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Gene: Gtf2h3 (general transcription factor IIH subunit 3) Rattus norvegicus

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Symbol:

Gtf2h3

Name:

general transcription factor IIH subunit 3

RGD ID:

1305494

Description:

Predicted to enable RNA polymerase II general transcription initiation factor activity. Predicted to be involved in nucleotide-excision repair and transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of core TFIIH complex portion of holo TFIIH complex; transcription factor TFIID complex; and transcription preinitiation complex. Orthologous to human GTF2H3 (general transcription factor IIH subunit 3); PARTICIPATES IN RNA polymerase II transcription initiation pathway; nucleotide excision repair pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; amitrole.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

general transcription factor IIH, polypeptide 3; LOC288651

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GTF2H3 (general transcription factor IIH subunit 3)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Gtf2h3 (general transcription factor IIH, polypeptide 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Gtf2h3 (general transcription factor IIH subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GTF2H3 (general transcription factor IIH subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GTF2H3 (general transcription factor IIH subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Gtf2h3 (general transcription factor IIH subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GTF2H3 (general transcription factor IIH subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GTF2H3 (general transcription factor IIH subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Gtf2h3 (general transcription factor IIH subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Gtf2h3 (general transcription factor IIH subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	STAG3 (STAG3 cohesin complex component)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	GTF2H3 (general transcription factor IIH subunit 3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Gtf2h3 (general transcription factor IIH, polypeptide 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	gtf2h3 (general transcription factor IIH, polypeptide 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	gtf-2H3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	gtf-2H3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	TFB4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	TFB4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Tfb4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	37,669,995 - 37,687,505 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	37,669,997 - 37,686,466 (-)	Ensembl				GRCr8
mRatBN7.2	12	32,009,010 - 32,025,484 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	32,009,014 - 32,025,497 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	33,187,754 - 33,203,819 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	33,799,075 - 33,815,140 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	32,850,942 - 32,867,007 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	37,427,556 - 37,444,027 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	37,427,546 - 37,444,282 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	39,298,569 - 39,315,037 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	12	33,121,881 - 33,138,233 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	33,698,431 - 33,714,902 (-)	NCBI		Celera
RGSC_v3.1	12	32,985,270 - 33,001,621 (-)	NCBI
Cytogenetic Map	12	q15	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-tribromophenol (ISO)

2-palmitoylglycerol (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

3-chloropropane-1,2-diol (EXP)

acrolein (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

amitrole (EXP)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

carbon nanotube (ISO)

chromium(6+) (ISO)

clofibric acid (EXP)

DDE (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (EXP,ISO)

dicrotophos (ISO)

epoxiconazole (ISO)

fenthion (ISO)

folic acid (ISO)

gentamycin (EXP)

glyphosate (ISO)

GSK-J4 (ISO)

imiquimod (ISO)

inulin (ISO)

ivermectin (ISO)

ketamine (EXP)

methidathion (ISO)

ozone (ISO)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

sodium arsenite (ISO)

Soman (EXP)

testosterone (ISO)

trimellitic anhydride (ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

urethane (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

DNA damage response (IEA)

DNA repair (IEA)

nucleotide-excision repair (IBA,IEA)

regulation of DNA-templated transcription (IEA)

transcription by RNA polymerase II (IEA,ISO,ISS)

transcription initiation at RNA polymerase II promoter (IBA)

Cellular Component

core TFIIH complex portion of holo TFIIH complex (IEA,ISO,ISS)

nucleoplasm (IEA,ISO)

nucleus (IEA,ISO,ISS)

transcription factor TFIID complex (IEA,ISO)

transcription factor TFIIH core complex (IBA,IEA)

transcription factor TFIIH holo complex (IBA,IEA,ISO,ISS)

transcription preinitiation complex (IEA,ISO)

Molecular Function

metal ion binding (IEA)

protein binding (ISO)

RNA polymerase II general transcription initiation factor activity (IBA,IEA,ISO)

zinc ion binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

nucleotide excision repair pathway (IEA)

RNA polymerase II transcription initiation pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	A history of TFIIH: two decades of molecular biology on a pivotal transcription/repair factor.	Egly JM and Coin F, DNA Repair (Amst). 2011 Jul 15;10(7):714-21. doi: 10.1016/j.dnarep.2011.04.021. Epub 2011 May 17.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
6.	GOA pipeline	RGD automated data pipeline
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Comprehensive gene review and curation	RGD comprehensive gene curation

Additional References at PubMed

PMID:8652557	PMID:9852112	PMID:12477932	PMID:27193682

Genomics

Comparative Map Data

Gtf2h3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	37,669,995 - 37,687,505 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	37,669,997 - 37,686,466 (-)	Ensembl				GRCr8
mRatBN7.2	12	32,009,010 - 32,025,484 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	32,009,014 - 32,025,497 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	33,187,754 - 33,203,819 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	33,799,075 - 33,815,140 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	32,850,942 - 32,867,007 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	37,427,556 - 37,444,027 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	37,427,546 - 37,444,282 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	39,298,569 - 39,315,037 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	12	33,121,881 - 33,138,233 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	33,698,431 - 33,714,902 (-)	NCBI		Celera
RGSC_v3.1	12	32,985,270 - 33,001,621 (-)	NCBI
Cytogenetic Map	12	q15	NCBI

GTF2H3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	123,633,829 - 123,662,604 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	123,633,739 - 123,662,604 (+)	Ensembl			hg38	GRCh38
GRCh37	12	124,118,376 - 124,147,151 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	122,684,334 - 122,711,287 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	12	122,643,260 - 122,670,214	NCBI
Celera	12	123,714,817 - 123,741,772 (+)	NCBI		Celera
Cytogenetic Map	12	q24.31	NCBI
HuRef	12	121,079,532 - 121,108,395 (+)	NCBI		HuRef
CHM1_1	12	123,939,235 - 123,968,101 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	123,632,693 - 123,661,470 (+)	NCBI		T2T-CHM13v2.0

Gtf2h3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	124,717,211 - 124,735,743 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	124,717,203 - 124,735,743 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	5	124,579,148 - 124,597,680 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	124,579,140 - 124,597,680 (+)	Ensembl			mm10	GRCm38
MGSCv37	5	125,029,157 - 125,047,689 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	5	124,839,789 - 124,857,459 (+)	NCBI		MGSCv36	mm8
Celera	5	121,655,848 - 121,674,546 (+)	NCBI		Celera
Cytogenetic Map	5	F	NCBI
cM Map	5	63.67	NCBI

Gtf2h3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955482	5,365,142 - 5,380,047 (-)	Ensembl
ChiLan1.0	NW_004955482	5,365,669 - 5,380,047 (-)	NCBI	ChiLan1.0	ChiLan1.0

GTF2H3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	131,708,349 - 131,737,682 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	131,704,710 - 131,734,059 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	121,218,813 - 121,246,807 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	125,445,381 - 125,473,763 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	125,445,381 - 125,473,763 (+)	Ensembl			panPan2	panpan1.1

