Cdh20 (cadherin 20) - Rat Genome Database

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Pathways
Gene: Cdh20 (cadherin 20) Rattus norvegicus
Analyze
Symbol: Cdh20
Name: cadherin 20
RGD ID: 1305438
Description: Predicted to enable beta-catenin binding activity and cadherin binding activity. Predicted to be involved in several processes, including calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; cell-cell adhesion mediated by cadherin; and cell-cell junction organization. Predicted to be located in plasma membrane. Predicted to be part of catenin complex. Predicted to be active in adherens junction. Orthologous to human CDH20 (cadherin 20); INTERACTS WITH bisphenol A; cadmium dichloride; copper atom.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Cad20; cadherin-20; LOC363948
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81321,252,272 - 21,583,526 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1321,515,123 - 21,584,349 (+)EnsemblGRCr8
mRatBN7.21320,737,640 - 21,069,746 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1320,738,081 - 21,068,676 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1321,347,754 - 21,410,721 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01322,632,507 - 22,695,474 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01321,316,387 - 21,379,354 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01324,630,298 - 24,914,463 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1324,823,488 - 24,913,884 (+)Ensemblrn6Rnor6.0
Rnor_5.01330,018,338 - 30,085,298 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41310,970,187 - 11,038,947 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1320,896,704 - 20,961,175 (+)NCBICelera
RGSC_v3.11310,970,186 - 11,038,946 (+)NCBI
Cytogenetic Map13p11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
syndactyly  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:18801203   PMID:34240415  


Genomics

Comparative Map Data
Cdh20
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81321,252,272 - 21,583,526 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1321,515,123 - 21,584,349 (+)EnsemblGRCr8
mRatBN7.21320,737,640 - 21,069,746 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1320,738,081 - 21,068,676 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1321,347,754 - 21,410,721 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01322,632,507 - 22,695,474 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01321,316,387 - 21,379,354 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01324,630,298 - 24,914,463 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1324,823,488 - 24,913,884 (+)Ensemblrn6Rnor6.0
Rnor_5.01330,018,338 - 30,085,298 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41310,970,187 - 11,038,947 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1320,896,704 - 20,961,175 (+)NCBICelera
RGSC_v3.11310,970,186 - 11,038,946 (+)NCBI
Cytogenetic Map13p11NCBI
CDH20
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381861,333,430 - 61,555,779 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1861,333,430 - 61,555,779 (+)Ensemblhg38GRCh38
GRCh371859,000,663 - 59,223,012 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361857,308,755 - 57,373,345 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341857,308,754 - 57,373,345NCBI
Celera1855,875,642 - 55,940,232 (+)NCBICelera
Cytogenetic Map18q21.33NCBI
HuRef1855,867,814 - 55,931,773 (+)NCBIHuRef
CHM1_11859,153,227 - 59,217,972 (+)NCBICHM1_1
T2T-CHM13v2.01861,536,681 - 61,759,001 (+)NCBIT2T-CHM13v2.0
Cdh20
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391104,696,245 - 104,923,202 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1104,696,254 - 104,923,206 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381104,768,340 - 104,995,481 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1104,768,529 - 104,995,481 (+)Ensemblmm10GRCm38
MGSCv371106,665,396 - 106,892,058 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361106,596,366 - 106,823,028 (+)NCBIMGSCv36mm8
Celera1107,630,046 - 107,857,575 (+)NCBICelera
Cytogenetic Map1E2.1NCBI
cM Map149.42NCBI
Cdh20
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540245,340,223 - 45,543,256 (+)Ensembl
ChiLan1.0NW_00495540245,340,824 - 45,543,088 (+)NCBIChiLan1.0ChiLan1.0
CDH20
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21778,858,063 - 79,080,155 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11864,550,654 - 64,772,871 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01854,706,558 - 54,928,744 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11858,028,849 - 58,250,790 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1858,028,533 - 58,250,790 (+)EnsemblpanPan2panpan1.1
CDH20
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1115,172,681 - 15,388,327 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl115,183,350 - 15,234,880 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha116,150,908 - 16,202,432 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0115,054,279 - 15,259,002 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl115,054,288 - 15,106,347 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1115,079,685 - 15,131,164 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0115,014,314 - 15,066,051 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0115,260,942 - 15,312,507 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cdh20
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494428,387,140 - 28,587,898 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364973,625,601 - 3,699,564 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364973,626,181 - 3,827,024 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDH20
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1159,817,159 - 159,917,145 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11159,817,091 - 160,024,985 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21177,316,697 - 177,367,332 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CDH20
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11818,207,407 - 18,426,620 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1818,207,415 - 18,269,551 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660607,259,763 - 7,481,337 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cdh20
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247926,902,931 - 7,159,514 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247926,903,439 - 7,158,708 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Cdh20
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11090,758,174 - 91,015,616 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cdh20
2203 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:54
Count of miRNA genes:48
Interacting mature miRNAs:52
Transcripts:ENSRNOT00000019907
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2317027Aia22Adjuvant induced arthritis QTL 222.29joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)13134785618Rat
2302275Gluco37Glucose level QTL 373.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)131244842148744906Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)131186625456866254Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
2317034Aia9Adjuvant induced arthritis QTL 94.62joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131228551734884386Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)13308875548088755Rat
1300163Cardf1Cardiac cell morphology QTL 14.18aorta morphology trait (VT:0000272)artery lesion measurement (CMO:0000975)131244842147969993Rat
631672Iddm12Insulin dependent diabetes mellitus QTL 122.20.0032blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)13600200837088115Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131238432057384320Rat
2303031Bp326Blood pressure QTL 326arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131228551723516549Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131746828262468282Rat
2303030Bp327Blood pressure QTL 327arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)13143736554Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131238432057384320Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13742179187286911Rat
2317044Aia23Adjuvant induced arthritis QTL 232.3joint integrity trait (VT:0010548)ankle joint diameter (CMO:0002148)131228551734884386Rat
61339Bp24Blood pressure QTL 240.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13600200847359539Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131771133662711336Rat
738036Lnnr4Liver neoplastic nodule remodeling QTL 43.64liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)13134785618Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)131186625456866254Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
12 11 64 143 46 51 25 11 25 6 218 99 7 130 74 90 26 14 14

Sequence


Ensembl Acc Id: ENSRNOT00000019907   ⟹   ENSRNOP00000019907
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1321,515,123 - 21,584,349 (+)Ensembl
mRatBN7.2 Ensembl1320,738,081 - 21,068,676 (+)Ensembl
Rnor_6.0 Ensembl1324,823,488 - 24,913,884 (+)Ensembl
RefSeq Acc Id: NM_001012748   ⟹   NP_001012766
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81321,515,267 - 21,583,282 (+)NCBI
mRatBN7.21321,000,659 - 21,068,676 (+)NCBI
Rnor_6.01324,846,480 - 24,913,440 (+)NCBI
Rnor_5.01330,018,338 - 30,085,298 (+)NCBI
RGSC_v3.41310,970,187 - 11,038,947 (+)RGD
Celera1320,896,704 - 20,961,175 (+)RGD
Sequence:
RefSeq Acc Id: XM_017598871   ⟹   XP_017454360
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81321,252,272 - 21,583,526 (+)NCBI
mRatBN7.21320,737,640 - 21,069,746 (+)NCBI
Rnor_6.01324,630,298 - 24,914,463 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017598872   ⟹   XP_017454361
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81321,450,576 - 21,583,526 (+)NCBI
mRatBN7.21320,935,161 - 21,068,676 (+)NCBI
Rnor_6.01324,821,898 - 24,914,463 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001012766 (Get FASTA)   NCBI Sequence Viewer  
  XP_017454360 (Get FASTA)   NCBI Sequence Viewer  
  XP_017454361 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAD90596 (Get FASTA)   NCBI Sequence Viewer  
  EDL91729 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000019907
GenBank Protein Q5DWV1 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001012766   ⟸   NM_001012748
- Peptide Label: precursor
- UniProtKB: Q5DWV1 (UniProtKB/Swiss-Prot),   A6JST1 (UniProtKB/TrEMBL),   G3V7W5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017454360   ⟸   XM_017598871
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017454361   ⟸   XM_017598872
- Peptide Label: isoform X1
- UniProtKB: Q5DWV1 (UniProtKB/Swiss-Prot),   G3V7W5 (UniProtKB/TrEMBL),   A6JST1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000019907   ⟸   ENSRNOT00000019907
Protein Domains
Cadherin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5DWV1-F1-model_v2 AlphaFold Q5DWV1 1-801 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305438 AgrOrtholog
BioCyc Gene G2FUF-18641 BioCyc
Ensembl Genes ENSRNOG00000014556 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000019907 ENTREZGENE
Gene3D-CATH 4.10.900.10 UniProtKB/Swiss-Prot
  Cadherins UniProtKB/Swiss-Prot
InterPro Cadherin UniProtKB/Swiss-Prot
  Cadherin-like_dom UniProtKB/Swiss-Prot
  Cadherin-like_sf UniProtKB/Swiss-Prot
  Cadherin_CS UniProtKB/Swiss-Prot
  Cadherin_cytoplasmic-dom UniProtKB/Swiss-Prot
  Catenin_binding_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:363948 UniProtKB/Swiss-Prot
NCBI Gene 363948 ENTREZGENE
PANTHER CADHERIN-20 UniProtKB/Swiss-Prot
  PTHR24027 UniProtKB/Swiss-Prot
Pfam Cadherin UniProtKB/Swiss-Prot
  Cadherin_C UniProtKB/Swiss-Prot
PhenoGen Cdh20 PhenoGen
PRINTS CADHERIN UniProtKB/Swiss-Prot
PROSITE CADHERIN_1 UniProtKB/Swiss-Prot
  CADHERIN_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000014556 RatGTEx
SMART SM00112 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49313 UniProtKB/Swiss-Prot
UniProt A6JST1 ENTREZGENE, UniProtKB/TrEMBL
  CAD20_RAT UniProtKB/Swiss-Prot
  G3V7W5 ENTREZGENE, UniProtKB/TrEMBL
  Q5DWV1 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Cdh20  cadherin 20  Cdh20_predicted  cadherin 20 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Cdh20_predicted  cadherin 20 (predicted)      Symbol and Name status set to approved 70820 APPROVED