Plk4 (polo-like kinase 4) - Rat Genome Database

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Gene: Plk4 (polo-like kinase 4) Rattus norvegicus
Analyze
Symbol: Plk4
Name: polo-like kinase 4
RGD ID: 1305390
Description: Predicted to enable identical protein binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including centriole assembly; positive regulation of centriole replication; and trophoblast giant cell differentiation. Predicted to be located in several cellular components, including XY body; deuterosome; and microtubule organizing center. Predicted to be part of procentriole replication complex. Predicted to be active in nucleus. Biomarker of diabetic retinopathy. Human ortholog(s) of this gene implicated in microcephaly and chorioretinopathy 2. Orthologous to human PLK4 (polo like kinase 4); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC310344; PLK-4; polo-like kinase 4 (Drosophila); serine/threonine-protein kinase PLK4; serine/threonine-protein kinase Sak
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82125,730,480 - 125,748,894 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2125,730,460 - 125,748,892 (+)EnsemblGRCr8
mRatBN7.22123,802,527 - 123,820,942 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2123,802,512 - 123,820,942 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2130,373,009 - 130,391,421 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02128,485,441 - 128,503,853 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02123,114,577 - 123,132,993 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02127,686,911 - 127,705,518 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2127,686,925 - 127,705,518 (+)Ensemblrn6Rnor6.0
Rnor_5.02147,289,950 - 147,308,585 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42127,760,508 - 127,779,640 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2118,710,474 - 118,728,860 (+)NCBICelera
RGSC_v3.12127,710,374 - 127,729,098 (+)NCBI
Cytogenetic Map2q26NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (ISO)
2-methylcholine  (ISO)
2-palmitoylglycerol  (ISO)
3-methylcholanthrene  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
butan-1-ol  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
corticosterone  (EXP)
coumestrol  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
dexamethasone  (EXP)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dicrotophos  (ISO)
dieldrin  (EXP)
diminazene diaceturate  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
Echimidine  (ISO)
Enterolactone  (ISO)
furan  (EXP)
genistein  (ISO)
glycidol  (EXP)
Lasiocarpine  (ISO)
lead diacetate  (EXP,ISO)
lucanthone  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methotrexate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monocrotaline  (ISO)
monoethyl phthalate  (ISO)
N-nitrosodiethylamine  (ISO)
nickel dichloride  (EXP)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
pirinixic acid  (EXP)
piroxicam  (ISO)
progesterone  (ISO)
propanal  (ISO)
resveratrol  (ISO)
riddelliine  (ISO)
rotenone  (EXP)
senecionine  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
succimer  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
Tiron  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trans-caffeic acid  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
centriole  (IEA,ISO,ISS)
centrosome  (IEA,ISO,ISS)
cleavage furrow  (IEA)
deuterosome  (IEA,ISO,ISS)
nucleolus  (IEA,ISO,ISS)
nucleus  (IBA)
procentriole  (IEA,ISO)
XY body  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Loss of KLF14 triggers centrosome amplification and tumorigenesis. Fan G, etal., Nat Commun. 2015 Oct 6;6:8450. doi: 10.1038/ncomms9450.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Aberrant methylation of Polo-like kinase CpG islands in Plk4 heterozygous mice. Ward A, etal., BMC Cancer. 2011 Feb 15;11:71. doi: 10.1186/1471-2407-11-71.
8. MicroRNA‑126 suppresses the proliferation and migration of endothelial cells in experimental diabetic retinopathy by targeting polo‑like kinase 4. Zheng Y, etal., Int J Mol Med. 2021 Jan;47(1):151-160. doi: 10.3892/ijmm.2020.4775. Epub 2020 Oct 30.
Additional References at PubMed
PMID:12477932   PMID:16189514   PMID:16244668   PMID:17174311   PMID:17681131   PMID:17891141   PMID:21399614   PMID:21725316   PMID:22020124   PMID:22349705   PMID:22854038   PMID:24240477  
PMID:24997597   PMID:25416956   PMID:27107012   PMID:27796307   PMID:37914064  


Genomics

Comparative Map Data
Plk4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82125,730,480 - 125,748,894 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2125,730,460 - 125,748,892 (+)EnsemblGRCr8
mRatBN7.22123,802,527 - 123,820,942 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2123,802,512 - 123,820,942 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2130,373,009 - 130,391,421 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02128,485,441 - 128,503,853 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02123,114,577 - 123,132,993 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02127,686,911 - 127,705,518 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2127,686,925 - 127,705,518 (+)Ensemblrn6Rnor6.0
Rnor_5.02147,289,950 - 147,308,585 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42127,760,508 - 127,779,640 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2118,710,474 - 118,728,860 (+)NCBICelera
RGSC_v3.12127,710,374 - 127,729,098 (+)NCBI
Cytogenetic Map2q26NCBI
PLK4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384127,880,893 - 127,899,224 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4127,880,890 - 127,899,224 (+)Ensemblhg38GRCh38
GRCh374128,802,048 - 128,820,379 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364129,021,495 - 129,039,803 (+)NCBIBuild 36Build 36hg18NCBI36
Build 344129,159,705 - 129,177,532NCBI
Celera4126,180,969 - 126,199,332 (+)NCBICelera
Cytogenetic Map4q28.1NCBI
HuRef4124,529,792 - 124,548,157 (+)NCBIHuRef
CHM1_14128,778,476 - 128,796,837 (+)NCBICHM1_1
T2T-CHM13v2.04131,183,905 - 131,202,250 (+)NCBIT2T-CHM13v2.0
Plk4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39340,754,463 - 40,771,318 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl340,754,454 - 40,771,318 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38340,799,951 - 40,816,883 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl340,800,019 - 40,816,883 (+)Ensemblmm10GRCm38
MGSCv37340,603,873 - 40,620,805 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36340,896,599 - 40,913,432 (+)NCBIMGSCv36mm8
Celera340,529,562 - 40,546,495 (+)NCBICelera
Cytogenetic Map3BNCBI
cM Map319.54NCBI
Plk4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542813,549,000 - 13,566,516 (-)Ensembl
ChiLan1.0NW_00495542813,548,485 - 13,566,786 (-)NCBIChiLan1.0ChiLan1.0
PLK4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23125,641,740 - 125,662,398 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14125,907,865 - 125,928,520 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04120,044,423 - 120,062,544 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14131,349,562 - 131,367,832 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4131,349,562 - 131,371,054 (+)EnsemblpanPan2panpan1.1
PLK4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11913,041,739 - 13,060,300 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1913,041,742 - 13,060,072 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1913,230,516 - 13,249,086 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01913,131,767 - 13,150,342 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1913,131,770 - 13,150,336 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11913,104,502 - 13,123,557 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01913,390,106 - 13,408,959 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01913,852,450 - 13,871,021 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Plk4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530161,544,655 - 61,562,496 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366422,837,022 - 2,855,103 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366422,837,041 - 2,855,369 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLK4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl896,991,847 - 97,013,461 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1896,989,011 - 97,013,324 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28103,855,622 - 103,876,526 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PLK4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1775,005,468 - 75,023,768 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl775,006,431 - 75,023,730 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603754,141,868 - 54,160,207 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Plk4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247778,804,593 - 8,825,257 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247778,804,372 - 8,825,669 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Plk4
151 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:50
Count of miRNA genes:41
Interacting mature miRNAs:49
Transcripts:ENSRNOT00000016946
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)2105628029150628029Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)282947902127947902Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)284056790132859658Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1358360Sradr2Stress Responsive Adrenal Weight QTL 210.24adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)2124103798154505346Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2124537199209621565Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
2317886Alcrsp23Alcohol response QTL 232.40.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)295142371140142371Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1582257Gluco21Glucose level QTL 213.10.0035blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2120039407159440891Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2100807373145807373Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2106869825151869825Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
5135226Leukc2Leukocyte quantity QTL 2eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)2120039407151869825Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)228652666139067443Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)293602631145807373Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
61392Bp6Blood pressure QTL 67arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)282214549127214549Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
7488933Bp368Blood pressure QTL 3680.004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2104957381149957381Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
738007Anxrr7Anxiety related response QTL 74.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2120339555165339555Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979159440891Rat
1581552Pur12Proteinuria QTL 125.190.0009urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)2114032149150226270Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)2114440891159440891Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
1354594Despr10Despair related QTL 102e-06locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)2116804572161804572Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)261051541143746880Rat

Markers in Region
Stk18  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22123,808,409 - 123,808,600 (+)MAPPERmRatBN7.2
Rnor_6.02127,692,823 - 127,693,013NCBIRnor6.0
Rnor_5.02147,295,890 - 147,296,080UniSTSRnor5.0
RGSC_v3.42127,766,406 - 127,766,596UniSTSRGSC3.4
Celera2118,716,330 - 118,716,520UniSTS
Cytogenetic Map2q26UniSTS
RH130777  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22123,820,517 - 123,820,700 (+)MAPPERmRatBN7.2
Rnor_6.02127,705,094 - 127,705,276NCBIRnor6.0
Rnor_5.02147,308,161 - 147,308,343UniSTSRnor5.0
RGSC_v3.42127,779,218 - 127,779,400UniSTSRGSC3.4
Celera2118,728,438 - 118,728,620UniSTS
RH 3.4 Map2661.4UniSTS
Cytogenetic Map2q26UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 11 66 165 91 90 59 91 59 6 353 189 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000016946   ⟹   ENSRNOP00000016946
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2125,730,460 - 125,748,892 (+)Ensembl
mRatBN7.2 Ensembl2123,802,527 - 123,820,942 (+)Ensembl
Rnor_6.0 Ensembl2127,686,972 - 127,705,518 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000086653   ⟹   ENSRNOP00000070950
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2123,802,512 - 123,820,940 (+)Ensembl
Rnor_6.0 Ensembl2127,686,925 - 127,705,516 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000093651
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2123,802,512 - 123,807,759 (+)Ensembl
Rnor_6.0 Ensembl2127,687,155 - 127,692,172 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095320   ⟹   ENSRNOP00000086620
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2125,730,958 - 125,748,482 (+)Ensembl
mRatBN7.2 Ensembl2123,803,062 - 123,820,942 (+)Ensembl
RefSeq Acc Id: NM_001395103   ⟹   NP_001382032
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82125,730,480 - 125,748,894 (+)NCBI
mRatBN7.22123,802,527 - 123,820,942 (+)NCBI
RefSeq Acc Id: XM_006232300   ⟹   XP_006232362
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82125,731,427 - 125,748,894 (+)NCBI
mRatBN7.22123,802,754 - 123,820,533 (+)NCBI
Rnor_6.02127,687,907 - 127,705,518 (+)NCBI
Rnor_5.02147,289,950 - 147,308,585 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017590857   ⟹   XP_017446346
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82125,730,792 - 125,748,894 (+)NCBI
mRatBN7.22123,802,844 - 123,820,942 (+)NCBI
Rnor_6.02127,687,220 - 127,705,518 (+)NCBI
Sequence:
RefSeq Acc Id: XP_006232362   ⟸   XM_006232300
- Peptide Label: isoform X2
- UniProtKB: A0A0G2JZ86 (UniProtKB/TrEMBL),   A6II34 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017446346   ⟸   XM_017590857
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A6C6 (UniProtKB/TrEMBL),   A6II36 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016946   ⟸   ENSRNOT00000016946
Ensembl Acc Id: ENSRNOP00000070950   ⟸   ENSRNOT00000086653
Ensembl Acc Id: ENSRNOP00000086620   ⟸   ENSRNOT00000095320
RefSeq Acc Id: NP_001382032   ⟸   NM_001395103
- UniProtKB: B2GUY1 (UniProtKB/Swiss-Prot),   A0A8L2Q8F8 (UniProtKB/TrEMBL)
Protein Domains
Cryptic POLO box 1 (CPB1)   Cryptic POLO box 2 (CPB2)   POLO box   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B2GUY1-F1-model_v2 AlphaFold B2GUY1 1-924 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691304
Promoter ID:EPDNEW_R1829
Type:single initiation site
Name:Plk4_1
Description:polo-like kinase 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02127,686,940 - 127,687,000EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305390 AgrOrtholog
BioCyc Gene G2FUF-53256 BioCyc
Ensembl Genes ENSRNOG00000011654 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000016946 ENTREZGENE
  ENSRNOT00000095320 ENTREZGENE
Gene3D-CATH 2.40.50.930 UniProtKB/Swiss-Prot
  3.30.1120.120 UniProtKB/Swiss-Prot
  3.30.1120.130 UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:8371068 IMAGE-MGC_LOAD
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Plk4-like_POLO_box_2_sf UniProtKB/Swiss-Prot
  POLO_box_dom UniProtKB/Swiss-Prot
  POLO_box_Plk4_1 UniProtKB/Swiss-Prot
  POLO_box_Plk4_2 UniProtKB/Swiss-Prot
  POLO_box_Plk4_C UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser_Thr-PK_POLO_box_1_sf UniProtKB/Swiss-Prot
  Tyr_kinase_AS UniProtKB/Swiss-Prot
MGC_CLONE MGC:187673 IMAGE-MGC_LOAD
NCBI Gene 310344 ENTREZGENE
PANTHER PTHR24345:SF89 UniProtKB/Swiss-Prot
  SERINE/THREONINE-PROTEIN KINASE PLK UniProtKB/Swiss-Prot
Pfam Pkinase UniProtKB/Swiss-Prot
  Plk4_PB1 UniProtKB/Swiss-Prot
  Plk4_PB2 UniProtKB/Swiss-Prot
PhenoGen Plk4 PhenoGen
PROSITE CPB1 UniProtKB/Swiss-Prot
  CPB2 UniProtKB/Swiss-Prot
  POLO_BOX UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011654 RatGTEx
Superfamily-SCOP Polo-box domain UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
UniProt A0A0G2JZ86 ENTREZGENE
  A0A8I6A6C6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2Q8F8 ENTREZGENE, UniProtKB/TrEMBL
  A6II34 ENTREZGENE, UniProtKB/TrEMBL
  A6II36 ENTREZGENE, UniProtKB/TrEMBL
  B2GUY1 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Plk4  polo-like kinase 4  Plk4  polo-like kinase 4 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Plk4  polo-like kinase 4 (Drosophila)   Plk4_predicted  polo-like kinase 4 (Drosophila) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Plk4_predicted  polo-like kinase 4 (Drosophila) (predicted)      Symbol and Name status set to approved 70820 APPROVED