Atg7 (autophagy related 7) - Rat Genome Database

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Gene: Atg7 (autophagy related 7) Rattus norvegicus
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Symbol: Atg7
Name: autophagy related 7
RGD ID: 1304817
Description: Predicted to enable Atg12 activating enzyme activity; Atg8 activating enzyme activity; and protein homodimerization activity. Involved in several processes, including cellular response to morphine; negative regulation of programmed cell death; and positive regulation of macroautophagy. Located in axon. Used to study cardiac arrest; degenerative disc disease; and high grade glioma. Biomarker of artery disease (multiple); diabetic retinopathy; metabolic dysfunction-associated steatotic liver disease (multiple); neurodegenerative disease; and paraplegia. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 31. Orthologous to human ATG7 (autophagy related 7); PARTICIPATES IN autophagy pathway; mitochondrial autophagy pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2-methoxyethanol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: APG7-like; Apg7l; ATG12-activating enzyme E1 ATG7; ATG7 autophagy related 7 homolog; ATG7 autophagy related 7 homolog (S. cerevisiae); autophagy 7-like; autophagy 7-like (S. cerevisiae); autophagy related 7 homolog; autophagy related 7 homolog (S. cerevisiae); autophagy-related 7; autophagy-related 7 (yeast); autophagy-related protein 7; LOC312647; ubiquitin-activating enzyme E1-like protein; ubiquitin-like modifier-activating enzyme ATG7
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84149,390,000 - 149,597,534 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4149,391,390 - 149,598,319 (+)EnsemblGRCr8
mRatBN7.24147,718,663 - 147,925,656 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4147,718,752 - 147,925,593 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4153,970,841 - 154,149,831 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04149,753,892 - 149,932,881 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04148,377,731 - 148,556,715 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04146,570,113 - 146,777,093 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4146,598,413 - 146,777,124 (+)Ensemblrn6Rnor6.0
Rnor_5.04209,861,459 - 210,067,618 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44150,814,706 - 150,992,704 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4136,643,475 - 136,821,326 (+)NCBICelera
RGSC_v3.14151,059,546 - 151,153,422 (+)NCBI
Cytogenetic Map4q42NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-Tetrandrine  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-[2-(3,4-dichlorophenyl)ethyl]-4-methylpiperazine  (ISO)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2-(2-Chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2-(tert-butylimino)-5-phenyl-3-(propan-2-yl)-1,3,5-thiadiazinan-4-one  (ISO)
2-deoxy-D-glucose  (ISO)
2-methoxyethanol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (ISO)
4'-epidoxorubicin  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nonylphenol  (EXP)
acrolein  (ISO)
actinomycin D  (ISO)
Aescin  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP)
alginic acid  (ISO)
all-trans-retinoic acid  (ISO)
alpha-amanitin  (EXP,ISO)
alpha-D-galactose  (EXP,ISO)
Alpinetin  (ISO)
amiodarone  (ISO)
amsacrine  (ISO)
antirheumatic drug  (ISO)
apigenin  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atazanavir sulfate  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
berberine  (EXP)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
buprofezin  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfide  (ISO)
caffeine  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
cantharidin  (EXP,ISO)
carbon nanotube  (EXP,ISO)
chenodeoxycholic acid  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
Curcumol  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
D-glucose  (EXP)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dinitrogen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
epoxiconazole  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (EXP,ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
fenofibrate  (ISO)
fenthion  (ISO)
ferrostatin-1  (ISO)
fingolimod hydrochloride  (ISO)
flavokawain B  (ISO)
flutamide  (ISO)
folic acid  (ISO)
Fusaric acid  (ISO)
galactose  (EXP,ISO)
gefitinib  (ISO)
geraniol  (ISO)
glucose  (EXP)
glutathione  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
indometacin  (EXP,ISO)
inositol  (EXP)
inulin  (ISO)
ivermectin  (ISO)
L-leucine  (ISO)
lanthanum trichloride  (EXP)
lead diacetate  (EXP)
lead(0)  (EXP)
levamisole  (ISO)
levetiracetam  (EXP)
lipopolysaccharide  (ISO)
LY294002  (ISO)
lycopene  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
melatonin  (ISO)
mirtazapine  (EXP,ISO)
N,N-diethyl-m-toluamide  (EXP)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methylnicotinate  (ISO)
nefazodone  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nitrates  (ISO)
nobiletin  (ISO)
Nonidet P-40  (ISO)
ochratoxin A  (ISO)
oleic acid  (ISO)
oligopeptide  (ISO)
onjisaponin B  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
parthenolide  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phenobarbital  (EXP,ISO)
pirinixic acid  (ISO)
platycodin D  (ISO)
promethazine  (ISO)
pterostilbene  (ISO)
pyrroloquinoline quinone  (ISO)
quercetin  (EXP,ISO)
quercitrin  (ISO)
rotenone  (ISO)
rottlerin  (ISO)
ruthenium red  (EXP)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (EXP,ISO)
staurosporine  (ISO)
tamoxifen  (ISO)
taurine  (ISO)
temozolomide  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
thymoquinone  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
tyloxapol  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zinc oxide  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult walking behavior  (ISO)
autophagosome assembly  (IBA,IEA,ISO)
autophagy  (IEA,ISO,ISS)
autophagy of mitochondrion  (ISO)
cardiac muscle cell development  (ISO)
cell population proliferation  (IMP)
cellular response to hyperoxia  (IEA,ISO,ISS)
cellular response to morphine  (IEP)
cellular response to nitrogen starvation  (IBA)
cellular response to reactive oxygen species  (ISO)
cellular response to sodium arsenite  (IMP)
cellular response to starvation  (IEA,ISO,ISS)
cellular response to stress  (IEA,ISO)
central nervous system neuron axonogenesis  (ISO)
cerebellar Purkinje cell layer development  (ISO)
cerebral cortex development  (ISO)
chaperone-mediated autophagy  (IMP)
circadian rhythm  (IEP)
defense response to virus  (IEA,ISO)
dendrite arborization  (IMP)
innate immune response  (ISO)
intracellular amino acid homeostasis  (ISO)
intracellular sphingolipid homeostasis  (ISO)
liver development  (ISO)
macroautophagy  (IEA,ISO)
membrane organization  (ISO)
mitochondrion organization  (ISO)
mitophagy  (IBA,IEA,ISO)
negative regulation of apoptotic process  (IMP,ISO)
negative regulation of cardiac muscle cell apoptotic process  (IEA,IMP)
negative regulation of dendrite extension  (IMP)
negative regulation of mitochondrial DNA replication  (IMP)
negative regulation of neuron apoptotic process  (IMP)
negative regulation of phagocytosis  (ISO)
negative regulation of programmed necrotic cell death  (IMP)
negative regulation of sphingolipid biosynthetic process  (ISO)
negative stranded viral RNA replication  (ISO)
nervous system process  (ISO)
neuron projection development  (ISO)
piecemeal microautophagy of the nucleus  (IBA)
positive regulation of apoptotic process  (IEA,ISO,ISS)
positive regulation of autophagosome assembly  (IMP)
positive regulation of autophagy  (IDA,IMP)
positive regulation of catabolic process  (IEA)
positive regulation of insulin secretion involved in cellular response to glucose stimulus  (ISO)
positive regulation of mitophagy  (IMP)
positive regulation of mucus secretion  (ISO)
positive regulation of programmed cell death  (IMP)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (ISO)
positive regulation of protein catabolic process  (IEA,ISO,ISS)
positive regulation of protein modification process  (ISO)
post-embryonic development  (ISO)
protein catabolic process  (ISO)
protein lipidation  (ISO)
protein lipidation involved in autophagosome assembly  (ISO)
protein modification by small protein conjugation  (IBA,ISO)
protein transport  (IEA)
pyramidal neuron development  (ISO)
regulation of cell development  (ISO)
regulation of circadian rhythm  (ISO,ISS)
regulation of hemopoiesis  (ISO)
regulation of macromolecule metabolic process  (IEA)
regulation of primary metabolic process  (IEA)
regulation of protein ubiquitination  (ISO)
response to alcohol  (IEP)
response to fluoride  (IEP)
response to glucose  (IEP)
response to nutrient levels  (IEA,IEP)
response to starvation  (ISO)
rhythmic process  (IEA)
synaptic vesicle cycle  (ISO)

Cellular Component
axon  (IDA)
axoneme  (ISO,ISS)
cytoplasm  (IBA,IEA,ISO,ISS)
dopaminergic synapse  (ISO)
perinuclear region of cytoplasm  (ISO)
phagophore assembly site  (IBA,IEA,ISO)
presynapse  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Ischemia-induced autophagy contributes to neurodegeneration in cerebellar Purkinje cells in the developing rat brain and in primary cortical neurons in vitro. Au AK, etal., Biochim Biophys Acta. 2015 Sep;1852(9):1902-11. doi: 10.1016/j.bbadis.2015.06.007. Epub 2015 Jun 11.
2. Dysregulated Autophagy and Lysosome Function Are Linked to Exosome Production by Micro-RNA 155 in Alcoholic Liver Disease. Babuta M, etal., Hepatology. 2019 Dec;70(6):2123-2141. doi: 10.1002/hep.30766. Epub 2019 Jun 24.
3. Autophagy is altered in skeletal and cardiac muscle of spontaneously hypertensive rats. Bloemberg D, etal., Acta Physiol (Oxf). 2014 Feb;210(2):381-91. doi: 10.1111/apha.12178. Epub 2013 Nov 5.
4. Autophagy protects the retina from light-induced degeneration. Chen Y, etal., J Biol Chem. 2013 Mar 15;288(11):7506-7518. doi: 10.1074/jbc.M112.439935. Epub 2013 Jan 22.
5. Melatonin protects against developmental PBDE-47 neurotoxicity by targeting the AMPK/mitophagy axis. Dong L, etal., J Pineal Res. 2023 Aug;75(1):e12871. doi: 10.1111/jpi.12871. Epub 2023 Apr 27.
6. Upregulation of miR-96-5p by bone marrow mesenchymal stem cells and their exosomes alleviate non-alcoholic steatohepatitis: Emphasis on caspase-2 signaling inhibition. El-Derany MO and AbdelHamid SG, Biochem Pharmacol. 2021 Aug;190:114624. doi: 10.1016/j.bcp.2021.114624. Epub 2021 May 27.
7. Decreased mitochondrial DNA copy number in the hippocampus and peripheral blood during opiate addiction is mediated by autophagy and can be salvaged by melatonin. Feng YM, etal., Autophagy. 2013 Sep;9(9):1395-406. doi: 10.4161/auto.25468. Epub 2013 Jun 20.
8. Paraplegia increases skeletal muscle autophagy. Fry CS, etal., Muscle Nerve. 2012 Nov;46(5):793-8. doi: 10.1002/mus.23423.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Involvement of autophagy in hypoxic-excitotoxic neuronal death. Ginet V, etal., Autophagy. 2014 May;10(5):846-60. doi: 10.4161/auto.28264. Epub 2014 Mar 11.
11. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
12. Akebia Saponin D Decreases Hepatic Steatosis through Autophagy Modulation. Gong LL, etal., J Pharmacol Exp Ther. 2016 Dec;359(3):392-400. doi: 10.1124/jpet.116.236562. Epub 2016 Sep 26.
13. A novel protective mechanism for mitochondrial aldehyde dehydrogenase (ALDH2) in type i diabetes-induced cardiac dysfunction: role of AMPK-regulated autophagy. Guo Y, etal., Biochim Biophys Acta. 2015 Feb;1852(2):319-31. doi: 10.1016/j.bbadis.2014.05.017. Epub 2014 May 27.
14. Infusion of a glucose solution reduces autophagy in the liver after LPS-induced systemic inflammation. Hagiwara S, etal., Inflammation. 2012 Feb;35(1):249-58. doi: 10.1007/s10753-011-9311-y.
15. Roux-en-Y gastric bypass reduces lipid overaccumulation in liver by upregulating hepatic autophagy in obese diabetic rats. He B, etal., Obes Surg. 2015 Jan;25(1):109-18. doi: 10.1007/s11695-014-1342-7.
16. The preventive effect of liraglutide on the lipotoxic liver injury via increasing autophagy. He Y, etal., Ann Hepatol. 2020 Jan - Feb;19(1):44-52. doi: 10.1016/j.aohep.2019.06.023. Epub 2019 Sep 24.
17. Autophagy signaling in skeletal muscle of infarcted rats. Jannig PR, etal., PLoS One. 2014 Jan 10;9(1):e85820. doi: 10.1371/journal.pone.0085820. eCollection 2014.
18. Suppression of autophagy is protective in high glucose-induced cardiomyocyte injury. Kobayashi S, etal., Autophagy. 2012 Apr;8(4):577-92. doi: 10.4161/auto.18980. Epub 2012 Apr 1.
19. Chronic alcohol consumption disrupts myocardial protein balance and function in aged, but not adult, female F344 rats. Lang CH and Korzick DH, Am J Physiol Regul Integr Comp Physiol. 2014 Jan 1;306(1):R23-33. doi: 10.1152/ajpregu.00414.2013. Epub 2013 Nov 13.
20. Hydrogen sulfide alleviates myocardial fibrosis in mice with alcoholic cardiomyopathy by downregulating autophagy. Liang B, etal., Int J Mol Med. 2017 Dec;40(6):1781-1791. doi: 10.3892/ijmm.2017.3191. Epub 2017 Oct 16.
21. Murine macrophage autophagy protects against alcohol-induced liver injury by degrading interferon regulatory factor 1 (IRF1) and removing damaged mitochondria. Liang S, etal., J Biol Chem. 2019 Aug 16;294(33):12359-12369. doi: 10.1074/jbc.RA119.007409. Epub 2019 Jun 24.
22. δ-Catenin engages the autophagy pathway to sculpt the developing dendritic arbor. Ligon C, etal., J Biol Chem. 2020 Aug 7;295(32):10988-11001. doi: 10.1074/jbc.RA120.013058. Epub 2020 Jun 17.
23. Age-related changes of cell death pathways in rat extraocular muscle. McMullen CA, etal., Exp Gerontol. 2009 Jun-Jul;44(6-7):420-5. doi: 10.1016/j.exger.2009.03.006. Epub 2009 Mar 31.
24. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
25. Diurnal Rhythmicity of Autophagy Is Impaired in the Diabetic Retina. Qi X, etal., Cells. 2020 Apr 7;9(4):905. doi: 10.3390/cells9040905.
26. ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and cell death. Radoshevich L, etal., Cell. 2010 Aug 20;142(4):590-600. doi: 10.1016/j.cell.2010.07.018.
27. GOA pipeline RGD automated data pipeline
28. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. Comprehensive gene review and curation RGD comprehensive gene curation
31. Early and sustained activation of autophagy in degenerating axons after spinal cord injury. Ribas VT, etal., Brain Pathol. 2015 Mar;25(2):157-70. doi: 10.1111/bpa.12170. Epub 2014 Sep 12.
32. White Adipose Tissue Autophagy and Adipose-Liver Crosstalk Exacerbate Nonalcoholic Fatty Liver Disease in Mice. Sakane S, etal., Cell Mol Gastroenterol Hepatol. 2021;12(5):1683-1699. doi: 10.1016/j.jcmgh.2021.07.008. Epub 2021 Jul 22.
33. RNA-binding protein HuR suppresses senescence through Atg7 mediated autophagy activation in diabetic intervertebral disc degeneration. Shao Z, etal., Cell Prolif. 2021 Feb;54(2):e12975. doi: 10.1111/cpr.12975. Epub 2020 Dec 28.
34. Hepatic interferon regulatory factor 8 expression mediates liver ischemia/reperfusion injury in mice. Shi G, etal., Biochem Pharmacol. 2021 Oct;192:114728. doi: 10.1016/j.bcp.2021.114728. Epub 2021 Aug 13.
