Sulf2 (sulfatase 2) - Rat Genome Database

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Gene: Sulf2 (sulfatase 2) Rattus norvegicus
Analyze
Symbol: Sulf2
Name: sulfatase 2
RGD ID: 1305078
Description: Predicted to enable N-acetylglucosamine-6-sulfatase activity; arylsulfatase activity; and glycosaminoglycan binding activity. Involved in positive regulation of endothelin production. Predicted to be located in extracellular region. Predicted to be active in cell surface; endoplasmic reticulum; and plasma membrane. Orthologous to human SULF2 (sulfatase 2); INTERACTS WITH (+)-schisandrin B; 1,2-dimethylhydrazine; 1-nitropropane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: extracellular sulfatase Sulf-2; LOC311642; sulfatase FP2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83175,241,322 - 175,323,808 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3175,241,322 - 175,323,651 (-)EnsemblGRCr8
mRatBN7.23154,822,079 - 154,904,566 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3154,822,085 - 154,904,415 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3158,622,880 - 158,705,277 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03167,121,880 - 167,204,286 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03164,863,526 - 164,945,933 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03162,791,349 - 162,872,984 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3162,791,355 - 162,872,831 (-)Ensemblrn6Rnor6.0
Rnor_5.03168,962,194 - 169,044,229 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43157,197,256 - 157,298,389 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3153,407,025 - 153,487,534 (-)NCBICelera
RGSC_v3.13157,103,302 - 157,193,066 (-)NCBI
Cytogenetic Map3q42NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1-nitropropane  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-diaminotoluene  (EXP)
2,6-diaminotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP,ISO)
2-methylcholine  (ISO)
2-nitro-p-phenylenediamine  (EXP)
2-nitropropane  (EXP)
2-palmitoylglycerol  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-acetylaminofluorene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-nitro-1,2-phenylenediamine  (EXP)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
acrylamide  (ISO)
adefovir pivoxil  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-Zearalanol  (EXP)
amiodarone  (ISO)
amitrole  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chloroacetaldehyde  (ISO)
cidofovir anhydrous  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
curcumin  (ISO)
cyclosporin A  (EXP,ISO)
DDE  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dichloroacetic acid  (ISO)
dicrotophos  (ISO)
diethyl maleate  (EXP)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenofibrate  (EXP,ISO)
fenvalerate  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
genistein  (ISO)
glyphosate  (EXP)
hexadecanoic acid  (ISO)
ibuprofen  (ISO)
ifosfamide  (ISO)
indometacin  (ISO)
inulin  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
lucanthone  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercury dibromide  (ISO)
metformin  (EXP)
methapyrilene  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monoethyl phthalate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (ISO)
nefazodone  (EXP)
nickel sulfate  (ISO)
okadaic acid  (ISO)
oxycodone  (EXP)
panobinostat  (ISO)
paracetamol  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propanal  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sotorasib  (ISO)
succimer  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trametinib  (ISO)
triphenyl phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (EXP,ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
vitamin D  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Sulfatase 2 mediates, partially, the expression of endothelin-1 and the additive effect of Ang II-induced endothelin-1 expression by CXCL8 in vascular smooth muscle cells from spontaneously hypertensive rats. Kim HY, etal., Cytokine. 2019 Feb;114:98-105. doi: 10.1016/j.cyto.2018.11.007. Epub 2018 Nov 20.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12368295   PMID:12477932   PMID:16139897   PMID:16174644   PMID:17593974   PMID:17720696   PMID:18213582   PMID:18687675   PMID:19520866   PMID:19900405   PMID:20479257   PMID:21719793  
PMID:23740243   PMID:25448158   PMID:26464246  


Genomics

Comparative Map Data
Sulf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83175,241,322 - 175,323,808 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3175,241,322 - 175,323,651 (-)EnsemblGRCr8
