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Gene: Smc2 (structural maintenance of chromosomes 2) Rattus norvegicus

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Symbol:

Smc2

Name:

structural maintenance of chromosomes 2

RGD ID:

1305227

Description:

Predicted to enable chromatin binding activity and single-stranded DNA binding activity. Predicted to be involved in mitotic chromosome condensation; positive regulation of chromosome condensation; and regulation of chromosome segregation. Predicted to act upstream of or within kinetochore organization; meiotic chromosome condensation; and meiotic chromosome segregation. Predicted to be located in condensed nuclear chromosome and cytoplasm. Predicted to be part of condensin complex. Predicted to be active in chromatin and condensed chromosome. Human ortholog(s) of this gene implicated in colon adenocarcinoma. Orthologous to human SMC2 (structural maintenance of chromosomes 2); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

CAP-E; CAPE; chromosome-associated protein E; LOC362519; SMC2 structural maintenance of chromosomes 2-like 1; SMC2 structural maintenance of chromosomes 2-like 1 (yeast); Smc2l1; structural maintenance of chromosomes protein 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SMC2 (structural maintenance of chromosomes 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Smc2 (structural maintenance of chromosomes 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Smc2 (structural maintenance of chromosomes 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SMC2 (structural maintenance of chromosomes 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SMC2 (structural maintenance of chromosomes 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Smc2 (structural maintenance of chromosomes 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SMC2 (structural maintenance of chromosomes 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SMC2 (structural maintenance of chromosomes 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Smc2 (structural maintenance of chromosomes 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Smc2 (structural maintenance of chromosomes 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	MED10 (mediator complex subunit 10)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	SMC2 (structural maintenance of chromosomes 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Smc2 (structural maintenance of chromosomes 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	smc2 (structural maintenance of chromosomes 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	mix-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	mix-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	SMC2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	SMC2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	smc2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	smc2	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	71,592,428 - 71,648,636 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	71,602,308 - 71,648,632 (+)	Ensembl				GRCr8
mRatBN7.2	5	66,806,882 - 66,853,478 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	66,807,011 - 66,853,242 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	68,710,446 - 68,756,648 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	70,528,861 - 70,575,059 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	70,499,195 - 70,545,399 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	68,717,509 - 68,764,080 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	68,717,519 - 68,763,850 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	73,151,967 - 73,198,538 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	69,561,142 - 69,607,373 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	60,812,631 - 60,858,839 (-)	NCBI		Celera
RGSC_v3.1	5	69,566,160 - 69,612,480 (+)	NCBI
Cytogenetic Map	5	q23	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

colon adenocarcinoma (ISO)

colorectal cancer (ISO)

Experimental Liver Cirrhosis (ISO)

Lung Neoplasms (ISO)

Microsatellite Instability (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

1,1-dichloroethene (ISO)

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

1-naphthyl isothiocyanate (EXP)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP,ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,4'-trichlorobiphenyl (ISO)

2,4,6-trinitrobenzenesulfonic acid (ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

2-butoxyethanol (ISO)

4,4'-diaminodiphenylmethane (EXP,ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

acetamide (EXP)

aflatoxin B1 (ISO)

aflatoxin M1 (ISO)

all-trans-retinoic acid (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

azathioprine (ISO)

benzene (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[b]fluoranthene (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

calcitriol (ISO)

carbon nanotube (ISO)

chlorpyrifos (ISO)

chromium(6+) (ISO)

cisplatin (ISO)

clozapine (ISO)

cobalt dichloride (ISO)

copper atom (ISO)

copper(0) (ISO)

coumestrol (ISO)

cyclosporin A (ISO)

DDE (ISO)

dicrotophos (ISO)

diethylstilbestrol (EXP)

dimethyl sulfoxide (ISO)

doxorubicin (ISO)

Enterolactone (ISO)

enzyme inhibitor (ISO)

folic acid (ISO)

genistein (ISO)

gentamycin (EXP)

ivermectin (ISO)

levetiracetam (EXP)

lidocaine (EXP)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

methapyrilene (EXP)

methyl methanesulfonate (ISO)

N-nitrosodiethylamine (ISO)

N-nitrosodimethylamine (EXP)

N-Nitrosopyrrolidine (ISO)

nickel atom (ISO)

oxaliplatin (EXP)

ozone (ISO)

paracetamol (EXP,ISO)

PCB138 (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

phenobarbital (ISO)

phenytoin (EXP)

pirinixic acid (ISO)

piroxicam (ISO)

potassium chromate (ISO)

progesterone (ISO)

propanal (ISO)

quercetin (ISO)

resveratrol (EXP,ISO)

rotenone (EXP)

senecionine (EXP)

Senkirkine (EXP)

silicon dioxide (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

succimer (ISO)

sunitinib (ISO)

testosterone (ISO)

testosterone enanthate (ISO)

tetrachloromethane (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

topotecan (EXP)

trichloroethene (EXP)

trimellitic anhydride (ISO)

triphenyl phosphate (EXP,ISO)

troglitazone (ISO)

trovafloxacin (ISO)

tungsten (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

B cell differentiation (IEA,ISO)

cell development (IEA,ISO)

cell division (IEA)

cerebral cortex development (IEA,ISO)

chromosome condensation (IEA)

chromosome organization (IEA)

immunoglobulin heavy chain V-D-J recombination (IEA,ISO)

kinetochore organization (ISO)

meiotic cell cycle (IEA)

meiotic chromosome condensation (ISO)

meiotic chromosome segregation (ISO)

mitotic chromosome condensation (IBA,IEA,ISO)

nuclear chromosome segregation (IEA)

nuclear division (IEA)

positive regulation of chromosome condensation (IEA,ISO)

positive regulation of chromosome segregation (IEA,ISO)

positive regulation of chromosome separation (IEA,ISO)

Cellular Component

chromatin (IBA)

chromosome (IEA)

condensed chromosome (IBA,IEA,ISO)

condensed nuclear chromosome (IEA,ISO)

condensin complex (IBA,IEA,ISO)

cytoplasm (IEA,ISO)

nuclear chromosome (IEA,ISO)

nuclear lumen (IEA)

nucleolus (IEA,ISO)

nucleoplasm (IEA,ISO)

nucleus (IEA,ISO)

Molecular Function

ATP binding (IEA)

ATP hydrolysis activity (IEA)

chromatin binding (IBA,IEA,ISO)

nucleotide binding (IEA)

protein binding (ISO)

single-stranded DNA binding (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Diminished Condensin Gene Expression Drives Chromosome Instability That May Contribute to Colorectal Cancer Pathogenesis.	Baergen AK, etal., Cancers (Basel). 2019 Jul 28;11(8). pii: cancers11081066. doi: 10.3390/cancers11081066.
2.	Human SMC2 protein, a core subunit of human condensin complex, is a novel transcriptional target of the WNT signaling pathway and a new therapeutic target.	Dávalos V, etal., J Biol Chem. 2012 Dec 21;287(52):43472-81. doi: 10.1074/jbc.M112.428466. Epub 2012 Oct 24.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
5.	Mutational and expressional analysis of SMC2 gene in gastric and colorectal cancers with microsatellite instability.	Je EM, etal., APMIS. 2014 Jun;122(6):499-504. doi: 10.1111/apm.12193. Epub 2014 Feb 1.
6.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
7.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
8.	GOA pipeline	RGD automated data pipeline
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:8889548	PMID:9789013	PMID:10958694	PMID:11136719	PMID:12589063	PMID:14660695	PMID:19056867	PMID:20139420	PMID:21795393	PMID:23531880	PMID:25474630

Genomics

Comparative Map Data

Smc2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	71,592,428 - 71,648,636 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	71,602,308 - 71,648,632 (+)	Ensembl				GRCr8
mRatBN7.2	5	66,806,882 - 66,853,478 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	66,807,011 - 66,853,242 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	68,710,446 - 68,756,648 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	70,528,861 - 70,575,059 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	70,499,195 - 70,545,399 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	68,717,509 - 68,764,080 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	68,717,519 - 68,763,850 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	73,151,967 - 73,198,538 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	69,561,142 - 69,607,373 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	60,812,631 - 60,858,839 (-)	NCBI		Celera
RGSC_v3.1	5	69,566,160 - 69,612,480 (+)	NCBI
Cytogenetic Map	5	q23	NCBI

SMC2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	104,088,263 - 104,141,419 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	104,093,695 - 104,144,486 (+)	Ensembl			hg38	GRCh38
GRCh37	9	106,856,590 - 106,903,700 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	105,896,362 - 105,943,521 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	9	103,936,161 - 103,981,492	NCBI
Celera	9	77,361,453 - 77,408,608 (+)	NCBI		Celera
Cytogenetic Map	9	q31.1	NCBI
HuRef	9	76,458,199 - 76,505,354 (+)	NCBI		HuRef
CHM1_1	9	107,002,961 - 107,050,087 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	9	116,267,420 - 116,315,130 (+)	NCBI		T2T-CHM13v2.0

Smc2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	52,438,966 - 52,488,365 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	52,439,243 - 52,488,260 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	4	52,439,221 - 52,488,365 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	52,439,243 - 52,488,260 (+)	Ensembl			mm10	GRCm38
MGSCv37	4	52,452,121 - 52,501,132 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	4	52,460,349 - 52,509,360 (+)	NCBI		MGSCv36	mm8
Celera	4	52,415,636 - 52,464,543 (+)	NCBI		Celera
Cytogenetic Map	4	B2	NCBI
cM Map	4	28.31	NCBI

Smc2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955419	22,245,843 - 22,294,508 (-)	Ensembl
ChiLan1.0	NW_004955419	22,245,843 - 22,294,508 (-)	NCBI	ChiLan1.0	ChiLan1.0

SMC2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	35,245,512 - 35,293,674 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	35,248,110 - 35,296,043 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	75,273,163 - 75,323,486 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	103,402,526 - 103,449,949 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	103,402,967 - 103,449,949 (+)	Ensembl			panPan2	panpan1.1

