Ppm1l (protein phosphatase, Mg2+/Mn2+ dependent, 1L) - Rat Genome Database

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Gene: Ppm1l (protein phosphatase, Mg2+/Mn2+ dependent, 1L) Rattus norvegicus
Analyze
Symbol: Ppm1l
Name: protein phosphatase, Mg2+/Mn2+ dependent, 1L
RGD ID: 1305220
Description: Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within MAPK cascade and cell surface receptor protein serine/threonine kinase signaling pathway. Predicted to be located in membrane. Orthologous to human PPM1L (protein phosphatase, Mg2+/Mn2+ dependent 1L); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC310506; protein phosphatase 1 (formerly 2C)-like; protein phosphatase 1L
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82155,876,605 - 156,149,371 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2155,876,605 - 156,149,371 (+)EnsemblGRCr8
mRatBN7.22153,566,653 - 153,839,434 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2153,566,653 - 153,839,434 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2160,709,923 - 160,983,202 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02158,760,422 - 159,033,713 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02153,393,224 - 153,666,515 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02165,932,240 - 166,218,774 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2166,140,112 - 166,218,774 (+)Ensemblrn6Rnor6.0
Rnor_5.02185,291,754 - 185,575,777 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42159,385,829 - 159,662,846 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2147,916,729 - 148,187,619 (+)NCBICelera
RGSC_v3.12159,335,793 - 159,605,142 (+)NCBI
Cytogenetic Map2q32NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
obesity  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
7,12-dimethyltetraphene  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
aflatoxin M1  (ISO)
all-trans-retinoic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
budesonide  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP)
Cyclopamine  (ISO)
cyclosporin A  (ISO)
deoxycholic acid  (ISO)
dibutyl phthalate  (ISO)
dorsomorphin  (ISO)
Echimidine  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
folic acid  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
L-methionine  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methapyrilene  (EXP)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monocrotaline  (ISO)
monoethyl phthalate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
nickel atom  (ISO)
oxaliplatin  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
riddelliine  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
topotecan  (EXP)
triamcinolone acetonide  (ISO)
triphenyl phosphate  (ISO)
urethane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12556533   PMID:12823230   PMID:18165232   PMID:19199708  


Genomics

Comparative Map Data
Ppm1l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82155,876,605 - 156,149,371 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2155,876,605 - 156,149,371 (+)EnsemblGRCr8
mRatBN7.22153,566,653 - 153,839,434 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2153,566,653 - 153,839,434 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2160,709,923 - 160,983,202 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02158,760,422 - 159,033,713 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02153,393,224 - 153,666,515 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02165,932,240 - 166,218,774 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2166,140,112 - 166,218,774 (+)Ensemblrn6Rnor6.0
Rnor_5.02185,291,754 - 185,575,777 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42159,385,829 - 159,662,846 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2147,916,729 - 148,187,619 (+)NCBICelera
RGSC_v3.12159,335,793 - 159,605,142 (+)NCBI
Cytogenetic Map2q32NCBI
PPM1L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383160,756,231 - 161,078,902 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3160,755,602 - 161,078,902 (+)Ensemblhg38GRCh38
GRCh373160,474,019 - 160,796,690 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363161,956,690 - 162,271,511 (+)NCBIBuild 36Build 36hg18NCBI36
Build 343162,042,702 - 162,271,518NCBI
Celera3158,896,208 - 159,211,045 (+)NCBICelera
Cytogenetic Map3q25.33-q26.1NCBI
HuRef3157,872,656 - 158,187,261 (+)NCBIHuRef
CHM1_13160,436,915 - 160,751,844 (+)NCBICHM1_1
T2T-CHM13v2.03163,530,851 - 163,853,639 (+)NCBIT2T-CHM13v2.0
Ppm1l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39369,224,251 - 69,468,131 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl369,224,194 - 69,468,135 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38369,316,918 - 69,560,798 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl369,316,861 - 69,560,802 (+)Ensemblmm10GRCm38
MGSCv37369,120,840 - 69,359,326 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36369,404,847 - 69,643,333 (+)NCBIMGSCv36mm8
Celera369,424,232 - 69,663,151 (+)NCBICelera
Cytogenetic Map3E1NCBI
cM Map332.21NCBI
Ppm1l
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544811,266,462 - 11,541,886 (+)Ensembl
ChiLan1.0NW_00495544811,265,988 - 11,548,258 (+)NCBIChiLan1.0ChiLan1.0
PPM1L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22158,689,921 - 159,006,047 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13158,694,649 - 159,009,093 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03157,775,284 - 158,093,293 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13165,823,299 - 166,139,732 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3165,823,649 - 166,129,984 (+)EnsemblpanPan2panpan1.1
PPM1L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13426,770,442 - 27,060,892 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3426,770,569 - 27,057,910 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3430,813,316 - 31,106,275 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03426,827,264 - 27,122,050 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3426,827,377 - 27,121,061 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13426,757,747 - 27,050,929 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03426,717,524 - 27,005,848 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03426,957,884 - 27,284,254 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ppm1l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560292,688,860 - 92,964,078 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936708727,610 - 996,607 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936708724,878 - 1,006,405 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPM1L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13100,443,011 - 100,756,039 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.113100,442,445 - 100,759,968 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213108,997,677 - 109,155,070 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPM1L
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11529,801,953 - 30,096,073 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1529,802,637 - 29,925,199 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660412,307,814 - 2,608,603 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppm1l
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473038,610,874 - 38,978,466 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473038,610,107 - 38,985,146 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ppm1l
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1385,756,567 - 85,761,334 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ppm1l
4159 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:50
Count of miRNA genes:46
Interacting mature miRNAs:47
Transcripts:ENSRNOT00000074564
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149957381221199885Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2138595962205135428Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2124537199209621565Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2145807215220931416Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085199723085Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2145807215190807215Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085199723085Rat
10043139Iddm55Insulin dependent diabetes mellitus QTL 553.10.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2150313808195313808Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085199723085Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085199723085Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
12879845Cm89Cardiac mass QTL 890.008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085178247591Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2143565208188565208Rat
12879846Cm90Cardiac mass QTL 900.011heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)2154723085178247591Rat
12879847Am4Aortic mass QTL 40.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085178247591Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2154723085199723085Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2139067258192287892Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1582257Gluco21Glucose level QTL 213.10.0035blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2120039407159440891Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2144882354205135428Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2139067258184067258Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
2301415Cm67Cardiac mass QTL 670.003heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085178247591Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2143746578205135428Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
11565180Kidm56Kidney mass QTL 560.003kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085178247591Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150096616195096616Rat
11565181Bw176Body weight QTL 1760.002body mass (VT:0001259)body weight (CMO:0000012)2154723085178247591Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2145306936212705578Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2147287892192287892Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
738007Anxrr7Anxiety related response QTL 74.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2120339555165339555Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660223841096Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979159440891Rat
631520Bp73Blood pressure QTL 730.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149806826170653323Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150096616195096616Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)2114440891159440891Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
1354594Despr10Despair related QTL 102e-06locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)2116804572161804572Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2145807215173074435Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat

Markers in Region
D2Got112  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22153,718,301 - 153,718,443 (+)MAPPERmRatBN7.2
Rnor_6.02166,092,640 - 166,092,781NCBIRnor6.0
Rnor_5.02185,450,718 - 185,450,859UniSTSRnor5.0
RGSC_v3.42159,540,616 - 159,540,758RGDRGSC3.4
RGSC_v3.42159,540,617 - 159,540,758UniSTSRGSC3.4
Celera2148,067,064 - 148,067,198UniSTS
RGSC_v3.12159,490,579 - 159,490,721RGD
RH 3.4 Map21003.0RGD
RH 3.4 Map21003.0UniSTS
Cytogenetic Map2q32UniSTS
D2Got399  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr82155,884,541 - 155,884,680 (+)Marker Load Pipeline
