 11,276,915 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fbxl14
15 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482798864152731274Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4109827074154827074Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4109827074154827074Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4119428175157578333Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132642577167139601Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4147278504167139601Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4148090542168069246Rat
61446Coreg2Compensatory renal growth QTL 23.5kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)4148423102157580971Rat

Markers in Region
RH133478  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24152,665,128 - 152,665,308 (+)MAPPERmRatBN7.2
mRatBN7.2855,696,821 - 55,697,000 (+)MAPPERmRatBN7.2
Rnor_6.0859,890,213 - 59,890,391NCBIRnor6.0
Rnor_6.04151,989,475 - 151,989,654NCBIRnor6.0
Rnor_5.0858,471,021 - 58,471,199UniSTSRnor5.0
Rnor_5.04219,075,421 - 219,075,600UniSTSRnor5.0
RGSC_v3.44155,827,384 - 155,827,563UniSTSRGSC3.4
RGSC_v3.4858,869,564 - 58,869,742UniSTSRGSC3.4
Celera855,181,702 - 55,181,880UniSTS
Celera4141,520,162 - 141,520,341UniSTS
RH 3.4 Map8614.59UniSTS
Cytogenetic Map4q42UniSTS
Cytogenetic Map8q24UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000094505   ⟹   ENSRNOP00000089410
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4152,662,542 - 152,666,360 (+)Ensembl
RefSeq Acc Id: NM_001271276   ⟹   NP_001258205
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,334,820 - 154,338,638 (+)NCBI
mRatBN7.24152,662,542 - 152,666,360 (+)NCBI
Rnor_6.04151,986,890 - 151,990,706 (+)NCBI
Rnor_5.04219,072,836 - 219,076,652 (+)NCBI
Celera4141,517,575 - 141,521,393 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001258205 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM02056 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000089410
  ENSRNOP00000089410.1
Reference Protein Sequences
RefSeq Acc Id: NP_001258205   ⟸   NM_001271276
- UniProtKB: A0A8I6GI29 (UniProtKB/TrEMBL),   A6IL86 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000089410   ⟸   ENSRNOT00000094505
Protein Domains
F-box

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305523 AgrOrtholog
BioCyc Gene G2FUF-43217 BioCyc
Ensembl Genes ENSRNOG00000070828 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000094505 ENTREZGENE
  ENSRNOT00000094505.1 UniProtKB/TrEMBL
Gene3D-CATH 3.80.10.10 UniProtKB/TrEMBL
InterPro F-box-like_dom_sf UniProtKB/TrEMBL
  F-box_dom UniProtKB/TrEMBL
  FBXL14_F-box UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_Cys-con_subtyp UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/TrEMBL
KEGG Report rno:312675 UniProtKB/TrEMBL
NCBI Gene 312675 ENTREZGENE
PANTHER F-BOX/LRR-REPEAT PROTEIN 14 UniProtKB/TrEMBL
  UNCHARACTERIZED UniProtKB/TrEMBL
Pfam F-box-like UniProtKB/TrEMBL
  LRR_6 UniProtKB/TrEMBL
PhenoGen Fbxl14 PhenoGen
RatGTEx ENSRNOG00000070828 RatGTEx
SMART LRR_CC UniProtKB/TrEMBL
Superfamily-SCOP RNI-like UniProtKB/TrEMBL
  SSF81383 UniProtKB/TrEMBL
UniProt A0A8I6GI29 ENTREZGENE, UniProtKB/TrEMBL
  A6IL86 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Fbxl14  F-box and leucine-rich repeat protein 14   Fbxl14_predicted  F-box and leucine-rich repeat protein 14 (predicted)  'predicted' is removed 2292626 APPROVED
2008-01-09 Fbxl14_predicted  F-box and leucine-rich repeat protein 14 (predicted)  LOC681623  similar to F-box/LRR-repeat protein 14 (F-box and leucine-rich repeat protein 14)  Data merged from RGD:1592908 1643240 APPROVED
2006-11-20 LOC681623  similar to F-box/LRR-repeat protein 14 (F-box and leucine-rich repeat protein 14)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-12 Fbxl14_predicted  F-box and leucine-rich repeat protein 14 (predicted)      Symbol and Name status set to approved 70820 APPROVED