SMC2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	11	60,091,728 - 60,155,295 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	11	60,091,457 - 60,151,442 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	11	58,551,880 - 58,615,431 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	11	61,224,131 - 61,287,560 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	11	61,224,153 - 61,282,017 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	11	59,747,900 - 59,811,305 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	11	59,760,321 - 59,823,705 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	11	60,447,777 - 60,511,198 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Smc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	175,259,249 - 175,308,528 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936793	910,654 - 958,811 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936793	909,663 - 958,883 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SMC2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	245,410,147 - 245,475,929 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	1	245,409,559 - 245,459,032 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	274,583,155 - 274,632,093 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SMC2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	35,377,381 - 35,423,218 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	35,374,947 - 35,423,364 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666035	7,188,249 - 7,235,374 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Smc2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624758	7,268,474 - 7,317,919 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624758	7,267,024 - 7,318,930 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Smc2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	1	103,184,672 - 103,232,152 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Smc2
240 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	158
Count of miRNA genes:	114
Interacting mature miRNAs:	135
Transcripts:	ENSRNOT00000066226
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1578776	Stresp18	Stress response QTL 18	2.9		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	5	32751649	77751649	Rat
1298067	Scl15	Serum cholesterol level QTL 15	4.8	0.001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	38011670	83011670	Rat
1300115	Hrtrt7	Heart rate QTL 7	2.76		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	5	52665372	94894052	Rat
6907115	Mcs29	Mammary carcinoma susceptibility QTL 29			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	38004331	83004331	Rat
1549845	Scl44	Serum cholesterol level QTL 44	6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	44924861	153890773	Rat
1358353	Srcrtb2	Stress Responsive Cort Basal QTL 2	3.48	0.003	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	23671493	79046465	Rat
70212	Niddm25	Non-insulin dependent diabetes mellitus QTL 25	3.54		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	38207390	136631402	Rat
61386	Bp49	Blood pressure QTL 49	16.6		cerebrum integrity trait (VT:0010549)	brain infarction volume (CMO:0001013)	5	65089051	103648916	Rat
1331801	Rf33	Renal function QTL 33	4.149		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	5	48523123	134369373	Rat
1598807	Glom12	Glomerulus QTL 12	2.7		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	5	38011670	83011670	Rat
1302786	Kidm8	Kidney mass QTL 8	28.15		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	5	38011670	83011670	Rat
61393	Bp7	Blood pressure QTL 7	4.5	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	65089051	166764498	Rat
1331782	Rf36	Renal function QTL 36	3.296		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	39019942	102105896	Rat
6903292	Stl28	Serum triglyceride level QTL 28	2.6	0.0073	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	5	33311673	78311673	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	51657967	166600247	Rat
1578767	Stresp17	Stress response QTL 17	4.3	0.01	blood aldosterone amount (VT:0005346)	plasma aldosterone level (CMO:0000551)	5	32751649	77751649	Rat
1576312	Emca8	Estrogen-induced mammary cancer QTL 8	4.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	55124766	172190305	Rat
1641912	Alcrsp18	Alcohol response QTL 18			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	5	39985948	84985948	Rat
1576314	Eutr1	Estrogen induced uterine response QTL 1			uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	6922282	81330203	Rat
6903306	Scl35	Serum cholesterol QTL 35	2.6	0.0073	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	33311673	78311673	Rat
1576317	Eutr2	Estrogen induced uterine response QTL 2		0.01	uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	39526924	84526924	Rat
1331773	Scl26	Serum cholesterol level QTL 26	3.065		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	48523123	91770353	Rat
1578673	Bmd13	Bone mineral density QTL 13	4.9		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	5	69474415	114474415	Rat
70189	Mcs5	Mammary carcinoma susceptibility QTL 5	10.51		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	60601597	137492949	Rat
1331771	Rf35	Renal function QTL 35	4.36965		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	10019064	91770353	Rat
61359	Eaex	Experimental allergic encephalomyelitis QTL x	3		nervous system integrity trait (VT:0010566)	post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)	5	60511627	105511627	Rat
8662454	Vetf3	Vascular elastic tissue fragility QTL 3	27.4		artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	5	7065535	74335773	Rat
2290448	Scl54	Serum cholesterol level QTL 54	2.93		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	36460764	136631402	Rat
61426	Scl2	Serum cholesterol level QTL 2	7.3	0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	64589016	109589016	Rat
2290005	Mcs24	Mammary carcinoma susceptibility QTL 24			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	69835120	114835120	Rat
1331756	Rf34	Renal function QTL 34	4.16275		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	10019064	87027358	Rat
2306971	Anxrr21	Anxiety related response QTL 21	9.47		fear/anxiety-related behavior trait (VT:1000241)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	5	70969494	136328156	Rat
2316954	Rf57	Renal function QTL 57	0		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	5	64589016	93503770	Rat
2316959	Gluco59	Glucose level QTL 59	4.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	56546393	101546393	Rat
2316957	Pur21	Proteinuria QTL 21	6.2		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	5	64589016	91762830	Rat

Markers in Region

Fin16

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	66,853,024 - 66,853,161 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	68,763,643 - 68,763,779	NCBI	Rnor6.0
Rnor_5.0	5	73,198,101 - 73,198,237	UniSTS	Rnor5.0
RGSC_v3.4	5	69,607,156 - 69,607,292	UniSTS	RGSC3.4
Celera	5	60,812,712 - 60,812,848	UniSTS
Cytogenetic Map	5	q23	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001108666	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006238165	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063287920	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AI639509	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BE119797	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BF396223	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BQ202586	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB719228	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB729201	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB762997	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474056	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CO388936	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CR471273	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CV074555	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	EV770551	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ225485	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ225518	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000066226 ⟹ ENSRNOP00000061673

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	71,602,308 - 71,648,632 (+)	Ensembl
mRatBN7.2 Ensembl	5	66,807,011 - 66,853,242 (+)	Ensembl
Rnor_6.0 Ensembl	5	68,717,519 - 68,763,850 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000113988 ⟹ ENSRNOP00000091386

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	71,602,308 - 71,648,632 (+)	Ensembl
mRatBN7.2 Ensembl	5	66,807,011 - 66,853,242 (+)	Ensembl

RefSeq Acc Id:

NM_001108666 ⟹ NP_001102136

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	71,602,405 - 71,648,636 (+)	NCBI
mRatBN7.2	5	66,807,011 - 66,853,242 (+)	NCBI
Rnor_6.0	5	68,717,629 - 68,763,860 (+)	NCBI
Rnor_5.0	5	73,151,967 - 73,198,538 (+)	NCBI
RGSC_v3.4	5	69,561,142 - 69,607,373 (+)	RGD
Celera	5	60,812,631 - 60,858,839 (-)	RGD

Sequence:

