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Gene: Spta1 (spectrin, alpha, erythrocytic 1) Rattus norvegicus

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Symbol:

Spta1

Name:

spectrin, alpha, erythrocytic 1

RGD ID:

1305194

Description:

Predicted to enable actin filament binding activity. Predicted to be involved in actin cytoskeleton organization. Predicted to act upstream of or within several processes, including lymphocyte homeostasis; porphyrin-containing compound biosynthetic process; and positive regulation of T cell proliferation. Located in axon and cytoplasmic side of plasma membrane. Human ortholog(s) of this gene implicated in hereditary pyropoikilocytosis; hereditary spherocytosis; and hereditary spherocytosis type 3. Orthologous to human SPTA1 (spectrin alpha, erythrocytic 1); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

erythroid spectrin alpha; LOC289257; spectrin alpha 1; spectrin alpha chain, erythrocyte; spectrin alpha chain, erythrocytic 1; spectrin, alpha, erythrocytic 1 (elliptocytosis 2); Spna1

RGD Orthologs

Alliance Orthologs

More Info

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More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SPTA1 (spectrin alpha, erythrocytic 1)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB
Mus musculus (house mouse):	Spta1 (spectrin alpha, erythrocytic 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Spta1 (spectrin alpha, erythrocytic 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SPTA1 (spectrin alpha, erythrocytic 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SPTA1 (spectrin alpha, erythrocytic 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Spta1 (spectrin alpha, erythrocytic 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SPTA1 (spectrin alpha, erythrocytic 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SPTA1 (spectrin alpha, erythrocytic 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Spta1 (spectrin alpha, erythrocytic 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Spta1 (spectrin alpha, erythrocytic 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	SPTA1 (spectrin alpha, erythrocytic 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Spta1 (spectrin alpha, erythrocytic 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	sptbn4a (spectrin, beta, non-erythrocytic 4a)	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Caenorhabditis elegans (roundworm):	spc-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	alpha-Spec	Alliance	DIOPT (Hieranoid\|OrthoFinder\|PANTHER\|PhylomeDB)

Allele / Splice:

Spta1^{Tn(sb-T2/Bart3)2.315Mcwi}

Genetic Models:

F344-Spta1^{Tn(sb-T2/Bart3)2.315Mcwi}

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	88,735,833 - 88,811,697 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	88,735,833 - 88,811,697 (+)	Ensembl				GRCr8
mRatBN7.2	13	86,203,504 - 86,279,371 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	86,203,504 - 86,279,371 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	88,714,968 - 88,786,574 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	90,115,246 - 90,186,848 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	87,299,995 - 87,371,589 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	92,264,231 - 92,340,091 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	92,264,231 - 92,340,083 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	13	96,782,387 - 96,860,327 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	13	89,951,924 - 90,028,592 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	13	85,806,253 - 85,882,378 (+)	NCBI		Celera
RGSC_v3.1	13	90,140,807 - 90,217,468 (+)	NCBI
Cytogenetic Map	13	q24	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

anemia (ISO)

congenital hemolytic anemia (ISO)

Elliptocytosis 2 (ISO)

genetic disease (ISO)

hemolytic anemia (ISO)

hereditary elliptocytosis (ISO)

hereditary pyropoikilocytosis (ISO)

hereditary spherocytosis (ISO)

hereditary spherocytosis type 1 (ISS)

hereditary spherocytosis type 3 (ISO,ISS)

sickle cell anemia (ISS)

thrombosis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

1,2-dichloroethane (ISO)

1,4-phenylenediamine (ISO)

1-chloro-2,4-dinitrobenzene (ISO)

17beta-estradiol (EXP,ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,4'-trichlorobiphenyl (ISO)

2,4-D (ISO)

2-butoxyethanol (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (EXP)

aldehydo-D-glucose (ISO)

all-trans-retinoic acid (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

Brodifacoum (EXP)

C60 fullerene (EXP)

cadmium dichloride (EXP)

cobalt dichloride (EXP)

Cuprizon (EXP)

D-glucose (ISO)

decabromodiphenyl ether (ISO)

dibutyl phthalate (ISO)

diethyl maleate (ISO)

dioxygen (EXP,ISO)

ferric oxide (EXP)

fructose (ISO)

gentamycin (EXP)

glucose (ISO)

glycidol (EXP)

isoprenaline (ISO)

lipopolysaccharide (ISO)

mono(2-ethylhexyl) phthalate (ISO)

nickel sulfate (ISO)

okadaic acid (ISO)

oxaliplatin (EXP)

ozone (ISO)

paracetamol (EXP)

PCB138 (ISO)

phenylephrine (EXP)

pirinixic acid (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

sodium arsenite (ISO)

sodium fluoride (ISO)

tert-butyl hydroperoxide (ISO)

tetrachloromethane (EXP,ISO)

titanium dioxide (ISO)

topotecan (EXP)

trichloroethene (EXP)

triptonide (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin cytoskeleton organization (IBA,IEA,ISO)

actin filament capping (IEA)

biological_process (ND)

hemopoiesis (ISO)

lymphocyte homeostasis (ISO)

plasma membrane organization (ISO)

porphyrin-containing compound biosynthetic process (ISO)

positive regulation of T cell proliferation (ISO)

regulation of cell shape (IEA,ISO)

Cellular Component

axon (IDA)

cell cortex (IEA)

cell junction (IBA)

cell projection (IBA)

cortical actin cytoskeleton (IBA)

cortical cytoskeleton (IEA,ISO)

cuticular plate (IEA,ISO)

cytoplasmic side of plasma membrane (IDA)

cytoskeleton (IEA)

membrane (IEA,ISO)

plasma membrane (IBA)

spectrin (IEA,ISO)

spectrin-associated cytoskeleton (IEA,ISO)

Molecular Function

actin binding (IEA)

actin filament binding (IBA)

calcium ion binding (IEA)

metal ion binding (IEA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Different impacts of alleles alphaLEPRA and alphaLELY as assessed versus a novel, virtually null allele of the SPTA1 gene in trans.	Delaunay J, etal., Br J Haematol. 2004 Oct;127(1):118-22.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Mutant forms of spectrin alpha-subunits in hereditary elliptocytosis.	Marchesi SL, etal., J Clin Invest. 1987 Jul;80(1):191-8.
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
7.	GOA pipeline	RGD automated data pipeline
8.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
10.	Comprehensive gene review and curation	RGD comprehensive gene curation
11.	Immunological heterogeneity of synaptic and extrasynaptic forms of non-erythroid alpha-spectrin in the rat retina.	Schmitz F Neurosci Lett. 2001 Nov 2;313(1-2):25-8.
12.	Hematopoietic cells from -spectrin-deficient mice are sufficient to induce thrombotic events in hematopoietically ablated recipients.	Wandersee NJ, etal., Blood. 1998 Dec 15;92(12):4856-63.
13.	Defective spectrin integrity and neonatal thrombosis in the first mouse model for severe hereditary elliptocytosis.	Wandersee NJ, etal., Blood. 2001 Jan 15;97(2):543-50.
14.	Murine recessive hereditary spherocytosis, sph/sph, is caused by a mutation in the erythroid alpha-spectrin gene.	Wandersee NJ, etal., Hematol J. 2000;1(4):235-42.

Additional References at PubMed

PMID:379653	PMID:658175	PMID:1934076	PMID:6234993	PMID:6841965	PMID:7059672	PMID:7684329	PMID:8195289	PMID:8889548	PMID:18723693	PMID:20016102	PMID:20585040
PMID:23106098	PMID:35352799	PMID:36374586

Genomics

Comparative Map Data

Spta1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	88,735,833 - 88,811,697 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	88,735,833 - 88,811,697 (+)	Ensembl				GRCr8
mRatBN7.2	13	86,203,504 - 86,279,371 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	86,203,504 - 86,279,371 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	88,714,968 - 88,786,574 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	90,115,246 - 90,186,848 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	87,299,995 - 87,371,589 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	92,264,231 - 92,340,091 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	92,264,231 - 92,340,083 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	13	96,782,387 - 96,860,327 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	13	89,951,924 - 90,028,592 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	13	85,806,253 - 85,882,378 (+)	NCBI		Celera
RGSC_v3.1	13	90,140,807 - 90,217,468 (+)	NCBI
Cytogenetic Map	13	q24	NCBI

SPTA1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	158,610,704 - 158,686,715 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	158,610,704 - 158,686,715 (-)	Ensembl			hg38	GRCh38
GRCh37	1	158,580,494 - 158,656,505 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	156,847,120 - 156,923,130 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	1	155,393,568 - 155,469,561	NCBI
Celera	1	131,651,547 - 131,727,219 (-)	NCBI		Celera
Cytogenetic Map	1	q23.1	NCBI
HuRef	1	129,938,262 - 130,013,934 (-)	NCBI		HuRef
CHM1_1	1	159,976,850 - 160,052,530 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	157,747,803 - 157,823,815 (-)	NCBI		T2T-CHM13v2.0

Spta1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	174,000,305 - 174,076,015 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	174,000,342 - 174,076,016 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	1	174,172,739 - 174,248,449 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	174,172,776 - 174,248,450 (+)	Ensembl			mm10	GRCm38
MGSCv37	1	176,102,907 - 176,178,580 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	1	176,009,543 - 176,084,742 (+)	NCBI		MGSCv36	mm8
MGSCv36	1	175,481,229 - 175,556,592 (+)	NCBI		MGSCv36	mm8
Celera	1	181,280,976 - 181,363,312 (+)	NCBI		Celera
Cytogenetic Map	1	H3	NCBI
cM Map	1	80.97	NCBI

Spta1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955468	10,472,671 - 10,545,313 (-)	Ensembl
ChiLan1.0	NW_004955468	10,472,601 - 10,545,402 (-)	NCBI	ChiLan1.0	ChiLan1.0

SPTA1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	91,161,251 - 91,236,695 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	90,905,096 - 90,980,575 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	133,969,717 - 134,045,301 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	137,760,188 - 137,836,131 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	137,760,942 - 137,835,927 (-)	Ensembl			panPan2	panpan1.1

SPTA1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	38	23,052,046 - 23,118,933 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	38	23,051,563 - 23,118,966 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	38	23,074,219 - 23,141,493 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	38	23,183,707 - 23,251,018 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	38	23,183,635 - 23,250,966 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	38	22,946,752 - 23,013,687 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	38	23,481,482 - 23,548,479 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	38	23,912,752 - 23,979,956 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Spta1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	4,995,049 - 5,068,389 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936740	1,686,218 - 1,759,078 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936740	1,686,218 - 1,759,083 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SPTA1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	91,485,067 - 91,640,063 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	4	91,573,470 - 91,640,057 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	99,567,778 - 99,634,336 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SPTA1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	5,238,246 - 5,314,204 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	5,238,447 - 5,313,887 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666038	4,407,178 - 4,482,460 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Spta1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624794	2,639,039 - 2,714,591 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624794	2,638,605 - 2,715,934 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Spta1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	10	52,873,789 - 52,941,570 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Spta1
293 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	44
Count of miRNA genes:	22
Interacting mature miRNAs:	22
Transcripts:	ENSRNOT00000004716, ENSRNOT00000066509
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
738027	Lnnr6	Liver neoplastic nodule remodeling QTL 6	3.3		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	13	65613454	109350286	Rat
7207885	Glom27	Glomerulus QTL 27	3.9		kidney glomerulus integrity trait (VT:0010546)	kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)	13	21120177	109350286	Rat
7387280	Uae43	Urinary albumin excretion QTL 43	5.69	0.4174	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	68983334	109350286	Rat
1298066	Bp159	Blood pressure QTL 159		0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	48639634	93639634	Rat
10755495	Bp387	Blood pressure QTL 387	3.78		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	37216241	90057603	Rat
2293702	Bss34	Bone structure and strength QTL 34	4.61	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	13	67635937	109350286	Rat
1576318	Schws5	Schwannoma susceptibility QTL 5		0.0351	nervous system integrity trait (VT:0010566)	post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)	13	64497900	109350286	Rat
1354621	Rf47	Renal function QTL 47	3.7		kidney renin amount (VT:0010559)	kidney renin level (CMO:0002166)	13	11081740	103588154	Rat
1354655	Bp241	Blood pressure QTL 241	3.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	38975045	103588154	Rat
8655951	Rf63	Renal function QTL 63	12.2		blood urea nitrogen amount (VT:0005265)	plasma urea nitrogen level (CMO:0000586)	13	71610804	109350286	Rat
4889606	Gluco63	Glucose level QTL 63	2.86	0.003	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	13	83286150	109350286	Rat
8655945	Rf61	Renal function QTL 61	3.6		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	13	71610804	89333251	Rat
1331783	Bp221	Blood pressure QTL 221	3.72886		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	71610804	89333251	Rat
8655959	Pur32	Proteinuria QTL 32	8.4		urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	13	72984506	99745408	Rat
1300166	Kidm6	Kidney mass QTL 6	3.93		kidney mass (VT:0002707)	single kidney wet weight to body weight ratio (CMO:0000622)	13	71610804	89333251	Rat
2293687	Bss26	Bone structure and strength QTL 26	4.6	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	13	67635937	109350286	Rat
12879475	Bp400	Blood pressure QTL 400			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	64375743	109350286	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	1	103588154	Rat
724564	Uae11	Urinary albumin excretion QTL 11	5.7		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	13	47354258	94285672	Rat
2293341	Glom15	Glomerulus QTL 15	9.1		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	13	67635937	109350286	Rat

Genetic Models

This gene Spta1 is modified in the following models/strains:

F344-Spta1^{Tn(sb-T2/Bart3)2.315Mcwi}

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
8	10	65	164	89	88	57	74	57	6	323	170	11	136	80	68	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001011908	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC107095	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC117091	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AI639523	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY238342	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CA504635	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DY314141	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	EB480501	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000004716 ⟹ ENSRNOP00000004716

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	86,203,504 - 86,279,371 (+)	Ensembl
Rnor_6.0 Ensembl	13	92,264,231 - 92,340,083 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000066509 ⟹ ENSRNOP00000061853

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	88,735,833 - 88,811,697 (+)	Ensembl
mRatBN7.2 Ensembl	13	86,203,504 - 86,279,371 (+)	Ensembl
Rnor_6.0 Ensembl	13	92,264,231 - 92,340,083 (+)	Ensembl

RefSeq Acc Id:

NM_001011908 ⟹ NP_001011908

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	88,735,833 - 88,811,697 (+)	NCBI
mRatBN7.2	13	86,203,504 - 86,279,371 (+)	NCBI
Rnor_6.0	13	92,264,231 - 92,340,091 (+)	NCBI
Rnor_5.0	13	96,782,387 - 96,860,327 (+)	NCBI
RGSC_v3.4	13	89,951,924 - 90,028,592 (+)	RGD
Celera	13	85,806,253 - 85,882,378 (+)	RGD

Sequence:

show sequence

GAGATAATGCTGACTGTTCACGCTTGGCGGGATTCTAAAGGATTCTAAAAATTTTTTTCTCTGG
GTCTTTGCCACTTTCACATTTCTGTCATTCCTATGTGAAGTGGACTGGATATTCAAAGAACTGT
TTTTCTCTCTTAGCTTCATTTCATCTGGCAAAGCCTTAGACTCTGAGGAGAGATGGAAACTCCA
AAGGAAACTGCTGTTGAAAGCAGTGGACCAAAGGTTCTAGAAACAGCAGAAGAAATCCAGCACA
GGAGGCAGGAGGTGTTAGACCAATACCAGAGGTTCAAGGAGCGCGTGGCCGAGAGGGGTCAGAA
GCTTGAGGAATCTTATCACTATCAAGTTTTCAGGAGAGATGCAGACGACCTGGAGAAGTGGATC
ATGGAGAAGCTTGAAATTACAAAAGATAAGACATATGAACCCACAAATATACAGGGGAAATATC
AGAAGCACGAATCCTTTGTATCAGAGGTGCAAGCCAAATCAAGAGTGCTTCCTGAGCTGGAGGA
AATCAGGGAGGCTCGATTTGCAGAAGATCATTTTGCCCATGAAGCCACCAAGACGCATCTGAAG
GAACTTCGCCACTTGTGGGATCTGCTGTTGGAGTTGACCCAAGAGAAAAGTGACATCCTGCTGA
GGGCACTGAAGTTCTATCAGTACTGTCAGGAGTGTGAAGACATCTTGGAGTGGGTCAAAGAGAA
GGAAGCTATAGTGACATTAGTGGAGCTGGGAGATGACTGGGAACGAACAGAGGTCCTGCATAAG
AAGTTTGAAGAATTCCAGGAAGAACTGACAGCTCGGAAAGGAAAAGTGGACAGAGTGAACCAAT
ATGCTAATGAGTGTGCCCAGGAGCAACACCCTAAGTTGCCTGAGATAAAGGCAAAACAAGATGA
AGTCAATGCTGCCTGGGATCGTCTCTGGAGCCTGGCTCTCAAGAGACGAGAAAGTCTATCAAAT
GCTGCAGACCTCCAGCGCTTTAAAAGGGATGTCAATGAAGCCATCCAGTGGATGGAGGAGAAGG
AGCCTCTACTCACCTCTGAGGACTATGGCAAAGATCTTGTTAGTTCTGAGGCTCTGTTTCACAG
TCACAAGAGGCTCGAGAGGAATCTTGCTGTCATGGATGACAAGGTGAAGGAGCTTTGTGCCAAA
GCAGACAAGCTGATGGTTTCCCACTCTGCAGATGCACCTCAGATCCAGCAGATGAAAATGGATC
TAGTCTCCAACTGGGAACTCATCCGCGCCTTGGCCACTAACAGATATGCAAAGCTGAAGGCTTC
TTATGGGTACCATCGGTTCTTATCTGACTATGATGAGCTCACAGGCTGGATGGAGGAAAAGACA
GCTCTGATCAATGCTGATGAGCTGCCAACAGATGTGGCCAGTGGGGAAGCCCTGCTAGCCAGGC
ACCAGCAGCATAAGCATGAGATTGACTCCTATGATGATCGATTTCAAACTGCTGAGGCAACTGG
TCAAGATCTGCTGGATGGCAATCACGAAGCCTCGGATGAAATTCGAGAGAAGATGACAATACTT
GCCCATGACTGGGCTGCCCTGCGGGAACTCTGGAACAAGTGTCAGCATCAGTACCGCCAGAGTC
TGGATTTCCACCTCTTCTACCGAGACAGCGAACAAGTGGATAGTTGGATGAGCAGACAAGAGGC
TTTTCTGGAAAATGAAGACCTGGGAAACTCAGTGGGTAGCGTGGAAGCCCTTCTTCAGAAGCAT
GATGACTTTGAAGAAGCATTCACTGCCCAGGAAGAAAAGATTATAACCTTGGATGAGACTGCGA
CCAAGCTCATAGACAATGACCACTATGACTCCGAGAACATTGCTGCTATCCGTGATGGGCTCCT
GGCCAGACGTGATGCCCTGCGTGAAAGGGCTGCCACCAGAAGAAAATTGTTGGTAGATTCACAA
CTTCTCCAACAACTGTATCAAGACTCAGATGACCTAAAAACCTGGATCAATAAGAAGAAGAAGT
TAGCTGATGATGAAGATTACAAGGATGTACAGAACTTGAAGAGCCGGGTTCAGAAGCAACAGGA
CTTTGAAGAGGAATTGGCAGCAAATGAGATTATGCTCAACAACCTGGAGAGAACTGGCCAGGAC
ATGATTGAGAATGATCACTATGCCTCTGATGCTGTGGCTGCTCGCATGAGCGAGGTCGCCAACC
TCTGGAAGGAGTTGCTGGAAGCAACAGCACAAAAAGGGACACAGCTGTATGAAGCCAACCAGCT
GCTACAATTTGAGAACAATGCGGAAGACCTGAAGCGCTGGCTGGAGGAGGTGGAGCGGCAGGTT
GCCTCTGAGGATTATGGGAAAGGTCTGGCCGATGTGCAGAATCTACTGAGAAAACATGGCCTCC
TAGAGTCAGCTGTGCTTGCTCGCCAGGATCAAGTGGACACCCTCACAGACATGGCTGCACATTT
TGAAGAAATAGGACATCCTGACTCTGAGAATATATGTGCAAGGCAAGAATCCTTGCTTTCTCGT
TTTGAGGCTCTGAAAGAGCCACTGGCCACTCGGAAGAAGAAACTCATTGACCTACTCAAGCTAC
AGCAGATTTGCAGAGACTCAGAAGATGAGGAGGCCTGGATCCAGGAGACTGAGCCCTCAGCAGC
TTCCACTCATCTTGGCAAGGACTTGGTTGCAGCCAAGAATCTTCTAAACAGACATGAAGTCATT
TTGGCAGACATTGCCAGCCATGAACCACGGATTCAAACCATAACAGAGAGGGGAAACAAAATGG
TGGAGGAAGGACACTTCGCTTCAGAAGACATAGCATCTAGGGTTGAGAGCTTGAACAAAAATAT
GGAGTCTCTCCGTGCTCGTGCTATTAGACGGGAGAATGACCTTAAGGCCAATGTCCAGCTCCAA
CAGTACCTGGCAGATCTGCATGAAGCAGAAGCATGGATTAAAGAGAAAGAACCCATTGTAGACA
ACAAAAATTATGGAGCTGATGAAGAAGCAGCTGGGGCCCTTCTCAAAAAGCATGAGGCCTTCCT
GGTGGACCTCAACGCATTTGGAAACAGCATAAAGGCTCTGGGGGATCAGGCAGAGGCCTGCCAG
CAACAACAGGCAGCACCAGTGGATGAGGCTGGTCGAGAAGCTAGGGTCATAGCTCTGTATGACT
TTGAGGCTCGCAGCCGTAGAGAGGTCAGCATGAAGAAGAATGATGTCTTAACTCTGCTCAGTTC
CATCAACAAGGACTGGTGGAAGGTTGAAGCTGACGATCACCAGGGCTTTGTGCCAGCGGTCTAT
GTCAGGAAACTGGCACACGATGAACTCCCAGGGTTCCCACAGCAACGGCGAGAGGAACCAGTCA
ACATCCCTCAGCTCCAGGAGCAGATCGAGACCCTGTACCACTCCCTCCTAGATCGGGCAGAAGA
ACGCAGGCGTCGCCTGCTGCAGCGGTACAATGAGTTTCTGCTAGCCTATGAGGCAGGAGACATG
TTGGAGTGGATCCAAGAGAAAAAGACAGAAAACACTGGGGTGGAACTGGATGATGTTTGGGAAC
TGCAGAAGAAATTTGACGAGTTCCAGAGGGATCTGAAGAGCAACGAGCCTCGGTTAAAAGATAT
CAATAAGGTGGCTGATGAACTGCTCTTTGAAGACCTCCTAACCCCAGAAGGATCTCACATACGG
CAGGAGTTGAACACCCGCTGGAGTTCCTTGAAGAGGCTGGCAGATGAGCAGTATCAGCTGCTGA
GCAGTGCACATGCCGTTGAGATGTTTCTCAGAGAAGCAGATGATGTCAAGGAACAGATTGATAA
GAAATGCCAGGCTCTCAATGCTGCTGACCCTGGCTCTGACCTGCTCAGTGTCCAGGCCCTCCAG
AGGCAGCATGAGGTCTTTGAGAGAGACATCATCCCCCTGGGAGAAAAGGTGACGACACTGGGGG
AGACAGCTGAGCGTCTCTGTGAATCACACCCCGATGCCACTGAGGACTTACAGAAGCAGCGAAC
AGAGCTGAATGAGGCTTGGGATACGCTACAAGGTCTTACCAGTGATCGAAAGGAGAGTCTGAAT
GAAGCTCATAAATTCTTCCTCTTCCTTAGCAAGGCCAGTGATCTAGAGAATTGGATCAAGGCCA
TTGGTGGTGTAATATCATCACCTGAGCTGGCTGAGGACTTAACTGGCACAGAGATCTTGCTGGA
GCGACACCAGGAGCATTATGATGACATAAAAAGAGAAGACCCCACTTTCCAAGCCTTAGAAGAC
TTTGGTAGAGAACTTATAGACAGAGGCCACCGTAATAGCCACGAAATTGAAACTACTCTCCAGG
ATATTAAATTAAAGAGAGACGATTTGGAAAAGAATTGGGAAAACCGCAAGAAGATGCTAGACCA
GTGCCTAGAACTGCAGCTGTTCCGAGGGAAGTGTGAACAGGTTGAGAGCTGGATGGTGGCACGT
GAGAATTCCCTGAGGTCAGATGACAGGGATCACTTAAACAGTCTACAGGCTTTGATGAAAAAAC
GGGATGACCTGGACAAAGCAATCGCTGCTCAGGAAGGGAAGATTGCTGACCTAGAGAACCATGC
CACAAGGCTCATGGACAATGACCACTATGCTAAGGAAGAGATTGCTGCTCGCCTCCAACGTGTA
CTAGACAGGTGGAAGGATCTCAAAACACAGCTGCTTGCTGAACTGGGAAAGCTAGGAGACTATG
CCGACCTGAAACAGTTCTATCGTGACCTCGAGGACCTGGAGGAATGGATCAGTGAGATGCTGCC
CGTAGCCTGTGATGAATCTTACAAAGATCCCACTAATATCCAGCAAAGGAAATATCTGAAACAT
CAAGCCTTTGAAAATGAAGTCAATGGCCGTGCCGAGCAGGTGGAAGGGGTCATCAACCTGGGGA
AATCCCTGATTGAGCGCAGAGTGTGTGATGGGGATGAAGAGAACATGCAGGAGCAACTGGACAA
ACTAAAGGAGAACTGGGACTATCTCCTAGAGAGAACAACTGACAAAGGGCAGAAGCTCAACGAG
GCCAGTCGGCAGCAAAGGTTCAACACAAGTATCCGGGACTTTGAGTTCTGGCTTTCAGAGGCAG
AAGGCTTGCTGGCCATGAAGGATCAGGCCAGGGACTTAACTTCAGCAGGAAACCTACTTAAGAA
GCATCAGCTATTGGAAGCAGAGATGTTGGCACGAGAGGACCCTCTCAAAGATCTGAATGGTCTG
GCTAAGGAGCTGATCTCCAGTGGGACTTTCAACATTGAGCAGATAGAAGAGAAAATGAATGGTG
TCAATGAGCGTTTCAAAAATGTCCAGAGTTTGGCAGCTGCACACCATGAGAAACTGAAAGAGAC
CTATGCCTTATTCCAGTTCTTCCAAGACCTGGATGATGAGGAAGCCTGGATAGAGGAGAAGTTG
CTACGAGTGAGCTCCCAGGACTGTGGGAGGGATCTTCAGAGTGTTCAGAACTTACTGAAAAAAC
ACAGACGCCTAGAGGGGGAGCTGGTGGCACATGAACCTGCTGTCCAGAATGTGCTGGATACAGC
AGAAAGCCTGAAAGACAAGGCTGCTGTAGGGAAAGAGGAGATCCAGGAGCGACTGGCTCAGTTT
GTCCAGCATTGGGAAAAGCTCAAAGAATTGGCGAAGACACGAGGGGTGAATTTGGAGGAGTCTC
TTCAGTATCTGCAATTCATGGAGAATGCAGAGGAAGAAGAAGCATGGCTGGGTGAAAAGGATGC
ACTGGTTAGCCGAGGAGATTCTGGAGACACACTGGCTGCTACTCAGAGTTTGCTAAAGAAGCAC
GAAGCTTTGGAGAATGACTTTGCTGTACACAAGAACCGGGTACAAGATGTTTGTGCACAAGGAG
AAGACATTCTCAGTAAGGAAGAAACTCAAAACAAGGATAAGATTTCCACCAAGATTGAAGTTCT
GAATGAAAAGACAGCATCTCTGACCAAGGCCTTAGCTGCTTGGAAGTCACAGCTGGACGAAGTG
CATGCCTTTCAGCAGTTTAACTGGAAGGCTGATGTCGTGGAATCCTGGATAGGTGAGAAGGAGG
CAAGCCTGAAGACCAAGAGCAATGGTGCAGACCTCACTGCCTTCCTCACACTCCTGGCAAAGCA
AGACACGCTGGATGCCAGTCTTCAGAGCTTCCAGCAAGAAAGGCTTTCTGAAATCACTGATCTG
AAGGACGAGCTGCTGGCTGCTGAGCACAGCCAAAGCAAAGCCATTGAGGAACGGCACGCAGCCC
TGCTGAGGCGCTGGGAACAACTGCTGGAGGCATGTAGAGTTCACAGGCAGAAGCTATTGGAGAA
GCAGCTGCCTCTACAGAAGGCTGAGGAGCTATTCATGGAATTTGCACACAAAGCTTCAGCCTTC
AACAACTGGTGTGAGAACGCTGAAGAGGACTTGTCAGAACCTGTGCATTGTGTCTCTCTAAATG
AGATCCGGCAGCTGCAGAAGGAGCATGAAGCCTTCTTGGCCTCTATGGTTGGGGCTCAAGAGGA
TTTCAACTATTTGTTGGCACTAGACCAGCAAATTAAAGCCTTAAATGTGTCCTCCAGTCCTTAT
ACCTGGTTAACAGTGGATGTGCTGGGCAGGATCTGGAAGCACCTACCTGAAATCATCAAGGAAC
GGGAGCAGGAGCTACAGAAAGAAGAGGCTAGGCAGATCAAGAATTTTGAAATGTGCCAGGAGTT
TGAACAGAATGCCAGTGCCTTCCTTCAGTGGATCCAGGAGACCAGGGCTTATTTTCTGGATGGA
TCGTTGCTCAAGGAAACAGGAACTCTGGAATCCCAACTTGAAGCAAATAAAAGGAAGCAGAAGG
AGATTCAAGCAATGAAGCGTCATCTCACCAAGATTGAAGACCTGGGGGACAGCATGGAAGAGGC
TTTGATCCTTGATATCAAATACAGCACCATTGGACTGGCCCAGCAGTGGGATCAGCTGCACCAG
CTGGGGATGCGAATGCAGCACAATTTGGAGCAACAGATTCAAGCCAAAGACACCATAGGTGTGA
GTGAGGAGACACTGAAAGAATTTAGCACCACATATAAACACTTCGATGAGAATTTGACAGGGCG
ATTGACTCACAAAGAGTTCCGGTCATGCCTGAGAGGACTCAACTACTATTTGCCTATGGTTGAG
GAAGGTGAACCTGAGCCCAAGTTTGAGAAATTTCTGAATGCTGTGGATCCAGGGAGGAAAGGCT
ATGTGTCACTGGAGGACTACACATCATTCCTGATTGACAAGGAGTCAGAGAATATCAAGACAAG
TGATGACATAGAGAGTGGATTCCAAGCCCTGGCAGAAGGCAAGGCCTACATTACCAAGGAGGAC
ATGAAACAGGCTCTAACCCCAGAACAAGTGTCATTCTGTACCATACATATGCAGCAATATATGG
ACCCGCGGGGTCGGAGCCAACCTGCTGGCTACGACTATGTTGGCTTCACCAATTCATTCTTTGG
CAACTGATAGGCAGATTCTTATGTACCATAGAAGATCATAGTGTGGCAACAAGTGATGGGAAAA
AAGAGGCACAAACAAGTGTTAAAGAAAAATATTGCTCCTGGTGCTGCTGCTGCTGCTGCTGCTG
CTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGTGTGTGTGTGTGTGTGTGTGTGTGT
GTGTGTGTGTGTTCCATTTATTGCAGGATTTAAAAATTTATCAAGTATATGGGCAGGAGTTCAA
AAAATGCTATAAGATTATGTAACTAGTCTCTACTTAGGGTAGGAAGCTCTTTGTGTGTGTGTGT
GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATTCTGCACACCTTTAGTATTTTGCTGCAT
TTCTGATTATAGGATCAGTATTTTTAAAAATGAAATTTAACTAGAGTTATGCTTTTGTATTTTC
AGAACCATTATTATTACTAAGTATAAGCTGTTAATTATACTGTGAAAAGTACAATAATAAAGTA
GATAAATAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001011908	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAQ02378	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000061853
	ENSRNOP00000061853.4

RefSeq Acc Id:

NP_001011908 ⟸ NM_001011908

- UniProtKB:

D4A678 (UniProtKB/TrEMBL), F7FC39 (UniProtKB/TrEMBL), Q6XDA1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

METPKETAVESSGPKVLETAEEIQHRRQEVLDQYQRFKERVAERGQKLEESYHYQVFRRDADDL
EKWIMEKLEITKDKTYEPTNIQGKYQKHESFVSEVQAKSRVLPELEEIREARFAEDHFAHEATK
THLKELRHLWDLLLELTQEKSDILLRALKFYQYCQECEDILEWVKEKEAIVTLVELGDDWERTE
VLHKKFEEFQEELTARKGKVDRVNQYANECAQEQHPKLPEIKAKQDEVNAAWDRLWSLALKRRE
SLSNAADLQRFKRDVNEAIQWMEEKEPLLTSEDYGKDLVSSEALFHSHKRLERNLAVMDDKVKE
LCAKADKLMVSHSADAPQIQQMKMDLVSNWELIRALATNRYAKLKASYGYHRFLSDYDELTGWM
EEKTALINADELPTDVASGEALLARHQQHKHEIDSYDDRFQTAEATGQDLLDGNHEASDEIREK
MTILAHDWAALRELWNKCQHQYRQSLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSVGSVEAL
LQKHDDFEEAFTAQEEKIITLDETATKLIDNDHYDSENIAAIRDGLLARRDALRERAATRRKLL
VDSQLLQQLYQDSDDLKTWINKKKKLADDEDYKDVQNLKSRVQKQQDFEEELAANEIMLNNLER
TGQDMIENDHYASDAVAARMSEVANLWKELLEATAQKGTQLYEANQLLQFENNAEDLKRWLEEV
ERQVASEDYGKGLADVQNLLRKHGLLESAVLARQDQVDTLTDMAAHFEEIGHPDSENICARQES
LLSRFEALKEPLATRKKKLIDLLKLQQICRDSEDEEAWIQETEPSAASTHLGKDLVAAKNLLNR
HEVILADIASHEPRIQTITERGNKMVEEGHFASEDIASRVESLNKNMESLRARAIRRENDLKAN
VQLQQYLADLHEAEAWIKEKEPIVDNKNYGADEEAAGALLKKHEAFLVDLNAFGNSIKALGDQA
EACQQQQAAPVDEAGREARVIALYDFEARSRREVSMKKNDVLTLLSSINKDWWKVEADDHQGFV
PAVYVRKLAHDELPGFPQQRREEPVNIPQLQEQIETLYHSLLDRAEERRRRLLQRYNEFLLAYE
AGDMLEWIQEKKTENTGVELDDVWELQKKFDEFQRDLKSNEPRLKDINKVADELLFEDLLTPEG
SHIRQELNTRWSSLKRLADEQYQLLSSAHAVEMFLREADDVKEQIDKKCQALNAADPGSDLLSV
QALQRQHEVFERDIIPLGEKVTTLGETAERLCESHPDATEDLQKQRTELNEAWDTLQGLTSDRK
ESLNEAHKFFLFLSKASDLENWIKAIGGVISSPELAEDLTGTEILLERHQEHYDDIKREDPTFQ
ALEDFGRELIDRGHRNSHEIETTLQDIKLKRDDLEKNWENRKKMLDQCLELQLFRGKCEQVESW
MVARENSLRSDDRDHLNSLQALMKKRDDLDKAIAAQEGKIADLENHATRLMDNDHYAKEEIAAR
LQRVLDRWKDLKTQLLAELGKLGDYADLKQFYRDLEDLEEWISEMLPVACDESYKDPTNIQQRK
YLKHQAFENEVNGRAEQVEGVINLGKSLIERRVCDGDEENMQEQLDKLKENWDYLLERTTDKGQ
KLNEASRQQRFNTSIRDFEFWLSEAEGLLAMKDQARDLTSAGNLLKKHQLLEAEMLAREDPLKD
LNGLAKELISSGTFNIEQIEEKMNGVNERFKNVQSLAAAHHEKLKETYALFQFFQDLDDEEAWI
EEKLLRVSSQDCGRDLQSVQNLLKKHRRLEGELVAHEPAVQNVLDTAESLKDKAAVGKEEIQER
LAQFVQHWEKLKELAKTRGVNLEESLQYLQFMENAEEEEAWLGEKDALVSRGDSGDTLAATQSL
LKKHEALENDFAVHKNRVQDVCAQGEDILSKEETQNKDKISTKIEVLNEKTASLTKALAAWKSQ
LDEVHAFQQFNWKADVVESWIGEKEASLKTKSNGADLTAFLTLLAKQDTLDASLQSFQQERLSE
ITDLKDELLAAEHSQSKAIEERHAALLRRWEQLLEACRVHRQKLLEKQLPLQKAEELFMEFAHK
ASAFNNWCENAEEDLSEPVHCVSLNEIRQLQKEHEAFLASMVGAQEDFNYLLALDQQIKALNVS
SSPYTWLTVDVLGRIWKHLPEIIKEREQELQKEEARQIKNFEMCQEFEQNASAFLQWIQETRAY
FLDGSLLKETGTLESQLEANKRKQKEIQAMKRHLTKIEDLGDSMEEALILDIKYSTIGLAQQWD
QLHQLGMRMQHNLEQQIQAKDTIGVSEETLKEFSTTYKHFDENLTGRLTHKEFRSCLRGLNYYL
PMVEEGEPEPKFEKFLNAVDPGRKGYVSLEDYTSFLIDKESENIKTSDDIESGFQALAEGKAYI
TKEDMKQALTPEQVSFCTIHMQQYMDPRGRSQPAGYDYVGFTNSFFGN

hide sequence

Ensembl Acc Id:

ENSRNOP00000004716 ⟸ ENSRNOT00000004716

Ensembl Acc Id:

ENSRNOP00000061853 ⟸ ENSRNOT00000066509

Protein Domains

EF-hand SH3

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4A678-F1-model_v2	AlphaFold	D4A678	1-2416	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305194	AgrOrtholog
BioCyc Gene	G2FUF-17256	BioCyc
Ensembl Genes	ENSRNOG00000003537	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000066509	ENTREZGENE
	ENSRNOT00000066509.6	UniProtKB/TrEMBL
Gene3D-CATH	1.20.5.170	UniProtKB/TrEMBL
	1.20.58.60	UniProtKB/TrEMBL
	EF-hand	UniProtKB/TrEMBL
	SH3 Domains	UniProtKB/TrEMBL
InterPro	EF-hand-like_dom	UniProtKB/TrEMBL
	EF-hand_Ca_insen	UniProtKB/TrEMBL
	EF_hand_Ca-bd	UniProtKB/TrEMBL
	SH3-like_dom	UniProtKB/TrEMBL
	SH3_domain	UniProtKB/TrEMBL
	Spectrin/alpha-actinin	UniProtKB/TrEMBL
	Spectrin_repeat	UniProtKB/TrEMBL
KEGG Report	rno:289257	UniProtKB/TrEMBL
NCBI Gene	289257	ENTREZGENE
PANTHER	SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN	UniProtKB/TrEMBL
Pfam	efhand_Ca_insen	UniProtKB/TrEMBL
	SH3_1	UniProtKB/TrEMBL
	Spectrin	UniProtKB/TrEMBL
PhenoGen	Spta1	PhenoGen
PRINTS	SPECTRNALPHA	UniProtKB/TrEMBL
PROSITE	EF_HAND_2	UniProtKB/TrEMBL
	SH3	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000003537	RatGTEx
SMART	efhand_Ca_insen	UniProtKB/TrEMBL
	SH3	UniProtKB/TrEMBL
	SPEC	UniProtKB/TrEMBL
Superfamily-SCOP	SH3	UniProtKB/TrEMBL
	Spectrin repeat	UniProtKB/TrEMBL
	SSF47473	UniProtKB/TrEMBL
UniProt	D4A678	ENTREZGENE, UniProtKB/TrEMBL
	F7FC39	ENTREZGENE
	Q6XDA1	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	F7FC39	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-09-18	Spta1	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	Spna1	spectrin alpha 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Spna1	spectrin alpha 1	Spna1_predicted	spectrin alpha 1 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Spna1_predicted	spectrin alpha 1 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

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Imported Disease Annotations - OMIM