Plk4 (polo like kinase 4) - Rat Genome Database

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Gene: Plk4 (polo like kinase 4) Chinchilla lanigera
Analyze
Symbol: Plk4
Name: polo like kinase 4
RGD ID: 8837390
Description: ENCODES a protein that exhibits identical protein binding (ortholog); protein serine/threonine kinase activity (ortholog); INVOLVED IN centriole replication (ortholog); cilium assembly (ortholog); de novo centriole assembly involved in multi-ciliated epithelial cell differentiation (ortholog); ASSOCIATED WITH breast ductal carcinoma (ortholog); colon cancer (ortholog); diabetic retinopathy (ortholog); FOUND IN centriole (ortholog); centrosome (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: polo-like kinase 4; serine/threonine-protein kinase PLK4
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542813,549,000 - 13,566,516 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542813,548,485 - 13,566,786 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
Plk4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542813,549,000 - 13,566,516 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542813,548,485 - 13,566,786 (-)NCBIChiLan1.0ChiLan1.0
PLK4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384127,880,893 - 127,899,224 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4127,880,893 - 127,899,224 (+)EnsemblGRCh38hg38GRCh38
GRCh374128,802,048 - 128,820,379 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364129,021,495 - 129,039,803 (+)NCBINCBI36Build 36hg18NCBI36
Build 344129,159,705 - 129,177,532NCBI
Celera4126,180,969 - 126,199,332 (+)NCBICelera
Cytogenetic Map4q28.1NCBI
HuRef4124,529,792 - 124,548,157 (+)NCBIHuRef
CHM1_14128,778,476 - 128,796,837 (+)NCBICHM1_1
T2T-CHM13v2.04131,183,905 - 131,202,250 (+)NCBIT2T-CHM13v2.0
Plk4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39340,754,463 - 40,771,318 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl340,754,454 - 40,771,318 (+)EnsemblGRCm39 Ensembl
GRCm38340,799,951 - 40,816,883 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl340,800,019 - 40,816,883 (+)EnsemblGRCm38mm10GRCm38
MGSCv37340,603,873 - 40,620,805 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36340,896,599 - 40,913,432 (+)NCBIMGSCv36mm8
Celera340,529,562 - 40,546,495 (+)NCBICelera
Cytogenetic Map3BNCBI
cM Map319.54NCBI
Plk4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82125,730,480 - 125,748,894 (+)NCBIGRCr8
mRatBN7.22123,802,527 - 123,820,942 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2123,802,512 - 123,820,942 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2130,373,009 - 130,391,421 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02128,485,441 - 128,503,853 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02123,114,577 - 123,132,993 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02127,686,911 - 127,705,518 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2127,686,925 - 127,705,518 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02147,289,950 - 147,308,585 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42127,760,508 - 127,779,640 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12127,710,374 - 127,729,098 (+)NCBI
Celera2118,710,474 - 118,728,860 (+)NCBICelera
Cytogenetic Map2q26NCBI
PLK4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23125,641,740 - 125,662,398 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14125,907,865 - 125,928,520 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04120,044,423 - 120,062,544 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14131,349,562 - 131,367,832 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4131,349,562 - 131,371,054 (+)Ensemblpanpan1.1panPan2
PLK4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11913,041,739 - 13,060,300 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1913,041,742 - 13,060,072 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1913,230,516 - 13,249,086 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01913,131,767 - 13,150,342 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1913,131,770 - 13,150,336 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11913,104,502 - 13,123,557 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01913,390,106 - 13,408,959 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01913,852,450 - 13,871,021 (-)NCBIUU_Cfam_GSD_1.0
Plk4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530161,544,655 - 61,562,496 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366422,837,022 - 2,855,103 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366422,837,041 - 2,855,369 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLK4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl896,991,847 - 97,013,461 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1896,989,011 - 97,013,324 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28103,855,622 - 103,876,526 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PLK4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1775,005,468 - 75,023,768 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl775,006,431 - 75,023,730 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603754,141,868 - 54,160,207 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Plk4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247778,804,593 - 8,825,257 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247778,804,372 - 8,825,669 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000005133   ⟹   ENSCLAP00000005040
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542813,549,000 - 13,566,516 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000005134   ⟹   ENSCLAP00000005041
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542813,549,000 - 13,566,516 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000005135   ⟹   ENSCLAP00000005042
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542813,549,000 - 13,566,324 (-)Ensembl
RefSeq Acc Id: XM_005386739   ⟹   XP_005386796
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542813,548,485 - 13,566,786 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005386796 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000005040
  ENSCLAP00000005040.1
  ENSCLAP00000005041.1
  ENSCLAP00000005042.1
Reference Protein Sequences
RefSeq Acc Id: XP_005386796   ⟸   XM_005386739
- UniProtKB: A0A8C2UTM8 (UniProtKB/TrEMBL),   A0A8C2USW4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000005041   ⟸   ENSCLAT00000005134
RefSeq Acc Id: ENSCLAP00000005040   ⟸   ENSCLAT00000005133
RefSeq Acc Id: ENSCLAP00000005042   ⟸   ENSCLAT00000005135
Protein Domains
Cryptic POLO box 1 (CPB1)   Cryptic POLO box 2 (CPB2)   POLO box   Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000003579 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000005133 ENTREZGENE
  ENSCLAT00000005133.1 UniProtKB/TrEMBL
  ENSCLAT00000005134.1 UniProtKB/TrEMBL
  ENSCLAT00000005135.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.50.930 UniProtKB/TrEMBL
  3.30.1120.120 UniProtKB/TrEMBL
  3.30.1120.130 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  Plk4-like_POLO_box_2_sf UniProtKB/TrEMBL
  POLO_box_dom UniProtKB/TrEMBL
  POLO_box_Plk4_1 UniProtKB/TrEMBL
  POLO_box_Plk4_2 UniProtKB/TrEMBL
  POLO_box_Plk4_C UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser_Thr-PK_POLO_box_1_sf UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
NCBI Gene Plk4 ENTREZGENE
PANTHER PTHR24345:SF89 UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE PLK UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
  Plk4_PB1 UniProtKB/TrEMBL
  Plk4_PB2 UniProtKB/TrEMBL
PROSITE CPB1 UniProtKB/TrEMBL
  CPB2 UniProtKB/TrEMBL
  POLO_BOX UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
Superfamily-SCOP Polo-box domain UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A8C2USW4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2UTM8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2UYL2_CHILA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Plk4  polo like kinase 4    polo-like kinase 4  Symbol and/or name change 5135510 APPROVED