show sequence

TGCCCGCCTCCGCGTCGAGTCGGAACTTTGCTGGTACCCCTGGCCGGCCACTTGGTGGTTGACC
TGGCCTGTAGCTTGCTGCCTAACAGGCTTAACCCAAGACAGTATAAAAAATGTATGTTAAATCA
ATCATTCTCGAAGGATTCAAGTCCTATGCACAAAGGACTGAAGTCAATGGTTTTGACCCCCTCT
TCAATGCGATCACTGGTTTGAATGGTAGTGGAAAATCCAATATATTGGATTCCATATGCTTTCT
CCTAGGCATCTCCAACCTGTCTCAGGTTCGGGCTTCAAATTTACAAGATCTGGTTTATAAAAAC
GGACAGGCTGGAATCACCAAAGCCTCTGTTTCAATCACTTTTGATAATTCTGACAAAAAGCAGA
GTCCATTAGGATTTGAAGCTCATGATGAAATCACTGTAACAAGACAGGTGGTTATTGGTGGCAG
AAATAAATACTTAATCAATGGAGTGAATGCCAACAACACCAGAGTCCAGGATCTCTTTTGTTCT
GTGGGCCTGAACGTGAATAACCCTCACTTTCTCATCATGCAGGGCAGAATTACGAAAGTATTAA
ATATGAAACCACCAGAGATATTATCCATGATCGAAGAAGCTGCTGGAACCAGGATGTATGAGTA
CAAAAAAATAGCTGCCCAGAAAACTATAGAAAAAAAGGAGGCTAAGCTGAAAGAAATAAAAACG
ATACTGGAAGAAGAGATTACGCCAACAATTCAAAAATTAAAAGAGGAAAGATCTTCTTACTTGG
AGTACCAGAAAGTGATGCGTGAGATCGAGCATCTGAGCCGTTTATATATTGCCTATCAGTTTTT
GCTGGCTGAAGATACCAAGGAACGCTCAGCTGGGGAGCTAAAGGAAATGCAGGATAAAATATTA
AAGCTTCAAGAAGTACTGTCAGAGAATGAAAAAAAGATAAAGGCTCTCAATTGTGAAATAGAAG
AATTGGAGAAGAGAAAAGATAAGGAAACTGGAGGCATCCTCCGATCTTTAGAGGATGCTTTTGC
AGAAGCTCAGCGAGTTAATACTAAGTCTCAAAGTGCATTTGACCTCAAGAAGAAAAACCTAGCC
AGTGAAGAAACCAAGCGCAAAGAGCTAGAGAAAAACATGGCTGAGGACTCTAAAGCATTAGCAG
CAAAGGAAAAGGAAGTTAAGAAGCTAACCGATGGACTGCACGGCCTTCAAGAAGCAAGCAATAA
AGATGCGGAAGCTCTGGCCGCCGCCCAGCAGCACTTCAATGCAGTGTCTGCTGGCTTGTCCAGT
AATGAAGATGGAGCAGAGGCAACTCTGGCCGGGCAGATGATGGCCTGTAAGAACGACATCAGCA
AAGCGCAGACCGGGGCCAAGCAGGCTCAGATGAAGTTGAAACATGCCCAACAGGAACTGAAGAA
TAAACAAGCAGAAGTTAGGAAGATGGATAGTGGGTACAAGAAGGATCAAGAAGCTTTTGAAGCT
GTGAAAAAAGTTAAAGAAAAACTTGAAACCGAAATGAAGAAGCTAAATTACGAAGACAACAAAG
AGGAAAGGCTTTTGGAAAAGCACAGGCAGGTGTCTCGTGACATCAGTAATCTAAAAGGAACCTA
CGAAGCTCTCTTGGCCAAGTTTCCCAATCTTCGATTTGCATACAAGGACCCAGAGAAGAACTGG
AATCGAAATTGTGTAAAAGGACTTGTAGCTTCTCTGATAAATGTGAAAGATAATTCTACAGCCA
CAGCTCTGGAATTGGTGGCTGGAGAACGACTCTACAATGTTGTAGTAGACACAGAGGTTACTGG
TAAGAAACTATTAGAAAAGGGGGAATTGAAGCGTCGATACACAATAATTCCTCTCAATAAGATT
TCAGCCAGATGTATTGCTCCTGAAACTCTGAGGGTCGCTCAGAATCTTGTTGGTCCTAACAATG
TTCATGTAGCTCTTTCCTTGGTTGACTACAAACCAGAACTTCAGAAAGCGATGGAATTTGTCTT
CGGAACAACATTTGTTTGTAACAATATGGATAATGCCAAAAAAGTGGCCTTTGATAAAAGAATA
ATGACCAGAACTGTAACCCTTGGGGGTGATGTATTTGATCCTCATGGAACATTGAGTGGAGGTG
CTAGGTCCCAGGCGGCTTCTATTTTAACCAAGTTTCAAGAACTCAAAGATGTTCAAGCTGAGCT
GAGGACAAAGGAGAAAGAACTGCAGGCTCTGGAAGAGGAATTGGCTGGTCTTAAAAATGTCGCT
GAAAAGTATCGCCAACTGAAACAGCAGTGGGAGATGAAGACAGAGGAGGGAGATTTGTTGCAAA
CCAAACTTCAGCAAAGCTCTTACCATAAGCAGCAAGAAGAATTAGATGCCCTTAAAAAAACCAT
TGAGGAAAGTGAGGAGACATTAAAAAACACAAAAGAAATCCAAAAGAAAGCTGAAGAAAAATAT
GAGGCATTGGAGAATAAAATGAAAAATGCAGAAGCTGAAAGAGAGAAAGAACTGAAGGATGCTC
AGAAAAAACTGGATTGTGCCAAAACAAAGGCTGATGCATCTAGCAAGAAAATGAAAGAAAAGCA
ACAGGAGGTTGAAGCTATCACTCTGGAGCTAGAGGAGCTCAAAAGAGAGCATGCATCTAACGAA
CAGCAGCTTGATGCTGTGAATGAAGCCATCAAAGCCTATGAAGGGCAGATTGAAATAATGGCAG
CTGAGGTGGCCAAAAACAAGGAATCAGTTAATAAAGCTCAAAATGAGCTGATGAAGCAAAAAGA
AATAATAAGTGCCCAGGACAACATAATTAAAGATAAATGTGCGGAAGTGGCAAAACACAATTTG
CAAAACAATGATTCTCAGCTTAAAATTAAGGAGTTAGACCACAGCATAAGCAAACACAAGCGGG
AAGCTGACGACGCTGCTGCGAAGGTATCCAAAATGTTGAATGATTATGACTGGATTAATGCTGA
GAAACACCTCTTTGGCCAACCTAATAGTGCCTATGATTTCAAAACAAACAACCCCAAAGAAGCT
GGCCAGAGACTTCAGAAGTTGCAAGAAGTAAAAGAGAAACTAGGGAGAAATGTCAACATGAGAG
CTATGAATGTGCTGACAGAAGCGGAAGAGCGGTATAATGATTTGATGAAGAAGAAAAGAATTGT
AGAAAATGACAAATCCAAAATCCTTGCAACTATAGAAGATCTTGACCAGAAGAAAAATCAGGCC
CTAAATATTGCTTGGCAAAAGGTGAACAAAGACTTTGGCTCTATTTTTTCTACCCTTTTGCCTG
GTGCCAATGCTATGCTTGCACCACCAGAAGGGCAGACAGTTTTAGATGGTCTGGAGTTCAAGGT
TGCCTTAGGAAATACATGGAAAGAAAACCTAACTGAGCTTAGTGGTGGTCAGAGGTCTCTGGTG
GCTCTCTCACTAATATTGTCCATGCTCCTCTTCAAACCTGCTCCAATTTATATCTTGGACGAGG
TGGATGCGGCCTTAGATCTTTCTCATACCCAGAACATCGGACAGATGCTGCGAACTCACTTCAC
ACATTCTCAATTCATTGTGGTATCCCTCAAAGAAGGTATGTTCAACAATGCAAACGTTCTCTTC
AAAACCAAGTTTGTGGATGGTGTTTCTACAGTAGCCAGATTTACACAGAGTCAAAATGGGAGGA
TTCCAAAGGAGGCAAAGGCCAAGGGCAAAGGACCCAGCTGAGTGCATGCCAGAAGTTCAGAGTG
CGGGCGTCTCACCTTGACCTTTTACACATGAACGTTTTCAAGGATTTGGGATCTAAAGTTGTTT
ATATAATAATGTTAACATTATTTCCATAAGTAATTTTTGTAGCACCGGTAAAAGAGCAGATTCC
TCTTTTTTTACCTAGTGTGATTATGGTCCAATTATTGTAGTTGTGATTGCATATTTTTCTTACA
AAAATCTTTTTTATGTATTAAAGAACCTGAGGTACATCGAGTTGGTAAATTCTGTATGCAAATG
CCAAAATACAAAGAAACAGATGAAGTTATAGGATAAATATAGCTGATAGTCAGCTTTTAACTAG
TTTAATTTCTAAGGACAGTATTAATGAGTCTTCTTTTGCTTATAAAATCATTCGAATACAGAGT
ATTTATAAAGAAAGTCACTGGGCCAACAAAGGGGGAACATAGCAATTATGCATACACAAAGCTA
TTTGAGGTCGGTCCTTGTAGGGATGCAATGCCAGATCCTTGGATGGGAAATGGACCTGGAAACA
ATTTTTCACTGTAATGATGTTGGACTATCATGTTTATGCATGTTTAATAATTGATCTCACAAGC
TTGAAATTTGCATGTTTTTTATCTTTGAGTATTTTAGTAGAAACCTGGGAAGAAATGTGTTACA
TAGTATTATACCTAGATTGCTCTATCTGAAGTCCTGTAATATTTTTTAAGATTTTTATCAGACT
CTCATAGTCTAATCAATAATTTTTTGGACCTAGCAGATTAAATGAAAAGTATATTTTATAAGAG
TCTGATAAACCTAAATAAGTCTGCCTTTTCTACCAAGAAAGTCTCCAAAGCTTGATGATTGCTG
AAATTCTTGGTGCCTTCGGCTTGTCCAGGTTGAAAGTAAACTCCTTTAGAAAGCAGGAGGGGGC
CAGTACACACCCTGAGAGCCTGCAGCTCGTACTGTCTCTACAGACATTTCCACGTCAGCACAGT
CATGCTCGTAGTTTTCAGAGCTCTAATGTGACCTGATCTGATTTAATGATTGTGGCCCTATTTC
TTCCTGATACTTAGCCTTCAGTGTTTTGCTGTTCTACTTTCTTTGATGCACCATACAGGCCCTG
AGTTGGACATTTCTCAAACTTCATTTGCCATATATATCTGTGATGTTACATAGACCTTAAGTAA
TTTGTACCCTTGGACATTTTGGAAATTATTTCATCTGGAGGGAAGAGACAGTAAGCTGTAATAT
TCACTGAGCGATAGTAAAGATCACAGATAATGAACCTACACAATGTTTTGTTTTCCAAGGTCTT
ATAAACTGTTGGTCAAAACAGTTGTGTTTATTACACTGTCACTGATACAGTATTCTAATTTGAT
CACAATCTAATCAATGCCAGCTGCTAATATTTTGTATTAGGCAGTTATAAAACAGCATTGAATT
CCTGTCTTAACAAACTACTTTGTTTGATTTCCTTTGTGTATAAATTATTTCCTTGTATGCATTT
CTGTTTTGTGTTCTTTTGTTTTTGTATTATATATAGTTTCACTCTTGAAATTTTTGTGCATATA
TTAAATTTCTTTGAGGCATATTAAA

hide sequence

RefSeq Acc Id:

XM_006238165 ⟹ XP_006238227

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	71,592,428 - 71,648,636 (+)	NCBI
mRatBN7.2	5	66,806,882 - 66,853,478 (+)	NCBI
Rnor_6.0	5	68,717,509 - 68,764,080 (+)	NCBI
Rnor_5.0	5	73,151,967 - 73,198,538 (+)	NCBI

Sequence:

show sequence

CTTTGCTCGCGCCGAAATTCAAAGAAACAGTTCCGGCACGGTTGTTGGCTACGGCGGATGCTGT
GGCCGGGATGTTGGCGTTCTCCCGGTAGCTCCCGAATACAGACCTGGCCTGTAGCTTGCTGCCT
AACAGGCTTAACCCAAGACAGTATAAAAAATGTATGTTAAATCAATCATTCTCGAAGGATTCAA
GTCCTATGCACAAAGGACTGAAGTCAATGGTTTTGACCCCCTCTTCAATGCGATCACTGGTTTG
AATGGTAGTGGAAAATCCAATATATTGGATTCCATATGCTTTCTCCTAGGCATCTCCAACCTGT
CTCAGGTTCGGGCTTCAAATTTACAAGATCTGGTTTATAAAAACGGACAGGCTGGAATCACCAA
AGCCTCTGTTTCAATCACTTTTGATAATTCTGACAAAAAGCAGAGTCCATTAGGATTTGAAGCT
CATGATGAAATCACTGTAACAAGACAGGTGGTTATTGGTGGCAGAAATAAATACTTAATCAATG
GAGTGAATGCCAACAACACCAGAGTCCAGGATCTCTTTTGTTCTGTGGGCCTGAACGTGAATAA
CCCTCACTTTCTCATCATGCAGGGCAGAATTACGAAAGTATTAAATATGAAACCACCAGAGATA
TTATCCATGATCGAAGAAGCTGCTGGAACCAGGATGTATGAGTACAAAAAAATAGCTGCCCAGA
AAACTATAGAAAAAAAGGAGGCTAAGCTGAAAGAAATAAAAACGATACTGGAAGAAGAGATTAC
GCCAACAATTCAAAAATTAAAAGAGGAAAGATCTTCTTACTTGGAGTACCAGAAAGTGATGCGT
GAGATCGAGCATCTGAGCCGTTTATATATTGCCTATCAGTTTTTGCTGGCTGAAGATACCAAGG
AACGCTCAGCTGGGGAGCTAAAGGAAATGCAGGATAAAATATTAAAGCTTCAAGAAGTACTGTC
AGAGAATGAAAAAAAGATAAAGGCTCTCAATTGTGAAATAGAAGAATTGGAGAAGAGAAAAGAT
AAGGAAACTGGAGGCATCCTCCGATCTTTAGAGGATGCTTTTGCAGAAGCTCAGCGAGTTAATA
CTAAGTCTCAAAGTGCATTTGACCTCAAGAAGAAAAACCTAGCCAGTGAAGAAACCAAGCGCAA
AGAGCTAGAGAAAAACATGGCTGAGGACTCTAAAGCATTAGCAGCAAAGGAAAAGGAAGTTAAG
AAGCTAACCGATGGACTGCACGGCCTTCAAGAAGCAAGCAATAAAGATGCGGAAGCTCTGGCCG
CCGCCCAGCAGCACTTCAATGCAGTGTCTGCTGGCTTGTCCAGTAATGAAGATGGAGCAGAGGC
AACTCTGGCCGGGCAGATGATGGCCTGTAAGAACGACATCAGCAAAGCGCAGACCGGGGCCAAG
CAGGCTCAGATGAAGTTGAAACATGCCCAACAGGAACTGAAGAATAAACAAGCAGAAGTTAGGA
AGATGGATAGTGGGTACAAGAAGGATCAAGAAGCTTTTGAAGCTGTGAAAAAAGTTAAAGAAAA
ACTTGAAACCGAAATGAAGAAGCTAAATTACGAAGACAACAAAGAGGAAAGGCTTTTGGAAAAG
CACAGGCAGGTGTCTCGTGACATCAGTAATCTAAAAGGAACCTACGAAGCTCTCTTGGCCAAGT
TTCCCAATCTTCGATTTGCATACAAGGACCCAGAGAAGAACTGGAATCGAAATTGTGTAAAAGG
ACTTGTAGCTTCTCTGATAAATGTGAAAGATAATTCTACAGCCACAGCTCTGGAATTGGTGGCT
GGAGAACGACTCTACAATGTTGTAGTAGACACAGAGGTTACTGGTAAGAAACTATTAGAAAAGG
GGGAATTGAAGCGTCGATACACAATAATTCCTCTCAATAAGATTTCAGCCAGATGTATTGCTCC
TGAAACTCTGAGGGTCGCTCAGAATCTTGTTGGTCCTAACAATGTTCATGTAGCTCTTTCCTTG
GTTGACTACAAACCAGAACTTCAGAAAGCGATGGAATTTGTCTTCGGAACAACATTTGTTTGTA
ACAATATGGATAATGCCAAAAAAGTGGCCTTTGATAAAAGAATAATGACCAGAACTGTAACCCT
TGGGGGTGATGTATTTGATCCTCATGGAACATTGAGTGGAGGTGCTAGGTCCCAGGCGGCTTCT
ATTTTAACCAAGTTTCAAGAACTCAAAGATGTTCAAGCTGAGCTGAGGACAAAGGAGAAAGAAC
TGCAGGCTCTGGAAGAGGAATTGGCTGGTCTTAAAAATGTCGCTGAAAAGTATCGCCAACTGAA
ACAGCAGTGGGAGATGAAGACAGAGGAGGGAGATTTGTTGCAAACCAAACTTCAGCAAAGCTCT
TACCATAAGCAGCAAGAAGAATTAGATGCCCTTAAAAAAACCATTGAGGAAAGTGAGGAGACAT
TAAAAAACACAAAAGAAATCCAAAAGAAAGCTGAAGAAAAATATGAGGCATTGGAGAATAAAAT
GAAAAATGCAGAAGCTGAAAGAGAGAAAGAACTGAAGGATGCTCAGAAAAAACTGGATTGTGCC
AAAACAAAGGCTGATGCATCTAGCAAGAAAATGAAAGAAAAGCAACAGGAGGTTGAAGCTATCA
CTCTGGAGCTAGAGGAGCTCAAAAGAGAGCATGCATCTAACGAACAGCAGCTTGATGCTGTGAA
TGAAGCCATCAAAGCCTATGAAGGGCAGATTGAAATAATGGCAGCTGAGGTGGCCAAAAACAAG
GAATCAGTTAATAAAGCTCAAAATGAGCTGATGAAGCAAAAAGAAATAATAAGTGCCCAGGACA
ACATAATTAAAGATAAATGTGCGGAAGTGGCAAAACACAATTTGCAAAACAATGATTCTCAGCT
TAAAATTAAGGAGTTAGACCACAGCATAAGCAAACACAAGCGGGAAGCTGACGACGCTGCTGCG
AAGGTATCCAAAATGTTGAATGATTATGACTGGATTAATGCTGAGAAACACCTCTTTGGCCAAC
CTAATAGTGCCTATGATTTCAAAACAAACAACCCCAAAGAAGCTGGCCAGAGACTTCAGAAGTT
GCAAGAAGTAAAAGAGAAACTAGGGAGAAATGTCAACATGAGAGCTATGAATGTGCTGACAGAA
GCGGAAGAGCGGTATAATGATTTGATGAAGAAGAAAAGAATTGTAGAAAATGACAAATCCAAAA
TCCTTGCAACTATAGAAGATCTTGACCAGAAGAAAAATCAGGCCCTAAATATTGCTTGGCAAAA
GGTGAACAAAGACTTTGGCTCTATTTTTTCTACCCTTTTGCCTGGTGCCAATGCTATGCTTGCA
CCACCAGAAGGGCAGACAGTTTTAGATGGTCTGGAGTTCAAGGTTGCCTTAGGAAATACATGGA
AAGAAAACCTAACTGAGCTTAGTGGTGGTCAGAGGTCTCTGGTGGCTCTCTCACTAATATTGTC
CATGCTCCTCTTCAAACCTGCTCCAATTTATATCTTGGACGAGGTGGATGCGGCCTTAGATCTT
TCTCATACCCAGAACATCGGACAGATGCTGCGAACTCACTTCACACATTCTCAATTCATTGTGG
TATCCCTCAAAGAAGGTATGTTCAACAATGCAAACGTTCTCTTCAAAACCAAGTTTGTGGATGG
TGTTTCTACAGTAGCCAGATTTACACAGAGTCAAAATGGGAGGATTCCAAAGGAGGCAAAGGCC
AAGGGCAAAGGACCCAGCTGAGTGCATGCCAGAAGTTCAGAGTGCGGGCGTCTCACCTTGACCT
TTTACACATGAACGTTTTCAAGGATTTGGGATCTAAAGTTGTTTATATAATAATGTTAACATTA
TTTCCATAAGTAATTTTTGTAGCACCGGTAAAAGAGCAGATTCCTCTTTTTTTACCTAGTGTGA
TTATGGTCCAATTATTGTAGTTGTGATTGCATATTTTTCTTACAAAAATCTTTTTTATGTATTA
AAGAACCTGAGGTACATCGAGTTGGTAAATTCTGTATGCAAATGCCAAAATACAAAGAAACAGA
TGAAGTTATAGGATAAATATAGCTGATAGTCAGCTTTTAACTAGTTTAATTTCTAAGGACAGTA
TTAATGAGTCTTCTTTTGCTTATAAAATCATTCGAATACAGAGTATTTATAAAGAAAGTCACTG
GGCCAACAAAGGGGGAACATAGCAATTATGCATACACAAAGCTATTTGAGGTCGGTCCTTGTAG
GGATGCAATGCCAGATCCTTGGATGGGAAATGGACCTGGAAACAATTTTTCACTGTAATGATGT
TGGACTATCATGTTTATGCATGTTTAATAATTGATCTCACAAGCTTGAAATTTGCATGTTTTTT
ATCTTTGAGTATTTTAGTAGAAACCTGGGAAGAAATGTGTTACATAGTATTATACCTAGATTGC
TCTATCTGAAGTCCTGTAATATTTTTTAAGATTTTTATCAGACTCTCATAGTCTAATCAATAAT
TTTTTGGACCTAGCAGATTAAATGAAAAGTATATTTTATAAGAGTCTGATAAACCTAAATAAGT
CTGCCTTTTCTACCAAGAAAGTCTCCAAAGCTTGATGATTGCTGAAATTCTTGGTGCCTTCGGC
TTGTCCAGGTTGAAAGTAAACTCCTTTAGAAAGCAGGAGGGGGCCAGTACACACCCTGAGAGCC
TGCAGCTCGTACTGTCTCTACAGACATTTCCACGTCAGCACAGTCATGCTCGTAGTTTTCAGAG
CTCTAATGTGACCTGATCTGATTTAATGATTGTGGCCCTATTTCTTCCTGATACTTAGCCTTCA
GTGTTTTGCTGTTCTACTTTCTTTGATGCACCATACAGGCCCTGAGTTGGACATTTCTCAAACT
TCATTTGCCATATATATCTGTGATGTTACATAGACCTTAAGTAATTTGTACCCTTGGACATTTT
GGAAATTATTTCATCTGGAGGGAAGAGACAGTAAGCTGTAATATTCACTGAGCGATAGTAAAGA
TCACAGATAATGAACCTACACAATGTTTTGTTTTCCAAGGTCTTATAAACTGTTGGTCAAAACA
GTTGTGTTTATTACACTGTCACTGATACAGTATTCTAATTTGATCACAATCTAATCAATGCCAG
CTGCTAATATTTTGTATTAGGCAGTTATAAAACAGCATTGAATTCCTGTCTTAACAAACTACTT
TGTTTGATTTCCTTTGTGTATAAATTATTTCCTTGTATGCATTTCTGTTTTGTGTTCTTTTGTT
TTTGTATTATATATAGTTTCACTCTTGAAATTTTTGTGCATATATTAAATTTCTTTGAGGCATA
TTAAATGTTTGCAATACTGGCTTATTTCTATACAGAAATTGTTATATATGTCTATATATTATTA
TATTATGTTATACATAATTGTTATATTATGTCTATATAGAAGTTGTTAAATACTAACATTTCGT
ATATTCATAAGAAGGTGATTAACAGGGTTGGGGATTTAGCTCAGTGGTGGAGCGCTTGCCTAGC
AAGCGCAAGGCCCTGGGTTCGGTCCTCAGCTCC