mRatBN7.23154,822,079 - 154,904,566 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3154,822,085 - 154,904,415 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3158,622,880 - 158,705,277 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03167,121,880 - 167,204,286 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03164,863,526 - 164,945,933 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03162,791,349 - 162,872,984 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3162,791,355 - 162,872,831 (-)Ensemblrn6Rnor6.0
Rnor_5.03168,962,194 - 169,044,229 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43157,197,256 - 157,298,389 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3153,407,025 - 153,487,534 (-)NCBICelera
RGSC_v3.13157,103,302 - 157,193,066 (-)NCBI
Cytogenetic Map3q42NCBI
SULF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382047,657,406 - 47,786,627 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2047,656,197 - 47,786,835 (-)Ensemblhg38GRCh38
GRCh372046,286,150 - 46,415,371 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362045,719,559 - 45,848,215 (-)NCBIBuild 36Build 36hg18NCBI36
Celera2042,999,802 - 43,129,055 (-)NCBICelera
Cytogenetic Map20q13.12NCBI
HuRef2043,027,474 - 43,156,926 (-)NCBIHuRef
CHM1_12046,189,453 - 46,318,659 (-)NCBICHM1_1
T2T-CHM13v2.02049,395,801 - 49,525,734 (-)NCBIT2T-CHM13v2.0
Sulf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392165,915,819 - 165,997,603 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2165,915,009 - 165,997,583 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm382166,073,899 - 166,155,683 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2166,073,089 - 166,155,663 (-)Ensemblmm10GRCm38
MGSCv372165,898,589 - 165,981,156 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362165,765,126 - 165,846,821 (-)NCBIMGSCv36mm8
Celera2172,011,524 - 172,094,475 (-)NCBICelera
Cytogenetic Map2H3NCBI
cM Map286.31NCBI
Sulf2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554459,920,789 - 10,020,491 (+)Ensembl
ChiLan1.0NW_0049554459,919,472 - 10,020,491 (+)NCBIChiLan1.0ChiLan1.0
SULF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22153,396,301 - 53,526,197 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12053,389,407 - 53,519,301 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02043,992,927 - 44,122,598 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12045,074,069 - 45,203,316 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2045,074,069 - 45,173,893 (-)EnsemblpanPan2panpan1.1
SULF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12434,732,000 - 34,850,347 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2434,732,037 - 34,828,569 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2434,191,687 - 34,280,428 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02435,439,403 - 35,557,819 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2435,439,411 - 35,536,496 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12434,679,921 - 34,768,517 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02434,814,508 - 34,903,572 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02435,355,060 - 35,443,790 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Sulf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640190,365,249 - 190,446,381 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365145,819,400 - 5,899,316 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365145,819,375 - 5,899,324 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SULF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1749,663,731 - 49,804,577 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11749,663,721 - 49,805,118 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21755,891,507 - 56,010,288 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SULF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1216,140,307 - 16,270,787 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl216,140,427 - 16,268,750 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605064,676,540 - 64,810,167 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sulf2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247907,129,815 - 7,228,454 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247907,129,863 - 7,228,406 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Sulf2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v15151,832,009 - 151,889,224 (+)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:102
