Pank1 (pantothenate kinase 1) - Rat Genome Database

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Gene: Pank1 (pantothenate kinase 1) Rattus norvegicus
Analyze
Symbol: Pank1
Name: pantothenate kinase 1
RGD ID: 1304677
Description: Predicted to enable acetyl-CoA binding activity; pantothenate kinase activity; and protein homodimerization activity. Predicted to be involved in coenzyme A biosynthetic process. Predicted to be located in cell periphery and cytoplasm. Predicted to be active in cytosol and nucleus. Orthologous to human PANK1 (pantothenate kinase 1); PARTICIPATES IN Fanconi syndrome pathway; fructose-1,6-bisphosphatase deficiency pathway; gluconeogenesis pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC294088
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81241,737,371 - 241,808,126 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1241,741,083 - 241,807,824 (-)EnsemblGRCr8
mRatBN7.21232,324,718 - 232,395,445 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1232,328,430 - 232,396,829 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1240,724,470 - 240,789,944 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01247,637,502 - 247,702,944 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01240,475,685 - 240,541,125 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01253,115,400 - 253,189,643 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1253,119,112 - 253,185,533 (-)Ensemblrn6Rnor6.0
Rnor_5.01260,338,622 - 260,408,174 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41238,797,912 - 238,857,586 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1229,441,874 - 229,506,938 (-)NCBICelera
RGSC_v3.11238,963,564 - 239,024,786 (-)NCBI
Cytogenetic Map1q53NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-methylcholine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
acetamide  (EXP)
actinomycin D  (ISO)
adefovir pivoxil  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
beta-D-glucosamine  (ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
camptothecin  (ISO)
carbon nanotube  (ISO)
chloroacetaldehyde  (ISO)
chlorpyrifos  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP)
copper(II) sulfate  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (EXP,ISO)
dextran sulfate  (ISO)
dichloroacetic acid  (ISO)
dioxygen  (ISO)
elemental selenium  (ISO)
ethyl methanesulfonate  (ISO)
fenofibrate  (EXP,ISO)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
hydrogen cyanide  (ISO)
ibuprofen  (EXP,ISO)
ifosfamide  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
metformin  (EXP)
methapyrilene  (EXP)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monoethyl phthalate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP)
nitrofen  (EXP)
Nutlin-3  (ISO)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perflubutane  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (ISO)
pirinixic acid  (EXP,ISO)
potassium cyanide  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
rotenone  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
sunitinib  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (EXP)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cell periphery  (IEA,ISO)
clathrin coat  (ISO)
cytoplasm  (IEA,ISO)
cytosol  (IBA,IEA,ISO)
nucleus  (IBA,ISO)
recycling endosome  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12095677   PMID:12095680   PMID:16040613   PMID:17631502   PMID:20559429   PMID:22072979   PMID:22815849   PMID:23152917  