hide sequence

RefSeq Acc Id:

XM_063287920 ⟹ XP_063143990

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	71,602,033 - 71,648,636 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001102136	(Get FASTA)	NCBI Sequence Viewer
	XP_006238227	(Get FASTA)	NCBI Sequence Viewer
	XP_063143990	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL78166	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000061673
	ENSRNOP00000061673.1
	ENSRNOP00000091386.2

RefSeq Acc Id:

NP_001102136 ⟸ NM_001108666

- UniProtKB:

D4A5Q2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MYVKSIILEGFKSYAQRTEVNGFDPLFNAITGLNGSGKSNILDSICFLLGISNLSQVRASNLQD
LVYKNGQAGITKASVSITFDNSDKKQSPLGFEAHDEITVTRQVVIGGRNKYLINGVNANNTRVQ
DLFCSVGLNVNNPHFLIMQGRITKVLNMKPPEILSMIEEAAGTRMYEYKKIAAQKTIEKKEAKL
KEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLLAEDTKERSAGELKEM
QDKILKLQEVLSENEKKIKALNCEIEELEKRKDKETGGILRSLEDAFAEAQRVNTKSQSAFDLK
KKNLASEETKRKELEKNMAEDSKALAAKEKEVKKLTDGLHGLQEASNKDAEALAAAQQHFNAVS
AGLSSNEDGAEATLAGQMMACKNDISKAQTGAKQAQMKLKHAQQELKNKQAEVRKMDSGYKKDQ
EAFEAVKKVKEKLETEMKKLNYEDNKEERLLEKHRQVSRDISNLKGTYEALLAKFPNLRFAYKD
PEKNWNRNCVKGLVASLINVKDNSTATALELVAGERLYNVVVDTEVTGKKLLEKGELKRRYTII
PLNKISARCIAPETLRVAQNLVGPNNVHVALSLVDYKPELQKAMEFVFGTTFVCNNMDNAKKVA
FDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKDVQAELRTKEKELQALEEELAG
LKNVAEKYRQLKQQWEMKTEEGDLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQKK
AEEKYEALENKMKNAEAEREKELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKRE
HASNEQQLDAVNEAIKAYEGQIEIMAAEVAKNKESVNKAQNELMKQKEIISAQDNIIKDKCAEV
AKHNLQNNDSQLKIKELDHSISKHKREADDAAAKVSKMLNDYDWINAEKHLFGQPNSAYDFKTN
NPKEAGQRLQKLQEVKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILATIEDLDQ
KKNQALNIAWQKVNKDFGSIFSTLLPGANAMLAPPEGQTVLDGLEFKVALGNTWKENLTELSGG
QRSLVALSLILSMLLFKPAPIYILDEVDAALDLSHTQNIGQMLRTHFTHSQFIVVSLKEGMFNN
ANVLFKTKFVDGVSTVARFTQSQNGRIPKEAKAKGKGPS

