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Gene: Klhl9 (kelch-like family member 9) Rattus norvegicus

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Symbol:

Klhl9

Name:

kelch-like family member 9

RGD ID:

1304814

Description:

Orthologous to human KLHL9 (kelch like family member 9); PARTICIPATES IN ubiquitin/proteasome degradation pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

kelch-like 9; kelch-like 9 (Drosophila); kelch-like protein 9; LOC313348; RGD1304814; similar to Hypothetical protein KIAA1354

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	KLHL9 (kelch like family member 9)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Klhl9 (kelch-like 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Klhl9 (kelch like family member 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	KLHL9 (kelch like family member 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	KLHL9 (kelch like family member 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Klhl9 (kelch like family member 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	KLHL9 (kelch like family member 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	KLHL9 (kelch like family member 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Klhl9 (kelch like family member 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Klhl9 (kelch like family member 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	KLHL9 (kelch like family member 9)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	KLHL9 (kelch like family member 9)	Alliance	DIOPT (HGNC)
Mus musculus (house mouse):	Klhl9 (kelch-like 9)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	klhl13 (kelch-like family member 13)	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	klhl13	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	108,449,492 - 108,453,676 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	108,437,583 - 108,454,140 (-)	Ensembl				GRCr8
mRatBN7.2	5	103,333,747 - 103,337,931 (-)	NCBI	mRatBN7.2	mRatBN7.2
UTH_Rnor_SHR_Utx	5	105,682,082 - 105,686,266 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	107,472,529 - 107,476,713 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	107,540,336 - 107,544,540 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	107,323,258 - 107,327,442 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	107,323,258 - 107,327,442 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	111,299,120 - 111,303,304 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	108,196,981 - 108,201,165 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	102,067,020 - 102,071,204 (-)	NCBI		Celera
RGSC_v3.1	5	108,203,022 - 108,206,163 (-)	NCBI
Cytogenetic Map	5	q32	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-methylcholine (ISO)

2-palmitoylglycerol (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

5-fluorouracil (ISO)

all-trans-retinoic acid (ISO)

antimycin A (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

avobenzone (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

captan (ISO)

CGP 52608 (ISO)

cisplatin (EXP)

cobalt dichloride (ISO)

copper atom (ISO)

copper(0) (ISO)

crocidolite asbestos (ISO)

dexamethasone (ISO)

Dibutyl phosphate (ISO)

dicrotophos (ISO)

elemental selenium (ISO)

fenthion (ISO)

folic acid (ISO)

folpet (ISO)

glyphosate (EXP)

hydralazine (ISO)

indometacin (ISO)

ketamine (EXP)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

methapyrilene (EXP)

methidathion (ISO)

methylmercury chloride (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

quercetin (ISO)

rimonabant (ISO)

rotenone (ISO)

selenium atom (ISO)

sodium arsenite (ISO)

sodium dichromate (ISO)

tebufenpyrad (ISO)

temozolomide (ISO)

titanium dioxide (ISO)

tributylstannane (EXP)

trichloroethene (EXP,ISO)

triphenyl phosphate (ISO)

urethane (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vitamin E (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell division (IEA)

protein ubiquitination (IEA,ISO)

regulation of cytokinesis (IEA,ISO)

Cellular Component

Cul3-RING ubiquitin ligase complex (IEA,ISO)

cytosol (IEA)

midbody (ISO)

Molecular Function

cullin family protein binding (ISO)

protein binding (ISO)

ubiquitin-protein transferase activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

ubiquitin/proteasome degradation pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
3.	GOA pipeline	RGD automated data pipeline
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:14528312	PMID:17543862	PMID:19995937

Genomics

Comparative Map Data

Klhl9
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	108,449,492 - 108,453,676 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	108,437,583 - 108,454,140 (-)	Ensembl				GRCr8
mRatBN7.2	5	103,333,747 - 103,337,931 (-)	NCBI	mRatBN7.2	mRatBN7.2
UTH_Rnor_SHR_Utx	5	105,682,082 - 105,686,266 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	107,472,529 - 107,476,713 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	107,540,336 - 107,544,540 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	107,323,258 - 107,327,442 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	107,323,258 - 107,327,442 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	111,299,120 - 111,303,304 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	108,196,981 - 108,201,165 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	102,067,020 - 102,071,204 (-)	NCBI		Celera
RGSC_v3.1	5	108,203,022 - 108,206,163 (-)	NCBI
Cytogenetic Map	5	q32	NCBI

KLHL9
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	21,329,665 - 21,335,404 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	21,320,024 - 21,335,404 (-)	Ensembl			hg38	GRCh38
GRCh37	9	21,329,664 - 21,335,403 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	21,321,018 - 21,325,429 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	9	21,321,019 - 21,325,371	NCBI
Celera	9	21,269,331 - 21,273,742 (-)	NCBI		Celera
Cytogenetic Map	9	p21.3	NCBI
HuRef	9	21,294,476 - 21,298,889 (-)	NCBI		HuRef
CHM1_1	9	21,330,834 - 21,335,247 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	9	21,343,833 - 21,349,574 (-)	NCBI		T2T-CHM13v2.0

Klhl9
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	88,636,529 - 88,640,745 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	88,636,529 - 88,640,702 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	4	88,718,292 - 88,722,508 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	88,718,292 - 88,722,465 (-)	Ensembl			mm10	GRCm38
MGSCv37	4	88,364,196 - 88,368,412 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	4	88,190,813 - 88,193,692 (-)	NCBI		MGSCv36	mm8
Celera	4	87,227,411 - 87,231,634 (-)	NCBI		Celera
Cytogenetic Map	4	C4	NCBI
cM Map	4	42.02	NCBI

Klhl9
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955472	12,851,352 - 12,854,245 (-)	NCBI	ChiLan1.0	ChiLan1.0

KLHL9
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	103,197,022 - 103,201,449 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	103,202,967 - 103,207,394 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	21,191,847 - 21,196,242 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	21,809,412 - 21,813,812 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	21,811,230 - 21,813,251 (-)	Ensembl			panPan2	panpan1.1

KLHL9
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	11	40,792,064 - 40,796,433 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	11	40,792,603 - 40,794,456 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	11	39,465,303 - 39,469,495 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	11	41,735,006 - 41,739,198 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
UMICH_Zoey_3.1	11	40,414,965 - 40,419,157 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	11	40,292,449 - 40,296,641 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	11	40,906,715 - 40,910,907 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Klhl9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	155,196,833 - 155,201,259 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936652	2,866,340 - 2,870,759 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

KLHL9
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	201,585,965 - 201,591,830 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	1	201,587,241 - 201,591,830 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	224,955,237 - 224,959,819 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

KLHL9
(Chlorocebus sabaeus - green monkey)

No map positions available.

Klhl9
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624736	25,158,528 - 25,160,381 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624736	25,156,647 - 25,160,895 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Klhl9
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	1	65,553,036 - 65,557,288 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Klhl9
22 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	172
Count of miRNA genes:	127
Interacting mature miRNAs:	141
Transcripts:	ENSRNOT00000008510
Prediction methods:	Miranda
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331796	Thshl2	Thyroid stimulating hormone level QTL 2	2.3		blood thyroid-stimulating hormone amount (VT:0005119)	serum thyroid stimulating hormone level (CMO:0001248)	5	102105698	152749382	Rat
1357396	Bw44	Body weight QTL 44	4.19		body mass (VT:0001259)	body weight (CMO:0000012)	5	73779642	118779642	Rat
2303586	Gluco52	Glucose level QTL 52	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	100826632	145826632	Rat
1549845	Scl44	Serum cholesterol level QTL 44	6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	44924861	153890773	Rat
70212	Niddm25	Non-insulin dependent diabetes mellitus QTL 25	3.54		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	38207390	136631402	Rat
1298070	Scl18	Serum cholesterol level QTL 18	3.7		blood LDL cholesterol amount (VT:0000181)	calculated plasma low density lipoprotein cholesterol level (CMO:0001245)	5	84630798	129630798	Rat
61452	Ciaa5	CIA Autoantibody QTL 5	3.5		blood autoantibody amount (VT:0003725)	calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)	5	99905133	172190305	Rat
1331801	Rf33	Renal function QTL 33	4.149		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	5	48523123	134369373	Rat
2302381	Bw84	Body weight QTL 84	4.47		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	5	73779642	118779642	Rat
1357402	Bw46	Body weight QTL 46	4.47		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	5	73779642	118779642	Rat
7411582	Foco3	Food consumption QTL 3	7.5	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	5	92583776	137583776	Rat
61393	Bp7	Blood pressure QTL 7	4.5	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	65089051	166764498	Rat
1598859	Cm66	Cardiac mass QTL 66	2		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	84630798	129630798	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	51657967	166600247	Rat
1582212	Livw2	Liver weight QTL 2	3.5	0.0004	liver mass (VT:0003402)	liver weight to body weight ratio (CMO:0000633)	5	104018576	124314782	Rat
7411564	Bw135	Body weight QTL 135		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	92583776	137583776	Rat
8657050	Bw146	Body weight QTL 146	19.84	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	98972960	143972960	Rat
1576312	Emca8	Estrogen-induced mammary cancer QTL 8	4.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	55124766	172190305	Rat
7411601	Foco12	Food consumption QTL 12	19.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	5	92583776	137583776	Rat
2303618	Vencon1	Ventilatory control QTL 1	3.8		respiration trait (VT:0001943)	oxygen consumption (CMO:0002169)	5	100826632	145826632	Rat
7394708	Emca11	Estrogen-induced mammary cancer QTL 11			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	73176602	118176602	Rat
1598846	Bp293	Blood pressure QTL 293	3.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	84630798	129630798	Rat
7394710	Emca12	Estrogen-induced mammary cancer QTL 12			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	94034903	139034903	Rat
1578673	Bmd13	Bone mineral density QTL 13	4.9		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	5	69474415	114474415	Rat
1358909	Kidm25	Kidney mass QTL 25	1.87		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	5	95062526	133270832	Rat
70189	Mcs5	Mammary carcinoma susceptibility QTL 5	10.51		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	60601597	137492949	Rat
1600362	Mcs19	Mammary carcinoma susceptibility QTL 19	2.5		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	82032155	127032155	Rat
1354598	Srn6	Serum renin concentration QTL 6	3.8		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	5	74335621	156302135	Rat
2290448	Scl54	Serum cholesterol level QTL 54	2.93		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	36460764	136631402	Rat
61426	Scl2	Serum cholesterol level QTL 2	7.3	0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	64589016	109589016	Rat
1298086	Bp156	Blood pressure QTL 156			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	89369373	134369373	Rat
2290005	Mcs24	Mammary carcinoma susceptibility QTL 24			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	69835120	114835120	Rat
2306971	Anxrr21	Anxiety related response QTL 21	9.47		fear/anxiety-related behavior trait (VT:1000241)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	5	70969494	136328156	Rat
1358895	Bp254	Blood pressure QTL 254	3.6	0.0003	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	5	97492524	133270832	Rat
2312671	Scl64	Serum cholesterol level QTL 64		0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	73779642	118779642	Rat
1358889	Bp261	Blood pressure QTL 261	2.86		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	5	95062526	133270832	Rat
6903316	Bw113	Body weight QTL 113	2	0.0103	body mass (VT:0001259)	body weight (CMO:0000012)	5	92881678	137881678	Rat
1358187	Emca1	Estrogen-induced mammary cancer QTL 1	4.4		mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	5	104262817	153890625	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001107944	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC168717	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473998	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000008510 ⟹ ENSRNOP00000061990

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	5	107,323,258 - 107,327,442 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000121693 ⟹ ENSRNOP00000102302

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	108,437,583 - 108,454,140 (-)	Ensembl

RefSeq Acc Id:

NM_001107944 ⟹ NP_001101414

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	108,449,492 - 108,453,676 (-)	NCBI
mRatBN7.2	5	103,333,747 - 103,337,931 (-)	NCBI
Rnor_6.0	5	107,323,258 - 107,327,442 (+)	NCBI
Rnor_5.0	5	111,299,120 - 111,303,304 (+)	NCBI
RGSC_v3.4	5	108,196,981 - 108,201,165 (-)	RGD
Celera	5	102,067,020 - 102,071,204 (-)	RGD

Sequence:

show sequence

TCCGGAAGGTCGAGCTGGGCGTCGGTGCTAGGCCGCCGTTCTAGGCCCAAGTCGGAATTCCAGG
CCCTGCTCCAAGCCAAGCCGGTGGCCGCAGAGACACATCGAAGACCGCAGAAGTCGCAGCCGCA
GCTCGCTGAGGTGCTGAACCTTGGAGGGCGGCAGCCCGGGTGCGCAGGCCGTGACGGCCCCTCC
CCCACCCTGAGCGCAGCGGCGAAGGACGACAACCCGGGCCGGACGAGGTGAAGCGGTCACGTAA
CTGCCTCAGGTGATGACTCACCGACTCTACTGTCAGATTTGACGTGCGTGGTGCTGCTGCAGGG
CGGACGTCGGTGTGCCCAGTGCGGTGCTGCGGCGACCGCTTGCCTGTTCGGCGGCCCTGCGTTT
CCCCAGAGCGTTCTCTTTGTAACGTCTGCGGCCTGCAGCTTGCTGCGAGCTCCGGGTTCTCCCA
TGAAGGTGTCGCTCGGTAACGGCGAGATGGGCGTCTCTGCCCACCTGCAGCCTTGCAAGGCTGG
AACTACGCGGTTTTTTACCAGCAATACGCACAGTTCTGTTGTATTGCAAGGCTTTGATCAGCTC
AGAATAGAGGGACTGCTTTGTGACGTGACTCTGGTACCAGGCGATGGAGAGGAAATCTTCCCAG
TTCATAGAGCCATGATGGCGTCTGCCAGTGATTATTTCAAGGCCATGTTCACAGGAGGAATGAA
GGAGAAAGATCTAATGTGCATTAAGCTTCATGGGGTGAACAAAGTTGGTCTGAAGAAAATCATT
GATTTTATTTATACTGCAAAACTCTCTCTCAATATGGACAATCTTCAGGATACTCTTGAGGCTG
CCAGCTTTCTACAGATCTTGCCGGTTTTGGATTTTTGTAAAGTATTTCTTATATCTGGTGTCTC
CTTAGATAACTGTGTTGAGGTTGGACGGATTGCTAACACCTACAATCTTATAGAAGTGGATAAA
TACGTAAATAATTTCATCCTGAAGAACTTTCCTGCCTTGTTGAGTACCGGGGAGTTTCTAAAAC
TCCCCTTTGAACGGCTTGCCTTTGTGCTTTCCAGCAATAGTCTCAAGCACTGTTCTGAACTTGA
ACTCTTCAAGGCAGCCTGCCGCTGGTTGAGGCTGGAAGACCCTCGGATGGACTATGCTGCAAAA
TTAATGAAGAATATTCGCTTCCCACTGATGACGCCACAGGATCTCATCAACTATGTGCAGACAG
TAGATTTCATGAGAACTGACAATACCTGTGTGAATTTACTTTTGGAAGCAAGCAATTACCAAAT
GATGCCATATATGCAGCCAGTGATGCAGTCAGACAGAACTGCCATTCGATCAGATTCTACTCAT
TTGGTTACGTTAGGAGGAGTTTTGAGGCAACAGCTGGTTGTAAGTAAAGAGTTACGGATGTACG
ACGAAAGGGCGCAGGAGTGGAAATCGTTAGCCCCTATGGATGCTCCTCGATACCAGCACGGCAT
TGCTGTTATTGGAAACTTCCTTTATGTAGTTGGTGGTCAGAGTAATTATGACACAAAAGGAAAA
ACTGCTGTTGATACAGTCTTCAGATTTGATCCTCGTTATAATAAGTGGATGCAGGTGGCATCAT
TAAACGAAAAGCGCACATTTTTTCACCTGAGTGCACTCAAAGGACATTTATATGCAGTTGGTGG
ACGCAGTGCAGCTGGTGAACTGGCCACAGTAGAATGTTACAACCCAAGAATGAATGAATGGAGC
TATGTTGCAAAAATGAGTGAACCCCACTATGGCCATGCTGGAACAGTATATGGGGGTTTAATGT
ATATATCCGGAGGAATTACCCATGACACTTTCCAAAATGAGCTCATGTGTTTTGACCCAGATAC
AGACAAATGGACACAGAAGGCTCCTATGACTACAGTCCGAGGTCTGCATTGCATGTGTACAGTT
GGAGACAAGCTGTATGTCATTGGTGGCAACCATTTCAGAGGAACAAGTGATTATGATGATGTCC
TAAGCTGCGAATACTATTCGCCAACTCTTGACCAGTGGACACCAATTGCTGCTATGCTAAGAGG
TCAGAGTGATGTTGGAGTTGCGGTCTTCGAAAACAAAATCTACGTTGTTGGTGGATATTCTTGG
AATAACCGCTGCATGGTAGAAATTGTCCAGAAATATGACCCAGAAAAAGATGAGTGGCATAAAG
TTTTTGATCTTCCAGAGTCACTTGGTGGCATTCGGGCTTGCACTCTCACAGTTTTTCCACCTGA
AGAAAACCCTGGGTCACCTTCTAGAGAATCACCTCTTTCAGCACCTTCAGATCATTCTTAGATT
CAAGGTGTAATACCTTTTCAGTGTATCAGGGATGGTGTTGTACTTCCCCTTCAATTGTCTCTCC
TTATTGCTACAGTTAATAGACAAAAAGGTAACTTAGGTTTTTTTTTTTGTTGTTGTTTGTTTGG
CTTCAAATTGTTTATTAGATGGCTAACAAGTGCATTTTGAAAAGTATTAAATATATTCAGCTGT
TTAACAAGTGAAAAAGATACATAGAAAATTAGATGTTTTTTGTAGTGTTACATATGTCAAATTG
TAGATCATAGTAAATGTGTAATGATGTCTATTATACTAAAAAATTGAAACATTTGATTTGACTG
AAACATTAAGTGGAGGCCCCTGTTCTAATCTAGAATAAAGATTGCCAGGTACCGCTACCTCCCT
CTTGGATAGTTTTGGACAATCTGTTAAACTAGGCTGTGTGATTAGTCTTAGAATATTTGAAGTT
TCTTAGGTAGTCAGAAATAGTGACAAAATTAGCGAGAAGAAACAGGTCAGGATTTGTTATCACT
GGAGGAAAAATAATAGATGTGTACACTAGTCAGATACACTCACACAAAACTTTGTGTGTACATA
TATATAAACTTTTAGACTTGGTAAAAACTTCAATTGTAGTGAAAATGACCTTATATTTTCTTCC
AGAAAGCAGCTAATTTTATTTCAATGAAAATTCAATACCAGAGAGTCCATGTCTAAAGTCTTAT
ACAGAATTTAGATGCTAAGGGCTACAACAAACTAAATTGACAGCCAAATTTGTCATTTAATGGA
ATCGTTTCTTTAAATAAAATTTAATTAGTTTTTCTGTATATTCTGTAGTTACATGCCTATAGAT
TATTTAGCAGAAGGCAAGTTTAGATTTTTTTTATCATTAACTTTTTAACCTGTGAAATTCAGGA
GTTAAGGAAGGCAAAGAAGCATTTTCAACAAAGCTCCGGGATTTTAAGTTTAGTCCTGCCTTAG
TCTCTCTGACCTGTTTATTATGTGATTTTGAGTGATTTCTGGTGCTGCTGTAGCTGGTAAGCAT
CCAGTAATGTGTGAGCTGCCTCAAGGCTGTGATCTGAGCAAACAGAGACACACCCTGTTCTGCA
TCTAATCAGAAATAGGCCTTTTTAGCCTTGACTCAAGGATAGAACCAACTTCAGGTCCTCTAAG
AAGTCAGCTGGTTTCTTTAAGGCCGTGCTTTAGTAGGTAGACCTTCAGTCTTCATTACTGTGGG
AATACTTTCTGACTGAGAATTACTGGGGAAAATCTTACAGGGAACTTATCAGATAAATGGAATT
ACAATGTCCCTTGGTAATGAGTGATACTGAATATGTACTTTCCTGGGAAAATTGTTCAACTGAA
GGAAAAAATAGACACACACACACACACACACACACACACACACACACACACACACGCATGTCTA
GCCCTGACAGTGCCAGAGTGTAAATCAGGAGCAATGCCATTAACAGTCCTTTAATGTAATTCAA
AAGGATTTGGCTTCTGGCATCTGAACTTTACTTACTGCCCATACATACATGTGTTGATTCATTT
TAATGCTTTTCATGATTTCTTCATTAACAGAATTTTCATACTTTGTTTTTTTAAAATGACTCCA
TTTTTTTTTTTGTTGTTGTTGTTAACTTCAGACATATTTGAGTGCTTTTAGAAGTTAAGGTAAA
AATTGCTACTAACTTTGTGTATTGAATAAGCAAGCAAGAAATTGCATCCTGATTTTTTTTTCTT
TTTTATTAATAGTAAGGTTGAATACTTGTGTATTTTGAAAAGCTACATTTTCTCTTTGGTCAAA
TGTTAATGTCCTTGTGATATCTTTTGGAGTTGCTTTGTTTTTCATATCAAGTTACAGGATCTCT
TTATATAATAAAACTACTTAACCAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001101414	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI68717	(Get FASTA)	NCBI Sequence Viewer
	EDL97739	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000082058.1
	ENSRNOP00000102302
	ENSRNOP00000102302.1

RefSeq Acc Id:

NP_001101414 ⟸ NM_001107944

- UniProtKB:

B5DEL5 (UniProtKB/TrEMBL), A0A8I5ZU85 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MKVSLGNGEMGVSAHLQPCKAGTTRFFTSNTHSSVVLQGFDQLRIEGLLCDVTLVPGDGEEIFP
VHRAMMASASDYFKAMFTGGMKEKDLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEA
ASFLQILPVLDFCKVFLISGVSLDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLK
LPFERLAFVLSSNSLKHCSELELFKAACRWLRLEDPRMDYAAKLMKNIRFPLMTPQDLINYVQT
VDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDSTHLVTLGGVLRQQLVVSKELRMY
DERAQEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVAS
LNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTVYGGLM
YISGGITHDTFQNELMCFDPDTDKWTQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDV
LSCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEWHK
VFDLPESLGGIRACTLTVFPPEENPGSPSRESPLSAPSDHS

hide sequence

Ensembl Acc Id:

ENSRNOP00000061990 ⟸ ENSRNOT00000008510

Ensembl Acc Id:

ENSRNOP00000102302 ⟸ ENSRNOT00000121693

Protein Domains

BTB

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-B5DEL5-F1-model_v2	AlphaFold	B5DEL5	1-617	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13693830

Promoter ID:

EPDNEW_R4355

Type:

initiation region

Name:

Klhl9_1

Description:

kelch-like family member 9

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	5	107,323,255 - 107,323,315	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1304814	AgrOrtholog
BioCyc Gene	G2FUF-40807	BioCyc
Ensembl Genes	ENSRNOG00000006335	Ensembl
	ENSRNOG00000014029	UniProtKB/TrEMBL
	ENSRNOG00000081634	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000106563.2	UniProtKB/TrEMBL
	ENSRNOT00000121693	ENTREZGENE
	ENSRNOT00000121693.1	UniProtKB/TrEMBL
Gene3D-CATH	1.25.40.420	UniProtKB/TrEMBL
	2.120.10.80	UniProtKB/TrEMBL
	Potassium Channel Kv1.1, Chain A	UniProtKB/TrEMBL
InterPro	BACK	UniProtKB/TrEMBL
	BTB/POZ-like	UniProtKB/TrEMBL
	BTB/POZ_fold	UniProtKB/TrEMBL
	Kelch-like_gigaxonin	UniProtKB/TrEMBL
	Kelch-typ_b-propeller	UniProtKB/TrEMBL
	Kelch_1	UniProtKB/TrEMBL
KEGG Report	rno:313348	UniProtKB/TrEMBL
NCBI Gene	313348	ENTREZGENE
PANTHER	KELCH-LIKE PROTEIN 13	UniProtKB/TrEMBL
	KELCH-LIKE PROTEIN 9	UniProtKB/TrEMBL
	LD33804P	UniProtKB/TrEMBL
Pfam	BACK	UniProtKB/TrEMBL
	BTB	UniProtKB/TrEMBL
	Kelch_1	UniProtKB/TrEMBL
	Kelch_KLHDC2_KLHL20_DRC7	UniProtKB/TrEMBL
PhenoGen	Klhl9	PhenoGen
PIRSF	Kelch-like_protein_gigaxonin	UniProtKB/TrEMBL
PROSITE	BTB	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000006335	RatGTEx
	ENSRNOG00000014029	RatGTEx
	ENSRNOG00000081634	RatGTEx
SMART	BACK	UniProtKB/TrEMBL
	BTB	UniProtKB/TrEMBL
	Kelch	UniProtKB/TrEMBL
Superfamily-SCOP	BTB/POZ_fold	UniProtKB/TrEMBL
	SSF117281	UniProtKB/TrEMBL
UniProt	A0A8I5ZU85	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0L1R1_RAT	UniProtKB/TrEMBL
	B5DEL5	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-02-06	Klhl9	kelch-like family member 9	Klhl9	kelch-like 9 (Drosophila)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Klhl9	kelch-like 9 (Drosophila)	Klhl9_predicted	kelch-like 9 (Drosophila) (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-30	Klhl9_predicted	kelch-like 9 (Drosophila) (predicted)	RGD1304814_predicted	similar to Hypothetical protein KIAA1354 (predicted)	Symbol and Name updated	1299863	APPROVED
2005-01-20	RGD1304814_predicted	similar to Hypothetical protein KIAA1354 (predicted)	LOC313348_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC313348_predicted	similar to Hypothetical protein KIAA1354 (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)