35. Sirtuin1 and autophagy protect cells from fluoride-induced cell stress. Suzuki M and Bartlett JD, Biochim Biophys Acta. 2014 Feb;1842(2):245-55. doi: 10.1016/j.bbadis.2013.11.023. Epub 2013 Dec 1.
36. LC3 conjugation system in mammalian autophagy. Tanida I, etal., Int J Biochem Cell Biol. 2004 Dec;36(12):2503-18.
37. Role of autophagy in arsenite-induced neurotoxicity: the involvement of alpha-synuclein. Teng YC, etal., Toxicol Lett. 2015 Mar 18;233(3):239-45. doi: 10.1016/j.toxlet.2015.01.018. Epub 2015 Jan 29.
38. Cellular mechanotransduction relies on tension-induced and chaperone-assisted autophagy. Ulbricht A, etal., Curr Biol. 2013 Mar 4;23(5):430-5. doi: 10.1016/j.cub.2013.01.064. Epub 2013 Feb 21.
39. Selective removal of mitochondria via mitophagy: distinct pathways for different mitochondrial stresses. Wei H, etal., Biochim Biophys Acta. 2015 Oct;1853(10 Pt B):2784-90. doi: 10.1016/j.bbamcr.2015.03.013. Epub 2015 Apr 1.
40. Autophagy in the heart and liver during normal aging and calorie restriction. Wohlgemuth SE, etal., Rejuvenation Res. 2007 Sep;10(3):281-92.
41. Increased expression of DRAM1 confers myocardial protection against ischemia via restoring autophagy flux. Wu X, etal., J Mol Cell Cardiol. 2018 Nov;124:70-82. doi: 10.1016/j.yjmcc.2018.08.018. Epub 2018 Aug 23.
42. Increased expression of ERp57/GRP58 is protective against pancreatic beta cell death caused by autophagic failure. Yamamoto E, etal., Biochem Biophys Res Commun. 2014 Oct 10;453(1):19-24. doi: 10.1016/j.bbrc.2014.09.040. Epub 2014 Sep 19.
43. Mammalian autophagy: core molecular machinery and signaling regulation. Yang Z and Klionsky DJ, Curr Opin Cell Biol. 2010 Apr;22(2):124-31. Epub 2009 Dec 23.
44. Autophagy inhibition improves the efficacy of curcumin/temozolomide combination therapy in glioblastomas. Zanotto-Filho A, etal., Cancer Lett. 2015 Mar 28;358(2):220-31. doi: 10.1016/j.canlet.2014.12.044. Epub 2014 Dec 24.
45. Geldanamycin Reduces Abeta-Associated Anxiety and Depression, Concurrent with Autophagy Provocation. Zare N, etal., J Mol Neurosci. 2015 Nov;57(3):317-24. doi: 10.1007/s12031-015-0619-1. Epub 2015 Jul 25.
46. Cerebral ischemia-reperfusion-induced autophagy protects against neuronal injury by mitochondrial clearance. Zhang X, etal., Autophagy. 2013 Sep;9(9):1321-33. doi: 10.4161/auto.25132. Epub 2013 Jun 12.
47. The protective effect of puerarin-loaded mesoporous silicon nanoparticles on alcoholic hepatitis through mTOR-mediated autophagy pathway. Zhang XX, etal., Biomed Microdevices. 2022 Oct 29;24(4):37. doi: 10.1007/s10544-022-00622-2.
Additional References at PubMed
PMID:11096062   PMID:11890701   PMID:12477932   PMID:12482611   PMID:12890687   PMID:14627652   PMID:15489334   PMID:15866887   PMID:16625205   PMID:16885219   PMID:17450150   PMID:17726112  
PMID:19279012   PMID:20080761   PMID:20543840   PMID:20577052   PMID:21402742   PMID:21617129   PMID:22354037   PMID:22496425   PMID:23152632   PMID:23290079   PMID:23704209   PMID:23863932  
PMID:23918799   PMID:23981124   PMID:23986436   PMID:24035364   PMID:24089209   PMID:24105478   PMID:24185898   PMID:24550300   PMID:24681637   PMID:25327288   PMID:25332431   PMID:28389568  
PMID:28860495   PMID:29311554   PMID:29937374   PMID:32043463   PMID:33491285   PMID:35256590   PMID:37059928   PMID:37815664   PMID:37964653  


Genomics

Comparative Map Data
Atg7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84149,390,000 - 149,597,534 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4149,391,390 - 149,598,319 (+)EnsemblGRCr8
mRatBN7.24147,718,663 - 147,925,656 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4147,718,752 - 147,925,593 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4153,970,841 - 154,149,831 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04149,753,892 - 149,932,881 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04148,377,731 - 148,556,715 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04146,570,113 - 146,777,093 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4146,598,413 - 146,777,124 (+)Ensemblrn6Rnor6.0
Rnor_5.04209,861,459 - 210,067,618 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44150,814,706 - 150,992,704 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4136,643,475 - 136,821,326 (+)NCBICelera
RGSC_v3.14151,059,546 - 151,153,422 (+)NCBI
Cytogenetic Map4q42NCBI
ATG7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38311,272,397 - 11,576,353 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl311,272,309 - 11,557,665 (+)Ensemblhg38GRCh38
GRCh37311,314,083 - 11,606,126 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36311,315,160 - 11,571,557 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34311,289,101 - 11,571,556NCBI
Celera311,249,448 - 11,534,544 (+)NCBICelera
Cytogenetic Map3p25.3NCBI
HuRef311,248,262 - 11,532,686 (+)NCBIHuRef
CHM1_1311,264,079 - 11,549,266 (+)NCBICHM1_1
T2T-CHM13v2.0311,267,348 - 11,571,596 (+)NCBIT2T-CHM13v2.0
Atg7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396114,620,075 - 114,837,565 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6114,620,058 - 114,837,575 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm386114,643,127 - 114,860,604 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6114,643,097 - 114,860,614 (+)Ensemblmm10GRCm38
MGSCv376114,593,143 - 114,809,954 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv366114,608,744 - 114,825,555 (+)NCBIMGSCv36mm8
Celera6116,482,450 - 116,697,418 (+)NCBICelera
Cytogenetic Map6E3NCBI
cM Map653.05NCBI
Atg7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542914,076,960 - 14,304,236 (+)Ensembl
ChiLan1.0NW_00495542914,076,976 - 14,301,034 (+)NCBIChiLan1.0ChiLan1.0
ATG7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2211,268,612 - 11,548,872 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1311,273,372 - 11,556,596 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0311,208,600 - 11,488,757 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1311,554,100 - 11,833,638 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl311,554,100 - 11,833,398 (+)EnsemblpanPan2panpan1.1
ATG7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1206,916,354 - 7,154,849 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl206,916,515 - 7,154,800 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha206,951,793 - 7,189,666 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0206,945,628 - 7,184,158 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl206,944,407 - 7,184,165 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1206,661,904 - 6,900,228 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0207,018,478 - 7,256,616 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0206,989,268 - 7,228,243 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Atg7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494216,730,443 - 16,981,101 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366021,935,507 - 2,179,256 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366021,938,720 - 2,179,239 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATG7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1367,417,938 - 67,707,654 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11367,301,756 - 67,699,141 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21374,636,936 - 74,915,764 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ATG7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12247,187,305 - 47,571,309 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2247,325,614 - 47,571,070 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666041118,943,702 - 119,213,969 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atg7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624943232,618 - 481,290 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624943231,978 - 480,933 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Atg7