hide sequence

RefSeq Acc Id:	XP_006238227 ⟸ XM_006238165
- Peptide Label:	isoform X1
- UniProtKB:	D4A5Q2 (UniProtKB/TrEMBL)
- Sequence:	show sequence MYVKSIILEGFKSYAQRTEVNGFDPLFNAITGLNGSGKSNILDSICFLLGISNLSQVRASNLQD LVYKNGQAGITKASVSITFDNSDKKQSPLGFEAHDEITVTRQVVIGGRNKYLINGVNANNTRVQ DLFCSVGLNVNNPHFLIMQGRITKVLNMKPPEILSMIEEAAGTRMYEYKKIAAQKTIEKKEAKL KEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLLAEDTKERSAGELKEM QDKILKLQEVLSENEKKIKALNCEIEELEKRKDKETGGILRSLEDAFAEAQRVNTKSQSAFDLK KKNLASEETKRKELEKNMAEDSKALAAKEKEVKKLTDGLHGLQEASNKDAEALAAAQQHFNAVS AGLSSNEDGAEATLAGQMMACKNDISKAQTGAKQAQMKLKHAQQELKNKQAEVRKMDSGYKKDQ EAFEAVKKVKEKLETEMKKLNYEDNKEERLLEKHRQVSRDISNLKGTYEALLAKFPNLRFAYKD PEKNWNRNCVKGLVASLINVKDNSTATALELVAGERLYNVVVDTEVTGKKLLEKGELKRRYTII PLNKISARCIAPETLRVAQNLVGPNNVHVALSLVDYKPELQKAMEFVFGTTFVCNNMDNAKKVA FDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKDVQAELRTKEKELQALEEELAG LKNVAEKYRQLKQQWEMKTEEGDLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQKK AEEKYEALENKMKNAEAEREKELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKRE HASNEQQLDAVNEAIKAYEGQIEIMAAEVAKNKESVNKAQNELMKQKEIISAQDNIIKDKCAEV AKHNLQNNDSQLKIKELDHSISKHKREADDAAAKVSKMLNDYDWINAEKHLFGQPNSAYDFKTN NPKEAGQRLQKLQEVKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILATIEDLDQ KKNQALNIAWQKVNKDFGSIFSTLLPGANAMLAPPEGQTVLDGLEFKVALGNTWKENLTELSGG QRSLVALSLILSMLLFKPAPIYILDEVDAALDLSHTQNIGQMLRTHFTHSQFIVVSLKEGMFNN ANVLFKTKFVDGVSTVARFTQSQNGRIPKEAKAKGKGPS hide sequence

Ensembl Acc Id:

ENSRNOP00000061673 ⟸ ENSRNOT00000066226

Ensembl Acc Id:

ENSRNOP00000091386 ⟸ ENSRNOT00000113988

RefSeq Acc Id:	XP_063143990 ⟸ XM_063287920
- Peptide Label:	isoform X1
- UniProtKB:	D4A5Q2 (UniProtKB/TrEMBL)

Protein Domains

SMC hinge

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4A5Q2-F1-model_v2	AlphaFold	D4A5Q2	1-1191	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13693738

Promoter ID:

EPDNEW_R4262

Type:

multiple initiation site

Name:

Smc2_1

Description:

structural maintenance of chromosomes 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	5	68,717,537 - 68,717,597	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305227	AgrOrtholog
BioCyc Gene	G2FUF-41307	BioCyc
Ensembl Genes	ENSRNOG00000022325	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000066226	ENTREZGENE
	ENSRNOT00000066226.4	UniProtKB/TrEMBL
	ENSRNOT00000113988.2	UniProtKB/TrEMBL
Gene3D-CATH	1.20.1060.20	UniProtKB/TrEMBL
	3.30.70.1620	UniProtKB/TrEMBL
	3.40.50.300	UniProtKB/TrEMBL
InterPro	P-loop_NTPase	UniProtKB/TrEMBL
	RecF/RecN/SMC_N	UniProtKB/TrEMBL
	SMC	UniProtKB/TrEMBL
	Smc2_ABC	UniProtKB/TrEMBL
	SMC_hinge	UniProtKB/TrEMBL
	SMC_hinge_sf	UniProtKB/TrEMBL
KEGG Report	rno:362519	UniProtKB/TrEMBL
NCBI Gene	362519	ENTREZGENE
PANTHER	STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3	UniProtKB/TrEMBL
Pfam	SMC_hinge	UniProtKB/TrEMBL
	SMC_N	UniProtKB/TrEMBL
PhenoGen	Smc2	PhenoGen
PIRSF	SMC	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000022325	RatGTEx
SMART	SMC_hinge	UniProtKB/TrEMBL
Superfamily-SCOP	SMC_hinge	UniProtKB/TrEMBL
	SSF52540	UniProtKB/TrEMBL
UniProt	A0A8I6ABI9_RAT	UniProtKB/TrEMBL
	D4A5Q2	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-03-07	Smc2	structural maintenance of chromosomes 2	Smc2l1_predicted	SMC2 structural maintenance of chromosomes 2-like 1 (yeast) (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-12	Smc2l1_predicted	SMC2 structural maintenance of chromosomes 2-like 1 (yeast) (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD