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Gene: S1pr4 (sphingosine-1-phosphate receptor 4) Rattus norvegicus

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Symbol:

S1pr4

Name:

sphingosine-1-phosphate receptor 4

RGD ID:

1304801

Description:

Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be located in membrane and mitochondrion. Predicted to be active in cytoplasm; plasma membrane; and presynapse. Orthologous to human S1PR4 (sphingosine-1-phosphate receptor 4); PARTICIPATES IN sphingosine 1-phosphate signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; aldehydo-D-glucose.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

Edg6; endothelial differentiation, G-protein-coupled receptor 6; endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 6; LOC314649; sphingosine 1-phosphate receptor 4

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	S1PR4 (sphingosine-1-phosphate receptor 4)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	S1pr4 (sphingosine-1-phosphate receptor 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	S1pr4 (sphingosine-1-phosphate receptor 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	S1PR4 (sphingosine-1-phosphate receptor 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	S1PR4 (sphingosine-1-phosphate receptor 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	S1pr4 (sphingosine-1-phosphate receptor 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	S1PR4 (sphingosine-1-phosphate receptor 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	S1PR4 (sphingosine-1-phosphate receptor 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	S1pr4 (sphingosine-1-phosphate receptor 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	S1pr4 (sphingosine-1-phosphate receptor 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	CFL1 (cofilin 1)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	S1PR4 (sphingosine-1-phosphate receptor 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	S1PR4 (sphingosine-1-phosphate receptor 4)	Alliance	DIOPT (HGNC\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	S1pr4 (sphingosine-1-phosphate receptor 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	S1pr4 (sphingosine-1-phosphate receptor 4)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	s1pr4 (sphingosine-1-phosphate receptor 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	s1pr4	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	s1pr4	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	8,858,528 - 8,860,804 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	7	8,858,904 - 8,860,800 (+)	Ensembl				GRCr8
mRatBN7.2	7	8,207,767 - 8,210,043 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	8,208,098 - 8,211,893 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	7	11,093,800 - 11,096,076 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	12,969,283 - 12,971,559 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	10,836,403 - 10,838,679 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	11,077,411 - 11,079,687 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	11,077,411 - 11,079,687 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	7	11,244,600 - 11,246,876 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	7	9,691,709 - 9,693,985 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	7	6,398,295 - 6,400,571 (+)	NCBI		Celera
RGSC_v3.1	7	9,692,102 - 9,693,986 (+)	NCBI
Cytogenetic Map	7	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Experimental Diabetes Mellitus (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dichloroethane (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

acetamide (EXP)

aflatoxin B1 (ISO)

aldehydo-D-glucose (EXP)

alpha-Zearalanol (EXP)

antirheumatic drug (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

C60 fullerene (EXP)

cadmium dichloride (EXP)

chlorpyrifos (ISO)

cisplatin (ISO)

D-glucose (EXP)

Dibutyl phosphate (ISO)

dimethylarsinic acid (ISO)

dioxygen (EXP,ISO)

folic acid (ISO)

glucose (EXP)

GSK-J4 (ISO)

methylarsonic acid (ISO)

nitrates (ISO)

ozone (ISO)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

streptozocin (EXP)

thioacetamide (EXP)

triphenyl phosphate (ISO)

valproic acid (ISO)

vanadium atom (ISO)

vanadium(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adenylate cyclase-activating G protein-coupled receptor signaling pathway (IBA,ISO)

G protein-coupled receptor signaling pathway (IEA,ISO)

signal transduction (IEA)

sphingosine-1-phosphate receptor signaling pathway (IEA,ISO)

Cellular Component

cytoplasm (IBA)

membrane (IEA)

mitochondrion (IEA,ISO)

plasma membrane (IBA,IEA)

presynapse (IEA,ISO)

Molecular Function

G protein-coupled receptor activity (IBA,IEA)

protein binding (ISO)

sphingosine-1-phosphate receptor activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

sphingosine 1-phosphate signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:11443127

Genomics

Comparative Map Data

S1pr4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	8,858,528 - 8,860,804 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	7	8,858,904 - 8,860,800 (+)	Ensembl				GRCr8
mRatBN7.2	7	8,207,767 - 8,210,043 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	8,208,098 - 8,211,893 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	7	11,093,800 - 11,096,076 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	12,969,283 - 12,971,559 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	10,836,403 - 10,838,679 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	11,077,411 - 11,079,687 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	11,077,411 - 11,079,687 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	7	11,244,600 - 11,246,876 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	7	9,691,709 - 9,693,985 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	7	6,398,295 - 6,400,571 (+)	NCBI		Celera
RGSC_v3.1	7	9,692,102 - 9,693,986 (+)	NCBI
Cytogenetic Map	7	q11	NCBI

S1PR4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	3,178,769 - 3,180,332 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	3,172,346 - 3,180,332 (+)	Ensembl			hg38	GRCh38
GRCh37	19	3,178,767 - 3,180,330 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	3,129,766 - 3,131,330 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	19	3,129,769 - 3,131,329	NCBI
Celera	19	3,115,117 - 3,116,711 (+)	NCBI		Celera
Cytogenetic Map	19	p13.3	NCBI
HuRef	19	2,945,831 - 2,947,425 (+)	NCBI		HuRef
CHM1_1	19	3,177,385 - 3,178,979 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	19	3,153,597 - 3,155,160 (+)	NCBI		T2T-CHM13v2.0

S1pr4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	81,333,579 - 81,335,971 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	81,333,581 - 81,335,966 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	10	81,497,745 - 81,500,137 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	81,497,747 - 81,500,132 (-)	Ensembl			mm10	GRCm38
MGSCv37	10	80,960,490 - 80,962,882 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	10	80,901,607 - 80,903,266 (-)	NCBI		MGSCv36	mm8
Celera	10	82,521,128 - 82,523,520 (-)	NCBI		Celera
Cytogenetic Map	10	C1	NCBI
cM Map	10	39.72	NCBI

S1pr4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955495	5,244,696 - 5,245,862 (-)	Ensembl
ChiLan1.0	NW_004955495	5,243,797 - 5,247,649 (-)	NCBI	ChiLan1.0	ChiLan1.0

S1PR4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	7,574,296 - 7,580,347 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	6,807,547 - 6,813,592 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	2,204,305 - 2,206,243 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	3,158,932 - 3,160,526 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2

S1PR4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	56,108,967 - 56,110,281 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	56,109,058 - 56,110,209 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	55,832,774 - 55,834,110 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	56,767,353 - 56,768,955 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	56,767,763 - 56,768,914 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	55,823,018 - 55,824,354 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	56,307,095 - 56,308,431 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	56,505,855 - 56,507,191 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

S1pr4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	216,011,722 - 216,013,083 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936588	1,821,721 - 1,822,872 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936588	1,821,654 - 1,822,872 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

S1PR4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	75,394,740 - 75,398,169 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	2	75,394,737 - 75,399,914 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	75,913,339 - 75,917,098 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

S1PR4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	2,941,446 - 2,943,452 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	2,941,901 - 2,943,055 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666081	5,637,197 - 5,640,577 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

S1pr4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624828	6,039,778 - 6,040,941 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624828	6,038,527 - 6,041,024 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

S1pr4
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	1	153,389,258 - 153,391,160 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in S1pr4
6 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	98
Count of miRNA genes:	76
Interacting mature miRNAs:	87
Transcripts:	ENSRNOT00000007117
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61410	Bw19	Body weight QTL 19	6.2	0.001	body mass (VT:0001259)	body weight (CMO:0000012)	7	1669658	46669658	Rat
1300176	Hrtrt10	Heart rate QTL 10	3.19		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	7	1	23748937	Rat
9590102	Sffal5	Serum free fatty acids level QTL 5	8.62	0.001	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	7	7216097	52216097	Rat
2290372	Gluco33	Glucose level QTL 33	2.71		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	7	1	31777942	Rat
1300149	Cm6	Cardiac mass QTL 6	4.09		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	7	1	104117804	Rat
631503	Bp102	Blood pressure QTL 102	1.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	1709527	46709527	Rat
634336	Anxrr17	Anxiety related response QTL 17	3.66		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	1509236	116977875	Rat
9590142	Scort5	Serum corticosterone level QTL 5	24.4	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	7	1	32612984	Rat
1582260	Bw72	Body weight QTL 72	3.2	0.0043	body mass (VT:0001259)	body weight (CMO:0000012)	7	1	39960528	Rat
1582261	Bw69	Body weight QTL 69	3.2	0.0048	body mass (VT:0001259)	body weight (CMO:0000012)	7	1	39960528	Rat
1582262	Bw75	Body weight QTL 75	3	0.0038	body mass (VT:0001259)	body weight (CMO:0000012)	7	1	39960528	Rat
2298550	Neuinf6	Neuroinflammation QTL 6	3.3		nervous system integrity trait (VT:0010566)	spinal cord RT1-B protein level (CMO:0002132)	7	1	29716167	Rat
724560	Plsm3	Polydactyly-luxate syndrome (PLS) morphotypes QTL 3		0.0003	tibia length (VT:0004357)	tibia length (CMO:0000450)	7	1	34650782	Rat
7411566	Bw136	Body weight QTL 136	10.4	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	7	1	32612984	Rat

Markers in Region

UniSTS:495940

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	8,208,768 - 8,208,862 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	11,078,413 - 11,078,506	NCBI	Rnor6.0
Rnor_5.0	7	11,245,602 - 11,245,695	UniSTS	Rnor5.0
RGSC_v3.4	7	9,692,711 - 9,692,804	UniSTS	RGSC3.4
Celera	7	6,399,297 - 6,399,390	UniSTS
Cytogenetic Map	7	q11	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	156	91	90	59	92	59	6	355	192	11	129	80	92	31	15	15

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001108075	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC127191	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474029	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000007117 ⟹ ENSRNOP00000007117

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	8,858,904 - 8,860,800 (+)	Ensembl
mRatBN7.2 Ensembl	7	8,208,098 - 8,211,893 (+)	Ensembl
Rnor_6.0 Ensembl	7	11,077,411 - 11,079,687 (+)	Ensembl

RefSeq Acc Id:

NM_001108075 ⟹ NP_001101545

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	8,858,528 - 8,860,804 (+)	NCBI
mRatBN7.2	7	8,207,767 - 8,210,043 (+)	NCBI
Rnor_6.0	7	11,077,411 - 11,079,687 (+)	NCBI
Rnor_5.0	7	11,244,600 - 11,246,876 (+)	NCBI
RGSC_v3.4	7	9,691,709 - 9,693,985 (+)	RGD
Celera	7	6,398,295 - 6,400,571 (+)	RGD

Sequence:

show sequence

CTTCCTGTGTACAGTTGACAAACATTTATTAGGTACCTGCTGTATATAAGCATGCTTGGAACGG
TTAGGCACAAGGAGGTGGGCGGAGGGGTTCTTGGGACCGGAGCAGGTGCCAGGTGATGCCCATT
GTCCAATAGTGACATCCCATCTAGTGCTCTGACTCCCATCCAAGGACAGCAATTCAGGCAGGGT
GGGGTGCCCAGAGGAGTCGTCCTCTCCAAGCCCCCAGAGTCACTCCAACGGTTGCTCAGATGCC
CCTCCCTGCCCTGGCCTCGCCCCCACCCACTCTGGGGCACCTTGAGCATAACAGGAAATGTCAA
ACAACAGGAAACCCAGGCCAGGCTGTGACTCCACCCTGCCGGGGGCCGCTCTCAGTCTATCCCC
GGGGAAGGCCATGAACATCAGTACCTGGTCCACGCTAGTGACCCCAGAGTCCTGCCACCGACTG
GCGGCTAGCGGTCACAGCCTGCTCATCGTCCTGCACTACAATCACAGCGGCAGGCTGGCTAGCC
GTGGGGGCCCTGAGGACAATGGCGGGCTGGGGATGCTGCGGGGGCCGTCGGTGGCAGCGGGCTG
CCTGGTGGTGCTGGAAAACGCCATGGTGCTGGCTGCCATCGCCATCCACATGCGCTCACGGCGC
TGGGTGTACTACTGCCTCCTGAACATCACCCTGAGCGACCTGCTCACAGGCCTGGCCTACGTGG
TCAACGTGCTGCTGTCAGGAACTCGCACCTTCCAGCTGTCACCTGTGCACTGGTTCCTGCGGGA
GGGCCTGCTCTTCATGGCCCTGGCTGCGTCCACCTTCAGTCTCCTCTTCACAGCCGGCGAGCGC
TTCGCCACCATGGTGCGGGTGGCTGAGAGCGGGGCCACCAAGACCAGCCGTGTGTATGGCTGCA
TCGGTCTGTGCTGGCTGCTGGCAGCTACCCTGGGCCTGCTGCCCCTGCTGGGCTGGAACTGTGT
GTGCGCCTTCCAGCGCTGCTCTAGCCTGCTGCCCCTCTACTCCAAGGGCTATGTGCTCTTTTGT
GTGGTGGTCTTCGCCCTAATCCTAGTGACTATCCTGAGCCTCTACGGGGCCATCTTTAGGGTGG
TCCGAGCCAACGGGCAGAAGTCCCCGCGTCCTCCTGCCCGCCGCAAGTCCCGCAGGCTACTCAA
CACCGTGCTGATGATCTTGGTGGCTTTTGTGGTGTGCTGGGGTCCCCTGTTTGGCCTGCTCCTG
GCCGACATCTTTGGATCTAATGTCTGGGCCCAGGAGTACCTGCGCGGCATGGACTGGATCCTGG
CCCTAGCTGTGCTCAACTCAGCCATCAATCCTCTCATCTATTCCTTCCGCAGCCGTGAGGTGCA
GCACGCTGTGCTGACCTTCCTGTGCTGCGGCTGCCTCAGGTTAGGCCTGAGAGGCCCTGGAGAC
TGCCTGACCCGGATCACCGAGGCCCACTCTGGGGCATCCACCACTGACAGCTCGCTGAGGCCCA
GGGACAGTTTTCGGACTTCGAGGTCACTCAGCTTCAAGATGCGAGAGCCGCTGTCCAGCGTTTC
CAGCATCCGCAGCGCCTAGAGCTTGAACCAGCCGGTCGCCCACCGAGCAGGCCCTCCCAGGAGA
GGTGAGAAGGGACTGGACACAAGATCTTAGCCTGACAGTGATTGAGAACATGCCTGCAGGCCCC
GGGTTCCTTCCACGAAACTCCCCATGATGAATGTTTGGCAGGGAGTGGCCAGATCCAGATCCAG
TGAGTCTGGGCCTCGATGGGGCTCCCAGGCAGCAAAGGGGGTGTCCATGTCCGAGGCCATGGAC
GGGACAGGGCCTTACGGTTATTTCTTAGACACATGTGTGCTGTGACCAGGATGCTGTAACATGT
CTCTTGGTCACAGTGCTTTGGGGGTGTGTCACTGGCACACAGTGCTTTGGGAGTGTGCTGGGAT
GGGGTACACCTGCACCATTTGTTTGAAGACAACCTGATGTGTTGTAAGAACTACAGGAGGGGCT
GGGGGCACCCCAGTCTGTCATCCATTCCTCTTCTCAGTGACTTCCCCATTGGGACAAGCAACCT
GCCCCCATGGCCTCTCTCCTCCGGGTTCTCTATCTCTCTGTGGGGAGATAGACCCACCCACCCG
AGGTCTGGGGCAATCTCAACTGGTCATGTAACCCTACAGCCTCGCCCTTCCGGTTCTGAATCAC
CAAGATATGCTGTGACAGGAAGCTGTGGACTCTACCTTGTGACAGTACAGCTGCGAACCACACA
GGACTGTGTAAAATGCATTAAAATGAGTGAAACCCAC

hide sequence

Protein Sequences


Protein RefSeqs	NP_001101545	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL89144	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000007117
	ENSRNOP00000007117.5

RefSeq Acc Id:

NP_001101545 ⟸ NM_001108075

- UniProtKB:

A6K874 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSNNRKPRPGCDSTLPGAALSLSPGKAMNISTWSTLVTPESCHRLAASGHSLLIVLHYNHSGRL
ASRGGPEDNGGLGMLRGPSVAAGCLVVLENAMVLAAIAIHMRSRRWVYYCLLNITLSDLLTGLA
YVVNVLLSGTRTFQLSPVHWFLREGLLFMALAASTFSLLFTAGERFATMVRVAESGATKTSRVY
GCIGLCWLLAATLGLLPLLGWNCVCAFQRCSSLLPLYSKGYVLFCVVVFALILVTILSLYGAIF
RVVRANGQKSPRPPARRKSRRLLNTVLMILVAFVVCWGPLFGLLLADIFGSNVWAQEYLRGMDW
ILALAVLNSAINPLIYSFRSREVQHAVLTFLCCGCLRLGLRGPGDCLTRITEAHSGASTTDSSL
RPRDSFRTSRSLSFKMREPLSSVSSIRSA

hide sequence

Ensembl Acc Id:

ENSRNOP00000007117 ⟸ ENSRNOT00000007117

Protein Domains

G-protein coupled receptors family 1 profile

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4AEH8-F1-model_v2	AlphaFold	D4AEH8	1-413	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1304801	AgrOrtholog
BioCyc Gene	G2FUF-35037	BioCyc
Ensembl Genes	ENSRNOG00000005370	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000007117	ENTREZGENE
	ENSRNOT00000007117.6	UniProtKB/TrEMBL
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/TrEMBL
InterPro	7TM_GPCR_Rhodpsn	UniProtKB/TrEMBL
	EDG6_rcpt	UniProtKB/TrEMBL
	GPCR_Rhodpsn_supfam	UniProtKB/TrEMBL
	S1P_rcpt	UniProtKB/TrEMBL
KEGG Report	rno:314649	UniProtKB/TrEMBL
NCBI Gene	314649	ENTREZGENE
PANTHER	G-PROTEIN COUPLED RECEPTOR	UniProtKB/TrEMBL
Pfam	7tm_1	UniProtKB/TrEMBL
PhenoGen	S1pr4	PhenoGen
PRINTS	EDG6RECEPTOR	UniProtKB/TrEMBL
	GPCRRHODOPSN	UniProtKB/TrEMBL
	S1PRECEPTOR	UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F1_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000005370	RatGTEx
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/TrEMBL
UniProt	A6K874	ENTREZGENE, UniProtKB/TrEMBL
	D4AEH8_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-05-20	S1pr4	sphingosine-1-phosphate receptor 4	Edg6	endothelial differentiation, G-protein-coupled receptor 6	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-04	Edg6	endothelial differentiation, G-protein-coupled receptor 6	Edg6_predicted	endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 6 (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Edg6_predicted	endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 6 (predicted)		endothelial differentiation, G-protein-coupled receptor 6 (predicted)	Name updated	1299863	APPROVED
2005-01-12	Edg6_predicted	endothelial differentiation, G-protein-coupled receptor 6 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

Imported Annotations - PID (archival)

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Imported Disease Annotations - CTD

Imported Annotations - PID (archival)