GTF2H3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	5,985,094 - 6,011,253 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	5,985,798 - 6,011,163 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	6,147,525 - 6,174,121 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	6,234,737 - 6,261,341 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	6,234,495 - 6,261,295 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	6,168,228 - 6,194,816 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	6,260,228 - 6,287,181 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	6,213,786 - 6,240,388 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Gtf2h3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	158,283,347 - 158,304,710 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936558	1,173,064 - 1,196,063 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936558	1,176,154 - 1,196,028 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GTF2H3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	29,335,582 - 29,355,435 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	14	29,335,715 - 29,355,465 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	31,029,684 - 31,047,752 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GTF2H3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	118,961,907 - 118,989,906 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	118,967,974 - 118,989,391 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666037	126,285,426 - 126,313,975 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gtf2h3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624747	23,422,319 - 23,435,926 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624747	23,422,289 - 23,437,193 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Gtf2h3
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	16	29,279,446 - 29,294,866 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Gtf2h3
153 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	133
Count of miRNA genes:	98
Interacting mature miRNAs:	115
Transcripts:	ENSRNOT00000001368
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631560	Apr1	Acute phase response QTL 1	6.1		orosomucoid 1 amount (VT:0010541)	plasma orosomucoid 1 level (CMO:0001467)	12	24805022	52308831	Rat
70213	Niddm27	Non-insulin dependent diabetes mellitus QTL 27	3.72		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	11200494	52308831	Rat
8552964	Pigfal17	Plasma insulin-like growth factor 1 level QTL 17	3.5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
8693635	Alc28	Alcohol consumption QTL 28	2.7	0.439	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	12	28717718	50386405	Rat
7411641	Foco19	Food consumption QTL 19	27.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
7411643	Foco20	Food consumption QTL 20		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	25989355	52308831	Rat
5684888	Pia42	Pristane induced arthritis QTL 42			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	3489416	48489416	Rat
1331739	Hrtrt14	Heart rate QTL 14	3.56232		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	12	1	38687564	Rat
1641928	Alcrsp5	Alcohol response QTL 5			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	12	18473041	52308831	Rat
1549829	Scl48	Serum cholesterol level QTL 48	5		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	12	15264248	52308831	Rat
8552912	Pigfal6	Plasma insulin-like growth factor 1 level QTL 6	5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200497	52308831	Rat
10059594	Kidm46	Kidney mass QTL 46	3.79	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	12	11743528	52308831	Rat
8552918	Pigfal7	Plasma insulin-like growth factor 1 level QTL 7			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
2293684	Bmd26	Bone mineral density QTL 26	4.4	0.0002	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	12	1	38635130	Rat
70169	Eae13	Experimental allergic encephalomyelitis QTL 13		0.032	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	12	29775522	42298555	Rat
1600386	Calcic2	Intracellular calcium level QTL 2		0.001	platelet physiology trait (VT:0005464)	platelet intracellular calcium level (CMO:0000922)	12	33700432	46784661	Rat
1300175	Cm5	Cardiac mass QTL 5	3.78		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	12	33700432	51558799	Rat
1556747	Calcic1	Intracellular calcium level QTL 1		3.6	platelet calcium amount (VT:0010500)	platelet intracellular calcium level (CMO:0000922)	12	33700432	46784661	Rat
631829	Alc6	Alcohol consumption QTL 6	4.7		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	12	34243475	43352593	Rat
61404	Bw120	Body weight QTL 120	5.1		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	12	17464979	46784661	Rat
1331786	Kidm11	Kidney mass QTL 11	3.571		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	12	16187438	52308831	Rat
8693658	Alc33	Alcohol consumption QTL 33	2.1	0.68	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	12	28717718	49212240	Rat
2293699	Bss49	Bone structure and strength QTL 49	5.61	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	12	16135029	52308831	Rat
1331761	Bp218	Blood pressure QTL 218	2.973		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	16187438	51213550	Rat
1331763	Wbc2	White blood cell count QTL 2	3.162		leukocyte quantity (VT:0000217)	total white blood cell count (CMO:0000365)	12	11200494	52308831	Rat
7411547	Bw129	Body weight QTL 129		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	11200494	52308831	Rat
7387292	Kidm42	Kidney mass QTL 42	3.03	0.0004	kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	12	1	41361854	Rat
1300157	Rf21	Renal function QTL 21	4.4		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	12	29636637	37764351	Rat
2303569	Gluco44	Glucose level QTL 44	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	18473041	52308831	Rat
1298081	Cia25	Collagen induced arthritis QTL 25	4.7		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	2747694	47747694	Rat
2303575	Insul14	Insulin level QTL 14	4		blood insulin amount (VT:0001560)	blood insulin level (CMO:0000349)	12	3087180	48087180	Rat
7411588	Foco6	Food consumption QTL 6		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
7243862	Mcs30	Mammary carcinoma susceptibility QTL 30	8.62		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	12	5633306	50633306	Rat
2300186	Bmd59	Bone mineral density QTL 59	7.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	12	16135029	52308831	Rat
7411597	Foco10	Food consumption QTL 10		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat

Markers in Region

RH134486

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	12	37,670,227 - 37,670,424 (+)	Marker Load Pipeline
mRatBN7.2	12	32,009,242 - 32,009,439 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	37,427,789 - 37,427,985	NCBI	Rnor6.0
Rnor_5.0	12	39,298,802 - 39,298,998	UniSTS	Rnor5.0
RGSC_v3.4	12	33,122,114 - 33,122,310	UniSTS	RGSC3.4
Celera	12	33,698,664 - 33,698,860	UniSTS
RH 3.4 Map	12	556.8	UniSTS
Cytogenetic Map	12	q15	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	163	91	90	59	92	59	6	356	192	11	142	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001024236	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063271173	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC127646	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC093380	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473973	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000001368 ⟹ ENSRNOP00000001368

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	37,669,997 - 37,686,466 (-)	Ensembl
mRatBN7.2 Ensembl	12	32,009,014 - 32,025,497 (-)	Ensembl
Rnor_6.0 Ensembl	12	37,427,546 - 37,444,282 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000097451 ⟹ ENSRNOP00000097521

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	37,669,997 - 37,685,388 (-)	Ensembl
mRatBN7.2 Ensembl	12	32,009,014 - 32,022,385 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000112340 ⟹ ENSRNOP00000090533

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	37,669,997 - 37,683,301 (-)	Ensembl
mRatBN7.2 Ensembl	12	32,009,014 - 32,022,319 (-)	Ensembl

RefSeq Acc Id:

NM_001024236 ⟹ NP_001019407

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	37,669,995 - 37,686,466 (-)	NCBI
mRatBN7.2	12	32,009,010 - 32,025,484 (-)	NCBI
Rnor_6.0	12	37,427,556 - 37,444,027 (-)	NCBI
Rnor_5.0	12	39,298,569 - 39,315,037 (-)	NCBI
RGSC_v3.4	12	33,121,881 - 33,138,233 (-)	RGD
Celera	12	33,698,431 - 33,714,902 (-)	RGD

Sequence:

show sequence

CTCTTCACCGAGGCATAGGGAGCCATGGCCGCGGACGAAGATGAGTTGAATCTTCTGGTTATCA
TAGTTGACACCAACCCGATTTGGTGGGGAAAGCAAGCGTTAAAGGAATCTCAGTTCACTCTGTC
CAAGTGCATGGATGCTGTGATGGTGCTGGCAAACGCCCACCTGTTCATGAACCGCTCCAACCAG
CTAGCGGTCATCGCCAGCCACATTCAGGAAAGTCGATTCTTATACCCGGGGAAGAACGGCCGAC
TCGGAGACTTCTTCGGAGATCCTGGCAACGCCCTTCCTGACTGTAATCCCTCTGGGAGTAAGGA
CGGGAAATATGAGCTGTTGACAGCGGCAAACGAGGTGATCGCCGAGGAGATCAAGGATCTGATG
ACCAAGAGTGACATCAAGGGCCAGCACACGGAGACCCTACTGGCAGGATCCCTCGCCAAGGCCC
TCTGCTACATTCACAGAGCGAGCAAGGCAGTGAAAGATAATCAGGAGATGAAATCAAGGATTTT
GGTCATCAAGGCTGCAGAGGACAGTGCACTGCAGTACATGAACTTCATGAACGTCATCTTTGCT
GCTCAGAAGCAGAATATCCTCATCGATGCCTGCGTCCTGGACTCGGATTCAGGGCTCCTCCAGC
AGGCTTGTGACATCACTGGGGGACTGTACCTGAAGGTGCCTCAGATGCCTTCTCTCCTGCAGTA
CTTACTGTGGGTTTTTCTTCCGGATCAAGACCAGCGATCTCAGCTAATCCTCCCACCTCCGATC
CACGTGGACTATAGGGCTGCCTGCTTCTGCCATCGAAGTCTCATTGAGATTGGCTATGTCTGCT
CTGTGTGTCTGTCTATTTTCTGCAACTTCAGCCCCATCTGCACCACGTGCGAGACAGCTTTTAA
GATCTCCCTCCCTCCTGTGCTGAAGGCCAAGAAAAAGAAACAGAAGGTGTCCCTGTGATGAGTG
ATACAAACTTCCCCATCTCTTCCCACCGGCTGCCTCTCTGTAGGGAGCACGGAAGACTTTGAAG
CACCGCCTTTGTTCTGTACTTTTAGGGTGTGAGGCTGGAGAGTACGCACCCCTCTGATTCATCT
GGAAGGGGGACGGCTTTGTAGGTTGTTGTGGGGTAGCAGGTGCCTGTCGGATGCTAATCTGTGG
CTGTTTTGTTAGTTGTTGCTTGGATGCTTGGTGCTGGGGTTTGAACCCTAGCCTTGCACGAGCT
AGCCCTACAGCCCACCTCAGAACTGCAGTGGGCCCCTGGGATTTTGTTTTCACATGATCCTCTG
TCAAAGCTTATGTGGTGGGTGCTGGGTCTTCTGTACTTCAGAAGTGTGTGAGGTTGGGACGTCG
TCTGGGAGGGTGACCGGCACCGGGTCACTGTGGGCCGTGACAGAATATCTTAGTTGCTCAGGTG
ATGCACGCCTGGAACCTTGAACTTAGGAGGCTGAGACAGGAAGGTTTGGGGTTCGGATCCTGCT
TGGGATATGTATGAAGTGCCGGCTTTTTTTCTTTCTTTCTTTTTTTCTTTTTTTAACAGAAGAA
CATTTTACTTCAAATAAATTGTTTCCTTCAACTGTTTTCAAATATAACCAGACATAAAGGCACA
GCCTTCCATCTCAGCACTCAGGGAGCCCAGACAAGTGCATCACTGCGTTTGAGGCCAGCCAGGT
CTACATAGTGAGTTCAGACCACACCAACCAGGGTTGCATCTTGCCACCTTGTTTACAAAAAATA
AAACCCCAAACCAGTCACGTTCACAGGGAGAACCGCTGACCATTAGAAATGTAAATGAGTTCAG
GAGAAACGTTTGTACTCTCAACAATAAAGTCCTATTTTTGTATTTACTAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_063271173 ⟹ XP_063127243

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	37,669,995 - 37,687,505 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001019407	(Get FASTA)	NCBI Sequence Viewer
	XP_063127243	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH93380	(Get FASTA)	NCBI Sequence Viewer
	EDM13571	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000001368
	ENSRNOP00000001368.4
GenBank Protein	Q561R7	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001019407 ⟸ NM_001024236

- UniProtKB:

Q561R7 (UniProtKB/Swiss-Prot), A6J0Y2 (UniProtKB/TrEMBL), A0A8I6ASU2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAADEDELNLLVIIVDTNPIWWGKQALKESQFTLSKCMDAVMVLANAHLFMNRSNQLAVIASHI
QESRFLYPGKNGRLGDFFGDPGNALPDCNPSGSKDGKYELLTAANEVIAEEIKDLMTKSDIKGQ
HTETLLAGSLAKALCYIHRASKAVKDNQEMKSRILVIKAAEDSALQYMNFMNVIFAAQKQNILI
DACVLDSDSGLLQQACDITGGLYLKVPQMPSLLQYLLWVFLPDQDQRSQLILPPPIHVDYRAAC
FCHRSLIEIGYVCSVCLSIFCNFSPICTTCETAFKISLPPVLKAKKKKQKVSL

hide sequence

Ensembl Acc Id:

ENSRNOP00000001368 ⟸ ENSRNOT00000001368

Ensembl Acc Id:

ENSRNOP00000097521 ⟸ ENSRNOT00000097451

Ensembl Acc Id:

ENSRNOP00000090533 ⟸ ENSRNOT00000112340

RefSeq Acc Id:	XP_063127243 ⟸ XM_063271173
- Peptide Label:	isoform X1
- UniProtKB:	Q561R7 (UniProtKB/Swiss-Prot), A6J0Y2 (UniProtKB/TrEMBL), A0A8I6ASU2 (UniProtKB/TrEMBL)

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q561R7-F1-model_v2	AlphaFold	Q561R7	1-309	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698607

Promoter ID:

EPDNEW_R9131

Type:

multiple initiation site

Name:

Gtf2h3_1

Description:

general transcription factor IIH subunit 3

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	12	37,444,047 - 37,444,107	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305494	AgrOrtholog
BioCyc Gene	G2FUF-19361	BioCyc
Ensembl Genes	ENSRNOG00000001035	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000001368	ENTREZGENE
	ENSRNOT00000001368.7	UniProtKB/Swiss-Prot
Gene3D-CATH	3.40.50.410	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7388486	IMAGE-MGC_LOAD
InterPro	TFIIH_Tfb4/GTF2H3	UniProtKB/Swiss-Prot
	vWFA_dom_sf	UniProtKB/Swiss-Prot
KEGG Report	rno:288651	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:112674	IMAGE-MGC_LOAD
NCBI Gene	288651	ENTREZGENE
PANTHER	GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 3	UniProtKB/Swiss-Prot
	PTHR12831	UniProtKB/Swiss-Prot
Pfam	Tfb4	UniProtKB/Swiss-Prot
PhenoGen	Gtf2h3	PhenoGen
RatGTEx	ENSRNOG00000001035	RatGTEx
UniProt	A0A8I6AA93_RAT	UniProtKB/TrEMBL
	A0A8I6ASU2	ENTREZGENE, UniProtKB/TrEMBL
	A6J0Y2	ENTREZGENE, UniProtKB/TrEMBL
	Q561R7	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-25	Gtf2h3	general transcription factor IIH subunit 3	Gtf2h3	general transcription factor IIH, polypeptide 3	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Gtf2h3	general transcription factor IIH, polypeptide 3	Gtf2h3_predicted	general transcription factor IIH, polypeptide 3 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Gtf2h3_predicted	general transcription factor IIH, polypeptide 3 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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RGD Manual Annotations

Imported Annotations - KEGG (archival)