mRatBN7.22153,574,589 - 153,574,728 (+)MAPPERmRatBN7.2
Rnor_6.02165,940,409 - 165,940,547NCBIRnor6.0
Rnor_5.02185,299,639 - 185,299,777UniSTSRnor5.0
RGSC_v3.42159,394,132 - 159,394,270UniSTSRGSC3.4
Celera2147,924,666 - 147,924,804UniSTS
Cytogenetic Map2q32UniSTS
RH142056  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22153,836,142 - 153,836,323 (+)MAPPERmRatBN7.2
Rnor_6.02166,215,483 - 166,215,663NCBIRnor6.0
Rnor_5.02185,572,486 - 185,572,666UniSTSRnor5.0
RGSC_v3.42159,659,555 - 159,659,735UniSTSRGSC3.4
Celera2148,184,328 - 148,184,508UniSTS
RH 3.4 Map21007.2UniSTS
Cytogenetic Map2q32UniSTS
RH132200  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22153,839,100 - 153,839,307 (+)MAPPERmRatBN7.2
Rnor_6.02166,218,441 - 166,218,647NCBIRnor6.0
Rnor_5.02185,575,444 - 185,575,650UniSTSRnor5.0
RGSC_v3.42159,662,513 - 159,662,719UniSTSRGSC3.4
Celera2148,187,286 - 148,187,492UniSTS
RH 3.4 Map21007.2UniSTS
Cytogenetic Map2q32UniSTS
BF397820  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22153,721,629 - 153,721,803 (+)MAPPERmRatBN7.2
Rnor_6.02166,095,968 - 166,096,141NCBIRnor6.0
Rnor_5.02185,454,046 - 185,454,219UniSTSRnor5.0
RGSC_v3.42159,543,945 - 159,544,118UniSTSRGSC3.4
Celera2148,070,385 - 148,070,558UniSTS
RH 3.4 Map21001.3UniSTS
Cytogenetic Map2q32UniSTS
BE107865  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22153,587,391 - 153,587,575 (+)MAPPERmRatBN7.2
Rnor_6.02165,952,988 - 165,953,171NCBIRnor6.0
Rnor_5.02185,312,218 - 185,312,401UniSTSRnor5.0
RGSC_v3.42159,407,476 - 159,407,659UniSTSRGSC3.4
RH 3.4 Map21007.2UniSTS
Cytogenetic Map2q32UniSTS
RH135323  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera2147,939,382 - 147,940,673UniSTS
RH 3.4 Map21001.9UniSTS
Cytogenetic Map2q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000074564   ⟹   ENSRNOP00000064781
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2166,140,112 - 166,218,774 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095588   ⟹   ENSRNOP00000082838
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2153,566,653 - 153,839,434 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000100342   ⟹   ENSRNOP00000085836
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2153,711,793 - 153,839,434 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000129498   ⟹   ENSRNOP00000112533
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2155,876,605 - 156,149,371 (+)Ensembl
RefSeq Acc Id: NM_001107681   ⟹   NP_001101151
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82155,876,605 - 156,149,371 (+)NCBI
mRatBN7.22153,566,653 - 153,839,434 (+)NCBI
Rnor_6.02165,932,240 - 166,218,774 (+)NCBI
Rnor_5.02185,291,754 - 185,575,777 (+)NCBI
RGSC_v3.42159,385,829 - 159,662,846 (+)RGD
Celera2147,916,729 - 148,187,619 (+)RGD
Sequence:
RefSeq Acc Id: XM_017590865   ⟹   XP_017446354
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82156,061,167 - 156,149,162 (+)NCBI
mRatBN7.22153,751,381 - 153,839,250 (+)NCBI
Rnor_6.02166,128,576 - 166,218,774 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039102287   ⟹   XP_038958215
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82155,882,635 - 156,149,162 (+)NCBI
mRatBN7.22153,591,490 - 153,839,250 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001101151 (Get FASTA)   NCBI Sequence Viewer  
  XP_017446354 (Get FASTA)   NCBI Sequence Viewer  
  XP_038958215 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM00906 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000112533
  ENSRNOP00000112533.1
RefSeq Acc Id: NP_001101151   ⟸   NM_001107681
- UniProtKB: A0A8I5ZU99 (UniProtKB/TrEMBL),   A6J5N2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017446354   ⟸   XM_017590865
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A4H5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000064781   ⟸   ENSRNOT00000074564
RefSeq Acc Id: XP_038958215   ⟸   XM_039102287
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000082838   ⟸   ENSRNOT00000095588
Ensembl Acc Id: ENSRNOP00000085836   ⟸   ENSRNOT00000100342
Ensembl Acc Id: ENSRNOP00000112533   ⟸   ENSRNOT00000129498
Protein Domains
PPM-type phosphatase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R5V1-F1-model_v2 AlphaFold M0R5V1 1-228 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305220 AgrOrtholog
BioCyc Gene G2FUF-52824 BioCyc
Ensembl Genes ENSRNOG00000046168 Ensembl
  ENSRNOG00000067239 Ensembl
  ENSRNOG00000075763 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000129498 ENTREZGENE
  ENSRNOT00000129498.1 UniProtKB/TrEMBL
Gene3D-CATH 3.60.40.10 UniProtKB/TrEMBL
InterPro PP2C UniProtKB/TrEMBL
  PP2C_BS UniProtKB/TrEMBL
  PPM-type_dom_sf UniProtKB/TrEMBL
  PPM-type_phosphatase_dom UniProtKB/TrEMBL
KEGG Report rno:310506 UniProtKB/TrEMBL
NCBI Gene 310506 ENTREZGENE
PANTHER PROTEIN PHOSPHATASE UniProtKB/TrEMBL
Pfam PP2C UniProtKB/TrEMBL
PhenoGen Ppm1l PhenoGen
PROSITE PPM_1 UniProtKB/TrEMBL
  PPM_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000046168 RatGTEx
  ENSRNOG00000067239 RatGTEx
  ENSRNOG00000075763 RatGTEx
SMART PP2C_SIG UniProtKB/TrEMBL
  PP2Cc UniProtKB/TrEMBL
Superfamily-SCOP SSF81606 UniProtKB/TrEMBL
UniProt A0A8I5ZU99 ENTREZGENE
  A0A8I6A4H5 ENTREZGENE
  A0ABK0M317_RAT UniProtKB/TrEMBL
  A6J5N2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Ppm1l  protein phosphatase, Mg2+/Mn2+ dependent, 1L  Ppm1l  protein phosphatase 1 (formerly 2C)-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Ppm1l  protein phosphatase 1 (formerly 2C)-like   Ppm1l_predicted  protein phosphatase 1 (formerly 2C)-like (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Ppm1l_predicted  protein phosphatase 1 (formerly 2C)-like (predicted)      Symbol and Name status set to approved 70820 APPROVED