Genomics

Comparative Map Data
Pank1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81241,737,371 - 241,808,126 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1241,741,083 - 241,807,824 (-)EnsemblGRCr8
mRatBN7.21232,324,718 - 232,395,445 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1232,328,430 - 232,396,829 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1240,724,470 - 240,789,944 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01247,637,502 - 247,702,944 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01240,475,685 - 240,541,125 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01253,115,400 - 253,189,643 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1253,119,112 - 253,185,533 (-)Ensemblrn6Rnor6.0
Rnor_5.01260,338,622 - 260,408,174 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41238,797,912 - 238,857,586 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1229,441,874 - 229,506,938 (-)NCBICelera
RGSC_v3.11238,963,564 - 239,024,786 (-)NCBI
Cytogenetic Map1q53NCBI
PANK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381089,579,495 - 89,645,242 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1089,579,497 - 89,645,242 (-)Ensemblhg38GRCh38
GRCh371091,339,252 - 91,404,999 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361091,332,729 - 91,395,195 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341091,332,728 - 91,393,627NCBI
Celera1085,089,566 - 85,152,033 (-)NCBICelera
Cytogenetic Map10q23.31NCBI
HuRef1084,973,212 - 85,039,292 (-)NCBIHuRef
CHM1_11091,621,351 - 91,687,428 (-)NCBICHM1_1
T2T-CHM13v2.01090,463,392 - 90,529,134 (-)NCBIT2T-CHM13v2.0
Pank1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391934,784,335 - 34,862,420 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1934,784,340 - 34,856,855 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381934,806,935 - 34,883,423 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1934,806,940 - 34,879,455 (-)Ensemblmm10GRCm38
MGSCv371934,885,384 - 34,953,945 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361934,876,891 - 34,943,914 (-)NCBIMGSCv36mm8
Celera1935,587,739 - 35,653,112 (-)NCBICelera
Cytogenetic Map19C1NCBI
cM Map1929.79NCBI
Pank1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554253,384,200 - 3,432,431 (+)Ensembl
ChiLan1.0NW_0049554253,384,023 - 3,433,808 (+)NCBIChiLan1.0ChiLan1.0
PANK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28101,601,436 - 101,722,040 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110101,606,750 - 101,727,618 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01086,302,702 - 86,428,635 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11089,847,888 - 89,912,765 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1089,847,888 - 89,912,765 (-)EnsemblpanPan2panpan1.1
PANK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1284,476,920 - 4,534,501 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha284,711,397 - 4,768,480 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0284,698,818 - 4,755,649 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl284,695,285 - 4,757,129 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1284,449,253 - 4,506,347 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0284,491,681 - 4,548,997 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0284,627,511 - 4,685,087 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pank1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721342,945,529 - 43,006,702 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366014,578,394 - 4,638,170 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366014,578,132 - 4,639,305 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PANK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14101,409,253 - 101,473,945 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.114101,410,139 - 101,512,498 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214110,396,399 - 110,498,885 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PANK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1982,959,606 - 83,069,759 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl982,961,004 - 83,021,850 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604843,630,697 - 43,753,361 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pank1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624737471,485 - 544,545 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624737474,996 - 544,766 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Pank1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1234,422,365 - 34,491,054 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pank1
346 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:188
Count of miRNA genes:137
Interacting mature miRNAs:170
Transcripts:ENSRNOT00000067822
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8693637Alc29Alcohol consumption QTL 292.70.258drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1217412367243666627Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1207243873252243873Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1210980612255980612Rat
61455Niddm7Non-insulin dependent diabetes mellitus QTL 75.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1223964326248681945Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1226175591270518180Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1218829748263829748Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1210980612255980612Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1237995023269633915Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1233480549270108840Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1200449456256003563Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1234540191270518180Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1233480549270108840Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1207163993269633915Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1210980612255980612Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1223134011262090599Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1210980612255980612Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1207243873252243873Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2314011Gluco56Glucose level QTL 56blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1209203273254203273Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1202543537247543537Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1225108840270108840Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1228180370266453608Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
1358292Cm37Cardiac mass QTL 376.28e-07heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1205674651250674651Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1207243873252243873Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1208479811269633915Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1224633915269633915Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1232312773270518180Rat
2316896Gluco57Glucose level QTL 577.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1238398865255849249Rat
1358916Kidm22Kidney mass QTL 223.32kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1212738576257738576Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1188241285250779312Rat
2292218Kidm35Kidney mass QTL 35kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1208798288253798288Rat
61400Niddm1Non-insulin dependent diabetes mellitus QTL 111blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1228180243255849249Rat
61403Niddm4Non-insulin dependent diabetes mellitus QTL 4blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1201464383246464383Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1203675682248675682Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1205674651250674651Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1210980612255980612Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1210980612255980612Rat
7387289Uae45Urinary albumin excretion QTL 452.860.0021urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1233204160270518180Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1207099883252099883Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1241569529269633915Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1210980612255980612Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1226175591270518180Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233349180270518180Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1210980612255980612Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1228174566270518180Rat

Markers in Region
BB440150  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21232,392,480 - 232,392,649 (+)MAPPERmRatBN7.2
Rnor_6.01253,184,207 - 253,184,375NCBIRnor6.0
Rnor_5.01260,402,748 - 260,402,916UniSTSRnor5.0
RGSC_v3.41238,856,260 - 238,856,428UniSTSRGSC3.4
Celera1229,505,612 - 229,505,780UniSTS
Cytogenetic Map1q52UniSTS
AA850195  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21232,328,438 - 232,328,563 (+)MAPPERmRatBN7.2
Rnor_6.01253,119,121 - 253,119,245NCBIRnor6.0
Rnor_5.01260,338,645 - 260,338,769UniSTSRnor5.0
Celera1229,441,882 - 229,442,037UniSTS
RH 3.4 Map4511.02UniSTS
Cytogenetic Map1q52UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 74 168 91 90 59 92 59 6 381 200 12 149 98 94 31 19 19

Sequence


Ensembl Acc Id: ENSRNOT00000067822   ⟹   ENSRNOP00000063874
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1241,741,083 - 241,806,463 (-)Ensembl
mRatBN7.2 Ensembl1232,328,430 - 232,393,807 (-)Ensembl
Rnor_6.0 Ensembl1253,119,112 - 253,185,533 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096368   ⟹   ENSRNOP00000083785
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1241,741,083 - 241,806,278 (-)Ensembl
mRatBN7.2 Ensembl1232,328,430 - 232,393,622 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100218   ⟹   ENSRNOP00000082596
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1241,741,083 - 241,807,824 (-)Ensembl
mRatBN7.2 Ensembl1232,328,430 - 232,396,829 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000135780   ⟹   ENSRNOP00000107764
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1241,749,309 - 241,807,824 (-)Ensembl
RefSeq Acc Id: NM_001106373   ⟹   NP_001099843
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81241,741,083 - 241,806,463 (-)NCBI
mRatBN7.21232,328,430 - 232,393,807 (-)NCBI
Rnor_6.01253,119,112 - 253,185,533 (-)NCBI
Rnor_5.01260,338,622 - 260,408,174 (-)NCBI
RGSC_v3.41238,797,912 - 238,857,586 (-)RGD
Celera1229,441,874 - 229,506,938 (-)RGD
Sequence:
RefSeq Acc Id: XM_006231276   ⟹   XP_006231338
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81241,737,371 - 241,808,116 (-)NCBI
mRatBN7.21232,324,718 - 232,395,445 (-)NCBI
Rnor_6.01253,115,400 - 253,189,639 (-)NCBI
Rnor_5.01260,338,622 - 260,408,174 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006231277   ⟹   XP_006231339
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81241,737,371 - 241,808,126 (-)NCBI
mRatBN7.21232,324,718 - 232,395,445 (-)NCBI
Rnor_6.01253,115,400 - 253,189,643 (-)NCBI
Rnor_5.01260,338,622 - 260,408,174 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006231278   ⟹   XP_006231340
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81241,737,371 - 241,807,023 (-)NCBI
mRatBN7.21232,324,718 - 232,394,357 (-)NCBI
Rnor_6.01253,115,400 - 253,186,127 (-)NCBI
Rnor_5.01260,338,622 - 260,408,174 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039109256   ⟹   XP_038965184
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81241,737,371 - 241,807,268 (-)NCBI
mRatBN7.21232,324,718 - 232,394,625 (-)NCBI
RefSeq Acc Id: NP_001099843   ⟸   NM_001106373
- UniProtKB: D3ZWD3 (UniProtKB/TrEMBL),   A6I140 (UniProtKB/TrEMBL),   A6I139 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231339   ⟸   XM_006231277
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006231338   ⟸   XM_006231276
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZUU2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231340   ⟸   XM_006231278
- Peptide Label: isoform X3
- UniProtKB: A6I139 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000063874   ⟸   ENSRNOT00000067822
RefSeq Acc Id: XP_038965184   ⟸   XM_039109256
- Peptide Label: isoform X4
- UniProtKB: A0A8I6G9G6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000083785   ⟸   ENSRNOT00000096368
Ensembl Acc Id: ENSRNOP00000082596   ⟸   ENSRNOT00000100218
Ensembl Acc Id: ENSRNOP00000107764   ⟸   ENSRNOT00000135780

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZWD3-F1-model_v2 AlphaFold D3ZWD3 1-373 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690868
Promoter ID:EPDNEW_R1393
Type:multiple initiation site
Name:Pank1_1
Description:pantothenate kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01253,185,469 - 253,185,529EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304677 AgrOrtholog
BioCyc Gene G2FUF-55865 BioCyc
BioCyc Pathway COA-PWY-1 [superpathway of coenzyme A biosynthesis III (mammals)] BioCyc
BioCyc Pathway Image COA-PWY-1 BioCyc
Ensembl Genes ENSRNOG00000018944 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000067822 ENTREZGENE
  ENSRNOT00000067822.4 UniProtKB/TrEMBL
  ENSRNOT00000096368 ENTREZGENE
  ENSRNOT00000096368.2 UniProtKB/TrEMBL
  ENSRNOT00000100218 ENTREZGENE
  ENSRNOT00000100218.2 UniProtKB/TrEMBL
  ENSRNOT00000135780.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.420.40 UniProtKB/TrEMBL
  3.30.420.510 UniProtKB/TrEMBL
InterPro ATPase_NBD UniProtKB/TrEMBL
  PanK_eukar UniProtKB/TrEMBL
KEGG Report rno:294088 UniProtKB/TrEMBL
NCBI Gene 294088 ENTREZGENE
PANTHER PANTOTHENATE KINASE 1 UniProtKB/TrEMBL
  PTHR12280 UniProtKB/TrEMBL
Pfam Fumble UniProtKB/TrEMBL
PhenoGen Pank1 PhenoGen
RatGTEx ENSRNOG00000018944 RatGTEx
Superfamily-SCOP SSF53067 UniProtKB/TrEMBL
UniProt A0A8I5ZUU2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G9G6 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LUD8_RAT UniProtKB/TrEMBL
  A6I139 ENTREZGENE, UniProtKB/TrEMBL
  A6I140 ENTREZGENE, UniProtKB/TrEMBL
  D3ZWD3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Pank1  pantothenate kinase 1   Pank1_predicted  pantothenate kinase 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Pank1_predicted  pantothenate kinase 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED