Pdzrn3 (PDZ domain containing RING finger 3) - Rat Genome Database

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Gene: Pdzrn3 (PDZ domain containing RING finger 3) Rattus norvegicus
Analyze
Symbol: Pdzrn3
Name: PDZ domain containing RING finger 3
RGD ID: 1305250
Description: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in neuromuscular junction development and protein ubiquitination. Predicted to be located in cytoplasm. Predicted to be active in neuromuscular junction. Orthologous to human PDZRN3 (PDZ domain containing ring finger 3); INTERACTS WITH 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: E3 ubiquitin-protein ligase PDZRN3; LOC312607; PDZ domain-containing RING finger protein 3; RING-type E3 ubiquitin transferase PDZRN3; semaphorin cytoplasmic domain-associated protein 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84135,327,082 - 135,553,294 (-)NCBIGRCr8
mRatBN7.24133,770,736 - 133,996,959 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4133,770,736 - 133,996,959 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4139,182,993 - 139,416,031 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04134,963,779 - 135,196,808 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04133,584,382 - 133,817,407 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04133,717,139 - 133,951,282 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4133,717,139 - 133,951,264 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04198,194,465 - 198,429,457 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44136,044,210 - 136,254,969 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14136,260,810 - 136,311,636 (-)NCBI
Celera4122,607,053 - 122,831,741 (-)NCBICelera
Cytogenetic Map4q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
amitrole  (EXP)
andrographolide  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
calcitriol  (ISO)
CGP 52608  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
dexamethasone  (ISO)
dibenzofurans  (ISO)
dorsomorphin  (ISO)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (EXP)
glafenine  (EXP)
haloperidol  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
inulin  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
methapyrilene  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenformin  (EXP)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
profenofos  (EXP)
SB 431542  (ISO)
Securinine  (ISO)
senecionine  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
neuromuscular junction  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15057822   PMID:15458844   PMID:17576800   PMID:22609016   PMID:28623232  


Genomics

Comparative Map Data
Pdzrn3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84135,327,082 - 135,553,294 (-)NCBIGRCr8
mRatBN7.24133,770,736 - 133,996,959 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4133,770,736 - 133,996,959 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4139,182,993 - 139,416,031 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04134,963,779 - 135,196,808 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04133,584,382 - 133,817,407 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04133,717,139 - 133,951,282 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4133,717,139 - 133,951,264 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04198,194,465 - 198,429,457 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44136,044,210 - 136,254,969 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14136,260,810 - 136,311,636 (-)NCBI
Celera4122,607,053 - 122,831,741 (-)NCBICelera
Cytogenetic Map4q34NCBI
PDZRN3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38373,382,431 - 73,624,941 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl373,382,431 - 73,624,941 (-)EnsemblGRCh38hg38GRCh38
GRCh37373,431,582 - 73,674,092 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36373,514,342 - 73,756,762 (-)NCBINCBI36Build 36hg18NCBI36
Celera373,365,735 - 73,608,750 (-)NCBICelera
Cytogenetic Map3p13NCBI
HuRef373,434,331 - 73,676,506 (-)NCBIHuRef
CHM1_1373,385,013 - 73,627,407 (-)NCBICHM1_1
T2T-CHM13v2.0373,423,926 - 73,666,429 (-)NCBIT2T-CHM13v2.0
Pdzrn3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396101,126,568 - 101,354,858 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6101,126,570 - 101,354,858 (-)EnsemblGRCm39 Ensembl
GRCm386101,149,607 - 101,377,897 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6101,149,609 - 101,377,897 (-)EnsemblGRCm38mm10GRCm38
MGSCv376101,099,601 - 101,327,891 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366101,115,712 - 101,343,995 (-)NCBIMGSCv36mm8
Celera6103,016,258 - 103,244,142 (-)NCBICelera
Cytogenetic Map6D3NCBI
cM Map646.95NCBI
Pdzrn3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542114,648,524 - 14,877,822 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542114,648,436 - 14,878,759 (+)NCBIChiLan1.0ChiLan1.0
PDZRN3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2273,337,666 - 73,581,399 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1373,342,455 - 73,586,188 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0373,322,613 - 73,565,929 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1375,245,623 - 75,488,415 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl375,246,558 - 75,488,499 (-)Ensemblpanpan1.1panPan2
PDZRN3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12018,621,960 - 18,859,620 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2018,622,069 - 18,859,550 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2018,594,042 - 18,830,979 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02018,656,854 - 18,893,815 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2018,656,915 - 18,893,825 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12018,344,911 - 18,581,831 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02018,685,052 - 18,922,922 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02018,750,258 - 18,987,822 (+)NCBIUU_Cfam_GSD_1.0
Pdzrn3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049424,218,675 - 4,420,201 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366034,218,212 - 4,420,087 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366034,218,675 - 4,423,450 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDZRN3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1354,659,589 - 54,904,809 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11354,659,657 - 54,904,742 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21360,422,724 - 60,650,319 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PDZRN3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12234,325,208 - 34,567,748 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2234,326,144 - 34,567,633 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041132,201,578 - 132,443,428 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pdzrn3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247737,900,934 - 8,144,003 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247737,901,560 - 8,144,455 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pdzrn3
1319 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:50
Count of miRNA genes:45
Interacting mature miRNAs:50
Transcripts:ENSRNOT00000039201
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4106649412151649412Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)495174120140174120Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4109827074154827074Rat
1300116Hrtrt5Heart rate QTL 53.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)4116179486151161268Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4119428175157578333Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4109827074154827074Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)490850165135850165Rat
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)485253748148090731Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)4106805662151805662Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132642577167139601Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4103194656148194656Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482798864152731274Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
2293840Kiddil9Kidney dilation QTL 92.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)4120926564148090731Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4105789505150789505Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
12798527Anxrr58Anxiety related response QTL 584.110.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4119463257147278687Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)485253748150276390Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
70201Gcr1Gastric cancer resistance QTL 12.7stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)4120260281147278687Rat

Markers in Region
D4Rat58  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24133,821,995 - 133,822,342 (+)MAPPERmRatBN7.2
Rnor_6.04133,776,133 - 133,776,479NCBIRnor6.0
Rnor_5.04198,254,543 - 198,254,889UniSTSRnor5.0
RGSC_v3.44136,095,832 - 136,096,179RGDRGSC3.4
RGSC_v3.44136,095,833 - 136,096,179UniSTSRGSC3.4
RGSC_v3.14136,340,671 - 136,341,022RGD
Celera4122,658,291 - 122,658,637UniSTS
SHRSP x BN Map460.61RGD
SHRSP x BN Map460.61UniSTS
Cytogenetic Map4q34UniSTS
RH128427  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.04198,194,524 - 198,194,708NCBIRnor5.0
RGSC_v3.44136,044,276 - 136,044,459UniSTSRGSC3.4
Celera4122,607,113 - 122,607,296UniSTS
RH 3.4 Map4809.0UniSTS
Cytogenetic Map4q34UniSTS
RH129369  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24133,884,426 - 133,884,636 (+)MAPPERmRatBN7.2
Rnor_6.04133,838,559 - 133,838,768NCBIRnor6.0
Rnor_5.04198,316,969 - 198,317,178UniSTSRnor5.0
RGSC_v3.44136,158,259 - 136,158,468UniSTSRGSC3.4
Celera4122,720,663 - 122,720,872UniSTS
RH 3.4 Map4808.9UniSTS
Cytogenetic Map4q34UniSTS
BF395872  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24133,893,687 - 133,893,880 (+)MAPPERmRatBN7.2
Rnor_6.04133,847,819 - 133,848,011NCBIRnor6.0
Rnor_5.04198,326,229 - 198,326,421UniSTSRnor5.0
RGSC_v3.44136,167,519 - 136,167,711UniSTSRGSC3.4
Celera4122,729,914 - 122,730,106UniSTS
RH 3.4 Map4810.32UniSTS
Cytogenetic Map4q34UniSTS
RH141666  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24133,837,561 - 133,837,742 (+)MAPPERmRatBN7.2
Rnor_6.04133,791,699 - 133,791,879NCBIRnor6.0
Rnor_5.04198,270,109 - 198,270,289UniSTSRnor5.0
RGSC_v3.44136,111,399 - 136,111,579UniSTSRGSC3.4
Celera4122,673,857 - 122,674,037UniSTS
RH 3.4 Map4808.0UniSTS
Cytogenetic Map4q34UniSTS
AI008935  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24133,919,855 - 133,920,036 (+)MAPPERmRatBN7.2
Rnor_6.04133,873,953 - 133,874,133NCBIRnor6.0
Rnor_5.04198,352,042 - 198,352,222UniSTSRnor5.0
RGSC_v3.44136,178,084 - 136,178,264UniSTSRGSC3.4
Celera4122,755,027 - 122,755,207UniSTS
RH 3.4 Map4810.32UniSTS
Cytogenetic Map4q34UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 34 12 4 4 8 11 69 24 30 9 8
Low 9 45 37 19 37 5 11 11 2
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000090506   ⟹   ENSRNOP00000073080
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4133,770,736 - 133,996,959 (-)Ensembl
Rnor_6.0 Ensembl4133,717,139 - 133,951,264 (-)Ensembl
RefSeq Acc Id: NM_001271251   ⟹   NP_001258180
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84135,327,082 - 135,553,294 (-)NCBI
mRatBN7.24133,770,736 - 133,996,959 (-)NCBI
Rnor_6.04133,717,139 - 133,951,264 (-)NCBI
Rnor_5.04198,194,465 - 198,429,457 (-)NCBI
Celera4122,607,053 - 122,831,741 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017592642   ⟹   XP_017448131
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84135,327,082 - 135,375,082 (-)NCBI
mRatBN7.24133,770,736 - 133,818,888 (-)NCBI
Rnor_6.04133,717,470 - 133,775,301 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001258180 (Get FASTA)   NCBI Sequence Viewer  
  XP_017448131 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL91453 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000073080
  ENSRNOP00000073080.2
GenBank Protein P68907 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001258180   ⟸   NM_001271251
- UniProtKB: P68907 (UniProtKB/Swiss-Prot),   A0A0G2K4K7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017448131   ⟸   XM_017592642
- Peptide Label: isoform X1
- UniProtKB: A6IBI4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000073080   ⟸   ENSRNOT00000090506
Protein Domains
PDZ   RING-type   TRAF-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P68907-F1-model_v2 AlphaFold P68907 1-1062 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305250 AgrOrtholog
BioCyc Gene G2FUF-43521 BioCyc
Ensembl Genes ENSRNOG00000057556 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000090506 ENTREZGENE
  ENSRNOT00000090506.2 UniProtKB/TrEMBL
Gene3D-CATH 2.30.42.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_TRAF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 312607 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE PDZRN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ DOMAIN CONTAINING RING FINGER PROTEIN 3, 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-C3HC4_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pdzrn3 PhenoGen
PROSITE PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_RING_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_TRAF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000057556 RatGTEx
SMART PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50156 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRAF domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K4K7 ENTREZGENE, UniProtKB/TrEMBL
  A6IBI4 ENTREZGENE, UniProtKB/TrEMBL
  P68907 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Pdzrn3  PDZ domain containing RING finger 3   Pdzrn3_predicted  PDZ domain containing RING finger 3 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Pdzrn3_predicted  PDZ domain containing RING finger 3 (predicted)      Symbol and Name status set to approved 70820 APPROVED