Vill (villin-like) - Rat Genome Database

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Gene: Vill (villin-like) Rattus norvegicus
Analyze
Symbol: Vill
Name: villin-like
RGD ID: 1304843
Description: Predicted to enable actin filament binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in actin filament severing; actin polymerization or depolymerization; and barbed-end actin filament capping. Predicted to be active in actin cytoskeleton and cytoplasm. Orthologous to human VILL (villin like); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC301057; RGD1304843; similar to villin-like protein; villin-like protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88127,654,491 - 127,672,742 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8127,654,595 - 127,672,753 (+)EnsemblGRCr8
mRatBN7.28118,776,718 - 118,794,983 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8118,776,742 - 118,794,983 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8124,378,572 - 124,396,786 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08122,577,522 - 122,595,736 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08120,410,236 - 120,428,445 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08127,735,233 - 127,753,313 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8127,735,258 - 127,753,349 (+)Ensemblrn6Rnor6.0
Rnor_5.08126,952,224 - 126,970,442 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48124,009,465 - 124,022,873 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8117,954,342 - 117,967,987 (+)NCBICelera
RGSC_v3.18124,029,201 - 124,042,468 (+)NCBI
Cytogenetic Map8q32NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Vill
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88127,654,491 - 127,672,742 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8127,654,595 - 127,672,753 (+)EnsemblGRCr8
mRatBN7.28118,776,718 - 118,794,983 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8118,776,742 - 118,794,983 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8124,378,572 - 124,396,786 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08122,577,522 - 122,595,736 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08120,410,236 - 120,428,445 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08127,735,233 - 127,753,313 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8127,735,258 - 127,753,349 (+)Ensemblrn6Rnor6.0
Rnor_5.08126,952,224 - 126,970,442 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48124,009,465 - 124,022,873 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8117,954,342 - 117,967,987 (+)NCBICelera
RGSC_v3.18124,029,201 - 124,042,468 (+)NCBI
Cytogenetic Map8q32NCBI
VILL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38337,987,978 - 38,007,185 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl337,987,978 - 38,007,188 (+)Ensemblhg38GRCh38
GRCh37338,029,469 - 38,048,676 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36338,010,082 - 38,023,680 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34338,013,630 - 38,023,680NCBI
Celera337,969,450 - 37,983,047 (+)NCBICelera
Cytogenetic Map3p22.2NCBI
HuRef337,977,764 - 37,991,362 (+)NCBIHuRef
CHM1_1337,986,727 - 38,000,328 (+)NCBICHM1_1
T2T-CHM13v2.0337,992,157 - 38,011,362 (+)NCBIT2T-CHM13v2.0
Vill
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399118,881,797 - 118,900,593 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9118,881,846 - 118,900,593 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm389119,052,729 - 119,071,525 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9119,052,778 - 119,071,525 (+)Ensemblmm10GRCm38
MGSCv379118,961,896 - 118,980,643 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv369118,901,500 - 118,920,024 (+)NCBIMGSCv36mm8
Celera9119,520,677 - 119,539,421 (+)NCBICelera
Cytogenetic Map9F3NCBI
cM Map971.32NCBI
Vill
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554214,842,852 - 4,856,040 (+)Ensembl
ChiLan1.0NW_0049554214,837,688 - 4,856,129 (+)NCBIChiLan1.0ChiLan1.0
VILL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2237,939,287 - 37,961,464 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1337,944,050 - 37,966,227 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0337,883,869 - 37,906,054 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1338,172,789 - 38,189,189 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl338,172,789 - 38,189,188 (+)EnsemblpanPan2panpan1.1
VILL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1237,767,028 - 7,782,167 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl237,770,290 - 7,782,174 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha237,807,005 - 7,824,245 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0238,054,063 - 8,071,405 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl238,058,903 - 8,071,244 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1237,868,484 - 7,885,722 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0238,009,560 - 8,026,849 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0238,001,970 - 8,019,262 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Vill
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118194,211,476 - 194,225,690 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493647327,351,126 - 27,364,197 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VILL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1322,831,915 - 22,851,275 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11322,831,867 - 22,851,282 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21324,848,157 - 24,870,099 (-)NCBISscrofa10.2Sscrofa10.2susScr3
VILL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1151,395,763 - 1,412,352 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl151,395,776 - 1,409,351 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606310,126,268 - 10,142,971 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Vill
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477320,130,853 - 20,144,417 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Vill
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v18110,293,536 - 110,311,444 (+)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:50
Count of miRNA genes:49
Interacting mature miRNAs:50
Transcripts:ENSRNOT00000015888
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)8102413464132782436Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8103375781129871912Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)8105462581132782436Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)884192326132782436Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)885348065130348065Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)879394435132782436Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)891340911131690273Rat
10450865Bw175Body weight QTL 1754.1total fat pad mass (VT:0015008)adipose tissue molecular composition measurement (CMO:0000484)884192326129192326Rat

Markers in Region
MARC_21622-21623:1033069530:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28118,789,397 - 118,790,275 (+)MAPPERmRatBN7.2
Rnor_6.08127,747,716 - 127,748,593NCBIRnor6.0
Rnor_5.08126,964,845 - 126,965,722UniSTSRnor5.0
RGSC_v3.48124,017,288 - 124,018,165UniSTSRGSC3.4
Celera8117,962,398 - 117,963,275UniSTS
Cytogenetic Map8q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 11 62 126 91 90 59 25 59 6 283 119 9 100 81 92 31 2 2

Sequence


Ensembl Acc Id: ENSRNOT00000015888   ⟹   ENSRNOP00000015888
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8127,654,595 - 127,672,753 (+)Ensembl
mRatBN7.2 Ensembl8118,776,742 - 118,794,983 (+)Ensembl
Rnor_6.0 Ensembl8127,735,258 - 127,753,349 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117046   ⟹   ENSRNOP00000086551
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8118,782,575 - 118,794,983 (+)Ensembl
RefSeq Acc Id: NM_001191617   ⟹   NP_001178546
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88127,654,681 - 127,672,742 (+)NCBI
mRatBN7.28118,776,922 - 118,794,983 (+)NCBI
Rnor_6.08127,739,712 - 127,753,301 (+)NCBI
Rnor_5.08126,952,224 - 126,970,442 (+)NCBI
Celera8117,954,342 - 117,967,987 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063265303   ⟹   XP_063121373
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88127,654,494 - 127,672,094 (+)NCBI
RefSeq Acc Id: XM_063265304   ⟹   XP_063121374
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88127,654,491 - 127,671,492 (+)NCBI
RefSeq Acc Id: NP_001178546   ⟸   NM_001191617
- UniProtKB: D3Z8F1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000015888   ⟸   ENSRNOT00000015888
Ensembl Acc Id: ENSRNOP00000086551   ⟸   ENSRNOT00000117046
RefSeq Acc Id: XP_063121374   ⟸   XM_063265304
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063121373   ⟸   XM_063265303
- Peptide Label: isoform X1
- UniProtKB: D3Z8F1 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3Z8F1-F1-model_v2 AlphaFold D3Z8F1 1-857 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696366
Promoter ID:EPDNEW_R6889
Type:multiple initiation site
Name:Vill_1
Description:villin-like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08127,735,284 - 127,735,344EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304843 AgrOrtholog
BioCyc Gene G2FUF-28809 BioCyc
Ensembl Genes ENSRNOG00000011446 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015888 ENTREZGENE
  ENSRNOT00000015888.9 UniProtKB/TrEMBL
Gene3D-CATH 1.10.950.10 UniProtKB/TrEMBL
  3.40.20.10 UniProtKB/TrEMBL
InterPro ADF-H/Gelsolin-like_dom UniProtKB/TrEMBL
  Gelsolin UniProtKB/TrEMBL
  Gelsolin-like_dom_sf UniProtKB/TrEMBL
  Gelsolin_dom UniProtKB/TrEMBL
  Villin_headpiece UniProtKB/TrEMBL
  Villin_headpiece_dom_sf UniProtKB/TrEMBL
KEGG Report rno:301057 UniProtKB/TrEMBL
NCBI Gene 301057 ENTREZGENE
PANTHER Gelsolin UniProtKB/TrEMBL
  PTHR11977:SF30 UniProtKB/TrEMBL
Pfam Gelsolin UniProtKB/TrEMBL
  VHP UniProtKB/TrEMBL
PhenoGen Vill PhenoGen
PRINTS GELSOLIN UniProtKB/TrEMBL
PROSITE PS51089 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011446 RatGTEx
SMART GEL UniProtKB/TrEMBL
  VHP UniProtKB/TrEMBL
Superfamily-SCOP Actin depolymerizing proteins UniProtKB/TrEMBL
  SSF82754 UniProtKB/TrEMBL
  VHP UniProtKB/TrEMBL
UniProt D3Z8F1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Vill  villin-like   Vill_predicted  villin-like (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Vill_predicted  villin-like (predicted)  RGD1304843_predicted  similar to villin-like protein (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-20 RGD1304843_predicted  similar to villin-like protein (predicted)  LOC301057_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC301057_predicted  similar to villin-like protein (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL