Imported Disease Annotations - CTDObject Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Rubcn | Rat | Spinocerebellar Ataxias | | ISO | RUBCN (Homo sapiens) | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Imported Disease Annotations - CTDObject Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Rubcn | Rat | Spinocerebellar Ataxias | | ISO | RUBCN (Homo sapiens) | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| # | Reference Title | Reference Citation |
| 1. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
| 2. | OMIM Disease Annotation Pipeline | OMIM Disease Annotation Pipeline |
| 3. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 4. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
| 5. | Comprehensive gene review and curation | RGD comprehensive gene curation |
| 6. | Mammalian autophagy: core molecular machinery and signaling regulation. | Yang Z and Klionsky DJ, Curr Opin Cell Biol. 2010 Apr;22(2):124-31. Epub 2009 Dec 23. |
| Rubcn (Rattus norvegicus - Norway rat) |
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| RUBCN (Homo sapiens - human) |
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| Rubcn (Mus musculus - house mouse) |
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| Rubcn (Chinchilla lanigera - long-tailed chinchilla) |
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| RUBCN (Pan paniscus - bonobo/pygmy chimpanzee) |
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| RUBCN (Canis lupus familiaris - dog) |
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| Rubcn (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| RUBCN (Sus scrofa - pig) |
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| RUBCN (Chlorocebus sabaeus - green monkey) |
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| Rubcn (Heterocephalus glaber - naked mole-rat) |
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| Rubcn (Rattus rattus - black rat) |
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Variants in Rubcn
327 total Variants
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| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
| RH127712 |
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| RH128519 |
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alimentary part of gastrointestinal system
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appendage
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circulatory system
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ectoderm
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endocrine system
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endoderm
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exocrine system
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hemolymphoid system
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hepatobiliary system
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integumental system
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mesenchyme
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mesoderm
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musculoskeletal system
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nervous system
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renal system
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reproductive system
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respiratory system
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sensory system
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visual system
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| 16 | 12 | 67 | 163 | 91 | 90 | 59 | 92 | 59 | 6 | 356 | 192 | 11 | 142 | 81 | 92 | 31 | 17 | 17 |
| RefSeq Transcripts | NM_001427089 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
| XM_001065343 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_006221165 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_006221166 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_008776733 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_017598222 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_039088921 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_039088924 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_039088925 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | CH473967 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
| JAXUCZ010000011 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
| Ensembl Acc Id: | ENSRNOT00000082435 ⟹ ENSRNOP00000075115 | ||||||||||||||||
| Type: | CODING | ||||||||||||||||
| Position: |
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| Ensembl Acc Id: | ENSRNOT00000082594 ⟹ ENSRNOP00000073717 | ||||||||||||||||
| Type: | CODING | ||||||||||||||||
| Position: |
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| Ensembl Acc Id: | ENSRNOT00000107263 ⟹ ENSRNOP00000097960 | ||||||||||||
| Type: | CODING | ||||||||||||
| Position: |
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| Ensembl Acc Id: | ENSRNOT00000109522 ⟹ ENSRNOP00000080345 | ||||||||||||
| Type: | CODING | ||||||||||||
| Position: |
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| Ensembl Acc Id: | ENSRNOT00000112016 ⟹ ENSRNOP00000088608 | ||||||||
| Type: | CODING | ||||||||
| Position: |
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| RefSeq Acc Id: | NM_001427089 ⟹ NP_001414018 | ||||||||
| RefSeq Status: | VALIDATED | ||||||||
| Type: | CODING | ||||||||
| Position: |
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| RefSeq Acc Id: | XM_039088921 ⟹ XP_038944849 | ||||||||||||
| Type: | CODING | ||||||||||||
| Position: |
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| RefSeq Acc Id: | XM_039088924 ⟹ XP_038944852 | ||||||||||||
| Type: | CODING | ||||||||||||
| Position: |
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| RefSeq Acc Id: | XM_039088925 ⟹ XP_038944853 | ||||||||||||
| Type: | CODING | ||||||||||||
| Position: |
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| Protein RefSeqs | NP_001414018 | (Get FASTA) | NCBI Sequence Viewer |
| XP_038944849 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_038944852 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_038944853 | (Get FASTA) | NCBI Sequence Viewer | |
| GenBank Protein | EDM11390 | (Get FASTA) | NCBI Sequence Viewer |
| EDM11391 | (Get FASTA) | NCBI Sequence Viewer | |
| EDM11392 | (Get FASTA) | NCBI Sequence Viewer | |
| Ensembl Protein | ENSRNOP00000073717 | ||
| ENSRNOP00000073717.2 | |||
| ENSRNOP00000075115.2 | |||
| ENSRNOP00000080345.1 | |||
| ENSRNOP00000097960 | |||
| ENSRNOP00000097960.2 |
| Ensembl Acc Id: | ENSRNOP00000075115 ⟸ ENSRNOT00000082435 |
| Ensembl Acc Id: | ENSRNOP00000073717 ⟸ ENSRNOT00000082594 |
| RefSeq Acc Id: | XP_038944853 ⟸ XM_039088925 |
| - Peptide Label: | isoform X3 |
| - UniProtKB: | A0A8I6GMR7 (UniProtKB/TrEMBL) |
| RefSeq Acc Id: | XP_038944849 ⟸ XM_039088921 |
| - Peptide Label: | isoform X1 |
| - UniProtKB: | A0A0G2K687 (UniProtKB/TrEMBL), A6IRN7 (UniProtKB/TrEMBL), A0A8I6GMR7 (UniProtKB/TrEMBL) |
| RefSeq Acc Id: | XP_038944852 ⟸ XM_039088924 |
| - Peptide Label: | isoform X2 |
| Ensembl Acc Id: | ENSRNOP00000097960 ⟸ ENSRNOT00000107263 |
| Ensembl Acc Id: | ENSRNOP00000080345 ⟸ ENSRNOT00000109522 |
| Ensembl Acc Id: | ENSRNOP00000088608 ⟸ ENSRNOT00000112016 |
| RefSeq Acc Id: | NP_001414018 ⟸ NM_001427089 |
| - UniProtKB: | A0A8I6GMR7 (UniProtKB/TrEMBL) |
| Name | Modeler | Protein Id | AA Range | Protein Structure |
| AF-A0A0G2K687-F1-model_v2 | AlphaFold | A0A0G2K687 | 1-962 | view protein structure |
| eQTL | View at Phenogen | |
| WGCNA | View at Phenogen | |
| Tissue/Strain Expression | View at Phenogen |
| Database | Acc Id | Source(s) |
| AGR Gene | RGD:1305422 | AgrOrtholog |
| BioCyc Gene | G2FUF-21117 | BioCyc |
| Ensembl Genes | ENSRNOG00000059880 | Ensembl, ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000082435.3 | UniProtKB/TrEMBL |
| ENSRNOT00000082594 | ENTREZGENE | |
| ENSRNOT00000082594.3 | UniProtKB/TrEMBL | |
| ENSRNOT00000107263 | ENTREZGENE | |
| ENSRNOT00000107263.2 | UniProtKB/TrEMBL | |
| ENSRNOT00000109522.2 | UniProtKB/TrEMBL | |
| Gene3D-CATH | 1.20.58.900 | UniProtKB/TrEMBL |
| InterPro | Autophagy_HostDef_Reg | UniProtKB/TrEMBL |
| RUBC_PIKBD | UniProtKB/TrEMBL | |
| Run_dom | UniProtKB/TrEMBL | |
| Run_dom_sf | UniProtKB/TrEMBL | |
| Zf-RING_9 | UniProtKB/TrEMBL | |
| NCBI Gene | 303885 | ENTREZGENE |
| PANTHER | PHOX (PX) DOMAIN-CONTAINING PROTEIN | UniProtKB/TrEMBL |
| RUN DOMAIN BECLIN-1-INTERACTING AND CYSTEINE-RICH DOMAIN-CONTAINING PROTEIN | UniProtKB/TrEMBL | |
| Pfam | RUBC_PIKBD | UniProtKB/TrEMBL |
| RUN | UniProtKB/TrEMBL | |
| zf-RING_9 | UniProtKB/TrEMBL | |
| PhenoGen | Rubcn | PhenoGen |
| PROSITE | RUN | UniProtKB/TrEMBL |
| RatGTEx | ENSRNOG00000059880 | RatGTEx |
| SMART | DUF4206 | UniProtKB/TrEMBL |
| RUN | UniProtKB/TrEMBL | |
| Superfamily-SCOP | SSF140741 | UniProtKB/TrEMBL |
| UniProt | A0A0G2K687 | ENTREZGENE, UniProtKB/TrEMBL |
| A0A0G2K9T0_RAT | UniProtKB/TrEMBL | |
| A0A8I5ZQF9_RAT | UniProtKB/TrEMBL | |
| A0A8I6GMR7 | ENTREZGENE, UniProtKB/TrEMBL | |
| A6IRN7 | ENTREZGENE, UniProtKB/TrEMBL |
| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2018-12-10 | Rubcn | rubicon autophagy regulator | Rubcn | RUN and cysteine rich domain containing beclin 1 interacting protein | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
| 2016-02-03 | Rubcn | RUN and cysteine rich domain containing beclin 1 interacting protein | Rubcn | RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
| 2015-10-26 | Rubcn | RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein | RGD1305422 | similar to mKIAA0226 protein | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
| 2008-04-30 | RGD1305422 | similar to mKIAA0226 protein | RGD1305422_predicted | similar to mKIAA0226 protein (predicted) | 'predicted' is removed | 2292626 | APPROVED |
| 2005-01-20 | RGD1305422_predicted | similar to mKIAA0226 protein (predicted) | LOC303885_predicted | Symbol and Name status set to approved | 1331353 | APPROVED | |
| 2005-01-12 | LOC303885_predicted | similar to mKIAA0226 protein (predicted) | Symbol and Name status set to provisional | 70820 | PROVISIONAL |