Zfp956 (zinc finger protein 956) - Rat Genome Database

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Gene: Zfp956 (zinc finger protein 956) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Zfp956
Name: zinc finger protein 956
RGD ID: 1304879
Description: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus; INTERACTS WITH 4,4'-sulfonyldiphenol; acrylamide; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hypothetical protein LOC312301; LOC100912199; LOC312301; MGC109278; RGD1304879; similar to Zinc finger protein 398 (Zinc finger DNA binding protein p52/p71); uncharacterized protein LOC312301; Zfp977; zinc finger protein 45-like; zinc finger protein 977
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8478,274,206 - 78,298,178 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl478,286,141 - 78,298,173 (+)EnsemblGRCr8
mRatBN7.2476,943,239 - 76,967,238 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl476,955,409 - 76,967,252 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx482,167,597 - 82,179,574 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0477,941,932 - 77,953,909 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0476,383,397 - 76,395,374 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd479,547,406 - 79,559,386 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive477,227,673 - 77,239,504 (+)NCBILyon_Normotensive
Lyon_Hypertensive477,744,607 - 77,756,438 (+)NCBILyon_Hypertensive
F344_StmMcwi477,634,057 - 77,646,037 (+)NCBIF344_StmMcwi
Rnor_6.0477,615,146 - 77,635,367 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl477,623,538 - 77,635,362 (+)Ensemblrn6Rnor6.0
Rnor_5.04142,287,117 - 142,305,002 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4476,081,462 - 76,093,288 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera471,902,975 - 71,914,818 (+)NCBICelera
RGSC_v3.1476,357,591 - 76,369,416 (+)NCBI
Cytogenetic Map4q24NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IBA,IEA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Genomics

Variants

.
Variants in Zfp956
242 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:45
Count of miRNA genes:42
Interacting mature miRNAs:45
Transcripts:ENSRNOT00000059263
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)439431983123203361Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)459753119104753119Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44140057786400577Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44442502489425024Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)474233320119233320Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)458817672103817672Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)426234499134199155Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)474233320119233320Rat
61336Bp21Blood pressure QTL 214.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45808014680212111Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)471647492116647492Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)427862204126119996Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44140060386400603Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)475939858140508796Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)43044896182336920Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)465060960127749483Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)451085655113588029Rat
2317588Eae27Experimental allergic encephalomyelitis QTL 27nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)469036742114036742Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)440490442117737312Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)457613339151163960Rat
4889969Bss96Bone structure and strength QTL 964.9tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)457613242102613242Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
4889972Bss97Bone structure and strength QTL 975.6tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)457613242102613242Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
5685012Bmd87Bone mineral density QTL 875.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)43511329080113290Rat
5685009Bmd86Bone mineral density QTL 863.7tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)457613242102613242Rat
634311Sach7Saccharin preference QTL 7taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)45807987582597589Rat
2306547Iddm38Insulin dependent diabetes mellitus QTL 38blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)468353567113353567Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41170660492690519Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)474169813134199155Rat
2312569Pur19Proteinuria QTL 193.40.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)459836842104836842Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)43726957782269577Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)475939858140508796Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)46104105794638356Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463245026129846354Rat
631651Bp124Blood pressure QTL 1243arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)464209744109209744Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1558651Swd3Spike wave discharge measurement QTL 34.620.000024brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)44140057786400577Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)457664252127749483Rat
631546Bp86Blood pressure QTL 863.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45807987592690793Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)465495851159259805Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463224393108224393Rat
7394826Bw126Body weight QTL 1260.002body mass (VT:0001259)body weight gain (CMO:0000420)46390045888813920Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)433538597116185060Rat
631671Iddm11Insulin dependent diabetes mellitus QTL 113.60.0012blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)45960331980216952Rat

Markers in Region
RH135194  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2476,966,900 - 76,967,110 (+)MAPPERmRatBN7.2
Rnor_6.0477,635,031 - 77,635,240NCBIRnor6.0
Rnor_5.04142,304,666 - 142,304,875UniSTSRnor5.0
RGSC_v3.4476,092,955 - 76,093,164UniSTSRGSC3.4
Celera471,914,485 - 71,914,694UniSTS
RH 3.4 Map4487.21UniSTS
Cytogenetic Map4q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000059263   ⟹   ENSRNOP00000056030
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl478,286,318 - 78,298,173 (+)Ensembl
mRatBN7.2 Ensembl476,957,547 - 76,967,232 (+)Ensembl
Rnor_6.0 Ensembl477,623,538 - 77,635,362 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000105916   ⟹   ENSRNOP00000080422
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl478,286,141 - 78,298,173 (+)Ensembl
mRatBN7.2 Ensembl476,955,409 - 76,967,252 (+)Ensembl
RefSeq Acc Id: NM_001014056   ⟹   NP_001014078
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8478,286,350 - 78,298,175 (+)NCBI
mRatBN7.2476,955,409 - 76,967,234 (+)NCBI
Dahl_SR_JrHsd479,547,406 - 79,559,386 (+)NCBI
Lyon_Normotensive477,227,673 - 77,239,504 (+)NCBI
Lyon_Hypertensive477,744,607 - 77,756,438 (+)NCBI
F344_StmMcwi477,634,057 - 77,646,037 (+)NCBI
Rnor_6.0477,623,538 - 77,635,364 (+)NCBI
Rnor_5.04142,287,117 - 142,305,002 (+)NCBI
RGSC_v3.4476,081,462 - 76,093,288 (+)RGD
Celera471,902,975 - 71,914,818 (+)RGD
Sequence:
RefSeq Acc Id: XM_039107543   ⟹   XP_038963471
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8478,277,853 - 78,298,178 (+)NCBI
mRatBN7.2476,948,146 - 76,967,238 (+)NCBI
RefSeq Acc Id: XM_039107546   ⟹   XP_038963474
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8478,290,465 - 78,298,178 (+)NCBI
mRatBN7.2476,959,381 - 76,967,238 (+)NCBI
RefSeq Acc Id: XM_063286022   ⟹   XP_063142092
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8478,277,853 - 78,298,178 (+)NCBI
RefSeq Acc Id: XM_063286023   ⟹   XP_063142093
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8478,277,853 - 78,298,178 (+)NCBI
RefSeq Acc Id: XM_063286024   ⟹   XP_063142094
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8478,277,853 - 78,298,178 (+)NCBI
RefSeq Acc Id: XM_063286025   ⟹   XP_063142095
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8478,274,206 - 78,298,178 (+)NCBI
RefSeq Acc Id: XM_063286026   ⟹   XP_063142096
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8478,281,446 - 78,298,178 (+)NCBI
RefSeq Acc Id: NP_001014078   ⟸   NM_001014056
- UniProtKB: Q5FVJ1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000056030   ⟸   ENSRNOT00000059263
RefSeq Acc Id: XP_038963471   ⟸   XM_039107543
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZPS4 (UniProtKB/TrEMBL),   A6K0D7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038963474   ⟸   XM_039107546
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000080422   ⟸   ENSRNOT00000105916
RefSeq Acc Id: XP_063142095   ⟸   XM_063286025
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZPS4 (UniProtKB/TrEMBL),   A6K0D7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063142093   ⟸   XM_063286023
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZPS4 (UniProtKB/TrEMBL),   A6K0D7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063142094   ⟸   XM_063286024
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZPS4 (UniProtKB/TrEMBL),   A6K0D7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063142092   ⟸   XM_063286022
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZPS4 (UniProtKB/TrEMBL),   A6K0D7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063142096   ⟸   XM_063286026
- Peptide Label: isoform X2
- UniProtKB: Q5FVJ1 (UniProtKB/TrEMBL)
Protein Domains
C2H2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5FVJ1-F1-model_v2 AlphaFold Q5FVJ1 1-447 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304879 AgrOrtholog
BioCyc Gene G2FUF-45003 BioCyc
Ensembl Genes ENSRNOG00000026874 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000059263 ENTREZGENE
  ENSRNOT00000059263.4 UniProtKB/TrEMBL
  ENSRNOT00000105916 ENTREZGENE
  ENSRNOT00000105916.2 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7312211 IMAGE-MGC_LOAD
InterPro Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
KEGG Report rno:312301 UniProtKB/TrEMBL
MGC_CLONE MGC:109278 IMAGE-MGC_LOAD
NCBI Gene 312301 ENTREZGENE
PANTHER KRUEPPEL-LIKE TRANSCRIPTION FACTOR UniProtKB/TrEMBL
  KRUPPEL-LIKE FACTOR 15 UniProtKB/TrEMBL
  ZINC FINGER PROTEIN 384 UniProtKB/TrEMBL
Pfam zf-C2H2 UniProtKB/TrEMBL
PhenoGen Zfp956 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000026874 RatGTEx
SMART ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/TrEMBL
UniProt A0A8I5ZPS4 ENTREZGENE, UniProtKB/TrEMBL
  A6K0D7 ENTREZGENE, UniProtKB/TrEMBL
  Q5FVJ1 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F7F9Y5 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Zfp956  zinc finger protein 956  LOC100912199  zinc finger protein 45-like  Data merged from RGD:6488348 737654 PROVISIONAL
2012-11-27 Zfp956  zinc finger protein 956  Zfp977  zinc finger protein 977  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-10 Zfp977  zinc finger protein 977  RGD1304879  similar to Zinc finger protein 398 (Zinc finger DNA binding protein p52/p71)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100912199  zinc finger protein 45-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-12-06 RGD1304879  similar to Zinc finger protein 398 (Zinc finger DNA binding protein p52/p71)  RGD1304879_predicted  similar to Zinc finger protein 398 (Zinc finger DNA binding protein p52/p71) (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1304879_predicted  similar to Zinc finger protein 398 (Zinc finger DNA binding protein p52/p71) (predicted)  LOC312301_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC312301_predicted  similar to Zinc finger protein 398 (Zinc finger DNA binding protein p52/p71) (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL