Tnks2 (tankyrase 2) - Rat Genome Database

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Gene: Tnks2 (tankyrase 2) Rattus norvegicus
Analyze
Symbol: Tnks2
Name: tankyrase 2
RGD ID: 1305026
Description: Predicted to enable NAD+ poly-ADP-ribosyltransferase activity; NAD+-protein mono-ADP-ribosyltransferase activity; and enzyme binding activity. Predicted to be involved in several processes, including positive regulation of canonical Wnt signaling pathway; post-translational protein modification; and regulation of telomere maintenance. Predicted to act upstream of or within regulation of growth. Predicted to be located in nuclear envelope; pericentriolar material; and perinuclear region of cytoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human TNKS2 (tankyrase 2); PARTICIPATES IN ADP-ribosylation pathway, mono and poly-ribosylation; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC100910717; LOC309512; poly [ADP-ribose] polymerase tankyrase-2; tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2; tankyrase-2; tankyrase-2-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81243,980,432 - 244,033,629 (+)NCBIGRCr8
mRatBN7.21234,567,888 - 234,621,079 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1234,567,858 - 234,621,079 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1242,957,470 - 243,010,368 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01249,885,628 - 249,938,508 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01242,723,807 - 242,776,700 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01255,478,794 - 255,532,143 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1255,479,261 - 255,532,143 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1255,479,261 - 255,532,143 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.01262,953,201 - 263,006,973 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41241,112,141 - 241,164,804NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11241,253,368 - 241,345,984NCBI
Celera1231,660,758 - 231,713,638NCBICelera
Cytogenetic Map1q53NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
Tnks2Rat(1->4)-beta-D-glucan multiple interactionsISOTnks2 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of TNKS2 mRNACTDPMID:36331819
Tnks2Rat1,2-dimethylhydrazine decreases expressionISOTnks2 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of TNKS2 mRNACTDPMID:22206623
Tnks2Rat17beta-estradiol decreases expressionISOTnks2 (Mus musculus)6480464Estradiol results in decreased expression of TNKS2 mRNACTDPMID:19484750
Tnks2Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of TNKS2 mRNACTDPMID:21215274
Tnks2Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOTNKS2 (Homo sapiens)6480464Tetrachlorodibenzodioxin results in decreased expression of TNKS2 mRNACTDPMID:17101203
Tnks2Rat2,6-dinitrotoluene affects expressionEXP 64804642 and 6-dinitrotoluene affects the expression of TNKS2 mRNACTDPMID:21346803
Tnks2Rat2-hydroxypropanoic acid decreases expressionISOTNKS2 (Homo sapiens)6480464Lactic Acid results in decreased expression of TNKS2 mRNACTDPMID:30851411
Tnks2Rat3-chloropropane-1,2-diol increases expressionEXP 6480464alpha-Chlorohydrin results in increased expression of TNKS2 mRNACTDPMID:28522335
Tnks2Rat3H-1,2-dithiole-3-thione decreases expressionEXP 64804641 and 2-dithiol-3-thione results in decreased expression of TNKS2 mRNACTDPMID:19162173
Tnks2Rat4,4'-sulfonyldiphenol decreases expressionISOTnks2 (Mus musculus)6480464bisphenol S results in decreased expression of TNKS2 mRNACTDPMID:39298647
Tnks2Rataflatoxin B1 decreases methylationISOTNKS2 (Homo sapiens)6480464Aflatoxin B1 results in decreased methylation of TNKS2 geneCTDPMID:27153756
Tnks2Rataflatoxin B1 increases expressionISOTnks2 (Mus musculus)6480464Aflatoxin B1 results in increased expression of TNKS2 mRNACTDPMID:19770486
Tnks2Ratarsenite(3-) multiple interactionsISOTNKS2 (Homo sapiens)6480464arsenite inhibits the reaction [G3BP1 protein binds to TNKS2 mRNA]CTDPMID:32406909
Tnks2Ratarsenous acid increases expressionISOTnks2 (Mus musculus)6480464Arsenic Trioxide results in increased expression of TNKS2 mRNACTDPMID:35676786
Tnks2Ratbenzo[a]pyrene increases mutagenesisISOTNKS2 (Homo sapiens)6480464Benzo(a)pyrene results in increased mutagenesis of TNKS2 geneCTDPMID:25435355
Tnks2Ratbenzo[a]pyrene diol epoxide I decreases expressionISOTNKS2 (Homo sapiens)64804647 more ...CTDPMID:19150397
Tnks2Ratbis(2-ethylhexyl) phthalate decreases expressionISOTnks2 (Mus musculus)6480464Diethylhexyl Phthalate results in decreased expression of TNKS2 mRNACTDPMID:33754040 and PMID:34319233
Tnks2Ratbisphenol A increases expressionEXP 6480464bisphenol A results in increased expression of TNKS2 mRNACTDPMID:25181051
Tnks2Ratbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of TNKS2 mRNACTDPMID:34947998
Tnks2Ratcaffeine increases expressionEXP 6480464Caffeine results in increased expression of TNKS2 mRNACTDPMID:20864626

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Biological Process
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Object Symbol
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Evidence
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Reference
Notes
Source
Original Reference(s)
Tnks2Ratbiological_process  ND 159840706/2018: no relevant rat dataRGD 
Tnks2Ratmulticellular organism growth acts_upstream_of_or_withinISOTnks2 (Mus musculus)1624291MGI:3621819 PMID:16507985RGDPMID:16507985
Tnks2Ratnegative regulation of telomere maintenance via telomere lengthening involved_inISOTNKS2 (Homo sapiens)1624291 PMID:25939383RGDPMID:25939383
Tnks2Ratnegative regulation of telomere maintenance via telomere lengthening involved_inIEAUniProtKB:Q9H2K2 and ensembl:ENSP000003606891600115GO_REF:0000107EnsemblGO_REF:0000107
Tnks2Ratpositive regulation of canonical Wnt signaling pathway involved_inISOTNKS2 (Homo sapiens)1624291 PMID:19759537 and PMID:25939383RGDPMID:19759537 and PMID:25939383
Tnks2Ratpositive regulation of canonical Wnt signaling pathway involved_inIEAUniProtKB:Q9H2K2 and ensembl:ENSP000003606891600115GO_REF:0000107EnsemblGO_REF:0000107
Tnks2Ratpositive regulation of canonical Wnt signaling pathway involved_inIBAFB:FBgn0027508 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Tnks2Ratpositive regulation of telomere capping involved_inISOTNKS2 (Homo sapiens)1624291 PMID:25939383RGDPMID:25939383
Tnks2Ratpositive regulation of telomere capping involved_inIEAUniProtKB:Q9H2K2 and ensembl:ENSP000003606891600115GO_REF:0000107EnsemblGO_REF:0000107
Tnks2Ratpositive regulation of telomere capping involved_inIBAPANTHER:PTN000652929 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Tnks2Ratprotein auto-ADP-ribosylation involved_inISOTNKS2 (Homo sapiens)1624291 PMID:21478859RGDPMID:21478859
Tnks2Ratprotein auto-ADP-ribosylation involved_inIEAUniProtKB:Q9H2K2 and ensembl:ENSP000003606891600115GO_REF:0000107EnsemblGO_REF:0000107
Tnks2Ratprotein localization to chromosome, telomeric region involved_inISOTNKS2 (Homo sapiens)1624291 PMID:11739745RGDPMID:11739745
Tnks2Ratprotein localization to chromosome, telomeric region involved_inIBAPANTHER:PTN000652929 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Tnks2Ratprotein localization to chromosome, telomeric region involved_inIEAUniProtKB:Q9H2K2 and ensembl:ENSP000003606891600115GO_REF:0000107EnsemblGO_REF:0000107
Tnks2Ratprotein poly-ADP-ribosylation involved_inISOTNKS2 (Homo sapiens)1624291 PMID:25043379RGDPMID:25043379
Tnks2Ratprotein poly-ADP-ribosylation involved_inIEAUniProtKB:Q9H2K2 and ensembl:ENSP000003606891600115GO_REF:0000107EnsemblGO_REF:0000107
Tnks2Ratprotein polyubiquitination involved_inISOTNKS2 (Homo sapiens)1624291 PMID:19759537 and PMID:21478859RGDPMID:19759537 and PMID:21478859
Tnks2Ratprotein polyubiquitination involved_inIEAUniProtKB:Q9H2K2 and ensembl:ENSP000003606891600115GO_REF:0000107EnsemblGO_REF:0000107
Tnks2Ratregulation of multicellular organism growth acts_upstream_of_or_withinISOTnks2 (Mus musculus)1624291MGI:3621924 PMID:16507984RGDPMID:16507984
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Cellular Component
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Object Symbol
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Reference
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Source
Original Reference(s)
Tnks2Ratcytoplasm is_active_inIBAFB:FBgn0027508 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Tnks2Ratcytoplasm located_inISOTNKS2 (Homo sapiens)1624291 PMID:11278563RGDPMID:11278563
Tnks2Ratcytoplasm located_inIEAUniProtKB:Q9H2K2 and ensembl:ENSP000003606891600115GO_REF:0000107EnsemblGO_REF:0000107
Tnks2Ratnuclear envelope located_inISOTNKS2 (Homo sapiens)1624291 PMID:11454873RGDPMID:11454873
Tnks2Ratnuclear envelope located_inIEAUniProtKB:Q9H2K2 and ensembl:ENSP000003606891600115GO_REF:0000107EnsemblGO_REF:0000107
Tnks2Ratnucleus located_inISOTNKS2 (Homo sapiens)1624291 PMID:11739745RGDPMID:11739745
Tnks2Ratnucleus located_inIEAUniProtKB:Q9H2K2 and ensembl:ENSP000003606891600115GO_REF:0000107EnsemblGO_REF:0000107
Tnks2Ratnucleus is_active_inIBAFB:FBgn0027508 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Tnks2Ratpericentriolar material located_inISOTNKS2 (Homo sapiens)1624291 PMID:11454873RGDPMID:11454873
Tnks2Ratpericentriolar material located_inIEAUniProtKB:Q9H2K2 and ensembl:ENSP000003606891600115GO_REF:0000107EnsemblGO_REF:0000107
Tnks2Ratperinuclear region of cytoplasm located_inISOTNKS2 (Homo sapiens)1624291 PMID:11454873RGDPMID:11454873
Tnks2Ratperinuclear region of cytoplasm located_inIEAUniProtKB:Q9H2K2 and ensembl:ENSP000003606891600115GO_REF:0000107EnsemblGO_REF:0000107
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Molecular Function
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Object Symbol
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Evidence
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Reference
Notes
Source
Original Reference(s)
Tnks2Ratenzyme binding enablesISOTNKS2 (Homo sapiens)1624291UniProtKB:Q9NWT6 and PMID:21251231RGDPMID:21251231
Tnks2Ratenzyme binding enablesIEAUniProtKB:Q9H2K2 and ensembl:ENSP000003606891600115GO_REF:0000107EnsemblGO_REF:0000107
Tnks2Ratglycosyltransferase activity enablesIEAUniProtKB-KW:KW-03281600115GO_REF:0000043UniProtGO_REF:0000043
Tnks2RatNAD+ poly-ADP-ribosyltransferase activity enablesISOTNKS2 (Homo sapiens)1624291 PMID:19759537 and PMID:21478859RGDPMID:19759537 and PMID:21478859
Tnks2RatNAD+ poly-ADP-ribosyltransferase activity enablesIEAUniProtKB:Q9H2K2 and ensembl:ENSP000003606891600115GO_REF:0000107EnsemblGO_REF:0000107
Tnks2RatNAD+ poly-ADP-ribosyltransferase activity enablesIEAInterPro:IPR0123171600115GO_REF:0000002InterProGO_REF:0000002
Tnks2RatNAD+ poly-ADP-ribosyltransferase activity enablesIBAFB:FBgn0027508 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Tnks2RatNAD+ poly-ADP-ribosyltransferase activity enablesIEAUniRule:UR0000784071600115GO_REF:0000104UniProtGO_REF:0000104
Tnks2RatNAD+-protein mono-ADP-ribosyltransferase activity enablesISOTNKS2 (Homo sapiens)1624291 PMID:11739745 and PMID:25043379RGDPMID:11739745 and PMID:25043379
Tnks2RatNAD+-protein mono-ADP-ribosyltransferase activity enablesIEAUniProtKB:Q9H2K2 and ensembl:ENSP000003606891600115GO_REF:0000107EnsemblGO_REF:0000107
Tnks2Ratnucleotidyltransferase activity enablesIEAUniProtKB-KW:KW-05481600115GO_REF:0000043UniProtGO_REF:0000043
Tnks2Ratprotein binding  IPICd2ap (Rattus norvegicus)13628742 RGD 
Tnks2Ratprotein binding enablesISOTNKS2 (Homo sapiens)1624291UniProtKB:O15084 more ...RGDPMID:11854288 more ...
Tnks2Rattransferase activity enablesIEAUniProtKB-KW:KW-08081600115GO_REF:0000043UniProtGO_REF:0000043
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RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tnks2RatADP-ribosylation pathway, mono and poly-ribosylation  ISOTNKS2 (Homo sapiens)11100038 RGD 

#
Reference Title
Reference Citation
1. Structures and Mechanisms of Enzymes Employed in the Synthesis and Degradation of PARP-Dependent Protein ADP-Ribosylation. Barkauskaite E, etal., Mol Cell. 2015 Jun 18;58(6):935-46. doi: 10.1016/j.molcel.2015.05.007.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Tankyrase inhibition aggravates kidney injury in the absence of CD2AP. Kuusela S, etal., Cell Death Dis. 2016 Jul 21;7:e2302. doi: 10.1038/cddis.2016.217.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
PMID:11278563   PMID:11454873   PMID:11739745   PMID:16507984   PMID:16507985   PMID:19759537   PMID:21251231   PMID:21478859   PMID:21531765   PMID:25043379   PMID:25939383  



Tnks2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81243,980,432 - 244,033,629 (+)NCBIGRCr8
mRatBN7.21234,567,888 - 234,621,079 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1234,567,858 - 234,621,079 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1242,957,470 - 243,010,368 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01249,885,628 - 249,938,508 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01242,723,807 - 242,776,700 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01255,478,794 - 255,532,143 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1255,479,261 - 255,532,143 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1255,479,261 - 255,532,143 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.01262,953,201 - 263,006,973 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41241,112,141 - 241,164,804NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11241,253,368 - 241,345,984NCBI
Celera1231,660,758 - 231,713,638NCBICelera
Cytogenetic Map1q53NCBI
TNKS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381091,798,426 - 91,865,475 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1091,798,426 - 91,865,475 (+)EnsemblGRCh38hg38GRCh38
GRCh371093,558,183 - 93,625,232 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361093,548,049 - 93,615,012 (+)NCBINCBI36Build 36hg18NCBI36
Build 341093,548,048 - 93,615,012NCBI
Celera1087,301,773 - 87,368,904 (+)NCBICelera
Cytogenetic Map10q23.32NCBI
HuRef1087,186,894 - 87,254,191 (+)NCBIHuRef
CHM1_11093,839,907 - 93,906,988 (+)NCBICHM1_1
T2T-CHM13v2.01092,681,611 - 92,748,788 (+)NCBIT2T-CHM13v2.0
Tnks2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391936,811,583 - 36,870,877 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1936,811,632 - 36,870,877 (+)EnsemblGRCm39 Ensembl
GRCm381936,834,129 - 36,893,477 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1936,834,232 - 36,893,477 (+)EnsemblGRCm38mm10GRCm38
MGSCv371936,908,722 - 36,967,967 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361936,832,583 - 36,958,617 (+)NCBIMGSCv36mm8
Celera1937,609,652 - 37,668,932 (+)NCBICelera
Cytogenetic Map19C2NCBI
cM Map1931.96NCBI
Tnks2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554251,417,679 - 1,492,267 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554251,419,013 - 1,492,267 (-)NCBIChiLan1.0ChiLan1.0
TNKS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28103,837,790 - 103,903,675 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110103,843,094 - 103,908,990 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01088,547,396 - 88,612,973 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11092,070,362 - 92,134,911 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1092,070,362 - 92,134,911 (+)Ensemblpanpan1.1panPan2
TNKS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1286,286,125 - 6,354,284 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl286,285,690 - 6,352,317 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha286,462,048 - 6,530,287 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0286,540,024 - 6,608,295 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl286,539,063 - 6,608,204 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1286,266,668 - 6,334,898 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0286,299,503 - 6,367,799 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0286,463,794 - 6,532,479 (+)NCBIUU_Cfam_GSD_1.0
Tnks2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721341,142,964 - 41,205,100 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366012,776,345 - 2,837,707 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366012,776,338 - 2,837,703 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TNKS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14103,396,459 - 103,461,821 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114103,396,424 - 103,461,830 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214112,909,835 - 112,975,236 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TNKS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1985,074,228 - 85,140,761 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl985,074,667 - 85,143,054 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604845,805,170 - 45,871,377 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tnks2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247373,059,265 - 3,136,105 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247373,059,222 - 3,136,104 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Tnks2
258 total Variants

Predicted Target Of
Summary Value
Count of predictions:646
Count of miRNA genes:296
Interacting mature miRNAs:386
Transcripts:ENSRNOT00000039942, ENSRNOT00000075210
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


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The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1197814409242814409Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1197697768242697768Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1201554356246554356Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
61455Niddm7Non-insulin dependent diabetes mellitus QTL 75.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1214537555238757011Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1216255568260522016Rat
1600392Bw123Body weight QTL 1230.001body mass (VT:0001259)body weight (CMO:0000012)1223201027260522016Rat

1 to 10 of 75 rows
RH130135  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21234,620,261 - 234,620,471 (+)MAPPERmRatBN7.2
Rnor_6.01255,531,326 - 255,531,535NCBIRnor6.0
Rnor_5.01263,006,156 - 263,006,365UniSTSRnor5.0
Rnor_5.01262,829,184 - 262,829,393UniSTSRnor5.0
RGSC_v3.41241,163,987 - 241,164,196UniSTSRGSC3.4
Celera1231,712,821 - 231,713,030UniSTS
RH 3.4 Map11583.2UniSTS
Cytogenetic Map1q53UniSTS
BF386861  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21234,618,677 - 234,618,837 (+)MAPPERmRatBN7.2
Rnor_6.01255,529,742 - 255,529,901NCBIRnor6.0
Rnor_5.01263,004,572 - 263,004,731UniSTSRnor5.0
Rnor_5.01262,827,600 - 262,827,759UniSTSRnor5.0
RGSC_v3.41241,162,403 - 241,162,562UniSTSRGSC3.4
Celera1231,711,237 - 231,711,396UniSTS
RH 3.4 Map11584.4UniSTS
Cytogenetic Map1q53UniSTS
BF394203  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21234,588,842 - 234,589,006 (+)MAPPERmRatBN7.2
Rnor_6.01255,499,911 - 255,500,074NCBIRnor6.0
Rnor_5.01262,974,127 - 262,974,290UniSTSRnor5.0
Rnor_5.01262,797,770 - 262,797,933UniSTSRnor5.0
RGSC_v3.41241,132,571 - 241,132,734UniSTSRGSC3.4
Celera1231,681,408 - 231,681,571UniSTS
RH 3.4 Map11583.0UniSTS
Cytogenetic Map1q53UniSTS
AI599623  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21234,608,259 - 234,608,400 (+)MAPPERmRatBN7.2
Rnor_6.01255,519,325 - 255,519,465NCBIRnor6.0
Rnor_5.01262,993,998 - 262,994,138UniSTSRnor5.0
Rnor_5.01262,817,184 - 262,817,324UniSTSRnor5.0
RGSC_v3.41241,151,985 - 241,152,125UniSTSRGSC3.4
Celera1231,700,822 - 231,700,962UniSTS
RH 3.4 Map11582.8UniSTS
Cytogenetic Map1q53UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
15 12 55 145 125 121 77 32 77 12 278 123 113 55 79 44



Ensembl Acc Id: ENSRNOT00000079808   ⟹   ENSRNOP00000068637
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1234,567,858 - 234,621,079 (+)Ensembl
Rnor_6.0 Ensembl1255,479,261 - 255,532,143 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000085497   ⟹   ENSRNOP00000073499
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1234,567,858 - 234,621,079 (+)Ensembl
RefSeq Acc Id: NM_001107607   ⟹   NP_001101077
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81243,980,746 - 244,033,629 (+)NCBI
mRatBN7.21234,568,190 - 234,621,079 (+)NCBI
Rnor_5.01262,953,201 - 263,006,973 (+)NCBI
RGSC_v3.41241,112,141 - 241,164,804 (+)RGD
Celera1231,660,758 - 231,713,638 (+)RGD
Sequence:
RefSeq Acc Id: XM_039080633   ⟹   XP_038936561
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81243,980,432 - 244,033,629 (+)NCBI
mRatBN7.21234,567,888 - 234,621,079 (+)NCBI
RefSeq Acc Id: XM_039080634   ⟹   XP_038936562
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81243,980,432 - 244,033,629 (+)NCBI
mRatBN7.21234,567,888 - 234,621,079 (+)NCBI
RefSeq Acc Id: XM_063265190   ⟹   XP_063121260
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81243,980,432 - 244,033,629 (+)NCBI
1 to 10 of 10 rows
Protein RefSeqs NP_001101077 (Get FASTA)   NCBI Sequence Viewer  
  XP_038936561 (Get FASTA)   NCBI Sequence Viewer  
  XP_038936562 (Get FASTA)   NCBI Sequence Viewer  
  XP_063121260 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM13189 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000068637
  ENSRNOP00000068637.1
  ENSRNOP00000073499
  ENSRNOP00000073499.2
  ENSRNOP00000098656
1 to 10 of 10 rows
RefSeq Acc Id: NP_001101077   ⟸   NM_001107607
- UniProtKB: A0A0G2JTB0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038936562   ⟸   XM_039080634
- Peptide Label: isoform X2
- UniProtKB: D3ZRP5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038936561   ⟸   XM_039080633
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000068637   ⟸   ENSRNOT00000079808
Ensembl Acc Id: ENSRNOP00000073499   ⟸   ENSRNOT00000085497
PARP catalytic   SAM

Name Modeler Protein Id AA Range Protein Structure
AF-D3ZRP5-F1-model_v2 AlphaFold D3ZRP5 1-1166 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 38 of 38 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-55817 BioCyc
Ensembl Genes ENSRNOG00000052664 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000079808 ENTREZGENE
  ENSRNOT00000079808.2 UniProtKB/TrEMBL
  ENSRNOT00000085497 ENTREZGENE
  ENSRNOT00000085497.2 UniProtKB/TrEMBL
  ENSRNOT00000132955 ENTREZGENE
Gene3D-CATH 1.10.150.50 UniProtKB/TrEMBL
  1.25.40.20 UniProtKB/TrEMBL
  3.90.228.10 UniProtKB/TrEMBL
  6.20.320.10 UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  Poly(ADP-ribose)pol_cat_dom UniProtKB/TrEMBL
  SAM UniProtKB/TrEMBL
  SAM_type UniProtKB/TrEMBL
KEGG Report rno:309512 UniProtKB/TrEMBL
NCBI Gene 309512 ENTREZGENE
PANTHER ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 UniProtKB/TrEMBL
  ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED UniProtKB/TrEMBL
Pfam Ank UniProtKB/TrEMBL
  Ank_2 UniProtKB/TrEMBL
  PARP UniProtKB/TrEMBL
  SAM_2 UniProtKB/TrEMBL
PhenoGen Tnks2 PhenoGen
PRINTS ANKYRIN UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/TrEMBL
  PARP_CATALYTIC UniProtKB/TrEMBL
  SAM_DOMAIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000052664 RatGTEx
SMART ANK UniProtKB/TrEMBL
  SAM UniProtKB/TrEMBL
Superfamily-SCOP ADP-ribosylation UniProtKB/TrEMBL
  ANK UniProtKB/TrEMBL
  SAM_homology UniProtKB/TrEMBL
UniProt A0A0G2JTB0 ENTREZGENE, UniProtKB/TrEMBL
  D3ZRP5 ENTREZGENE, UniProtKB/TrEMBL
1 to 38 of 38 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Tnks2  tankyrase 2  LOC100910717  tankyrase-2-like  Data merged from RGD:6496922 737654 PROVISIONAL
2016-03-08 Tnks2  tankyrase 2  Tnks2  tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100910717  tankyrase-2-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 Tnks2  tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2   Tnks2_predicted  tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Tnks2_predicted  tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED