Prtn3 (proteinase 3) - Rat Genome Database

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Gene: Prtn3 (proteinase 3) Rattus norvegicus
Analyze
Symbol: Prtn3
Name: proteinase 3
RGD ID: 1304898
Description: Predicted to enable enzyme binding activity; serine-type endopeptidase activity; and signaling receptor binding activity. Predicted to be involved in several processes, including mature conventional dendritic cell differentiation; membrane protein ectodomain proteolysis; and neutrophil extravasation. Predicted to be located in azurophil granule lumen and plasma membrane raft. Predicted to be active in extracellular space. Orthologous to human PRTN3 (proteinase 3); INTERACTS WITH acrylamide; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC314615; myeloblastin
RGD Orthologs
Human
Mouse
Bonobo
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,472,750 - 10,482,037 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl710,472,755 - 10,482,474 (-)EnsemblGRCr8
mRatBN7.279,822,123 - 9,831,300 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,822,122 - 9,831,944 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx712,702,828 - 12,706,274 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,580,909 - 14,584,355 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,440,584 - 12,444,030 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,643,712 - 12,646,951 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,643,516 - 12,646,960 (-)Ensemblrn6Rnor6.0
Rnor_5.0712,813,238 - 12,822,399 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4711,334,722 - 11,338,559 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera77,997,078 - 8,000,317 (-)NCBICelera
RGSC_v3.1711,334,722 - 11,338,559 (-)NCBI
Cytogenetic Map7q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-aminobenzohydrazide  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
arsenous acid  (ISO)
atrazine  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP)
bisphenol AF  (EXP)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
choline  (ISO)
cisplatin  (ISO)
cocaine  (ISO)
Cuprizon  (EXP)
cyclophosphamide  (ISO)
D-glucose  (ISO)
diarsenic trioxide  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
epoxiconazole  (ISO)
folic acid  (ISO)
fructose  (ISO)
gamma-tocopherol  (ISO)
glucose  (ISO)
herbicide  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
methotrexate  (ISO)
minocycline  (ISO)
N-nitrosodiethylamine  (ISO)
naphthalene  (ISO)
paracetamol  (ISO)
pazopanib  (ISO)
pirinixic acid  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sotorasib  (ISO)
streptozocin  (ISO)
sulforaphane  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
tocopherol  (ISO)
trametinib  (ISO)
trichloroethene  (EXP,ISO)
triptonide  (ISO)
tungsten  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11389039   PMID:16478888   PMID:16502470   PMID:17244676   PMID:17712045   PMID:18462208   PMID:19056867   PMID:20551380   PMID:20828556   PMID:21193407   PMID:21821719   PMID:22266279  
PMID:23202369   PMID:23533145   PMID:28240246  


Genomics

Comparative Map Data
Prtn3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,472,750 - 10,482,037 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl710,472,755 - 10,482,474 (-)EnsemblGRCr8
mRatBN7.279,822,123 - 9,831,300 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,822,122 - 9,831,944 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx712,702,828 - 12,706,274 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,580,909 - 14,584,355 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,440,584 - 12,444,030 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,643,712 - 12,646,951 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,643,516 - 12,646,960 (-)Ensemblrn6Rnor6.0
Rnor_5.0712,813,238 - 12,822,399 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4711,334,722 - 11,338,559 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera77,997,078 - 8,000,317 (-)NCBICelera
RGSC_v3.1711,334,722 - 11,338,559 (-)NCBI
Cytogenetic Map7q11NCBI
PRTN3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3819840,999 - 848,175 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl19840,999 - 848,175 (+)Ensemblhg38GRCh38
GRCh3719840,999 - 848,175 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3619791,985 - 799,175 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3419791,964 - 799,051NCBI
Celera19766,135 - 773,326 (+)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef19610,181 - 617,038 (+)NCBIHuRef
CHM1_119840,583 - 847,665 (+)NCBICHM1_1
T2T-CHM13v2.019796,963 - 804,283 (+)NCBIT2T-CHM13v2.0
Prtn3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391079,715,499 - 79,719,008 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1079,710,310 - 79,719,008 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381079,879,667 - 79,883,174 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1079,874,476 - 79,883,174 (+)Ensemblmm10GRCm38
MGSCv371079,342,412 - 79,345,919 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361079,282,796 - 79,286,303 (+)NCBIMGSCv36mm8
Celera1080,894,480 - 80,897,987 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
PRTN3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2205,171,167 - 5,180,414 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1194,409,659 - 4,418,867 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v019283,314 - 291,504 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.119810,237 - 817,588 (+)NCBIPanPan1.1PanPan1.1panPan2
PRTN3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl277,520,314 - 77,523,563 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1277,520,314 - 77,526,303 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2277,472,358 - 77,477,327 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PRTN3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.16590,193 - 598,829 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660818,318,743 - 8,324,146 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Prtn3
73 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:41
Count of miRNA genes:40
Interacting mature miRNAs:41
Transcripts:ENSRNOT00000014687
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7166965846669658Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)7123748937Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7721609752216097Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
2290372Gluco33Glucose level QTL 332.71blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)7131777942Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7170952746709527Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7132612984Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)71011291660150541Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7946087754460877Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7129716167Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134650782Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7132612984Rat

Markers in Region
AW531576  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.279,822,143 - 9,822,357 (+)MAPPERmRatBN7.2
Rnor_6.0712,643,537 - 12,643,750NCBIRnor6.0
Rnor_5.0712,813,259 - 12,813,472UniSTSRnor5.0
RGSC_v3.4711,334,547 - 11,334,760UniSTSRGSC3.4
Celera77,996,903 - 7,997,116UniSTS
Cytogenetic Map7q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 3 33 128 56 64 34 34 34 3 157 83 11 117 30 84 30 12 12

Sequence


Ensembl Acc Id: ENSRNOT00000014687   ⟹   ENSRNOP00000014687
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl710,472,755 - 10,476,196 (-)Ensembl
mRatBN7.2 Ensembl79,822,122 - 9,825,588 (-)Ensembl
Rnor_6.0 Ensembl712,643,516 - 12,646,960 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101903   ⟹   ENSRNOP00000097376
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl710,472,755 - 10,482,097 (-)Ensembl
mRatBN7.2 Ensembl79,822,122 - 9,831,944 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000146028   ⟹   ENSRNOP00000109925
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl710,472,755 - 10,481,630 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000174131   ⟹   ENSRNOP00000111169
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl710,472,755 - 10,482,474 (-)Ensembl
RefSeq Acc Id: NM_001024264   ⟹   NP_001019435
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,472,750 - 10,476,196 (-)NCBI
mRatBN7.279,822,123 - 9,825,569 (-)NCBI
Rnor_6.0712,643,712 - 12,646,951 (-)NCBI
Rnor_5.0712,813,238 - 12,822,399 (-)NCBI
RGSC_v3.4711,334,722 - 11,338,559 (-)RGD
Celera77,997,078 - 8,000,317 (-)RGD
Sequence:
RefSeq Acc Id: XM_039078973   ⟹   XP_038934901
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,472,750 - 10,482,037 (-)NCBI
mRatBN7.279,822,123 - 9,831,300 (-)NCBI
RefSeq Acc Id: NP_001019435   ⟸   NM_001024264
- Peptide Label: precursor
- UniProtKB: Q8K597 (UniProtKB/TrEMBL),   A6K8V9 (UniProtKB/TrEMBL),   F7FNG0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000014687   ⟸   ENSRNOT00000014687
RefSeq Acc Id: XP_038934901   ⟸   XM_039078973
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ARE6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000097376   ⟸   ENSRNOT00000101903
Ensembl Acc Id: ENSRNOP00000111169   ⟸   ENSRNOT00000174131
Ensembl Acc Id: ENSRNOP00000109925   ⟸   ENSRNOT00000146028
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F7FNG0-F1-model_v2 AlphaFold F7FNG0 1-256 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304898 AgrOrtholog
BioCyc Gene G2FUF-34894 BioCyc
Ensembl Genes ENSRNOG00000029814 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000014687 ENTREZGENE
  ENSRNOT00000014687.7 UniProtKB/TrEMBL
  ENSRNOT00000101903 ENTREZGENE
  ENSRNOT00000101903.2 UniProtKB/TrEMBL
  ENSRNOT00000146028.1 UniProtKB/TrEMBL
  ENSRNOT00000174131.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/TrEMBL
InterPro Peptidase_S1/S6_AS UniProtKB/TrEMBL
  Peptidase_S1_Elastase_sf UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1_S6 UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/TrEMBL
  Ser/Cys_Pept_Trypsin-like UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
KEGG Report rno:314615 UniProtKB/TrEMBL
NCBI Gene 314615 ENTREZGENE
PANTHER CHYMOTRYPSIN-LIKE ELASTASE FAMILY MEMBER UniProtKB/TrEMBL
  MYELOBLASTIN UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/TrEMBL
PhenoGen Prtn3 PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
RatGTEx ENSRNOG00000029814 RatGTEx
SMART Tryp_SPc UniProtKB/TrEMBL
Superfamily-SCOP Pept_Ser_Cys UniProtKB/TrEMBL
UniProt A0A8I6ARE6 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LJV5_RAT UniProtKB/TrEMBL
  A0ABK0M3Z2_RAT UniProtKB/TrEMBL
  A6K8V9 ENTREZGENE, UniProtKB/TrEMBL
  F7FNG0 ENTREZGENE, UniProtKB/TrEMBL
  Q8K597 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Prtn3  proteinase 3   Prtn3_predicted  proteinase 3 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Prtn3_predicted  proteinase 3 (predicted)      Symbol and Name status set to approved 70820 APPROVED