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1631,808,516 - 31,986,019 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Atg7
1467 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:100
Count of miRNA genes:84
Interacting mature miRNAs:89
Transcripts:ENSRNOT00000067532
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)486583980149763391Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4146370897184426481Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4107346299152346299Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4134095016179095016Rat
1300116Hrtrt5Heart rate QTL 53.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)4117737142152833657Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4146370897184426481Rat
1358364Sradr4Stress Responsive Adrenal Weight QTL 44.92adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)4131384565176384565Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4112427331157427331Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4112427331157427331Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4123870974168870974Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4117559384162559384Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4140059299181024663Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4111383604156383604Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)494638356168870820Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4106848959168870974Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4108206096153206096Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4127263297172263297Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4126334185171334185Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4147299608184426481Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4111383604156383604Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482944895154403548Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4124700988169700988Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)4100752691179366077Rat
1581566Eae21Experimental allergic encephalomyelitis QTL 216.2body mass (VT:0001259)maximum body weight loss to initial body weight ratio (CMO:0001400)4137447185182447185Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4137430611182430611Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)486709649168870974Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4134199006168870974Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4148121375176967367Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)465495851159259805Rat
2293840Kiddil9Kidney dilation QTL 92.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)4113634167149763391Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4116184844161184844Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)457613339151163960Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4148834094168870974Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000067532   ⟹   ENSRNOP00000063617
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4149,391,399 - 149,598,198 (+)Ensembl
mRatBN7.2 Ensembl4147,747,009 - 147,925,551 (+)Ensembl
Rnor_6.0 Ensembl4146,598,413 - 146,777,124 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095118   ⟹   ENSRNOP00000091366
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4149,391,390 - 149,529,398 (+)Ensembl
mRatBN7.2 Ensembl4147,718,752 - 147,842,012 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096019   ⟹   ENSRNOP00000090070
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4149,400,808 - 149,492,500 (+)Ensembl
mRatBN7.2 Ensembl4147,718,752 - 147,924,709 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099380   ⟹   ENSRNOP00000088044
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4149,391,390 - 149,598,319 (+)Ensembl
mRatBN7.2 Ensembl4147,718,752 - 147,924,887 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000104390   ⟹   ENSRNOP00000079344
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4149,391,390 - 149,481,262 (+)Ensembl
mRatBN7.2 Ensembl4147,718,752 - 147,841,307 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000109260   ⟹   ENSRNOP00000091777
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4149,391,390 - 149,598,257 (+)Ensembl
mRatBN7.2 Ensembl4147,747,009 - 147,925,593 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118521   ⟹   ENSRNOP00000091824
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4149,391,390 - 149,519,766 (+)Ensembl
mRatBN7.2 Ensembl4147,718,754 - 147,846,524 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000129687   ⟹   ENSRNOP00000111772
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4149,400,757 - 149,598,257 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000150233   ⟹   ENSRNOP00000103259
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4149,400,702 - 149,598,257 (+)Ensembl
RefSeq Acc Id: NM_001012097   ⟹   NP_001012097
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84149,419,650 - 149,597,534 (+)NCBI
mRatBN7.24147,747,014 - 147,924,905 (+)NCBI
Rnor_6.04146,598,416 - 146,776,407 (+)NCBI
Rnor_5.04209,861,459 - 210,067,618 (+)NCBI
RGSC_v3.44150,814,706 - 150,992,704 (+)RGD
Celera4136,643,475 - 136,821,326 (+)RGD
Sequence:
RefSeq Acc Id: XM_008763239   ⟹   XP_008761461
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84149,390,000 - 149,536,781 (+)NCBI
mRatBN7.24147,718,663 - 147,859,190 (+)NCBI
Rnor_6.04146,570,113 - 146,698,968 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063286089   ⟹   XP_063142159
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84149,390,000 - 149,597,534 (+)NCBI
RefSeq Acc Id: XR_005503229
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84149,419,646 - 149,597,534 (+)NCBI
mRatBN7.24147,747,010 - 147,925,656 (+)NCBI
RefSeq Acc Id: XR_010065647
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84149,419,646 - 149,597,534 (+)NCBI
RefSeq Acc Id: NP_001012097   ⟸   NM_001012097
- UniProtKB: Q641Y5 (UniProtKB/Swiss-Prot),   A6IKX0 (UniProtKB/TrEMBL),   A0A8L2QWN0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008761461   ⟸   XM_008763239
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AGV7 (UniProtKB/TrEMBL),   A0A8I6G565 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000063617   ⟸   ENSRNOT00000067532
Ensembl Acc Id: ENSRNOP00000088044   ⟸   ENSRNOT00000099380
Ensembl Acc Id: ENSRNOP00000091366   ⟸   ENSRNOT00000095118
Ensembl Acc Id: ENSRNOP00000090070   ⟸   ENSRNOT00000096019
Ensembl Acc Id: ENSRNOP00000091777   ⟸   ENSRNOT00000109260
Ensembl Acc Id: ENSRNOP00000079344   ⟸   ENSRNOT00000104390
Ensembl Acc Id: ENSRNOP00000091824   ⟸   ENSRNOT00000118521
RefSeq Acc Id: XP_063142159   ⟸   XM_063286089
- Peptide Label: isoform X2
- UniProtKB: Q641Y5 (UniProtKB/Swiss-Prot),   A6IKX0 (UniProtKB/TrEMBL),   A0A8L2QWN0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000111772   ⟸   ENSRNOT00000129687
Ensembl Acc Id: ENSRNOP00000103259   ⟸   ENSRNOT00000150233
Protein Domains
THIF-type NAD/FAD binding fold   Ubiquitin-like modifier-activating enzyme Atg7 N-

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q641Y5-F1-model_v2 AlphaFold Q641Y5 1-698 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304817 AgrOrtholog
BioCyc Gene G2FUF-43337 BioCyc
BioCyc Pathway PWY-7511 [protein ubiquitination] BioCyc
BioCyc Pathway Image PWY-7511 BioCyc
Ensembl Genes ENSRNOG00000007486 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000118521 ENTREZGENE
  ENSRNOT00000150233 ENTREZGENE
Gene3D-CATH 3.40.140.100 UniProtKB/Swiss-Prot
  3.40.140.70 UniProtKB/Swiss-Prot
  NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7132421 IMAGE-MGC_LOAD
InterPro Atg7 UniProtKB/Swiss-Prot
  Atg7_N UniProtKB/Swiss-Prot
  Atg7_N_1 UniProtKB/Swiss-Prot
  Atg7_N_2 UniProtKB/Swiss-Prot
  ThiF/MoeB/HesA UniProtKB/Swiss-Prot
  ThiF_NAD_FAD-bd UniProtKB/Swiss-Prot
  Ubiquitin-activating_enz UniProtKB/Swiss-Prot
KEGG Report rno:312647 UniProtKB/Swiss-Prot
MGC_CLONE MGC:95213 IMAGE-MGC_LOAD
NCBI Gene 312647 ENTREZGENE
PANTHER PTHR10953 UniProtKB/Swiss-Prot
  UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7 UniProtKB/Swiss-Prot
Pfam ATG7_N UniProtKB/Swiss-Prot
  ThiF UniProtKB/Swiss-Prot
PhenoGen Atg7 PhenoGen
RatGTEx ENSRNOG00000007486 RatGTEx
Superfamily-SCOP SSF69572 UniProtKB/Swiss-Prot
UniProt A0A8I6ABP9_RAT UniProtKB/TrEMBL
  A0A8I6AFU8_RAT UniProtKB/TrEMBL
  A0A8I6AGV7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G565 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GGN5_RAT UniProtKB/TrEMBL
  A0A8I6GJJ9_RAT UniProtKB/TrEMBL
  A0A8L2QWN0 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LRZ7_RAT UniProtKB/TrEMBL
  A0ABK0M775_RAT UniProtKB/TrEMBL
  A6IKX0 ENTREZGENE, UniProtKB/TrEMBL
  ATG7_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-06-07 Atg7  autophagy related 7  Atg7  ATG7 autophagy related 7 homolog (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-06-07 Atg7  autophagy related 7  Atg7  autophagy related 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-06-27 Atg7  ATG7 autophagy related 7 homolog (S. cerevisiae)  Atg7  autophagy related 7 homolog (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-12 Atg7  autophagy related 7 homolog (S. cerevisiae)  Atg7  autophagy-related 7 (yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Atg7  autophagy-related 7 (yeast)  Apg7l  autophagy 7-like (S. cerevisiae)  Symbol and Name updated 1299863 APPROVED
2005-12-06 Apg7l  autophagy 7-like (S. cerevisiae)  Apg7l_predicted  autophagy 7-like (S. cerevisiae) (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Apg7l_predicted  autophagy 7-like (S. cerevisiae) (predicted)      Symbol and Name status set to approved 70820 APPROVED