Elmo3 (engulfment and cell motility 3)

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Gene: Elmo3 (engulfment and cell motility 3) Rattus norvegicus

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Symbol:

Elmo3

Name:

engulfment and cell motility 3

RGD ID:

1304734

Description:

Predicted to enable SH3 domain binding activity. Predicted to be involved in actin filament organization and cell motility. Predicted to be located in cytoplasm. Orthologous to human ELMO3 (engulfment and cell motility 3); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; atrazine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

engulfment and cell motility 3, ced-12 homolog; engulfment and cell motility 3, ced-12 homolog (C. elegans); engulfment and cell motility protein 3; LOC291962; MGC124673

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ELMO3 (engulfment and cell motility 3)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Elmo3 (engulfment and cell motility 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Elmo3 (engulfment and cell motility 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ELMO3 (engulfment and cell motility 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ELMO3 (engulfment and cell motility 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Elmo3 (engulfment and cell motility 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ELMO3 (engulfment and cell motility 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ELMO3 (engulfment and cell motility 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Elmo3 (engulfment and cell motility 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	ELMO3 (engulfment and cell motility 3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Elmo3 (engulfment and cell motility 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	elmo3 (engulfment and cell motility 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ced-12	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Ced-12	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	elmo3	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	50,091,883 - 50,096,324 (+)	NCBI		GRCr8
mRatBN7.2	19	33,181,952 - 33,186,399 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	33,182,036 - 33,186,410 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	19	39,997,640 - 40,002,003 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	40,650,959 - 40,655,322 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	42,939,898 - 42,944,261 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	37,260,330 - 37,264,832 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	37,260,469 - 37,264,829 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	19	48,126,191 - 48,130,554 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	19	35,119,813 - 35,124,187 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	19	35,124,670 - 35,129,068 (+)	NCBI
Celera	19	32,610,812 - 32,615,147 (+)	NCBI		Celera
Cytogenetic Map	19	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant dyskeratosis congenita 6 (ISO)

Chromosome 16q12 Duplication Syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (EXP,ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

aflatoxin B1 (ISO)

amiodarone (ISO)

aristolochic acid A (ISO)

arsenite(3-) (ISO)

atrazine (EXP)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

butan-1-ol (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

chromium(6+) (ISO)

clofibrate (ISO)

cobalt dichloride (EXP)

Cuprizon (EXP)

cyclosporin A (ISO)

Dibutyl phosphate (ISO)

diuron (EXP)

epoxiconazole (ISO)

ethanol (ISO)

folic acid (ISO)

iron dichloride (ISO)

methapyrilene (EXP)

monosodium L-glutamate (ISO)

oxaliplatin (EXP)

ozone (ISO)

paclitaxel (ISO)

paracetamol (EXP)

PCB138 (ISO)

perfluorooctane-1-sulfonic acid (ISO)

sodium arsenite (ISO)

sodium dichromate (EXP)

sunitinib (ISO)

tamoxifen (ISO)

thioacetamide (EXP)

thiram (ISO)

topotecan (EXP)

triphenyl phosphate (ISO)

trovafloxacin (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin filament organization (IBA)

apoptotic process (IEA)

cell motility (IBA)

phagocytosis (IEA)

Cellular Component

cytoplasm (IEA)

Molecular Function

protein binding (ISO)

SH3 domain binding (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932

Genomics

Comparative Map Data

Elmo3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	50,091,883 - 50,096,324 (+)	NCBI		GRCr8
mRatBN7.2	19	33,181,952 - 33,186,399 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	33,182,036 - 33,186,410 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	19	39,997,640 - 40,002,003 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	40,650,959 - 40,655,322 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	42,939,898 - 42,944,261 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	37,260,330 - 37,264,832 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	37,260,469 - 37,264,829 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	19	48,126,191 - 48,130,554 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	19	35,119,813 - 35,124,187 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	19	35,124,670 - 35,129,068 (+)	NCBI
Celera	19	32,610,812 - 32,615,147 (+)	NCBI		Celera
Cytogenetic Map	19	q11	NCBI

ELMO3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	67,199,131 - 67,204,004 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	67,199,111 - 67,204,029 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	67,233,034 - 67,237,907 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	65,790,529 - 65,795,428 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	16	65,790,912 - 65,795,407	NCBI
Celera	16	51,741,260 - 51,746,159 (+)	NCBI		Celera
Cytogenetic Map	16	q22.1	NCBI
HuRef	16	53,106,204 - 53,111,104 (+)	NCBI		HuRef
CHM1_1	16	68,640,355 - 68,645,256 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	16	72,993,415 - 72,998,288 (+)	NCBI		T2T-CHM13v2.0

Elmo3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	106,032,240 - 106,036,625 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	106,032,233 - 106,037,392 (+)	Ensembl		GRCm39 Ensembl
GRCm38	8	105,305,461 - 105,310,623 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	105,305,601 - 105,310,760 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	107,829,501 - 107,834,523 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	108,194,738 - 108,199,889 (+)	NCBI		MGSCv36	mm8
Celera	8	109,528,749 - 109,533,772 (+)	NCBI		Celera
Cytogenetic Map	8	D3	NCBI
cM Map	8	53.04	NCBI

Elmo3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955484	9,416,605 - 9,421,252 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955484	9,414,573 - 9,421,255 (-)	NCBI	ChiLan1.0	ChiLan1.0

ELMO3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	76,728,815 - 76,733,760 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	82,641,380 - 82,646,303 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	47,544,739 - 47,550,137 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	66,933,133 - 66,938,007 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	66,933,133 - 66,938,007 (+)	Ensembl	panpan1.1		panPan2

ELMO3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	82,164,588 - 82,169,014 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	82,164,629 - 82,170,450 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	82,154,034 - 82,158,629 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	82,599,715 - 82,604,310 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	82,599,756 - 82,605,577 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	82,425,812 - 82,430,407 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	82,111,360 - 82,115,955 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	82,750,634 - 82,755,229 (-)	NCBI		UU_Cfam_GSD_1.0

Elmo3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	41,914,097 - 41,918,598 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936475	17,670,517 - 17,675,039 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936475	17,670,651 - 17,677,367 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ELMO3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	27,841,624 - 27,846,330 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	27,841,559 - 27,846,332 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	25,130,914 - 25,135,708 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ELMO3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	60,253,105 - 60,257,804 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	60,253,252 - 60,257,478 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666047	23,005,165 - 23,009,821 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Elmo3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624746	19,112,808 - 19,117,494 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624746	19,112,808 - 19,117,406 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Elmo3
2 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	43
Count of miRNA genes:	40
Interacting mature miRNAs:	43
Transcripts:	ENSRNOT00000021362
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61447	Tcas1	Tongue tumor susceptibility QTL 1	6.08		tongue integrity trait (VT:0010553)	squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)	19	2316121	47316121	Rat
9590298	Uminl5	Urine mineral level QTL 5	3.59	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	19	1	36824771	Rat
724546	Kidm3	Kidney mass QTL 3	3.1		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	19	29322490	57337602	Rat
1331737	Uae29	Urinary albumin excretion QTL 29	5.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	19	4096155	55283277	Rat
2298478	Eau8	Experimental allergic uveoretinitis QTL 8		0.0163	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	19	17154433	57337602	Rat
1578764	Stresp19	Stress response QTL 19	3.6	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	19	15630201	57337602	Rat
1558656	Prcs1	Prostate cancer susceptibility QTL 1	5		prostate integrity trait (VT:0010571)	percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)	19	15114598	34521833	Rat
9590090	Insglur8	Insulin/glucose ratio QTL 8	10.81	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	19	1	36824771	Rat
1331788	Rf45	Renal function QTL 45	2.818		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	19	15605023	46559041	Rat
1549835	Tcas7	Tongue tumor susceptibility QTL 7		0.001	tongue integrity trait (VT:0010553)	squamous cell carcinoma of the head and neck tumor number (CMO:0001876)	19	24817978	39654489	Rat
724566	Uae12	Urinary albumin excretion QTL 12	5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	19	2187927	56457239	Rat
1354633	Bw28	Body weight QTL 28	6.04		body mass (VT:0001259)	body weight (CMO:0000012)	19	27530207	37947399	Rat
724565	Tcas5	Tongue tumor susceptibility QTL 5	10.04		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	19	9977753	39654489	Rat
8552935	Pigfal10	Plasma insulin-like growth factor 1 level QTL 10	5.7		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	19	1	36824771	Rat
61350	Bp32	Blood pressure QTL 32		0.012	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	19	20483575	57337602	Rat
7411549	Bw130	Body weight QTL 130	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	19	15455860	57337602	Rat
724518	Uae19	Urinary albumin excretion QTL 19	5.5		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	19	7457249	42983518	Rat
8694186	Bw152	Body weight QTL 152	3.34	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	19	569374	45569374	Rat
61423	Cia14	Collagen induced arthritis QTL 14	3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	19	10827970	43544039	Rat
9590250	Scort11	Serum corticosterone level QTL 11	23.45	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	19	1	36824771	Rat
2317848	Alcrsp21	Alcohol response QTL 21	1.899999976158142	0.05	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	19	3204777	48204777	Rat
1354607	Gmadr1	Adrenal mass QTL 1	5.83		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	19	27530207	37947399	Rat
9589102	Slep13	Serum leptin concentration QTL 13	4.63	0.001	blood leptin amount (VT:0005667)	plasma leptin level (CMO:0000781)	19	569374	45569374	Rat
7247442	Uae39	Urinary albumin excretion QTL 39			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	19	2187927	46708701	Rat
1354600	Salc2	Saline consumption QTL 2	9.91	0.001	drinking behavior trait (VT:0001422)	saline drink intake rate (CMO:0001627)	19	27530207	37947399	Rat

Markers in Region

RH127566

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	19	33,181,504 - 33,181,684 (+)	MAPPER	mRatBN7.2
Rnor_6.0	19	37,259,938 - 37,260,117	NCBI	Rnor6.0
Rnor_5.0	19	48,125,660 - 48,125,839	UniSTS	Rnor5.0
RGSC_v3.4	19	35,119,282 - 35,119,461	UniSTS	RGSC3.4
Celera	19	32,610,281 - 32,610,460	UniSTS
RH 3.4 Map	19	360.81	UniSTS
Cytogenetic Map	19	q11	UniSTS

RH131523

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	19	33,186,165 - 33,186,366 (+)	MAPPER	mRatBN7.2
Rnor_6.0	19	37,264,599 - 37,264,799	NCBI	Rnor6.0
Rnor_5.0	19	48,130,321 - 48,130,521	UniSTS	Rnor5.0
RGSC_v3.4	19	35,123,954 - 35,124,154	UniSTS	RGSC3.4
RH 3.4 Map	19	363.01	UniSTS
Cytogenetic Map	19	q11	UniSTS

RH131578

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	19	33,188,378 - 33,188,537 (+)	MAPPER	mRatBN7.2
Rnor_6.0	19	37,266,810 - 37,266,968	NCBI	Rnor6.0
Rnor_5.0	19	48,132,532 - 48,132,690	UniSTS	Rnor5.0
RGSC_v3.4	19	35,126,165 - 35,126,323	UniSTS	RGSC3.4
Celera	19	32,616,981 - 32,617,139	UniSTS
RH 3.4 Map	19	363.91	UniSTS
Cytogenetic Map	19	q11	UniSTS

BI292813

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	19	33,186,678 - 33,186,842 (+)	MAPPER	mRatBN7.2
Rnor_6.0	19	37,265,112 - 37,265,275	NCBI	Rnor6.0
Rnor_5.0	19	48,130,834 - 48,130,997	UniSTS	Rnor5.0
RGSC_v3.4	19	35,124,467 - 35,124,630	UniSTS	RGSC3.4
RH 3.4 Map	19	276.21	UniSTS
Cytogenetic Map	19	q11	UniSTS

BE109595

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	19	33,181,773 - 33,181,924 (+)	MAPPER	mRatBN7.2
Rnor_6.0	19	37,260,207 - 37,260,357	NCBI	Rnor6.0
Rnor_5.0	19	48,125,929 - 48,126,079	UniSTS	Rnor5.0
RGSC_v3.4	19	35,119,551 - 35,119,701	UniSTS	RGSC3.4
Celera	19	32,610,550 - 32,610,700	UniSTS
RH 3.4 Map	19	363.91	UniSTS
Cytogenetic Map	19	q11	UniSTS

AA998249

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	19	33,181,552 - 33,181,692 (+)	MAPPER	mRatBN7.2
Rnor_6.0	19	37,259,986 - 37,260,125	NCBI	Rnor6.0
Rnor_5.0	19	48,125,708 - 48,125,847	UniSTS	Rnor5.0
RGSC_v3.4	19	35,119,330 - 35,119,469	UniSTS	RGSC3.4
Celera	19	32,610,329 - 32,610,468	UniSTS
RH 3.4 Map	19	361.22	UniSTS
Cytogenetic Map	19	q11	UniSTS

E2F4_601

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	19	33,181,030 - 33,181,826 (+)	MAPPER	mRatBN7.2
Rnor_6.0	19	37,259,464 - 37,260,259	NCBI	Rnor6.0
Rnor_5.0	19	48,125,186 - 48,125,981	UniSTS	Rnor5.0
RGSC_v3.4	19	35,118,808 - 35,119,603	UniSTS	RGSC3.4
Celera	19	32,609,807 - 32,610,602	UniSTS
Cytogenetic Map	19	q11	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001030028	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008772480	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017601224	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039097605	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039097606	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005496633	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005496634	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC120484	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC099761	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473972	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000019	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000021362 ⟹ ENSRNOP00000021362

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	19	33,182,036 - 33,186,410 (+)	Ensembl
Rnor_6.0 Ensembl	19	37,260,469 - 37,264,829 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000097929 ⟹ ENSRNOP00000076644

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	19	33,182,036 - 33,186,410 (+)	Ensembl

RefSeq Acc Id:

NM_001030028 ⟹ NP_001025199

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	50,091,961 - 50,096,324 (+)	NCBI
mRatBN7.2	19	33,182,036 - 33,186,399 (+)	NCBI
Rnor_6.0	19	37,260,469 - 37,264,832 (+)	NCBI
Rnor_5.0	19	48,126,191 - 48,130,554 (+)	NCBI
RGSC_v3.4	19	35,119,813 - 35,124,187 (+)	RGD
Celera	19	32,610,812 - 32,615,147 (+)	NCBI

Sequence:

show sequence

GAGCCCGACCAGGAGTAGGAGCCTGAACTGTGAATGCAGGCCACCGAAGCCAGACTCTAGACAG
AGGAAGGTCTTCCTAGACCCTAGATCAGTTGCACCCACGGCGGGAGGTGGCACGGCCACGGCGG
CTGGACTATGGCGCCCCCGCGGAATGTGGTGAAGATTGCCGTTCAGATGTCTGACGCCATCCCA
CAGCTTATCCAGCTAGACCAGGCAAAGCCCCTGGCCACTGTTCTGAAGGAGGTGTGTGACACGT
GGAGCCTGACTCATCCGGAGCACTATGCCCTTCAGTTTGCTGATGGGCACAGGAAATACATCAC
AGAGAATAACCGCTCGGAGATCAAGAATGGAAGCATCCTGTGCCTCAGTACTGCCCCAGATCTG
AAGGCCCAGCAGCTACTGAGTAGGCTGCAGAATGCGAGTCGTGAAGGGTGCTGTGAAGTCCTGA
GAAACCTGGTCCCGCTGGCCTCAGACATGACCTTTGCCCAGGAGGTCATCAGTCGTGATGGGCT
TCAGAAATTAAGCACCATCATTGAAAATGGGGATGACCTAGGGGAGATGCTGGCCCTTGGGCTA
AGGGCTTTCCTGGAGCTCATGGAACACGGAGTAGTGTCTTGGGAGACACTCAGCATTTCCTTTG
TCAGGAAGGTGGTATCTTATGTGAACATGAACTTGATGGATGCCTCTGTGCAGCCCCTGGCCCT
CAGGCTACTGGAGAGTGTGACCCTGAGCAGCCCTACCCTGGGCCAGCTGGTGAAGAGTGAGGTG
CCACTAGACAGGCTGCTAGTGCACCTGCAGGTAATGAACCAGCAGCTGCAAACCAAGGCTATGG
CACTGCTGACAGCCCTGCTGCAGGGGGCCAGCCCTGCTGAGCGTAAGGACATGCTTGACTGCCT
ATGGAAGAAGAATCTTCGCCAGTTCATCTACAAGAACATCATCCACAGTGCAGCACCCATGGGT
GACGAGATGGCTCATCACTTGTATGTGCTGCAGGCTCTAACACTGGGGCTGCTGGAGCCACGTA
TGCGGACACCCCTTGATCCCTACAGCCAGGAGCAGCGGGAGCAGCTACAGGCCCTGCGCCAGGC
AGCCTTTGAACCAGACGGGGAGTCCTTGGGCACAGGCCTGAGTGCTGACCGCCGCCGGTCTCTC
TGTGTCCGAGAGTTCCGCAAGCTAGGCTTCTCCAATAGCAGCCCGGCCCAGGACCTGGAACGTG
TGCCCCCTGGCCTACTGGCCCTGGACAACATGCTCTACTTCTCCAGACATGCGCCTAGTGCATA
CAGTCGGTTCGTGTTGGAGAACAGTAGCCGAGAGGACAAGCATGAATGCCCCTTTGCCCGGAGC
AGCATTCAGCTGACAGTGTTGCTGTGTGAGCTGCTCCATGTTGGGGAGCCTTGCTCCGAGACCG
CCCAGGACTTCTCACCCATGTTCTTCAGCCAAGACCACAGTTTCCATGAGCTCTTTTGTGTGGC
TATCCAGCTGCTGAATAAGACCTGGAAGGAAATGCGGGCAACACAGGAGGATTTTGACAAGGTA
ATGCAGGTGGTTCGGGAACAGCTAGCCCGTACCCTGGCTCTGAAGCCCACCTCTCTGGAGCTCT
TTCGAACCAAAGTAAATGCCCTCACCTATGGGGAAGTGTTGAGGCTGCGACAGACAGAGCGGCT
GCACCAAGAGGGCACATTGGCCCCTCCTATCTTGGAGCTCCGAGAGAAGCTGAAGCCAGAGCTC
ATGGGTTTAATCCGCCAGCAGCGTTTGCTCCGACTCTGTGAGGGAATGCTCTTCCGCAAGATCA
GCAGCCGGAGACGCCAGGACAAGCTATGGTTTTGCTGTTTATCCCCCAACCATAAAGTACTGCA
GTATGGCGATGTGGAGGAGGGCGCCAACCCTCCCACCTTAGAAAGCCTAACTGAACAACTCCCT
GTGGCTGACATCAGGGCACTCCTAATGGGCAAGGACTGCCCCCATGTCCGGGAGAAGGGCTCTG
GGAAGCAGAACAAGGACCTCTATGAGTTGGCCTTCTCCATCAGCTATGACCATGGGGAGGAAGA
AGCATACCTCAACTTCATTGCCCCCTCCAAACGGGATTTCTACCTGTGGACAGATGGACTGAGT
GCCCTGCTGGGCAGTACTATGGGGAGTGAACAGACTCGGCTAGACCTGGAGCAGCTGCTCACTA
TGGAGACCAAGTTGCGGTTGTTGGAACTGGAGAATGTGCCCATTCCTGAGCATCCTCCCCCAGT
ACCCCCACCTCCTACCAACTTTAACTTCTGCTATGACTACAGCATGACTGAGCCTTGACTGAAG
TTAGGCTACAGTTGATACTGCTGTAGCAGCCACAAAAAGGGTTGAGAATCACAGACAGCCTGAC
CAGAGCCTGTAGCAGAAATAAAGTTACCTTTGCTTATAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039097605 ⟹ XP_038953533

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	50,091,883 - 50,096,324 (+)	NCBI
mRatBN7.2	19	33,182,107 - 33,186,399 (+)	NCBI

RefSeq Acc Id:

XM_039097606 ⟹ XP_038953534

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	50,091,883 - 50,095,760 (+)	NCBI
mRatBN7.2	19	33,181,952 - 33,185,835 (+)	NCBI

RefSeq Acc Id:

XR_005496633

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	50,091,883 - 50,095,887 (+)	NCBI
mRatBN7.2	19	33,181,952 - 33,185,967 (+)	NCBI

RefSeq Acc Id:

XR_005496634

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	50,091,883 - 50,096,046 (+)	NCBI
mRatBN7.2	19	33,181,952 - 33,186,122 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001025199	(Get FASTA)	NCBI Sequence Viewer
	XP_038953533	(Get FASTA)	NCBI Sequence Viewer
	XP_038953534	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH99761	(Get FASTA)	NCBI Sequence Viewer
	EDL92365	(Get FASTA)	NCBI Sequence Viewer
	EDL92366	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000021362.6
	ENSRNOP00000076644.1
	ENSRNOP00055025280
	ENSRNOP00060016567
	ENSRNOP00065015704
GenBank Protein	Q499U2	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001025199 ⟸ NM_001030028

- UniProtKB:

Q499U2 (UniProtKB/Swiss-Prot), A0A8I5YBT5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAPPRNVVKIAVQMSDAIPQLIQLDQAKPLATVLKEVCDTWSLTHPEHYALQFADGHRKYITEN
NRSEIKNGSILCLSTAPDLKAQQLLSRLQNASREGCCEVLRNLVPLASDMTFAQEVISRDGLQK
LSTIIENGDDLGEMLALGLRAFLELMEHGVVSWETLSISFVRKVVSYVNMNLMDASVQPLALRL
LESVTLSSPTLGQLVKSEVPLDRLLVHLQVMNQQLQTKAMALLTALLQGASPAERKDMLDCLWK
KNLRQFIYKNIIHSAAPMGDEMAHHLYVLQALTLGLLEPRMRTPLDPYSQEQREQLQALRQAAF
EPDGESLGTGLSADRRRSLCVREFRKLGFSNSSPAQDLERVPPGLLALDNMLYFSRHAPSAYSR
FVLENSSREDKHECPFARSSIQLTVLLCELLHVGEPCSETAQDFSPMFFSQDHSFHELFCVAIQ
LLNKTWKEMRATQEDFDKVMQVVREQLARTLALKPTSLELFRTKVNALTYGEVLRLRQTERLHQ
EGTLAPPILELREKLKPELMGLIRQQRLLRLCEGMLFRKISSRRRQDKLWFCCLSPNHKVLQYG
DVEEGANPPTLESLTEQLPVADIRALLMGKDCPHVREKGSGKQNKDLYELAFSISYDHGEEEAY
LNFIAPSKRDFYLWTDGLSALLGSTMGSEQTRLDLEQLLTMETKLRLLELENVPIPEHPPPVPP
PPTNFNFCYDYSMTEP

hide sequence

Ensembl Acc Id:

ENSRNOP00000021362 ⟸ ENSRNOT00000021362

RefSeq Acc Id:	XP_038953534 ⟸ XM_039097606
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038953533 ⟸ XM_039097605
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I5YBT5 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000076644 ⟸ ENSRNOT00000097929

Protein Domains

ELMO PH

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q499U2-F1-model_v2	AlphaFold	Q499U2	1-720	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701070

Promoter ID:

EPDNEW_R11594

Type:

initiation region

Name:

Elmo3_1

Description:

engulfment and cell motility 3

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	19	37,260,447 - 37,260,507	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1304734	AgrOrtholog
BioCyc Gene	G2FUF-5842	BioCyc
Ensembl Genes	ENSRNOG00000015800	Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSRNOG00055018439	UniProtKB/Swiss-Prot
	ENSRNOG00060012384	UniProtKB/Swiss-Prot
	ENSRNOG00065012576	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000021362.7	UniProtKB/Swiss-Prot
	ENSRNOT00000097929.1	UniProtKB/TrEMBL
	ENSRNOT00055031322	UniProtKB/Swiss-Prot
	ENSRNOT00060020993	UniProtKB/Swiss-Prot
	ENSRNOT00065020447	UniProtKB/Swiss-Prot
Gene3D-CATH	1.25.10.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	2.30.29.30	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	6.10.250.810	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7930411	IMAGE-MGC_LOAD
InterPro	ARM-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ARM-type_fold	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	DUF3361	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ELMO_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ELMO_domain-containing	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PH-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PH_domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:291962	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:124673	IMAGE-MGC_LOAD
NCBI Gene	291962	ENTREZGENE
PANTHER	ENGULFMENT AND CELL MOTILITY	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR12771:SF16	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	DUF3361	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ELMO_CED12	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PH_12	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Elmo3	PhenoGen
PROSITE	ELMO	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000015800	RatGTEx
	ENSRNOG00055018439	RatGTEx
	ENSRNOG00060012384	RatGTEx
	ENSRNOG00065012576	RatGTEx
Superfamily-SCOP	PH domain-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF48371	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I5YBT5	ENTREZGENE, UniProtKB/TrEMBL
	A6IYN8_RAT	UniProtKB/TrEMBL
	ELMO3_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-10-28	Elmo3	engulfment and cell motility 3	Elmo3	engulfment and cell motility 3, ced-12 homolog (C. elegans)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Elmo3	engulfment and cell motility 3, ced-12 homolog (C. elegans)	Elmo3_predicted	engulfment and cell motility 3, ced-12 homolog (C. elegans) (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Elmo3_predicted	engulfment and cell motility 3, ced-12 homolog (C. elegans) (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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