Count of miRNA genes:84
Interacting mature miRNAs:93
Transcripts:ENSRNOT00000008478
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3141555229186555229Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141555229186555229Rat
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
1300113Bp176Blood pressure QTL 1763.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3166376089177728348Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3141555229186555229Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3141555229186555229Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3151075912189428310Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3141555229186555229Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3141555229186555229Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161492708189428310Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3166376089189428310Rat
61335Bp20Blood pressure QTL 203arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161799493176036425Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3161799270187311134Rat
1582213Insul6Insulin level QTL 63.70.0009blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
1598854Memor10Memory QTL 102exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)3166376089189428310Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3152055202189428310Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3142898802187898802Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)3145335553189428310Rat
1582256Insul9Insulin level QTL 94.40.0016blood insulin amount (VT:0001560)absolute change in serum insulin level (CMO:0002038)3155759447189428310Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3139299381184299381Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3141508991177728348Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)3131036586176036586Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3137114333182114333Rat
1582248Insul7Insulin level QTL 73.90.0041blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)3131036586176036586Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3151075912189428310Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3151075912189428310Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3141555229186555229Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3144575244189428310Rat

Markers in Region
RH127484  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23154,822,222 - 154,822,439 (+)MAPPERmRatBN7.2
Rnor_6.03162,791,493 - 162,791,709NCBIRnor6.0
Rnor_5.03168,962,338 - 168,962,554UniSTSRnor5.0
RGSC_v3.43157,197,394 - 157,197,610UniSTSRGSC3.4
Celera3153,407,163 - 153,407,379UniSTS
RH 3.4 Map31471.2UniSTS
Cytogenetic Map3q42UniSTS
AI013906  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23154,822,494 - 154,822,688 (+)MAPPERmRatBN7.2
Rnor_6.03162,791,765 - 162,791,958NCBIRnor6.0
Rnor_5.03168,962,610 - 168,962,803UniSTSRnor5.0
RGSC_v3.43157,197,666 - 157,197,859UniSTSRGSC3.4
Celera3153,407,435 - 153,407,628UniSTS
RH 3.4 Map31471.7UniSTS
Cytogenetic Map3q42UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
23 13 84 213 91 90 59 139 59 6 465 266 22 190 109 124 31 34 34

Sequence


Ensembl Acc Id: ENSRNOT00000008478   ⟹   ENSRNOP00000008478
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3175,241,322 - 175,323,651 (-)Ensembl
mRatBN7.2 Ensembl3154,822,085 - 154,904,415 (-)Ensembl
Rnor_6.0 Ensembl3162,791,355 - 162,872,831 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095721   ⟹   ENSRNOP00000087036
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3175,241,322 - 175,323,093 (-)Ensembl
mRatBN7.2 Ensembl3154,822,085 - 154,903,857 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106312   ⟹   ENSRNOP00000085144
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3175,241,322 - 175,304,812 (-)Ensembl
mRatBN7.2 Ensembl3154,822,085 - 154,885,573 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112492   ⟹   ENSRNOP00000085329
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3175,242,156 - 175,323,651 (-)Ensembl
mRatBN7.2 Ensembl3154,822,085 - 154,864,886 (-)Ensembl
RefSeq Acc Id: NM_001034927   ⟹   NP_001030099
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83175,241,322 - 175,323,651 (-)NCBI
mRatBN7.23154,822,085 - 154,904,415 (-)NCBI
Rnor_6.03162,791,355 - 162,872,831 (-)NCBI
Rnor_5.03168,962,194 - 169,044,229 (-)NCBI
RGSC_v3.43157,197,256 - 157,298,389 (-)RGD
Celera3153,407,025 - 153,487,534 (-)RGD
Sequence:
RefSeq Acc Id: XM_006235596   ⟹   XP_006235658
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83175,241,333 - 175,323,808 (-)NCBI
mRatBN7.23154,822,079 - 154,904,566 (-)NCBI
Rnor_6.03162,791,349 - 162,872,984 (-)NCBI
Rnor_5.03168,962,194 - 169,044,229 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039105137   ⟹   XP_038961065
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83175,241,333 - 175,322,633 (-)NCBI
mRatBN7.23154,822,079 - 154,903,400 (-)NCBI
RefSeq Acc Id: XM_063283881   ⟹   XP_063139951
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83175,241,333 - 175,323,037 (-)NCBI
RefSeq Acc Id: XM_063283882   ⟹   XP_063139952
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83175,241,333 - 175,304,658 (-)NCBI
RefSeq Acc Id: NP_001030099   ⟸   NM_001034927
- Peptide Label: precursor
- UniProtKB: Q3L472 (UniProtKB/TrEMBL),   A6JXG7 (UniProtKB/TrEMBL),   B2GUU3 (UniProtKB/TrEMBL),   F7F080 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235658   ⟸   XM_006235596
- Peptide Label: isoform X1
- UniProtKB: Q3L472 (UniProtKB/TrEMBL),   A6JXG7 (UniProtKB/TrEMBL),   B2GUU3 (UniProtKB/TrEMBL),   F7F080 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000008478   ⟸   ENSRNOT00000008478
RefSeq Acc Id: XP_038961065   ⟸   XM_039105137
- Peptide Label: isoform X1
- UniProtKB: Q3L472 (UniProtKB/TrEMBL),   A6JXG7 (UniProtKB/TrEMBL),   B2GUU3 (UniProtKB/TrEMBL),   F7F080 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000085329   ⟸   ENSRNOT00000112492
Ensembl Acc Id: ENSRNOP00000087036   ⟸   ENSRNOT00000095721
Ensembl Acc Id: ENSRNOP00000085144   ⟸   ENSRNOT00000106312
RefSeq Acc Id: XP_063139951   ⟸   XM_063283881
- Peptide Label: isoform X1
- UniProtKB: A6JXG7 (UniProtKB/TrEMBL),   F7F080 (UniProtKB/TrEMBL),   Q3L472 (UniProtKB/TrEMBL),   B2GUU3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139952   ⟸   XM_063283882
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GCI2 (UniProtKB/TrEMBL),   B2GUU3 (UniProtKB/TrEMBL)
Protein Domains
Extracellular sulfatase C-terminal   Sulfatase N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q3L472-F1-model_v2 AlphaFold Q3L472 1-875 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692682
Promoter ID:EPDNEW_R3207
Type:initiation region
Name:Sulf2_2
Description:sulfatase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R3208  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03162,872,445 - 162,872,505EPDNEW
RGD ID:13692683
Promoter ID:EPDNEW_R3208
Type:initiation region
Name:Sulf2_1
Description:sulfatase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R3207  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03162,872,925 - 162,872,985EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305078 AgrOrtholog
BioCyc Gene G2FUF-46783 BioCyc
Ensembl Genes ENSRNOG00000006052 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000008478 ENTREZGENE
  ENSRNOT00000008478.6 UniProtKB/TrEMBL
  ENSRNOT00000095721 ENTREZGENE
  ENSRNOT00000095721.2 UniProtKB/TrEMBL
  ENSRNOT00000106312 ENTREZGENE
  ENSRNOT00000106312.2 UniProtKB/TrEMBL
  ENSRNOT00000112492.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.720.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7320494 IMAGE-MGC_LOAD
  IMAGE:9026145 IMAGE-MGC_LOAD
InterPro Alkaline_phosphatase_core UniProtKB/TrEMBL
  Extracellular_sulfatase UniProtKB/TrEMBL
  Extracellular_sulfatase_C UniProtKB/TrEMBL
  Sulfatase UniProtKB/TrEMBL
  Sulfatase_CS UniProtKB/TrEMBL
KEGG Report rno:311642 UniProtKB/TrEMBL
MGC_CLONE MGC:109453 IMAGE-MGC_LOAD
  MGC:187254 IMAGE-MGC_LOAD
NCBI Gene 311642 ENTREZGENE
PANTHER EXTRACELLULAR SULFATASE SULF-2 UniProtKB/TrEMBL
  N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER UniProtKB/TrEMBL
Pfam DUF3740 UniProtKB/TrEMBL
  Sulfatase UniProtKB/TrEMBL
PhenoGen Sulf2 PhenoGen
PIRSF Sulf1 UniProtKB/TrEMBL
PROSITE SULFATASE_1 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006052 RatGTEx
Superfamily-SCOP Alkaline_phosphatase_core UniProtKB/TrEMBL
UniProt A0A8I6A3G4_RAT UniProtKB/TrEMBL
  A0A8I6GCI2 ENTREZGENE, UniProtKB/TrEMBL
  A6JXG7 ENTREZGENE, UniProtKB/TrEMBL
  A6JXG8_RAT UniProtKB/TrEMBL
  B2GUU3 ENTREZGENE, UniProtKB/TrEMBL
  F7F080 ENTREZGENE, UniProtKB/TrEMBL
  Q32KJ3_RAT UniProtKB/TrEMBL
  Q3L472 ENTREZGENE
  Q5BJQ8_RAT UniProtKB/TrEMBL
UniProt Secondary A0A8I5ZZX3 UniProtKB/TrEMBL
  Q3L472 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Sulf2  sulfatase 2  Sulf2_predicted  sulfatase 2 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Sulf2_predicted  sulfatase 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED