Heca (hdc homolog, cell cycle regulator) - Rat Genome Database

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Gene: Heca (hdc homolog, cell cycle regulator) Rattus norvegicus
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Symbol: Heca
Name: hdc homolog, cell cycle regulator
RGD ID: 1304818
Description: Predicted to be involved in negative regulation of mitotic cell cycle. Predicted to be located in cytoplasm and nucleus. Orthologous to human HECA (hdc homolog, cell cycle regulator); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: headcase homolog; headcase homolog (Drosophila); headcase protein homolog; LOC308624
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8114,345,306 - 14,395,226 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl114,345,306 - 14,395,191 (-)EnsemblGRCr8
mRatBN7.2112,525,445 - 12,575,358 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl112,525,135 - 12,576,427 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx112,297,510 - 12,311,261 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.011,262,708 - 1,276,459 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0112,505,476 - 12,519,257 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0113,036,909 - 13,050,644 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl113,036,909 - 13,050,644 (-)Ensemblrn6Rnor6.0
Rnor_5.0114,730,556 - 14,744,291 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4112,933,861 - 12,947,642 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera110,982,933 - 10,996,714 (-)NCBICelera
RGSC_v3.1112,937,222 - 12,983,495 (-)NCBI
Cytogenetic Map1p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA,ISO)
cytoplasmic stress granule  (IEA,ISO)
nucleus  (IEA,ISO)

Molecular Function
RNA binding  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:19643820   PMID:19946888   PMID:22100912  


Genomics

Comparative Map Data
Heca
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8114,345,306 - 14,395,226 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl114,345,306 - 14,395,191 (-)EnsemblGRCr8
mRatBN7.2112,525,445 - 12,575,358 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl112,525,135 - 12,576,427 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx112,297,510 - 12,311,261 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.011,262,708 - 1,276,459 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0112,505,476 - 12,519,257 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0113,036,909 - 13,050,644 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl113,036,909 - 13,050,644 (-)Ensemblrn6Rnor6.0
Rnor_5.0114,730,556 - 14,744,291 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4112,933,861 - 12,947,642 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera110,982,933 - 10,996,714 (-)NCBICelera
RGSC_v3.1112,937,222 - 12,983,495 (-)NCBI
Cytogenetic Map1p12NCBI
HECA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386139,135,080 - 139,180,802 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6139,135,080 - 139,180,807 (+)Ensemblhg38GRCh38
GRCh376139,456,217 - 139,501,939 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366139,497,942 - 139,543,639 (+)NCBIBuild 36Build 36hg18NCBI36
Build 346139,497,941 - 139,543,630NCBI
Celera6140,196,318 - 140,242,007 (+)NCBICelera
Cytogenetic Map6q24.1NCBI
HuRef6137,017,966 - 137,063,661 (+)NCBIHuRef
CHM1_16139,719,415 - 139,765,096 (+)NCBICHM1_1
T2T-CHM13v2.06140,323,625 - 140,369,329 (+)NCBIT2T-CHM13v2.0
Heca
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391017,774,788 - 17,823,785 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1017,744,360 - 17,823,815 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381017,899,040 - 17,948,067 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1017,868,612 - 17,948,067 (-)Ensemblmm10GRCm38
MGSCv371017,620,272 - 17,667,873 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361017,589,882 - 17,637,483 (-)NCBIMGSCv36mm8
Celera1017,796,891 - 17,812,404 (-)NCBICelera
Cytogenetic Map10A3NCBI
cM Map107.31NCBI
Heca
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543620,523,215 - 20,568,621 (-)Ensembl
ChiLan1.0NW_00495543620,523,215 - 20,569,403 (-)NCBIChiLan1.0ChiLan1.0
HECA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25159,103,549 - 159,149,260 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16156,998,402 - 157,042,983 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06136,898,465 - 136,943,055 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16141,008,515 - 141,021,150 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6141,008,515 - 141,021,150 (+)EnsemblpanPan2panpan1.1
HECA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1131,332,915 - 31,383,688 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl131,363,008 - 31,373,277 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha132,205,754 - 32,257,065 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0131,493,231 - 31,544,548 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl131,492,489 - 31,665,998 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1131,369,117 - 31,413,471 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0131,251,605 - 31,295,973 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0131,563,102 - 31,614,407 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Heca
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946126,344,690 - 126,431,119 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365606,165,459 - 6,210,357 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365606,165,465 - 6,210,335 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HECA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl125,316,456 - 25,364,297 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1125,316,448 - 25,364,083 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2128,516,816 - 28,531,163 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HECA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11334,205,005 - 34,250,779 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660406,350,815 - 6,396,617 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Heca
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475314,798,487 - 14,849,370 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Heca
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12218,954,110 - 218,999,689 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Heca
410 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:332
Count of miRNA genes:211
Interacting mature miRNAs:240
Transcripts:ENSRNOT00000036663
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313090Bmd69Bone mineral density QTL 694.40.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)1529322934184556Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1774611852746118Rat
4889451Eae29Experimental allergic encephalomyelitis QTL 295.51nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1774612152746121Rat
70179Xhs2X-ray hypersensitivity QTL 23.2intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)1143965634Rat
1354647Despr8Despair related QTL 80.0000341locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1126564886Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)11037949255379492Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1694102251941022Rat
2313070Bss52Bone structure and strength QTL 524.40.0001body length (VT:0001256)body length (CMO:0000013)1529322934184556Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)1690935351909353Rat
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1126564886Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)1690935351909353Rat
5684999Bss102Bone structure and strength QTL 1025.57e-07tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)1690935351909353Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11282049457820494Rat
2317755Glom22Glomerulus QTL 223.8urine protein amount (VT:0005160)urine protein level (CMO:0000591)1134184556Rat
1300170Rf6Renal function QTL 63.14renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)1128483164Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)11168446456684464Rat
2313053Bss51Bone structure and strength QTL 513.80.0001tibia length (VT:0004357)tibia length (CMO:0000450)1529322934184556Rat

Markers in Region
RH129011  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2112,525,561 - 12,525,760 (+)MAPPERmRatBN7.2
Rnor_6.0113,037,290 - 13,037,488NCBIRnor6.0
Rnor_5.0114,730,937 - 14,731,135UniSTSRnor5.0
RGSC_v3.4112,934,288 - 12,934,486UniSTSRGSC3.4
Celera110,983,360 - 10,983,558UniSTS
RH 3.4 Map1130.11UniSTS
Cytogenetic Map1p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000081259   ⟹   ENSRNOP00000073877
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl114,345,306 - 14,395,191 (-)Ensembl
mRatBN7.2 Ensembl112,525,135 - 12,576,427 (-)Ensembl
Rnor_6.0 Ensembl113,036,909 - 13,050,644 (-)Ensembl
RefSeq Acc Id: NM_001107514   ⟹   NP_001100984
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8114,345,306 - 14,395,191 (-)NCBI
mRatBN7.2112,525,445 - 12,575,336 (-)NCBI
Rnor_6.0113,036,909 - 13,050,644 (-)NCBI
Rnor_5.0114,730,556 - 14,744,291 (-)NCBI
RGSC_v3.4112,933,861 - 12,947,642 (-)RGD
Celera110,982,933 - 10,996,714 (-)RGD
Sequence:
RefSeq Acc Id: XM_039112451   ⟹   XP_038968379
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8114,345,309 - 14,395,208 (-)NCBI
mRatBN7.2112,528,636 - 12,575,357 (-)NCBI
RefSeq Acc Id: XM_039112456   ⟹   XP_038968384
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8114,345,309 - 14,395,226 (-)NCBI
mRatBN7.2112,528,636 - 12,575,358 (-)NCBI
RefSeq Acc Id: XM_063262262   ⟹   XP_063118332
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8114,350,535 - 14,395,210 (-)NCBI
RefSeq Acc Id: XR_010052133
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8114,348,501 - 14,395,208 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001100984 (Get FASTA)   NCBI Sequence Viewer  
  XP_038968379 (Get FASTA)   NCBI Sequence Viewer  
  XP_038968384 (Get FASTA)   NCBI Sequence Viewer  
  XP_063118332 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL93763 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000073877
  ENSRNOP00000073877.2
RefSeq Acc Id: NP_001100984   ⟸   NM_001107514
- UniProtKB: F1M590 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073877   ⟸   ENSRNOT00000081259
RefSeq Acc Id: XP_038968384   ⟸   XM_039112456
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038968379   ⟸   XM_039112451
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063118332   ⟸   XM_063262262
- Peptide Label: isoform X2
Protein Domains
Headcase middle   Headcase N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M590-F1-model_v2 AlphaFold F1M590 1-415 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304818 AgrOrtholog
BioCyc Gene G2FUF-62281 BioCyc
Ensembl Genes ENSRNOG00000060972 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000081259 ENTREZGENE
  ENSRNOT00000081259.3 UniProtKB/TrEMBL
InterPro Headcase UniProtKB/TrEMBL
  Headcase_mid UniProtKB/TrEMBL
  HECA_N UniProtKB/TrEMBL
KEGG Report rno:308624 UniProtKB/TrEMBL
NCBI Gene 308624 ENTREZGENE
PANTHER HEADCASE PROTEIN HOMOLOG UniProtKB/TrEMBL
  PTHR13425 UniProtKB/TrEMBL
Pfam Headcase UniProtKB/TrEMBL
  HECA UniProtKB/TrEMBL
PhenoGen Heca PhenoGen
RatGTEx ENSRNOG00000060972 RatGTEx
UniProt A6JP91_RAT UniProtKB/TrEMBL
  F1M590 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-30 Heca  hdc homolog, cell cycle regulator  Heca  headcase homolog (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-07-30 Heca  hdc homolog, cell cycle regulator  Heca  hdc homolog, cell cycle regulator  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Heca  headcase homolog (Drosophila)   Heca_predicted  headcase homolog (Drosophila) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Heca_predicted  headcase homolog (Drosophila) (predicted)      Symbol and Name status set to approved 70820 APPROVED