Ercc4l1 (excision repair cross-complementing rodent repair deficiency, complementation group 4-like 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Ercc4l1 (excision repair cross-complementing rodent repair deficiency, complementation group 4-like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Ercc4l1
Name: excision repair cross-complementing rodent repair deficiency, complementation group 4-like 1
RGD ID: 1304845
Description: Predicted to enable DNA binding activity and endonuclease activity. Predicted to be involved in DNA repair; PARTICIPATES IN nucleotide excision repair pathway; INTERACTS WITH indole-3-methanol.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: DNA repair endonuclease XPF; DNA repair endonuclease XPF-like; Ercc4; excision repair cross-complementing rodent repair deficiency, complementation group 4; LOC100909753; LOC103693257; LOC360465
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8101,462,146 - 1,500,409 (+)NCBIGRCr8
mRatBN7.210954,927 - 983,651 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10954,977 - 983,174 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.010975,653 - 1,010,029 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01011,655,960 - 11,690,620 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.110875,554 - 909,421 (+)NCBI
Celera1023,398 - 46,137 (+)NCBICelera
Cytogenetic Map10q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Comprehensive gene review and curation RGD comprehensive gene curation
7. Xeroderma pigmentosum group F caused by a defect in a structure-specific DNA repair endonuclease. Sijbers AM, etal., Cell. 1996 Sep 6;86(5):811-22.

Genomics

Variants

.
Variants in Ercc4l1
91 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10124158324Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000089404   ⟹   ENSRNOP00000074477
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10954,977 - 983,174 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000108933   ⟹   ENSRNOP00000087150
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10955,010 - 969,352 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000118820   ⟹   ENSRNOP00000083462
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10954,977 - 970,153 (+)Ensembl
RefSeq Acc Id: XM_063270016   ⟹   XP_063126086
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8101,462,146 - 1,500,409 (+)NCBI
Protein Sequences
Protein RefSeqs XP_063126086 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000083462.1
  ENSRNOP00000087150.1
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000087150   ⟸   ENSRNOT00000108933
RefSeq Acc Id: ENSRNOP00000074477   ⟸   ENSRNOT00000089404
RefSeq Acc Id: ENSRNOP00000083462   ⟸   ENSRNOT00000118820
RefSeq Acc Id: XP_063126086   ⟸   XM_063270016

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K855-F1-model_v2 AlphaFold A0A0G2K855 1-914 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSRNOG00000065745 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000108933.1 UniProtKB/TrEMBL
  ENSRNOT00000118820.1 UniProtKB/TrEMBL
NCBI Gene Ercc4l1 ENTREZGENE
PANTHER DNA REPAIR ENDONUCLEASE XPF UniProtKB/TrEMBL
  DNA REPAIR ENDONUCLEASE XPF UniProtKB/TrEMBL
PhenoGen Ercc4l1 PhenoGen
RatGTEx ENSRNOG00000065745 RatGTEx
UniProt A0A8I5ZX01_RAT UniProtKB/TrEMBL
  A0A8I6A5B1_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Ercc4l1  excision repair cross-complementing rodent repair deficiency, complementation group 4-like 1  LOC103693257  DNA repair endonuclease XPF-like  Data merged from RGD:9450399 737654 PROVISIONAL
2015-07-29 Ercc4l1  excision repair cross-complementing rodent repair deficiency, complementation group 4-like 1  LOC100909753  DNA repair endonuclease XPF-like  Data merged from RGD:6502047 737654 PROVISIONAL
2014-08-25 LOC103693257  DNA repair endonuclease XPF-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2012-07-05 LOC100909753  DNA repair endonuclease XPF-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-29 Ercc4l1  excision repair cross-complementing rodent repair deficiency, complementation group 4-like 1  Ercc4_predicted  excision repair cross-complementing rodent repair deficiency, complementation group 4 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-12 Ercc4_predicted  excision repair cross-complementing rodent repair deficiency, complementation group 4 (predicted)      Symbol and Name status set to approved 70820 APPROVED